JP2002508781A - 発泡性マルチユニット製剤形 - Google Patents
発泡性マルチユニット製剤形Info
- Publication number
- JP2002508781A JP2002508781A JP50700999A JP50700999A JP2002508781A JP 2002508781 A JP2002508781 A JP 2002508781A JP 50700999 A JP50700999 A JP 50700999A JP 50700999 A JP50700999 A JP 50700999A JP 2002508781 A JP2002508781 A JP 2002508781A
- Authority
- JP
- Japan
- Prior art keywords
- effervescent
- unit
- layer
- coating
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 5
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- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 4
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- 238000005303 weighing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9702533-2 | 1997-07-01 | ||
| SE9702533A SE9702533D0 (sv) | 1997-07-01 | 1997-07-01 | New oral formulation |
| PCT/SE1998/001209 WO1999001112A1 (en) | 1997-07-01 | 1998-06-22 | Multiple unit effervescent dosage form |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002508781A true JP2002508781A (ja) | 2002-03-19 |
| JP2002508781A5 JP2002508781A5 (https=) | 2005-12-22 |
Family
ID=20407594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50700999A Ceased JP2002508781A (ja) | 1997-07-01 | 1998-06-22 | 発泡性マルチユニット製剤形 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6284271B1 (https=) |
| EP (1) | EP1014952B1 (https=) |
| JP (1) | JP2002508781A (https=) |
| AT (1) | ATE247952T1 (https=) |
| AU (1) | AU733801B2 (https=) |
| CA (1) | CA2294744C (https=) |
| DE (1) | DE69817587T2 (https=) |
| SE (1) | SE9702533D0 (https=) |
| WO (1) | WO1999001112A1 (https=) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001199878A (ja) * | 1999-09-13 | 2001-07-24 | Lab Del Dr Esteve Sa | 酸に不安定ベンズイミダゾールを含有する修飾された放出特性の経口用固形製剤 |
| JP2002528482A (ja) * | 1998-10-30 | 2002-09-03 | エルテーエス ローマン テラピー−ジステーメ アーゲー | 長期胃内滞留時間を有する膨張性胃内保持治療システム |
| KR100674622B1 (ko) * | 2005-11-04 | 2007-01-29 | 재단법인 포항산업과학연구원 | 연료전지 발전시스템 |
| JP2011515438A (ja) * | 2008-03-28 | 2011-05-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 酸ペレットの製造方法 |
| JP2013501762A (ja) * | 2009-08-12 | 2013-01-17 | デブルジャ・ゼ・タソシエ・ファルマ | 浮遊微粒剤 |
| JP2018532746A (ja) * | 2015-11-10 | 2018-11-08 | エボニック テクノケミー ゲーエムベーハー | 胃貯留アクティブデリバリーシステム |
| JP2021063110A (ja) * | 2015-06-30 | 2021-04-22 | アモーレパシフィック コーポレーションＡｍｏｒｅｐａｃｉｆｉｃ Ｃｏｒｐｏｒａｔｉｏｎ | 速崩壊型顆粒丸毛髪洗浄用組成物 |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6699885B2 (en) * | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| US6645988B2 (en) | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US20050054682A1 (en) * | 1996-01-04 | 2005-03-10 | Phillips Jeffrey O. | Pharmaceutical compositions comprising substituted benzimidazoles and methods of using same |
| US6489346B1 (en) * | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| AU2001232020A1 (en) * | 2000-02-09 | 2001-08-20 | West Pharmaceutical Services Drug Delivery And Clinical Research Centre Limited | Floating drug delivery composition |
| US9522217B2 (en) | 2000-03-15 | 2016-12-20 | Orbusneich Medical, Inc. | Medical device with coating for capturing genetically-altered cells and methods for using same |
| US8088060B2 (en) | 2000-03-15 | 2012-01-03 | Orbusneich Medical, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
| WO2002026210A2 (en) * | 2000-09-29 | 2002-04-04 | Geneva Pharmaceuticals Inc. | Proton pump inhibitor formulation |
| US6555581B1 (en) | 2001-02-15 | 2003-04-29 | Jones Pharma, Inc. | Levothyroxine compositions and methods |
| US7067148B2 (en) | 2001-02-15 | 2006-06-27 | King Pharmaceutical Research & Development, Inc. | Stabilized pharmaceutical and thyroid hormone compositions and method of preparation |
| DE10111780B8 (de) * | 2001-03-13 | 2005-02-10 | Isaak Dr. Abramov | Brausetablette, Pille oder Dragee, sowie das Verfahren zu ihrer Herstellung |
| US20030198671A1 (en) * | 2001-08-10 | 2003-10-23 | Franz G. Andrew | Levothyroxine compositions having unique plasma AUC properties |
| US7101569B2 (en) | 2001-08-14 | 2006-09-05 | Franz G Andrew | Methods of administering levothyroxine pharmaceutical compositions |
| US20030171436A1 (en) * | 2001-10-29 | 2003-09-11 | Franz G. Andrew | Levothyroxine compositions having unique triiodothyronine Tmax properties |
| US20040006111A1 (en) * | 2002-01-25 | 2004-01-08 | Kenneth Widder | Transmucosal delivery of proton pump inhibitors |
| US20030228363A1 (en) * | 2002-06-07 | 2003-12-11 | Patel Mahendra R. | Stabilized pharmaceutical compositons containing benzimidazole compounds |
| WO2004056336A2 (en) * | 2002-12-20 | 2004-07-08 | Ranbaxy Laboratories Limited | Controlled release, multiple unit drug delivery systems |
| CA2520660C (en) * | 2003-03-28 | 2013-08-20 | Sigmoid Biotechnologies Limited | Solid oral dosage form containing seamless microcapsules |
| US7314640B2 (en) * | 2003-07-11 | 2008-01-01 | Mongkol Sriwongjanya | Formulation and process for drug loaded cores |
| US8993599B2 (en) | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| TW200533391A (en) | 2004-03-25 | 2005-10-16 | Sun Pharmaceutical Ind Ltd | Gastric retention drug delivery system |
| CA2579767A1 (en) * | 2004-04-30 | 2005-11-10 | Astellas Pharma Inc. | Oral pharmaceutical composition in timed-release particle form and fast-disintegrating tablets containing this composition |
| US8815916B2 (en) | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| US8906940B2 (en) | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| EP2444071A1 (en) * | 2004-09-27 | 2012-04-25 | Sigmoid Pharma Limited | Minicapsule formulations |
| GB0427455D0 (en) * | 2004-12-15 | 2005-01-19 | Jagotec Ag | Dosage forms |
| US7803817B2 (en) * | 2005-05-11 | 2010-09-28 | Vecta, Ltd. | Composition and methods for inhibiting gastric acid secretion |
| US7981908B2 (en) * | 2005-05-11 | 2011-07-19 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
| FR2902337B1 (fr) * | 2005-12-02 | 2010-09-17 | Vacher Dominique | Comprimes a liberation immediate et leur production |
| AU2007266574A1 (en) * | 2006-06-01 | 2007-12-06 | Dexcel Pharma Technologies Ltd. | Multiple unit pharmaceutical formulation |
| PL2046334T3 (pl) * | 2006-07-25 | 2015-02-27 | Vecta Ltd | Kompozycje i sposoby hamowania wydzielania kwasów żołądkowych z wykorzystaniem pochodnych małych kwasów dikarboksylowych w połączeniu z PPI |
| CA2661172A1 (en) | 2006-09-04 | 2008-05-29 | Panacea Biotec Limited | Programmable buoyant delivery technology |
| WO2008067037A2 (en) * | 2006-10-05 | 2008-06-05 | Santarus, Inc. | Novel formulations of proton pump inhibitors and methods of using these formulations |
| EP2079456B1 (en) | 2007-04-04 | 2012-12-05 | Sigmoid Pharma Limited | Pharmaceutical cyclosporin compositions |
| EP2586428B1 (en) * | 2007-04-26 | 2023-11-08 | Sublimity Therapeutics Limited | Manufacture of multiple minicapsules |
| CA2685591A1 (en) * | 2007-05-01 | 2008-11-06 | Sigmoid Pharma Limited | Pharmaceutical nimodipine compositions |
| HUP0700469A2 (en) * | 2007-07-09 | 2009-04-28 | Richter Gedeon Nyrt | Floating pharmaceutical composition of sustained release containing metronidazol |
| ES2649112T3 (es) | 2009-05-18 | 2018-01-10 | Sigmoid Pharma Limited | Composición que comprende gotas de aceite |
| FR2945947B1 (fr) * | 2009-05-29 | 2011-07-29 | Flamel Tech Sa | Compositions pharmaceutiques flottantes a liberation controlee |
| CN107582526A (zh) | 2009-08-12 | 2018-01-16 | 希格默伊德药业有限公司 | 包含聚合物基质和油相的免疫调节组合物 |
| GB2481005B (en) * | 2010-06-07 | 2012-08-08 | Cosmetic Warriors Ltd | Surfactant product comprising first and second effervescent materials |
| GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
| GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
| WO2014191806A2 (en) * | 2013-05-02 | 2014-12-04 | Effrx Pharmaceuticals Sa | Effervescent formulations that deliver particles which float in the stomach |
| GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
| EP3881829A1 (en) | 2014-11-07 | 2021-09-22 | Sublimity Therapeutics Limited | Compositions comprising cyclosporin |
| WO2016174664A1 (en) | 2015-04-29 | 2016-11-03 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
| US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
| WO2025235402A1 (en) | 2024-05-07 | 2025-11-13 | Herbalife International Of America, Inc. | Compositions and methods for effervescent systems with improved stability |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5512411B2 (https=) | 1974-03-12 | 1980-04-02 | ||
| SE450087B (sv) | 1985-10-11 | 1987-06-09 | Haessle Ab | Korn med kontrollerad frisettning av farmaceutiskt aktiva emnen som anbringats teckande pa ett kompakt olosligt kernmaterial |
| JPS62195323A (ja) * | 1986-02-24 | 1987-08-28 | Eisai Co Ltd | 胃内滞留型粒子 |
| GB2189698A (en) | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
| US4710384A (en) | 1986-07-28 | 1987-12-01 | Avner Rotman | Sustained release tablets made from microcapsules |
| US4814178A (en) | 1987-07-01 | 1989-03-21 | Sanford Bolton | Floating sustained release therapeutic compositions |
| US5445826A (en) | 1988-06-28 | 1995-08-29 | Cibus Pharmaceutical, Inc. | Delivery system containing a gel-forming dietary fiber and a drug |
| GB9224021D0 (en) | 1992-11-16 | 1993-01-06 | Boots Co Plc | Effervescent compositions |
| US5503846A (en) | 1993-03-17 | 1996-04-02 | Cima Labs, Inc. | Base coated acid particles and effervescent formulation incorporating same |
| EP0667149A1 (en) | 1994-02-14 | 1995-08-16 | E-PHARMA TRENTO S.p.A. | Ibuprofen based effervescent composition |
| DE4406424A1 (de) | 1994-02-28 | 1995-08-31 | Bayer Ag | Expandierbare Arzneiformen |
| DK0670160T3 (da) | 1994-03-01 | 2000-02-14 | Gerhard Gergely | Granulært præparat eller tablet omfattende et brusemiddel og et aktivt farmaceutisk stof samt fremgangsmåde til dets fremst |
| IE940292A1 (en) | 1994-04-06 | 1995-10-18 | Elan Corp Plc | Biodegradable microcapsules and method for their manufacture |
| EE03305B1 (et) | 1994-07-08 | 2000-12-15 | Astra Aktiebolag | Paljuosaline tableteeritud annusvorm I |
| SE9402422D0 (sv) | 1994-07-08 | 1994-07-08 | Astra Ab | New beads for controlled release and a pharmaceutical preparation containing the same |
| SE512835C2 (sv) | 1996-01-08 | 2000-05-22 | Astrazeneca Ab | Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare |
-
1997
- 1997-07-01 SE SE9702533A patent/SE9702533D0/xx unknown
-
1998
- 1998-06-22 CA CA002294744A patent/CA2294744C/en not_active Expired - Fee Related
- 1998-06-22 EP EP98931171A patent/EP1014952B1/en not_active Expired - Lifetime
- 1998-06-22 JP JP50700999A patent/JP2002508781A/ja not_active Ceased
- 1998-06-22 DE DE69817587T patent/DE69817587T2/de not_active Expired - Fee Related
- 1998-06-22 AU AU81357/98A patent/AU733801B2/en not_active Ceased
- 1998-06-22 AT AT98931171T patent/ATE247952T1/de not_active IP Right Cessation
- 1998-06-22 US US09/125,933 patent/US6284271B1/en not_active Expired - Fee Related
- 1998-06-22 WO PCT/SE1998/001209 patent/WO1999001112A1/en not_active Ceased
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002528482A (ja) * | 1998-10-30 | 2002-09-03 | エルテーエス ローマン テラピー−ジステーメ アーゲー | 長期胃内滞留時間を有する膨張性胃内保持治療システム |
| JP2001199878A (ja) * | 1999-09-13 | 2001-07-24 | Lab Del Dr Esteve Sa | 酸に不安定ベンズイミダゾールを含有する修飾された放出特性の経口用固形製剤 |
| KR100674622B1 (ko) * | 2005-11-04 | 2007-01-29 | 재단법인 포항산업과학연구원 | 연료전지 발전시스템 |
| JP2011515438A (ja) * | 2008-03-28 | 2011-05-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 酸ペレットの製造方法 |
| JP2013501762A (ja) * | 2009-08-12 | 2013-01-17 | デブルジャ・ゼ・タソシエ・ファルマ | 浮遊微粒剤 |
| JP2021063110A (ja) * | 2015-06-30 | 2021-04-22 | アモーレパシフィック コーポレーションＡｍｏｒｅｐａｃｉｆｉｃ Ｃｏｒｐｏｒａｔｉｏｎ | 速崩壊型顆粒丸毛髪洗浄用組成物 |
| JP2018532746A (ja) * | 2015-11-10 | 2018-11-08 | エボニック テクノケミー ゲーエムベーハー | 胃貯留アクティブデリバリーシステム |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69817587T2 (de) | 2004-06-24 |
| AU733801B2 (en) | 2001-05-24 |
| DE69817587D1 (de) | 2003-10-02 |
| EP1014952A1 (en) | 2000-07-05 |
| EP1014952B1 (en) | 2003-08-27 |
| AU8135798A (en) | 1999-01-25 |
| WO1999001112A1 (en) | 1999-01-14 |
| ATE247952T1 (de) | 2003-09-15 |
| CA2294744C (en) | 2006-10-17 |
| US6284271B1 (en) | 2001-09-04 |
| SE9702533D0 (sv) | 1997-07-01 |
| CA2294744A1 (en) | 1999-01-14 |
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