JP2002508765A - リポソーム被包ポリヌクレオチド組成物および方法 - Google Patents
リポソーム被包ポリヌクレオチド組成物および方法Info
- Publication number
- JP2002508765A JP2002508765A JP50493699A JP50493699A JP2002508765A JP 2002508765 A JP2002508765 A JP 2002508765A JP 50493699 A JP50493699 A JP 50493699A JP 50493699 A JP50493699 A JP 50493699A JP 2002508765 A JP2002508765 A JP 2002508765A
- Authority
- JP
- Japan
- Prior art keywords
- lipid
- liposome
- polynucleotide
- composition
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
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| US5049097P | 1997-06-23 | 1997-06-23 | |
| US60/050,490 | 1997-06-23 | ||
| PCT/US1998/012937 WO1998058630A1 (en) | 1997-06-23 | 1998-06-22 | Liposome-entrapped polynucleotide composition and method |
Publications (2)
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| JP2002508765A true JP2002508765A (ja) | 2002-03-19 |
| JP2002508765A5 JP2002508765A5 (https=) | 2005-12-22 |
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| JP50493699A Abandoned JP2002508765A (ja) | 1997-06-23 | 1998-06-22 | リポソーム被包ポリヌクレオチド組成物および方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6120798A (https=) |
| EP (1) | EP1017365B1 (https=) |
| JP (1) | JP2002508765A (https=) |
| AT (1) | ATE255882T1 (https=) |
| AU (1) | AU7983798A (https=) |
| CA (1) | CA2294579C (https=) |
| DE (1) | DE69820465T2 (https=) |
| DK (1) | DK1017365T3 (https=) |
| ES (1) | ES2212305T3 (https=) |
| TW (1) | TWI225412B (https=) |
| WO (1) | WO1998058630A1 (https=) |
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| JP2002536316A (ja) * | 1999-02-08 | 2002-10-29 | アルザ・コーポレーション | リポソームサイズを調節する方法 |
| JP2005535730A (ja) * | 2002-06-26 | 2005-11-24 | メディゲーネ オンコロギー ゲゼルシャフト ミット ベシュレンクテル ハフツング | 脂肪親和性化合物から成る陽イオン性リポソームの製法 |
| WO2007080902A1 (ja) | 2006-01-11 | 2007-07-19 | Kyowa Hakko Kogyo Co., Ltd. | 眼球において標的遺伝子の発現を抑制する組成物および眼球における疾患の治療剤 |
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| WO2012098692A1 (ja) | 2011-01-19 | 2012-07-26 | 協和発酵キリン株式会社 | 標的遺伝子の発現を抑制する組成物 |
| WO2013065825A1 (ja) | 2011-11-02 | 2013-05-10 | 協和発酵キリン株式会社 | カチオン性脂質 |
| WO2013089152A1 (ja) | 2011-12-12 | 2013-06-20 | 協和発酵キリン株式会社 | カチオン性脂質の組み合わせを含有する脂質ナノ粒子 |
| WO2013089151A1 (ja) | 2011-12-12 | 2013-06-20 | 協和発酵キリン株式会社 | カチオン性脂質を含有するドラッグデリバリーシステムのための脂質ナノ粒子 |
| WO2014007398A1 (ja) | 2012-07-06 | 2014-01-09 | 協和発酵キリン株式会社 | カチオン性脂質 |
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| JP2015518472A (ja) * | 2012-03-29 | 2015-07-02 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | 脂質誘導される中性ナノ粒子 |
| JP2016172778A (ja) * | 2002-06-28 | 2016-09-29 | プロティバ バイオセラピューティクス， インコーポレイテッド | リポソーム製造方法および装置 |
| WO2017111172A1 (ja) | 2015-12-25 | 2017-06-29 | 協和発酵キリン株式会社 | カチオン性脂質としての化合物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5855911A (en) * | 1995-08-29 | 1999-01-05 | Board Of Regents, The University Of Texas System | Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides |
| US7309692B1 (en) * | 1996-07-08 | 2007-12-18 | Board Of Regents, The University Of Texas System | Inhibition of chronic myelogenous leukemic cell growth by liposomal-antisense oligodeoxy-nucleotides targeting to GRB2 or CRK1 |
| US6977244B2 (en) * | 1996-10-04 | 2005-12-20 | Board Of Regents, The University Of Texas Systems | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
| US6056973A (en) * | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| US20030229040A1 (en) * | 1997-03-21 | 2003-12-11 | Georgetown University | Cationic liposomal delivery system and therapeutic use thereof |
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| US5855911A (en) * | 1995-08-29 | 1999-01-05 | Board Of Regents, The University Of Texas System | Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides |
| FR2751222B1 (fr) * | 1996-07-16 | 1998-10-09 | Capsulis | Compositions contenant au moins un acide nucleique et leurs applications dans le domaine biomedical, en particulier en therapie genique |
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- 1998-06-22 CA CA002294579A patent/CA2294579C/en not_active Expired - Fee Related
- 1998-06-22 JP JP50493699A patent/JP2002508765A/ja not_active Abandoned
- 1998-06-22 ES ES98930447T patent/ES2212305T3/es not_active Expired - Lifetime
- 1998-06-22 EP EP98930447A patent/EP1017365B1/en not_active Expired - Lifetime
- 1998-06-22 WO PCT/US1998/012937 patent/WO1998058630A1/en not_active Ceased
- 1998-06-22 AT AT98930447T patent/ATE255882T1/de not_active IP Right Cessation
- 1998-06-22 DK DK98930447T patent/DK1017365T3/da active
- 1998-06-22 DE DE69820465T patent/DE69820465T2/de not_active Expired - Fee Related
- 1998-06-22 TW TW087109984A patent/TWI225412B/zh not_active IP Right Cessation
- 1998-06-22 AU AU79837/98A patent/AU7983798A/en not_active Abandoned
- 1998-06-23 US US09/103,341 patent/US6120798A/en not_active Expired - Lifetime
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Also Published As
| Publication number | Publication date |
|---|---|
| ES2212305T3 (es) | 2004-07-16 |
| ATE255882T1 (de) | 2003-12-15 |
| DK1017365T3 (da) | 2004-03-29 |
| CA2294579C (en) | 2007-10-09 |
| CA2294579A1 (en) | 1998-12-30 |
| TWI225412B (en) | 2004-12-21 |
| US6120798A (en) | 2000-09-19 |
| DE69820465T2 (de) | 2004-09-16 |
| DE69820465D1 (de) | 2004-01-22 |
| HK1025906A1 (en) | 2000-12-01 |
| WO1998058630A1 (en) | 1998-12-30 |
| AU7983798A (en) | 1999-01-04 |
| EP1017365B1 (en) | 2003-12-10 |
| EP1017365A1 (en) | 2000-07-12 |
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