JP2002508970A - ヒトプロテアーゼ分子 - Google Patents

ヒトプロテアーゼ分子

Info

Publication number
JP2002508970A
JP2002508970A JP2000540252A JP2000540252A JP2002508970A JP 2002508970 A JP2002508970 A JP 2002508970A JP 2000540252 A JP2000540252 A JP 2000540252A JP 2000540252 A JP2000540252 A JP 2000540252A JP 2002508970 A JP2002508970 A JP 2002508970A
Authority
JP
Japan
Prior art keywords
seq
hupm
sequence
polynucleotide
purified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000540252A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002508970A5 (https=
Inventor
バンドマン、オルガ
ヒルマン、ジェニファー・エル
ユエ、ヘンリー
ゲグラー、カール・ジェイ
コーレイ、ニール・シー
タング、ワイ・トム
シャー、パルビ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Incyte Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Pharmaceuticals Inc filed Critical Incyte Pharmaceuticals Inc
Publication of JP2002508970A publication Critical patent/JP2002508970A/ja
Publication of JP2002508970A5 publication Critical patent/JP2002508970A5/ja
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472Cysteine endopeptidases (3.4.22)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478Aspartic endopeptidases (3.4.23)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2000540252A 1998-01-16 1999-01-12 ヒトプロテアーゼ分子 Pending JP2002508970A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/008,271 US6203979B1 (en) 1998-01-16 1998-01-16 Human protease molecules
US09/008,271 1998-01-16
PCT/US1999/000655 WO1999036550A2 (en) 1998-01-16 1999-01-12 Human protease molecules

Publications (2)

Publication Number Publication Date
JP2002508970A true JP2002508970A (ja) 2002-03-26
JP2002508970A5 JP2002508970A5 (https=) 2006-02-16

Family

ID=21730708

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000540252A Pending JP2002508970A (ja) 1998-01-16 1999-01-12 ヒトプロテアーゼ分子

Country Status (6)

Country Link
US (1) US6203979B1 (https=)
EP (1) EP1045913A2 (https=)
JP (1) JP2002508970A (https=)
AU (1) AU2113599A (https=)
CA (1) CA2317094A1 (https=)
WO (1) WO1999036550A2 (https=)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060587A (en) * 1996-01-29 2000-05-09 The Trustees Of The University Of Pennsylvania Cellular receptor for HIV-1 VPR essential for G2/M phase transition of the cell cycle
US6642013B1 (en) * 1997-08-21 2003-11-04 The University Of Arkansas For Medical Sciences Extracellular serine protease
EP0897986A3 (en) * 1997-08-21 2000-07-05 Smithkline Beecham Corporation Aspartic proteinase 5 (ASP5)
US7732163B2 (en) * 1997-08-21 2010-06-08 Board Of Trustees Of The University Of Arkansas Extracellular serine protease
US7157084B2 (en) * 1997-08-21 2007-01-02 The Board Of Trustees Of The University Of Arkansas System Extracellular serine protease
US20030060612A1 (en) * 1997-10-28 2003-03-27 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US7045333B1 (en) * 1998-01-16 2006-05-16 Incyte Corporation Human protease molecules
US6140056A (en) * 1999-01-27 2000-10-31 Millennium Pharmaceuticals, Inc. MSP-18 protein and nucleic acid molecules and uses therefor
US20020072089A1 (en) * 1999-11-23 2002-06-13 Holtzman Douglas A. Novel ITALY, Lor-2, STRIFE, TRASH, BDSF, LRSG, and STMST protein and nucleic acid molecules and uses therefor
AU2577699A (en) 1998-02-06 1999-08-23 Human Genome Sciences, Inc. Human serine protease and serpin polypeptides
JPH11225765A (ja) * 1998-02-13 1999-08-24 Suntory Ltd 新規セリンプロテアーゼ
US6861215B1 (en) * 1998-05-21 2005-03-01 Diadexus, Inc. Method of diagnosing, monitoring, and staging prostate cancer
CA2328138A1 (en) * 1998-05-21 1999-11-25 Diadexus Llc A novel method of diagnosing, monitoring, and staging lung cancer
US7160679B1 (en) * 1998-05-21 2007-01-09 Diadexus, Inc. Method of diagnosing, monitoring, and staging lung cancer
US6902721B1 (en) * 1998-07-10 2005-06-07 Osteoscreen, Inc. Inhibitors of proteasomal activity for stimulating bone growth
WO2000012758A1 (en) 1998-09-02 2000-03-09 Diadexus Llc A novel method of diagnosing, monitoring, staging, imaging and treating various cancers
US6902892B1 (en) * 1998-10-19 2005-06-07 Diadexus, Inc. Method of diagnosing, monitoring, staging, imaging and treating prostate cancer
US20030009013A1 (en) * 1998-12-30 2003-01-09 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
CA2378796A1 (en) * 1999-07-12 2001-01-18 Merck Patent Gesellschaft Mit Beschraenkter Haftung Seripancrin
US20020151047A1 (en) * 2001-01-08 2002-10-17 Yi Hu Novel human protease and polynucleotides encoding the same
CA2388450C (en) * 1999-10-20 2013-02-12 The Board Of Trustees Of The University Of Arkansas Tadg-15: an extracellular serine protease overexpressed in carcinomas
US6677442B1 (en) * 1999-10-29 2004-01-13 University Of Kentucky Research Foundation Nucleic acid encoding human REV1 protein
IL149340A0 (en) 1999-11-18 2002-11-10 Corvas Int Inc Nucleic acids encoding endotheliases, endotheliases and uses thereof
JP2004502402A (ja) * 2000-01-06 2004-01-29 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒトプロテアーゼおよびそれをコードするポリヌクレオチド
US6455668B1 (en) * 2000-01-28 2002-09-24 Eos Biotechnology, Inc. Methods of diagnosing colorectal cancer, compositions, and methods of screening for colorectal cancer modulators
EP1252300B1 (en) * 2000-02-03 2011-01-19 Dendreon Corporation Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon
US6750034B1 (en) * 2000-06-30 2004-06-15 Ortho-Mcneil Pharmaceutical, Inc. DNA encoding human serine protease D-G
WO2002072786A2 (en) 2001-03-13 2002-09-19 Corvas International, Inc. Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon
AU2002254357A1 (en) 2001-03-22 2002-10-08 Dendreon Corporation Nucleic acid molecules encoding serine protease cvsp14, the encoded polypeptides and methods based thereon
US6294368B1 (en) * 2001-03-22 2001-09-25 Applera Corporation Isolated human metalloprotease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof
CA2442089A1 (en) 2001-03-27 2002-10-03 Dendreon San Diego Llc Nucleic acid molecules encoding a transmembran serine protease 9, the encoded polypeptides and methods based thereon
US20040236091A1 (en) * 2001-03-28 2004-11-25 Chicz Roman M. Translational profiling
US7112430B2 (en) 2001-05-14 2006-09-26 Dendreon Corporation Nucleic acid molecules encoding a transmembrane serine protease 10, the encoded polypeptides and methods based thereon
US7196163B2 (en) * 2001-05-22 2007-03-27 Merk & Co., Inc. Assays using amyloid precursor proteins with modified β-secretase cleavage sites to monitor β-secretase activity
CA2448142A1 (en) * 2001-05-22 2002-11-28 Merck & Co., Inc. Beta-secretase substrates and uses thereof
AU2002341683A1 (en) * 2001-09-17 2003-04-01 Millennium Pharmaceuticals, Inc. Methods of using 22417, a novel human aminoprotease family member
WO2003027145A1 (fr) * 2001-09-26 2003-04-03 Riken Inducteur de mort cellulaire, cellules et animaux exprimant cet inducteur, et procede de criblage de medicament anti-mort cellulaire
CN1681487A (zh) * 2002-07-15 2005-10-12 美瑞德生物工程公司 化合物、组合物及其使用方法
EP1646357A4 (en) * 2003-06-27 2007-01-10 Diadexus Inc PRO104 ANTIBODY COMPOSITIONS AND APPLICATION PROCEDURES
EP1687630A2 (en) * 2003-10-17 2006-08-09 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with aminopeptidase-like 1 (npepl1)
DE102004004924B4 (de) * 2004-01-27 2007-04-26 Eberhard-Karls-Universität Tübingen Universitätsklinikum A141S-und G399S-Mutation im Omi/HtrA2-Protein bei Morbus Parkinson
WO2006013012A2 (en) * 2004-08-04 2006-02-09 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with napsin 1 (nap1)
WO2006013016A2 (en) * 2004-08-04 2006-02-09 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with eosinophil serine protease 1 (prss21)
EP1831370A4 (en) * 2004-12-13 2009-08-12 Alethia Biotherapeutics Inc POLYNUCLEOTIDES AND POLYPEPTIDE SEQUENCES INVOLVED IN BONE RESOLUTION

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0828003A3 (en) * 1996-09-06 2003-01-15 SmithKline Beecham plc Human serine protease
EP0941320A2 (en) 1996-11-13 1999-09-15 Sagami Chemical Research Center Human proteins having transmembrane domains and dnas encoding these proteins
WO1998022597A2 (en) 1996-11-20 1998-05-28 Oklahoma Medical Research Foundation Cloning and characterization of napsin, an aspartic protease
WO1998056804A1 (en) 1997-06-13 1998-12-17 Human Genome Sciences, Inc. 86 human secreted proteins
JP3809709B2 (ja) 1997-07-16 2006-08-16 小野薬品工業株式会社 新規な好酸球セリンプロテアーゼ
US7014993B1 (en) 1997-08-21 2006-03-21 The Board Of Trustees Of The University Of Arkansas Extracellular serine protease
NZ503343A (en) 1997-09-17 2002-09-27 Genentech Inc Secreted and transmembrane polypeptides and use to induce apoptosis of tumour cells
ES2312205T3 (es) 1998-03-10 2009-02-16 Genentech, Inc. Nuevo polipeptido y acidos nucleicos que lo codifican.
NZ531664A (en) 1998-09-01 2005-07-29 Genentech Inc Pro1317 polypeptides and sequences thereof with homology to the semaphorin B glycoprotein family

Also Published As

Publication number Publication date
WO1999036550A2 (en) 1999-07-22
AU2113599A (en) 1999-08-02
US6203979B1 (en) 2001-03-20
WO1999036550A3 (en) 1999-11-18
EP1045913A2 (en) 2000-10-25
CA2317094A1 (en) 1999-07-22

Similar Documents

Publication Publication Date Title
JP2002508970A (ja) ヒトプロテアーゼ分子
US20030148271A1 (en) Novel prostate-associated kallikrein
US6620606B2 (en) Human cathepsin
JP2001525666A (ja) ヒトセリンプロテアーゼ前駆体
JP2002513553A (ja) 成長関連プロテアーゼインヒビタ重鎖前駆体
JP2002522081A (ja) プロテアーゼ及び関連タンパク質
US6350448B1 (en) Human prostate-associated protease
JP2002500009A (ja) ヒトシグナルペプチド含有タンパク質
JP2002508185A (ja) ユビキチン様複合タンパク質
JP2001526914A (ja) ヒト・調節タンパク質
US6075136A (en) Prostate-associated serine protease
US6171790B1 (en) Human protease associated proteins
JP2002508176A (ja) ヒトホスファターゼ
US5998373A (en) Carboxypeptidase inhibitor
US6855811B2 (en) Human protease molecules
JP2002507419A (ja) ヒトプロテインホスファターゼ関連分子
US5858714A (en) Human metaxin protein
US6232454B1 (en) Human proteinase molecules
US20040038279A1 (en) Human E1-like protein
JP2001524312A (ja) ヒトcdc10相同体

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20051216

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20051216

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080624

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20081118