JP2002500886A5 - - Google Patents
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- Publication number
- JP2002500886A5 JP2002500886A5 JP2000528679A JP2000528679A JP2002500886A5 JP 2002500886 A5 JP2002500886 A5 JP 2002500886A5 JP 2000528679 A JP2000528679 A JP 2000528679A JP 2000528679 A JP2000528679 A JP 2000528679A JP 2002500886 A5 JP2002500886 A5 JP 2002500886A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- seq
- dna
- 1rrp1
- acpl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 description 74
- 229920001184 polypeptide Polymers 0.000 description 72
- 102000004196 processed proteins & peptides Human genes 0.000 description 72
- 108020004414 DNA Proteins 0.000 description 33
- 150000001413 amino acids Chemical class 0.000 description 17
- 102100035010 Interleukin-18 receptor accessory protein Human genes 0.000 description 16
- 101710138729 Interleukin-18 receptor accessory protein Proteins 0.000 description 16
- 239000012634 fragment Substances 0.000 description 12
- 238000009396 hybridization Methods 0.000 description 10
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 8
- 230000004927 fusion Effects 0.000 description 7
- 125000003275 alpha amino acid group Chemical group 0.000 description 6
- 239000002773 nucleotide Substances 0.000 description 6
- 125000003729 nucleotide group Chemical group 0.000 description 6
- 230000000295 complement effect Effects 0.000 description 5
- 108091026890 Coding region Proteins 0.000 description 4
- 239000013604 expression vector Substances 0.000 description 4
- 238000005406 washing Methods 0.000 description 3
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 description 2
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 description 2
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 description 2
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000003259 recombinant expression Methods 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7230198P | 1998-01-23 | 1998-01-23 | |
| US7883598P | 1998-03-20 | 1998-03-20 | |
| US60/072,301 | 1998-03-20 | ||
| US60/078,835 | 1998-03-20 | ||
| US9446998P | 1998-07-28 | 1998-07-28 | |
| US60/094,469 | 1998-07-28 | ||
| PCT/US1999/001419 WO1999037772A1 (en) | 1998-01-23 | 1999-01-22 | Il-18 receptors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002500886A JP2002500886A (ja) | 2002-01-15 |
| JP2002500886A5 true JP2002500886A5 (https=) | 2006-02-02 |
| JP4271850B2 JP4271850B2 (ja) | 2009-06-03 |
Family
ID=27372056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000528679A Expired - Fee Related JP4271850B2 (ja) | 1998-01-23 | 1999-01-22 | Ｉｌ−１８受容体 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US6589764B1 (https=) |
| EP (1) | EP1047781B1 (https=) |
| JP (1) | JP4271850B2 (https=) |
| AT (1) | ATE272114T1 (https=) |
| AU (1) | AU737592B2 (https=) |
| CA (1) | CA2318482C (https=) |
| DE (1) | DE69918946T2 (https=) |
| DK (1) | DK1047781T3 (https=) |
| ES (1) | ES2226335T3 (https=) |
| IL (2) | IL137178A0 (https=) |
| NZ (1) | NZ505880A (https=) |
| PT (1) | PT1047781E (https=) |
| WO (1) | WO1999037772A1 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6326472B1 (en) | 1997-10-15 | 2001-12-04 | Schering Corporation | Human receptor proteins; related reagents and methods |
| US6472179B2 (en) * | 1998-09-25 | 2002-10-29 | Regeneron Pharmaceuticals, Inc. | Receptor based antagonists and methods of making and using |
| US7083949B2 (en) | 1998-09-25 | 2006-08-01 | Regeneron Pharmaceuticals, Inc. | Receptor based antagonists and methods of making and using |
| US6927044B2 (en) | 1998-09-25 | 2005-08-09 | Regeneron Pharmaceuticals, Inc. | IL-1 receptor based cytokine traps |
| US20020155526A1 (en) | 1998-09-30 | 2002-10-24 | Busfield Samantha J. | Novel secreted immunomodulatory proteins and uses thereof |
| US6610286B2 (en) | 1999-12-23 | 2003-08-26 | Zymogenetics, Inc. | Method for treating inflammation using soluble receptors to interleukin-20 |
| JP4741139B2 (ja) * | 1999-12-23 | 2011-08-03 | ザイモジェネティクス， インコーポレイテッド | 可溶性インターロイキン−２０レセプター |
| US7122632B2 (en) | 1999-12-23 | 2006-10-17 | Zymogenetics, Inc. | Soluble Interleukin-20 receptor |
| TWI335336B (https=) | 2000-02-10 | 2011-01-01 | Abbott Gmbh & Co Kg | |
| US20020025317A1 (en) * | 2000-07-20 | 2002-02-28 | Schering Ag | Bispecific monoclonal antibodies to IL-12 and IL-18 |
| US20020052475A1 (en) * | 2000-07-20 | 2002-05-02 | Schering Ag | High affinity soluble interleukin-18 receptor |
| ES2381650T3 (es) | 2000-08-08 | 2012-05-30 | Zymogenetics, Inc. | Receptores de citoquinas Zcytor11 solubles |
| JP4908723B2 (ja) | 2000-09-15 | 2012-04-04 | ザイモジェネティクス， インコーポレイテッド | 炎症を治療するための方法 |
| CA2424983A1 (en) | 2000-10-11 | 2002-04-18 | Viron Therapeutics, Inc. | Nucleic acid molecules and polypeptides for immune modulation |
| US7718368B2 (en) * | 2000-12-04 | 2010-05-18 | Viron Therapeutics Inc. | Immunomodulatory protein and useful embodiments thereof |
| GB2375604A (en) * | 2001-05-18 | 2002-11-20 | Warner Lambert Co | Methods for screening using interleukin soluble trimolecular complex |
| PH12012502440A1 (en) | 2001-06-26 | 2013-06-17 | Amgen Inc | Antibodies to opgl |
| EP1293566A1 (en) * | 2001-09-17 | 2003-03-19 | Societe Des Produits Nestle S.A. | A soluble toll-like receptor |
| CA2467723C (en) | 2001-12-17 | 2011-09-27 | Zymogenetics, Inc. | Method for treating cervical cancer |
| AU2003259995B2 (en) | 2002-08-28 | 2009-07-02 | Immunex Corporation | Compositions and methods for treating cardiovascular disease |
| MXPA05003869A (es) | 2002-10-08 | 2005-06-22 | Ares Trading Sa | El uso de citocina capaz de enlazarse a la proteina de union a interleucina-18, y de inhibir la actividad de una segunda citocina. |
| EP1606316A2 (en) | 2003-03-24 | 2005-12-21 | ZymoGenetics, Inc. | Anti-il-20 antibodies and binding partners and methods of using in inflammation |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| US20050100965A1 (en) | 2003-11-12 | 2005-05-12 | Tariq Ghayur | IL-18 binding proteins |
| US7968684B2 (en) * | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| DE602004023965D1 (de) | 2003-11-21 | 2009-12-17 | Zymogenetics Inc | Anti-il-20-antikörper und bindungspartner und verfahren zur anwendung bei entzündungen |
| US7141382B1 (en) | 2004-10-12 | 2006-11-28 | Parikh Chirag R | Methods for detection of IL-18 as an early marker for diagnosis of acute renal failure and predictor of mortality |
| JP4898691B2 (ja) | 2004-10-22 | 2012-03-21 | ザイモジェネティクス， インコーポレイテッド | 抗ｉｌ−２２ｒａ抗体および結合パートナー、ならびに炎症における使用法 |
| AU2005327508A1 (en) * | 2005-02-15 | 2006-08-24 | Apollo Life Sciences Limited | Molecules and chimeric molecules thereof |
| JP2009527535A (ja) * | 2006-02-22 | 2009-07-30 | ユニバーシティ オブ チューリッヒ | 自己免疫疾患又は脱髄疾患を処置するための可溶性受容体及び方法 |
| JP5368301B2 (ja) | 2006-06-22 | 2013-12-18 | ノボ・ノルデイスク・エー／エス | 可溶性ヘテロ二量体レセプター及びその使用 |
| MX2009012343A (es) * | 2007-05-14 | 2010-02-10 | Biogen Idec Inc | Regiones fc (sc fc) de cadena sencilla, polipeptidos de enlace que comprenden las mismas, y metodos relacionados con ello. |
| CL2008002153A1 (es) | 2007-07-24 | 2009-06-05 | Amgen Inc | Anticuerpo aislado o fragmanto de unión de antigeno del mismo que se une al receptor de il-18 (il-18r); molecula de ácido nucleico codificante; celula huesped que la comprende; composición farmaceutica; uso médico para tratar o prevenir una condición asociada con il-18r; método in vitro para inhibir la unión de il-18 al il-18r. |
| BR112012021576A2 (pt) | 2010-02-26 | 2016-10-25 | Novo Nordisk As | composições estáveis contendo anticorpo. |
| RU2012153786A (ru) | 2010-05-28 | 2014-07-10 | Ново Нордиск А/С | Стабильные многодозовые композиции, содержащие антитело и консервант |
| SG10201505217WA (en) | 2010-07-09 | 2015-08-28 | Biogen Hemophilia Inc | Chimeric clotting factors |
| JP5813114B2 (ja) | 2010-08-25 | 2015-11-17 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｉｌ−１８ｒ１に対する抗体およびその使用 |
| US9376489B2 (en) | 2012-09-07 | 2016-06-28 | Novartis Ag | IL-18 binding molecules |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989004838A1 (en) | 1987-11-25 | 1989-06-01 | Immunex Corporation | Interleukin-1 receptors |
| EP0533006A1 (en) * | 1991-09-18 | 1993-03-24 | F.Hoffmann-La Roche & Co. Aktiengesellschaft | Chimaeric interleukin 5-receptor/immunoglobulin polypeptides |
| US5470952A (en) | 1993-10-20 | 1995-11-28 | Regeneron Pharmaceuticals, Inc. | CNTF and IL-6 antagonists |
| WO1996013593A2 (en) * | 1994-10-26 | 1996-05-09 | Procept, Inc. | Soluble single chain t cell receptors |
| US5853721A (en) | 1995-01-31 | 1998-12-29 | Hoffmann-La Roche Inc. | Antibody to interleukin-12 receptor |
| US5840530A (en) * | 1995-08-01 | 1998-11-24 | Hoffmann-La Roche Inc. | DNA encoding receptors for the beta-2 chain of human IL-12 |
| US5776731A (en) | 1996-02-21 | 1998-07-07 | Immunex Corporation | DNA encoding type-I interleukin-I receptor-like protein designated 2F1 |
| US7141393B2 (en) | 1996-12-26 | 2006-11-28 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Interleukin-18-receptor proteins |
| US6087116A (en) | 1997-03-12 | 2000-07-11 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Interleukin-18 (IL-18) receptor polypeptides and their uses |
| US6326472B1 (en) | 1997-10-15 | 2001-12-04 | Schering Corporation | Human receptor proteins; related reagents and methods |
| US6280955B1 (en) * | 1997-12-16 | 2001-08-28 | Tularik Inc. | Interleukin-1 receptor accessory proteins, nucleic acids and methods |
| US6472179B2 (en) | 1998-09-25 | 2002-10-29 | Regeneron Pharmaceuticals, Inc. | Receptor based antagonists and methods of making and using |
| US20020052475A1 (en) | 2000-07-20 | 2002-05-02 | Schering Ag | High affinity soluble interleukin-18 receptor |
-
1999
- 1999-01-22 EP EP99904222A patent/EP1047781B1/en not_active Expired - Lifetime
- 1999-01-22 ES ES99904222T patent/ES2226335T3/es not_active Expired - Lifetime
- 1999-01-22 CA CA2318482A patent/CA2318482C/en not_active Expired - Fee Related
- 1999-01-22 DE DE69918946T patent/DE69918946T2/de not_active Expired - Lifetime
- 1999-01-22 NZ NZ505880A patent/NZ505880A/xx not_active IP Right Cessation
- 1999-01-22 PT PT99904222T patent/PT1047781E/pt unknown
- 1999-01-22 IL IL13717899A patent/IL137178A0/xx active IP Right Grant
- 1999-01-22 WO PCT/US1999/001419 patent/WO1999037772A1/en not_active Ceased
- 1999-01-22 AT AT99904222T patent/ATE272114T1/de active
- 1999-01-22 JP JP2000528679A patent/JP4271850B2/ja not_active Expired - Fee Related
- 1999-01-22 DK DK99904222T patent/DK1047781T3/da active
- 1999-01-22 AU AU24668/99A patent/AU737592B2/en not_active Ceased
-
2000
- 2000-07-05 IL IL137178A patent/IL137178A/en not_active IP Right Cessation
- 2000-07-21 US US09/621,502 patent/US6589764B1/en not_active Expired - Fee Related
-
2003
- 2003-05-15 US US10/439,458 patent/US7169581B2/en not_active Expired - Fee Related
-
2007
- 2007-01-29 US US11/699,676 patent/US7704945B2/en not_active Expired - Fee Related
-
2010
- 2010-03-03 US US12/716,993 patent/US8053233B2/en not_active Expired - Fee Related
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