JP2002505907A - 細胞の接着性が低い表面を有する生体適合性基板 - Google Patents
細胞の接着性が低い表面を有する生体適合性基板Info
- Publication number
- JP2002505907A JP2002505907A JP2000535276A JP2000535276A JP2002505907A JP 2002505907 A JP2002505907 A JP 2002505907A JP 2000535276 A JP2000535276 A JP 2000535276A JP 2000535276 A JP2000535276 A JP 2000535276A JP 2002505907 A JP2002505907 A JP 2002505907A
- Authority
- JP
- Japan
- Prior art keywords
- substrate
- substrate according
- depressions
- cells
- pattern
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 230000021164 cell adhesion Effects 0.000 title claims abstract description 13
- 239000007943 implant Substances 0.000 claims abstract description 6
- 238000004049 embossing Methods 0.000 claims description 8
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- 238000000034 method Methods 0.000 description 11
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- 239000002609 medium Substances 0.000 description 9
- 238000012546 transfer Methods 0.000 description 7
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 6
- 239000010410 layer Substances 0.000 description 6
- 239000010936 titanium Substances 0.000 description 6
- 229910052719 titanium Inorganic materials 0.000 description 6
- 238000005530 etching Methods 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 238000005266 casting Methods 0.000 description 4
- 238000010894 electron beam technology Methods 0.000 description 4
- 239000005350 fused silica glass Substances 0.000 description 4
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- 238000000465 moulding Methods 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 229920003023 plastic Polymers 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 3
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 3
- 239000004793 Polystyrene Substances 0.000 description 3
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 3
- 229920002301 cellulose acetate Polymers 0.000 description 3
- 238000001020 plasma etching Methods 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 239000004926 polymethyl methacrylate Substances 0.000 description 3
- 229920002223 polystyrene Polymers 0.000 description 3
- 239000010703 silicon Substances 0.000 description 3
- 229910052710 silicon Inorganic materials 0.000 description 3
- 239000000377 silicon dioxide Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 210000002435 tendon Anatomy 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 238000004630 atomic force microscopy Methods 0.000 description 2
- 239000000560 biocompatible material Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910001424 calcium ion Inorganic materials 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 210000004292 cytoskeleton Anatomy 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 210000002889 endothelial cell Anatomy 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 210000001650 focal adhesion Anatomy 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 238000001746 injection moulding Methods 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229910001425 magnesium ion Inorganic materials 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000002061 nanopillar Substances 0.000 description 2
- 229910001120 nichrome Inorganic materials 0.000 description 2
- 229920002120 photoresistant polymer Polymers 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 210000002107 sheath cell Anatomy 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000012876 topography Methods 0.000 description 2
- VXEGSRKPIUDPQT-UHFFFAOYSA-N 4-[4-(4-methoxyphenyl)piperazin-1-yl]aniline Chemical compound C1=CC(OC)=CC=C1N1CCN(C=2C=CC(N)=CC=2)CC1 VXEGSRKPIUDPQT-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229910001252 Pd alloy Inorganic materials 0.000 description 1
- 229920005439 Perspex® Polymers 0.000 description 1
- 239000012979 RPMI medium Substances 0.000 description 1
- 239000012980 RPMI-1640 medium Substances 0.000 description 1
- 229910003902 SiCl 4 Inorganic materials 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 230000013228 contact guidance Effects 0.000 description 1
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- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000000609 electron-beam lithography Methods 0.000 description 1
- YQDHCCVUYCIGSW-LBPRGKRZSA-N ethyl (2s)-2-benzamido-5-(diaminomethylideneamino)pentanoate Chemical group NC(=N)NCCC[C@@H](C(=O)OCC)NC(=O)C1=CC=CC=C1 YQDHCCVUYCIGSW-LBPRGKRZSA-N 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000005095 gastrointestinal system Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000009477 glass transition Effects 0.000 description 1
- BBKFSSMUWOMYPI-UHFFFAOYSA-N gold palladium Chemical compound [Pd].[Au] BBKFSSMUWOMYPI-UHFFFAOYSA-N 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000010884 ion-beam technique Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 210000003632 microfilament Anatomy 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229940078707 opticlear Drugs 0.000 description 1
- 238000000059 patterning Methods 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000011253 protective coating Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 229940082569 selenite Drugs 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000005049 silicon tetrachloride Substances 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 210000001626 skin fibroblast Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 210000001179 synovial fluid Anatomy 0.000 description 1
- BYJAVTDNIXVSPW-UHFFFAOYSA-N tetryzoline Chemical compound N1CCN=C1C1C2=CC=CC=C2CCC1 BYJAVTDNIXVSPW-UHFFFAOYSA-N 0.000 description 1
- 238000002207 thermal evaporation Methods 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/08—Muscles; Tendons; Ligaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
- A61F2002/0086—Special surfaces of prostheses, e.g. for improving ingrowth for preferentially controlling or promoting the growth of specific types of cells or tissues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
- A61F2002/009—Special surfaces of prostheses, e.g. for improving ingrowth for hindering or preventing attachment of biological tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
- B29K2995/0037—Other properties
- B29K2995/0059—Degradable
- B29K2995/006—Bio-degradable, e.g. bioabsorbable, bioresorbable or bioerodible
Landscapes
- Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9805214.5 | 1998-03-11 | ||
| GBGB9805214.5A GB9805214D0 (en) | 1998-03-11 | 1998-03-11 | Cell adhesion |
| PCT/GB1999/000721 WO1999045860A1 (en) | 1998-03-11 | 1999-03-10 | Biocompatible substrate with a surface to which cells have a low tendency to attach |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002505907A true JP2002505907A (ja) | 2002-02-26 |
| JP2002505907A5 JP2002505907A5 (enExample) | 2006-04-27 |
Family
ID=10828391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000535276A Pending JP2002505907A (ja) | 1998-03-11 | 1999-03-10 | 細胞の接着性が低い表面を有する生体適合性基板 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6720469B1 (enExample) |
| EP (1) | EP1061864A1 (enExample) |
| JP (1) | JP2002505907A (enExample) |
| AU (1) | AU2739199A (enExample) |
| CA (1) | CA2322456C (enExample) |
| GB (1) | GB9805214D0 (enExample) |
| WO (1) | WO1999045860A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011155865A (ja) * | 2010-01-29 | 2011-08-18 | Institute Of Physical & Chemical Research | 基板、細胞培養装置、細胞チップおよび培養方法 |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6610067B2 (en) | 2000-05-01 | 2003-08-26 | Arthrosurface, Incorporated | System and method for joint resurface repair |
| EP2314257B9 (en) | 2000-05-01 | 2013-02-27 | ArthroSurface, Inc. | System for joint resurface repair |
| GB0121168D0 (en) * | 2001-08-31 | 2001-10-24 | Duckworth & Kent Ltd | Ophthalmic devices and procedures |
| DE10222872B4 (de) | 2002-05-23 | 2018-08-16 | Johnson & Johnson Medical Gmbh | Medizinisches Implantat und Verfahren zum Herstellen eines medizinischen Implantats |
| EP1416303B8 (en) * | 2002-10-30 | 2010-10-13 | Hitachi, Ltd. | Method for manufacturing functional substrates comprising columnar micro-pillars |
| US8388624B2 (en) | 2003-02-24 | 2013-03-05 | Arthrosurface Incorporated | Trochlear resurfacing system and method |
| US8097456B2 (en) | 2003-08-18 | 2012-01-17 | The Charles Stark Draper Laboratory | Nanotopographic compositions and methods for cellular organization in tissue engineered structures |
| US20050228491A1 (en) * | 2004-04-12 | 2005-10-13 | Snyder Alan J | Anti-adhesive surface treatments |
| US7557367B2 (en) | 2004-06-04 | 2009-07-07 | The Board Of Trustees Of The University Of Illinois | Stretchable semiconductor elements and stretchable electrical circuits |
| EP1765201A4 (en) | 2004-06-28 | 2013-01-23 | Arthrosurface Inc | SYSTEM FOR THE BENDING AREA |
| US8414907B2 (en) * | 2005-04-28 | 2013-04-09 | Warsaw Orthopedic, Inc. | Coatings on medical implants to guide soft tissue healing |
| US9119901B2 (en) * | 2005-04-28 | 2015-09-01 | Warsaw Orthopedic, Inc. | Surface treatments for promoting selective tissue attachment to medical impants |
| WO2007057693A2 (en) * | 2005-11-18 | 2007-05-24 | The University Court Of The University Of Glasgow | Biocompatible substrate and method for manufacture and use thereof |
| JPWO2007074747A1 (ja) * | 2005-12-26 | 2009-06-04 | 株式会社クラレ | 細胞培養用材料 |
| US9358029B2 (en) | 2006-12-11 | 2016-06-07 | Arthrosurface Incorporated | Retrograde resection apparatus and method |
| WO2008082192A1 (en) * | 2006-12-29 | 2008-07-10 | Iljin Copper Foil Co., Ltd. | Sn-b plating solution and plating method using it |
| TWI368082B (en) * | 2007-03-15 | 2012-07-11 | Au Optronics Corp | Display panel |
| US20090093879A1 (en) * | 2007-10-04 | 2009-04-09 | Debra Wawro | Micro- and nano-patterned surface features to reduce implant fouling and regulate wound healing |
| WO2009067482A1 (en) * | 2007-11-19 | 2009-05-28 | Massachusetts Institute Of Technology | Adhesive articles |
| WO2010036212A1 (en) * | 2008-09-24 | 2010-04-01 | Agency For Science, Technology And Research | A substrate having a surface thereon for inhibiting adhesion of a target cell thereon and a method of preparing the same |
| US8389862B2 (en) | 2008-10-07 | 2013-03-05 | Mc10, Inc. | Extremely stretchable electronics |
| US8372726B2 (en) * | 2008-10-07 | 2013-02-12 | Mc10, Inc. | Methods and applications of non-planar imaging arrays |
| US8886334B2 (en) | 2008-10-07 | 2014-11-11 | Mc10, Inc. | Systems, methods, and devices using stretchable or flexible electronics for medical applications |
| US8097926B2 (en) | 2008-10-07 | 2012-01-17 | Mc10, Inc. | Systems, methods, and devices having stretchable integrated circuitry for sensing and delivering therapy |
| WO2010042653A1 (en) | 2008-10-07 | 2010-04-15 | Mc10, Inc. | Catheter balloon having stretchable integrated circuitry and sensor array |
| FR2937857B1 (fr) * | 2008-10-30 | 2015-04-03 | Brothier Lab | Membrane chirurgicale antiadherence |
| EP2358860A1 (en) * | 2008-11-21 | 2011-08-24 | Corning Incorporated | Spaced projection substrates and devices for cell culture |
| DE112010000680T5 (de) * | 2009-02-23 | 2012-12-13 | Arthrosurface, Inc. | Nanorauhes Legierungssubstrat |
| GB0903040D0 (en) * | 2009-02-23 | 2009-04-08 | Univ Glasgow | Retention of a stem cell phenotype |
| US9283076B2 (en) | 2009-04-17 | 2016-03-15 | Arthrosurface Incorporated | Glenoid resurfacing system and method |
| US9662126B2 (en) | 2009-04-17 | 2017-05-30 | Arthrosurface Incorporated | Glenoid resurfacing system and method |
| WO2016154393A1 (en) | 2009-04-17 | 2016-09-29 | Arthrosurface Incorporated | Glenoid repair system and methods of use thereof |
| US8299341B2 (en) * | 2009-05-13 | 2012-10-30 | The California Institute Of Technology | Fabrication of vertically aligned metallic nanopillars |
| WO2011041727A1 (en) | 2009-10-01 | 2011-04-07 | Mc10, Inc. | Protective cases with integrated electronics |
| US20110218756A1 (en) * | 2009-10-01 | 2011-09-08 | Mc10, Inc. | Methods and apparatus for conformal sensing of force and/or acceleration at a person's head |
| US8481303B2 (en) | 2009-10-12 | 2013-07-09 | Corning Incorporated | Microfluidic device for cell culture |
| US9936574B2 (en) | 2009-12-16 | 2018-04-03 | The Board Of Trustees Of The University Of Illinois | Waterproof stretchable optoelectronics |
| JP6046491B2 (ja) | 2009-12-16 | 2016-12-21 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ | コンフォーマル電子機器を使用した生体内での電気生理学 |
| US10441185B2 (en) | 2009-12-16 | 2019-10-15 | The Board Of Trustees Of The University Of Illinois | Flexible and stretchable electronic systems for epidermal electronics |
| WO2011109836A1 (en) | 2010-03-05 | 2011-09-09 | Arthrosurface Incorporated | Tibial resurfacing system and method |
| US9358158B2 (en) * | 2010-03-16 | 2016-06-07 | Kci Licensing, Inc. | Patterned neo-epithelialization dressings, systems, and methods |
| CN105496423A (zh) * | 2010-03-17 | 2016-04-20 | 伊利诺伊大学评议会 | 基于生物可吸收基质的可植入生物医学装置 |
| US9263612B2 (en) | 2010-03-23 | 2016-02-16 | California Institute Of Technology | Heterojunction wire array solar cells |
| MX336139B (es) | 2010-04-28 | 2016-01-08 | Kimberly Clark Co | Dispositivos medicos para la entrega de arn de interferencia corta. |
| MX345837B (es) | 2010-04-28 | 2017-02-16 | Kimberly-Clark Worldwide Incorporated | Dispositivo para la entrega de un medicamento para la artritis reumatoide. |
| MX343238B (es) | 2010-04-28 | 2016-10-27 | Kimberly-Clark Worldwide Incorporated | Arreglo de microaguja compuesto incluyendo nanoestructuras sobre el mismo. |
| EP2563455A4 (en) | 2010-04-28 | 2014-02-19 | Kimberly Clark Co | METHOD FOR INCREASING THE PERMEABILITY OF AN EPITHELIAL BARRIER |
| US9492952B2 (en) | 2010-08-30 | 2016-11-15 | Endo-Surgery, Inc. | Super-hydrophilic structures |
| US20120143228A1 (en) | 2010-08-30 | 2012-06-07 | Agency For Science Technology And Research | Adhesive structure with stiff protrusions on adhesive surface |
| US9453197B2 (en) | 2010-12-16 | 2016-09-27 | General Electric Company | Methods of making cell carrier |
| US9453196B2 (en) | 2010-12-16 | 2016-09-27 | General Electric Company | Cell carrier, methods of making and use |
| US9534206B2 (en) | 2010-12-16 | 2017-01-03 | General Electric Company | Cell carrier, associated methods for making cell carrier and culturing cells using the same |
| US9926523B2 (en) | 2010-12-16 | 2018-03-27 | General Electric Company | Cell carriers and methods for culturing cells |
| US9518249B2 (en) | 2010-12-16 | 2016-12-13 | General Electric Company | Cell carrier, associated methods for making cell carrier and culturing cells using the same |
| WO2012158709A1 (en) | 2011-05-16 | 2012-11-22 | The Board Of Trustees Of The University Of Illinois | Thermally managed led arrays assembled by printing |
| JP2014523633A (ja) | 2011-05-27 | 2014-09-11 | エムシー10 インコーポレイテッド | 電子的、光学的、且つ/又は機械的装置及びシステム並びにこれらの装置及びシステムを製造する方法 |
| US8934965B2 (en) | 2011-06-03 | 2015-01-13 | The Board Of Trustees Of The University Of Illinois | Conformable actively multiplexed high-density surface electrode array for brain interfacing |
| US11110066B2 (en) * | 2011-10-27 | 2021-09-07 | Sorrento Therapeutics, Inc. | Implantable devices for delivery of bioactive agents |
| US20170246439A9 (en) | 2011-10-27 | 2017-08-31 | Kimberly-Clark Worldwide, Inc. | Increased Bioavailability of Transdermally Delivered Agents |
| EP3574950B1 (en) | 2011-10-27 | 2021-02-17 | Sorrento Therapeutics, Inc. | Transdermal delivery of high viscosity bioactive agents |
| JP6231489B2 (ja) | 2011-12-01 | 2017-11-15 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ | プログラム可能な変化を被るように設計された遷移デバイス |
| WO2013096746A1 (en) | 2011-12-22 | 2013-06-27 | Arthrosurface Incorporated | System and method for bone fixation |
| EP2797607B1 (en) | 2011-12-29 | 2018-11-07 | Ethicon, Inc. | Adhesive structure with tissue piercing protrusions on its surface |
| KR20150004819A (ko) | 2012-03-30 | 2015-01-13 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 표면에 상응하는 부속체 장착가능한 전자 장치 |
| US8926881B2 (en) | 2012-04-06 | 2015-01-06 | DePuy Synthes Products, LLC | Super-hydrophobic hierarchical structures, method of forming them and medical devices incorporating them |
| US8969648B2 (en) | 2012-04-06 | 2015-03-03 | Ethicon, Inc. | Blood clotting substrate and medical device |
| DE112013003358T5 (de) | 2012-07-03 | 2015-03-19 | Arthrosurface, Inc. | System und Verfahren für Gelenkoberflächenersatz und -reparatur |
| US9171794B2 (en) | 2012-10-09 | 2015-10-27 | Mc10, Inc. | Embedding thin chips in polymer |
| DE102013004574A1 (de) | 2013-03-11 | 2014-09-11 | Johnson & Johnson Medical Gmbh | Chirurgisches Implantat |
| CN103142298B (zh) * | 2013-03-27 | 2014-06-04 | 山东大学 | 一种多尺度表面结构植入体及其制备方法 |
| US9492200B2 (en) | 2013-04-16 | 2016-11-15 | Arthrosurface Incorporated | Suture system and method |
| DE102013208924A1 (de) | 2013-05-14 | 2014-12-04 | Johnson & Johnson Medical Gmbh | Chirurgisches Implantat umfassend einer Lage mit Öffnungen |
| US11607319B2 (en) | 2014-03-07 | 2023-03-21 | Arthrosurface Incorporated | System and method for repairing articular surfaces |
| US10624748B2 (en) | 2014-03-07 | 2020-04-21 | Arthrosurface Incorporated | System and method for repairing articular surfaces |
| US20150250472A1 (en) | 2014-03-07 | 2015-09-10 | Arthrosurface Incorporated | Delivery System for Articular Surface Implant |
| BR112017025609A2 (pt) | 2015-06-01 | 2018-08-07 | The Board Of Trustees Of The University Of Illinois | sistemas eletrônicos miniaturizados com potência sem fio e capacidades de comunicação de campo próximo |
| JP2018524566A (ja) | 2015-06-01 | 2018-08-30 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ | 代替的uvセンシング手法 |
| US10925543B2 (en) | 2015-11-11 | 2021-02-23 | The Board Of Trustees Of The University Of Illinois | Bioresorbable silicon electronics for transient implants |
| GB201521474D0 (en) * | 2015-12-04 | 2016-01-20 | Univ Manchester | Textured surfaces for implants |
| CA3108761A1 (en) | 2017-08-04 | 2019-02-07 | Arthrosurface Incorporated | Multicomponent articular surface implant |
| WO2020186099A1 (en) | 2019-03-12 | 2020-09-17 | Arthrosurface Incorporated | Humeral and glenoid articular surface implant systems and methods |
| CN113897569B (zh) * | 2021-09-01 | 2022-04-01 | 东北大学 | 一种提高细胞粘附与增殖的钛合金表面形貌及制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3116040C2 (de) | 1981-04-22 | 1983-04-28 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 8000 München | Bioverträgliche Kohlenstoffschichten zum Beschichten von flexiblen Materialien u. Verfahren zum Aufbringen der Schichten |
| US5061281A (en) * | 1985-12-17 | 1991-10-29 | Allied-Signal Inc. | Bioresorbable polymers and implantation devices thereof |
| CA1323959C (en) * | 1988-09-16 | 1993-11-09 | Andreas F. Von Recum | Soft tissue implant with micron-scale surface texture to optimize anchorage |
| US5011494A (en) * | 1988-09-16 | 1991-04-30 | Clemson University | Soft tissue implant with micron-scale surface texture to optimize anchorage |
| US5213742A (en) | 1990-09-11 | 1993-05-25 | Vitaphore Corporation | Method of producing pores of controlled geometry on a thermoplastic polymer |
| WO1992010218A1 (en) | 1990-12-06 | 1992-06-25 | W.L. Gore & Associates, Inc. | Implantable bioabsorbable article |
| EP0746273B1 (en) | 1993-11-02 | 2004-02-11 | Hospital For Joint Diseases | Control of cell growth |
| GB9403135D0 (en) | 1994-02-18 | 1994-04-06 | Univ Glasgow | Wound healing device |
| DE19507637C1 (de) * | 1995-03-04 | 1996-08-14 | Ortigao Jose Flavio Dr Ramalho | Bioverträgliches Produkt und Verfahren zu seiner Herstellung sowie Verwendung des Produkts |
| CA2197375C (en) | 1996-02-15 | 2003-05-06 | Yasuhiro Okuda | Artificial blood vessel |
-
1998
- 1998-03-11 GB GBGB9805214.5A patent/GB9805214D0/en not_active Ceased
-
1999
- 1999-03-10 JP JP2000535276A patent/JP2002505907A/ja active Pending
- 1999-03-10 WO PCT/GB1999/000721 patent/WO1999045860A1/en not_active Ceased
- 1999-03-10 AU AU27391/99A patent/AU2739199A/en not_active Abandoned
- 1999-03-10 EP EP99907761A patent/EP1061864A1/en not_active Withdrawn
- 1999-03-10 US US09/623,751 patent/US6720469B1/en not_active Expired - Fee Related
- 1999-03-10 CA CA002322456A patent/CA2322456C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011155865A (ja) * | 2010-01-29 | 2011-08-18 | Institute Of Physical & Chemical Research | 基板、細胞培養装置、細胞チップおよび培養方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1061864A1 (en) | 2000-12-27 |
| US6720469B1 (en) | 2004-04-13 |
| AU2739199A (en) | 1999-09-27 |
| CA2322456A1 (en) | 1999-09-16 |
| CA2322456C (en) | 2008-06-10 |
| GB9805214D0 (en) | 1998-05-06 |
| WO1999045860A1 (en) | 1999-09-16 |
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