JP2002508183A5 - - Google Patents
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- Publication number
- JP2002508183A5 JP2002508183A5 JP2000539141A JP2000539141A JP2002508183A5 JP 2002508183 A5 JP2002508183 A5 JP 2002508183A5 JP 2000539141 A JP2000539141 A JP 2000539141A JP 2000539141 A JP2000539141 A JP 2000539141A JP 2002508183 A5 JP2002508183 A5 JP 2002508183A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- nucleic acid
- amino acids
- ulbp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 description 23
- 108090000765 processed proteins & peptides Proteins 0.000 description 23
- 102000004196 processed proteins & peptides Human genes 0.000 description 23
- 150000007523 nucleic acids Chemical class 0.000 description 16
- 108020004707 nucleic acids Proteins 0.000 description 15
- 102000039446 nucleic acids Human genes 0.000 description 15
- 150000001413 amino acids Chemical group 0.000 description 12
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 6
- 230000000694 effects Effects 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 125000003275 alpha amino acid group Chemical group 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 102100037850 Interferon gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001270 agonistic effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000007905 drug manufacturing Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 125000002924 primary amino group Chemical class [H]N([H])* 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6985797P | 1997-12-17 | 1997-12-17 | |
| US60/069,857 | 1997-12-17 | ||
| US9294698P | 1998-07-15 | 1998-07-15 | |
| US60/092,946 | 1998-07-15 | ||
| PCT/US1998/027048 WO1999031241A1 (en) | 1997-12-17 | 1998-12-17 | Cell surface glycoproteins associated with human b cell lymphomas - ulbp, dna and polypeptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002508183A JP2002508183A (ja) | 2002-03-19 |
| JP2002508183A5 true JP2002508183A5 (https=) | 2006-02-02 |
| JP4255211B2 JP4255211B2 (ja) | 2009-04-15 |
Family
ID=26750491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000539141A Expired - Fee Related JP4255211B2 (ja) | 1997-12-17 | 1998-12-17 | ヒトｂ細胞リンパ腫に関連した細胞表面糖タンパク質−ｕｌｂｐ、ｄｎａ及びポリペプチド |
Country Status (12)
| Country | Link |
|---|---|
| US (7) | US6653447B1 (https=) |
| EP (1) | EP1037991B1 (https=) |
| JP (1) | JP4255211B2 (https=) |
| AT (1) | ATE305510T1 (https=) |
| AU (1) | AU742757C (https=) |
| CA (1) | CA2315251A1 (https=) |
| DE (1) | DE69831754T2 (https=) |
| DK (1) | DK1037991T3 (https=) |
| ES (1) | ES2251120T3 (https=) |
| IL (2) | IL136621A0 (https=) |
| NZ (1) | NZ505500A (https=) |
| WO (1) | WO1999031241A1 (https=) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020137890A1 (en) * | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| SK12572001A3 (sk) * | 1999-03-15 | 2002-03-05 | Takeda Chemical Industries, Ltd. | Proteín, peptid, protilátka, spôsob výroby a farmaceutický prostriedok |
| WO2002062997A1 (fr) * | 2001-02-05 | 2002-08-15 | Takeda Chemical Industries, Ltd. | Nouvelle proteine et son utilisation |
| US6821522B2 (en) | 2001-05-31 | 2004-11-23 | The Regents Of The University Of California | Tumor Therapy |
| US7364890B2 (en) | 2001-07-28 | 2008-04-29 | Midwest Research Institute | Thermal tolerant avicelase from Acidothermus cellulolyticus |
| DE60232742D1 (de) * | 2001-10-04 | 2009-08-06 | Immunex Corp | Ul16-bindungsprotein 4 |
| CA2483343A1 (en) * | 2002-04-22 | 2003-10-30 | Fred Hutchinson Cancer Research Center | Soluble mic polypeptides as markers for diagnosis, prognosis and treatment of cancer and autoimmune diseases or conditions |
| WO2004022706A2 (en) * | 2002-09-04 | 2004-03-18 | The Trustees Of The University Of Pennsylvania | Immune cell receptor ligand and immune cell receptor |
| EP1413316A1 (en) * | 2002-09-27 | 2004-04-28 | Bruno Robert | Bifunctional conjugates or fusion proteins |
| US9809654B2 (en) | 2002-09-27 | 2017-11-07 | Vaccinex, Inc. | Targeted CD1d molecules |
| ES2345200T3 (es) * | 2003-03-24 | 2010-09-17 | The Scripps Research Institute | Vacunas de adn contra el crecimiento tumoral y procedimientos de utilizacion de las mismas. |
| US7666417B2 (en) * | 2003-04-22 | 2010-02-23 | Fred Hutchinson Cancer Research Center | Methods and compositions for treating autoimmune diseases or conditions |
| GB0403491D0 (en) * | 2004-02-17 | 2004-03-24 | Univ Cambridge Tech | Polypeptides, methods and means |
| US7998481B2 (en) * | 2004-04-05 | 2011-08-16 | The Regents Of The University Of California | Modulation of NKG2D for treating or preventing solid organ allograft rejection |
| EP2289534B1 (en) | 2004-04-05 | 2017-08-30 | The Regents of The University of California | NKG2D antibodies for use in the treatment of rheumatoid arthritis or Crohn's disease |
| JP5149013B2 (ja) | 2004-11-29 | 2013-02-20 | セクエノム，インコーポレイティド | メチル化ｄｎａを検出する手段、及び方法 |
| US9249464B2 (en) | 2004-11-29 | 2016-02-02 | Sequenom, Inc. | Kits and methods for detecting methylated DNA |
| WO2007002905A1 (en) * | 2005-06-29 | 2007-01-04 | University Of Miami | Antibody-immune cell ligand fusion protein for cancer therapy |
| WO2007143245A2 (en) | 2006-06-01 | 2007-12-13 | Midwest Research Institute | An l-arabinose fermenting yeast |
| AU2008219020B2 (en) | 2007-02-21 | 2013-08-22 | Vaccinex, Inc. | Modulation of NKT cell activity with antigen-loaded CDId molecules |
| WO2009003145A1 (en) * | 2007-06-26 | 2008-12-31 | University Of Miami | Antibody-endostatin fusion protein and its variants |
| US9611313B2 (en) | 2007-06-26 | 2017-04-04 | University Of Miami | Antibody-endostatin fusion protein and its variants |
| US8070021B2 (en) * | 2007-10-31 | 2011-12-06 | Momentive Performance Materials | Hydraulic container evacuator and method |
| CN102325875B (zh) | 2009-01-08 | 2018-04-10 | 阿尔伯爱因斯坦医学有限公司 | 具有细胞壁结合神经酰胺类糖脂的细菌疫苗及其应用 |
| US20130101590A1 (en) | 2010-04-09 | 2013-04-25 | Heather A. Arnett | Btnl9 proteins, nucleic acids, and antibodies and uses thereof |
| WO2011130749A2 (en) | 2010-04-16 | 2011-10-20 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Identification of mutations in herpes simplex virus envelope glycoproteins that enable or enhance vector retargeting to novel non-hsv receptors |
| US9539427B2 (en) | 2010-11-08 | 2017-01-10 | The Johns Hopkins University | Methods for improving heart function |
| WO2013036799A2 (en) * | 2011-09-09 | 2013-03-14 | Fred Hutchinson Cancer Research Center | Methods and compositions involving nkg2d inhibitors and cancer |
| CA2848368C (en) | 2011-09-13 | 2023-02-14 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for brown fat induction and activity using fndc5 |
| US20130156808A1 (en) * | 2011-11-22 | 2013-06-20 | Stipan Jonjic | Vaccine comprising beta-herpesvirus |
| EP2875046B2 (en) | 2012-07-19 | 2025-04-30 | Amgen Inc. | Human btnl3 proteins, nucleic acids, and antibodies and uses thereof |
| UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
| US9371352B2 (en) | 2013-02-08 | 2016-06-21 | Vaccinex, Inc. | Modified glycolipids and methods of making and using the same |
| US9708375B2 (en) | 2013-03-15 | 2017-07-18 | Amgen Inc. | Inhibitory polypeptides specific to WNT inhibitors |
| AU2014296288B2 (en) | 2013-07-31 | 2020-02-13 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for modulating thermogenesis using PTH-related and EGF-related molecules |
| EP3041863A4 (en) | 2013-09-05 | 2017-08-16 | Amgen Inc. | Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles |
| BR112016009465A8 (pt) | 2013-10-28 | 2018-01-30 | Univ Pittsburgh Commonwealth Sys Higher Education | vetor de hsv oncolítico. |
| AU2015206603B9 (en) | 2014-01-14 | 2019-07-18 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for identification, assessment, prevention, and treatment of melanoma using PD-L1 isoforms |
| US10156562B2 (en) | 2014-05-16 | 2018-12-18 | Amgen Inc. | Assay for detecting Th1 and Th2 cell populations |
| US11117969B2 (en) * | 2014-12-05 | 2021-09-14 | Xyphos Biosciences Inc. | Insertable variable fragments of antibodies and modified α1-α2 domains of NKG2D ligands |
| CA2963274C (en) | 2014-12-05 | 2024-01-30 | Avidbiotics Corp. | Insertable variable fragments of antibodies and modified a1-a2 domains of nkg2d ligands |
| AU2016343978A1 (en) | 2015-10-29 | 2018-05-17 | Dana-Farber Cancer Institute, Inc. | Methods for identification, assessment, prevention, and treatment of metabolic disorders using PM20D1 and N-lipidated amino acids |
| KR20180136435A (ko) | 2016-01-27 | 2018-12-24 | 온코루스, 인크. | 종양 살상형 바이러스 벡터 및 그의 용도 |
| CN109475613B (zh) | 2016-06-14 | 2024-02-20 | 匹兹堡大学-属高等教育联邦体系 | 使癌细胞对胞毒免疫细胞攻击敏感的nkg2d活化配体蛋白表达 |
| AU2017290828A1 (en) | 2016-06-30 | 2019-01-24 | Virogin Biotech Canada Ltd | Pseudotyped oncolytic viral delivery of therapeutic polypeptides |
| MX2019007406A (es) | 2016-12-21 | 2019-12-16 | Creatus Biosciences Inc | Especie de metschnikowia productora de xilitol. |
| CA3047840A1 (en) | 2016-12-21 | 2018-06-28 | Creatus Biosciences Inc. | Method and organism expressing metschnikowia xylose transporters for increased xylose uptake |
| CA3056011A1 (en) | 2017-03-14 | 2018-09-20 | Amgen Inc. | Control of total afucosylated glycoforms of antibodies produced in cell culture |
| US11612625B2 (en) | 2017-07-26 | 2023-03-28 | Oncorus, Inc. | Oncolytic viral vectors and uses thereof |
| EP3731850A4 (en) | 2017-12-29 | 2021-12-01 | Oncorus, Inc. | ONCOLYTIC VIRUS DELIVERY OF THERAPEUTIC POLYPEPTIDES |
| US12325737B2 (en) | 2018-03-26 | 2025-06-10 | Amgen Inc. | Total afucosylated glycoforms of antibodies produced in cell culture |
| JOP20200234A1 (ar) | 2018-03-27 | 2020-09-15 | Xyphos Biosciences Inc | نطاقات a1-a2 معدلة لمركبات ترابطية nkg2d غير طبيعية ترتبط بمستقبلات nkg2d غير طبيعية. |
| WO2020051013A2 (en) * | 2018-08-24 | 2020-03-12 | The Trustees Of Columbia University In The City Of New York | Anti-cd33 and nkg2d ligand chimeras for treatment of myeloid malignancies |
| BR112022005583A2 (pt) | 2019-09-26 | 2022-09-20 | Amgen Inc | Métodos para a produção de composições de anticorpos |
| US20230273126A1 (en) | 2020-06-04 | 2023-08-31 | Amgen Inc. | Assessment of cleaning procedures of a biotherapeutic manufacturing process |
| KR20230087539A (ko) | 2020-10-15 | 2023-06-16 | 암젠 인크 | 항체 생산 방법에서의 상대적인 비결합 글리칸 |
| EP4352094A1 (en) | 2021-06-07 | 2024-04-17 | Amgen Inc. | Using fucosidase to control afucosylation level of glycosylated proteins |
| US20250076309A1 (en) | 2021-10-05 | 2025-03-06 | Amgen Inc. | Fc-gamma receptor ii binding and glycan content |
| EP4479080A1 (en) | 2022-02-16 | 2024-12-25 | Dana-Farber Cancer Institute, Inc. | Methods for decreasing pathologic alpha-synuclein using agents that modulate fndc5 or biologically active fragments thereof |
| WO2023215725A1 (en) | 2022-05-02 | 2023-11-09 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
| AU2024256160A1 (en) | 2023-04-20 | 2025-10-02 | Amgen Inc. | Methods of determining relative unpaired glycan content |
| WO2025038600A1 (en) | 2023-08-14 | 2025-02-20 | Amgen Inc. | Methods for reducing yellow color |
| WO2025101820A1 (en) | 2023-11-08 | 2025-05-15 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4959314A (en) * | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
| USRE38824E1 (en) * | 1986-08-04 | 2005-10-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Antibodies against human herpes virus-6(HHV-6) and method of use |
| US5834229A (en) * | 1991-05-24 | 1998-11-10 | Genentech, Inc. | Nucleic acids vectors and host cells encoding and expressing heregulin 2-α |
| US5474771A (en) * | 1991-11-15 | 1995-12-12 | The Trustees Of Columbia University In The City Of New York | Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same |
| US5464771A (en) * | 1994-04-29 | 1995-11-07 | The United States Of America As Represented By The Secretary Of Agriculture | Biologically pure culture of Actinomyces viscosus strain used for the bioremediation of chlorinated hydrocarbons |
| AU2304097A (en) * | 1996-04-05 | 1997-10-29 | Kieta Holding S.A. | Compositions and methods relating to drug discovery and detection and treatment of gastrointestinal diseases |
| US5912415A (en) * | 1996-05-16 | 1999-06-15 | Regents Of The University Of Minnesota | Arabidopsis spindly gene, methods of identification and use |
| US20030068623A1 (en) * | 1997-06-16 | 2003-04-10 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
-
1998
- 1998-12-17 CA CA002315251A patent/CA2315251A1/en not_active Abandoned
- 1998-12-17 AU AU20045/99A patent/AU742757C/en not_active Ceased
- 1998-12-17 NZ NZ505500A patent/NZ505500A/xx unknown
- 1998-12-17 WO PCT/US1998/027048 patent/WO1999031241A1/en not_active Ceased
- 1998-12-17 IL IL13662198A patent/IL136621A0/xx unknown
- 1998-12-17 EP EP98964802A patent/EP1037991B1/en not_active Expired - Lifetime
- 1998-12-17 DE DE69831754T patent/DE69831754T2/de not_active Expired - Lifetime
- 1998-12-17 AT AT98964802T patent/ATE305510T1/de not_active IP Right Cessation
- 1998-12-17 JP JP2000539141A patent/JP4255211B2/ja not_active Expired - Fee Related
- 1998-12-17 ES ES98964802T patent/ES2251120T3/es not_active Expired - Lifetime
- 1998-12-17 DK DK98964802T patent/DK1037991T3/da active
-
2000
- 2000-03-13 US US09/524,100 patent/US6653447B1/en not_active Expired - Fee Related
- 2000-03-22 US US09/532,856 patent/US6458350B1/en not_active Expired - Lifetime
- 2000-06-07 IL IL136621A patent/IL136621A/en not_active IP Right Cessation
-
2002
- 2002-08-05 US US10/212,507 patent/US6774224B2/en not_active Expired - Fee Related
-
2004
- 2004-06-23 US US10/875,869 patent/US7193058B2/en not_active Expired - Fee Related
-
2006
- 2006-12-13 US US11/638,966 patent/US7427669B2/en not_active Expired - Fee Related
-
2008
- 2008-08-04 US US12/221,490 patent/US7807796B2/en not_active Expired - Fee Related
-
2010
- 2010-08-24 US US12/862,629 patent/US8410252B2/en not_active Expired - Fee Related
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