JP2002241393A5 - - Google Patents

Download PDF

Info

Publication number
JP2002241393A5
JP2002241393A5 JP2001241033A JP2001241033A JP2002241393A5 JP 2002241393 A5 JP2002241393 A5 JP 2002241393A5 JP 2001241033 A JP2001241033 A JP 2001241033A JP 2001241033 A JP2001241033 A JP 2001241033A JP 2002241393 A5 JP2002241393 A5 JP 2002241393A5
Authority
JP
Japan
Prior art keywords
group
amino
oxo
nucleic acid
dihydropyrimidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2001241033A
Other languages
English (en)
Japanese (ja)
Other versions
JP4148662B2 (ja
JP2002241393A (ja
Filing date
Publication date
Application filed filed Critical
Priority to JP2001241033A priority Critical patent/JP4148662B2/ja
Priority claimed from JP2001241033A external-priority patent/JP4148662B2/ja
Publication of JP2002241393A publication Critical patent/JP2002241393A/ja
Priority to US10/430,705 priority patent/US7314923B2/en
Publication of JP2002241393A5 publication Critical patent/JP2002241393A5/ja
Priority to US11/881,775 priority patent/US7816333B2/en
Application granted granted Critical
Publication of JP4148662B2 publication Critical patent/JP4148662B2/ja
Priority to US12/804,500 priority patent/US8957201B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2001241033A 1999-02-12 2001-08-08 ヌクレオシド及びオリゴヌクレオチド類縁体を含有する核酸試薬及び医薬 Expired - Lifetime JP4148662B2 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2001241033A JP4148662B2 (ja) 2000-08-10 2001-08-08 ヌクレオシド及びオリゴヌクレオチド類縁体を含有する核酸試薬及び医薬
US10/430,705 US7314923B2 (en) 1999-02-12 2003-05-05 Nucleoside and oligonucleotide analogues
US11/881,775 US7816333B2 (en) 1999-02-12 2007-07-27 Oligonucleotide analogues and methods utilizing the same
US12/804,500 US8957201B2 (en) 1999-02-12 2010-07-22 Oligonucleotide analogues and methods utilizing the same

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000-242247 2000-08-10
JP2000242247 2000-08-10
JP2001241033A JP4148662B2 (ja) 2000-08-10 2001-08-08 ヌクレオシド及びオリゴヌクレオチド類縁体を含有する核酸試薬及び医薬

Publications (3)

Publication Number Publication Date
JP2002241393A JP2002241393A (ja) 2002-08-28
JP2002241393A5 true JP2002241393A5 (https=) 2005-06-23
JP4148662B2 JP4148662B2 (ja) 2008-09-10

Family

ID=26597701

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001241033A Expired - Lifetime JP4148662B2 (ja) 1999-02-12 2001-08-08 ヌクレオシド及びオリゴヌクレオチド類縁体を含有する核酸試薬及び医薬

Country Status (1)

Country Link
JP (1) JP4148662B2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050053981A1 (en) * 2003-09-09 2005-03-10 Swayze Eric E. Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
JP2013256452A (ja) * 2012-06-11 2013-12-26 Kawaken Fine Chem Co Ltd メラニン産生抑制剤とその組成物
US11028390B2 (en) 2017-07-10 2021-06-08 Osaka University Antisense oligonucleotide controlling expression amount of TDP-43 and use thereof
EP3819378A4 (en) 2018-07-04 2022-09-14 Aichi Medical University OLIGONUCLEOTIDES FOR CONTROL OF TAU SPLICING AND THEIR USES
US20240390508A1 (en) 2021-08-21 2024-11-28 Takeda Pharmaceutical Company Limited Human transferrin receptor binding peptide-drug conjugate
CN114437050B (zh) * 2021-12-28 2023-05-23 重庆第二师范学院 一种用于常山酮中间体的脱保护剂及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3756313B2 (ja) * 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
AU9063398A (en) * 1997-09-12 1999-04-05 Exiqon A/S Oligonucleotide analogues
CZ296576B6 (cs) * 1999-02-12 2006-04-12 Sankyo Company Limited Nukleosidový analog a oligonukleotidový analog a farmaceutický prostredek, sonda a primer s jeho obsahem
JP4151751B2 (ja) * 1999-07-22 2008-09-17 第一三共株式会社 新規ビシクロヌクレオシド類縁体
JP2002322192A (ja) * 2000-08-10 2002-11-08 Sankyo Co Ltd ２’−ｏ，４’−ｃ−架橋ヌクレオシドトリリン酸体

Similar Documents

Publication Publication Date Title
US12415828B2 (en) Modified oligonucleotides and methods for their synthesis
EP0506242B1 (en) Method and compounds for solid phase synthesis of oligonucleotides and oligonucleotide analogs
ES2968459T3 (es) Composiciones y métodos para escisión química y desprotección de oligonucleótidos unidos a superficie
CA2459347C (en) Locked nucleic acid (lna) compositions and uses thereof
US5883237A (en) Oligonucleotides having Rp and Sp linkages at predetermined locations
US7319148B2 (en) Combinatorial production of nucleotide and nucleoside (XiTP) analogues
US20040132684A1 (en) Polymeric nucleoside prodrugs
EP1113020B1 (en) Nucleosides and oligonucleotides containing boron clusters
EP0570514A1 (en) Methylene phosphonate nucleoside analogs and oligonucleotide analogs made therefrom
US5646267A (en) Method of making oligonucleotides and oligonucleotide analogs using phospholanes and enantiomerically resolved phospholane analogues
ES2253740T3 (es) Derivados de oligonucleotidos 3'-modificados.
JPH08501308A (ja) ユニバーサル型ヌクレオシドスペーサーを有するオリゴヌクレオチド
US20190194242A1 (en) Phosphorous protecting groups and methods of preparation and use thereof
JP2008113669A (ja) オリゴヌクレオチド・ハイブリダイゼーションにユニバーサル・ヌクレオシドとして使用されるｎ８−及びｃ８−連結プリン塩基、並びに構造的に関連したヘテロ環
JP2002241393A5 (https=)
WO2003051897A1 (en) Nucleoside analog libraries and compounds
JP2002249497A5 (https=)
Niziol et al. Boron nucleic acid bases, nucleosides and nucleotides
Prusoff et al. Approaches to antiviral drug development
EP1138688A1 (en) N8- and C8- linked purine bases as universal nucleosides used for oligonucleotide hybridization
WO1995031470A2 (en) Antisense inhibitors of gene expression
Kaiser et al. Acyclic Nucleoside Phosphonates Bearing (R)‐or (S)‐9‐[3‐Hydroxy‐2‐(phosphonoethoxy) propyl](HPEP) Moiety as Monomers for the Synthesis of Modified Oligonucleotides
Alanazi Design, synthesis, and biological evaluation of novel nucleotide prodrugs as potential therapeutics
Cosstick et al. Nucleotides and Nucleic Acids
Simulescu et al. Solid-phase Synthesis of Phosphorus Derivatives