JP2002205913A - Cosmetic composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic composition having excellent healthy and bleaching effects on the skin, excellent maintenance and reproduction of healthy hair for the hair. SOLUTION: This cosmetic composition comprises one or more kinds of components of a swine or equine-derived water-soluble elastin, a water-soluble collagen, a water-soluble navel string extract and a water-soluble hen's egg extract, and a polyphenol derivative.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION The present invention provides a cosmetic composition having excellent skin tone and whitening effects on the skin, and excellent maintenance and regeneration of healthy hair on the hair. That is, it shows sufficient moisturizing, skin-healing, and whitening effects on the skin, and prevents, reduces or improves dryness, rough skin, cracks, akagire, dandruff, kayumi, inflammatory diseases, and pigmentation, and gives hair On the other hand, the present invention relates to a cosmetic composition that acts to prevent dryness, split ends, cut hairs, hair loss, dryness, stiffness, gloss, hair growth promotion and the like by drying.

[0002]

2. Description of the Related Art Human skin and hair have a moderate level of moisture retention when they are in a healthy state and usually do not require special care. However, various environmental factors (for example, temperature change, humidity change) , Physical friction, dirty air, light, contact with water, etc.)
Or by contact with detergents or by physiological aging,
It often changes and hinders.

[0003] That is, the skin or hair having a reduced moisturizing function is dry, hard, loses its luster and elasticity, and becomes crumpled. In recent years, such dry skin has been pointed out to be associated with atopic dermatitis, which is on the rise,
It may cause various skin troubles. In addition, troubles such as loss of gloss, split ends, and cut hairs occur even in hair.

[0004] It is considered that the progress of these causes serious conditions such as pigmentation of spots and freckles, rough skin, wrinkles, and hair loss.

Conventionally, glycerin, propylene glycol, 1,3-butylene glycol, other polyhydric alcohols, oil and fat components, amino acids, proteins, polysaccharides, and the like have been used in external preparations such as cosmetics in order to prevent skin and hair from drying out. Mucopolysaccharides and the like have been used.

[0006] The purpose of these methods is to form a film by applying it to the skin or hair, to prevent the evaporation of moisture, and to make it closer to the natural moisturizing factor (NMF), a stratum corneum component called NMF (Natural Moisturizing Factar). It was.

[0007]

In the conventional moisturizing component,
It was not yet satisfactory in terms of feel, durability of moisturizing effect, safety, and physicochemical stability.
In particular, the moisturizing effect was temporary and was not sufficient in terms of maintaining or regenerating physiologically healthy skin or hair, such as prevention or improvement of rough skin, hair loss, and split ends.

Accordingly, the present inventors have started the development of an active ingredient which exhibits a physiologically healthy effect and a skin conditioning effect on skin and hair, and as a result of intensive research, have found that a water-soluble extract derived from pig and horse tissues, We found that a water-soluble extract derived from chicken eggs was extremely useful, and as a result of further research on its application, we found that it was used in combination with a polyphenol derivative, which has been previously recognized for its whitening, antioxidant, and hair soundening effects. It has been found that the composition of the present invention exhibits specific and many excellent beneficial effects.

That is, by the action of water-soluble elastin, water-soluble collagen, water-soluble umbilical cord extract, or water-soluble chicken egg extract derived from pigs and horses, the skin or hair is improved to a physiologically healthy state. The skin's skin, whitening effect, prevention of aging and inflammation, elasticity recovery, etc. work more beneficially, and for hair, firmness, stiffness, gloss, split ends and They have found that they also act similarly for preventing hair loss, and completed the cosmetic composition of the present invention.

[0010]

Means for Solving the Problems A cosmetic composition containing the following components (A) and (B) is provided. Component (A) a) Water-soluble elastin extracted from pig, equine nodal ligament or hydrolyzate thereof b) Water-soluble collagen extracted from pig, equine skin tissue or hydrolyzate thereof c) Pig, Water-soluble umbilical cord extract extracted from horse umbilical cord or hydrolyzate thereof d) Any one or more water-soluble components selected from water-soluble hen egg extract extracted from chicken egg or hydrolyzate thereof (B) Polyphenol derivative

[0011] The "pig" which is the source animal of the component (A) used in the present invention is a phylum Chordata, Mammalia, Artiodactyla (Bovidae), Subcarina (Bors), Sugaridae, Porcine Sus s
It is a crofa (domestic) and is divided into true beasts. Pig is a breed as a domestic animal, and naturally its wild boar (Japanese wild boar) Sus scrofa leucomystax, wild boar (Ryukyu wild boar) Sus scrofa riukiuanus and the like can be used. In addition, breed improvement as a pig is progressing, Berkshire, Yorkshire, Landrace, Hampshire, Polish China,
Any type such as Chinese pig, Inobuta, Guinea fogg, Göttingen (mini pig), Chinese pot berry pig, Duroc, Meishantong, or any of these hybrids can be used.

[0012] The term "horse" refers to the phylum Chordata, Mammalia, Equinoides (Epidoptera), Equinaceae, and the horse Equus caballus.
(domestic), American Miniature Horse, Arabic, Argentinean Miniature Horse, Willish Pony, Willish Mountain Pony, Gorgian Horse, Kiso Horse, Quarter Horse, Thoroughbred, Sara, Shetland Pony, Tsushima Horse (Tsushima Horse), Tokara horses, Hokkaido horses (Hokkaido Japanese horses), Noma horses, Hackney ponies, Falabella ponies, Bretons, Paint horses, Percherons, ponies, Midget ponies, miniature horses, Morgan, Yonaguni horses, etc. Any of these hybrids can also be used.

[0013] The term "chicken" refers to the phylum Chordata, Ornithidae, Phasianidae, Phasianidae, Sekishokuyakei (chicken) Ga
It is llus gallus (domestic), and it is Akaza-sauzaurao, Akaza-saigogo-nankin-shamo-kasaasa-o-shamo, Akazaasa-oagadori, Akazaasaoiki,
Akaza Sasatsudori, Akaza Sajitokko, Akazasachabo, Akazasaminohiki, Alocana, Igechabo, Iwatejidori, Udan, Ukkokei, Uzurao, Utai Chuan, Australope, Ouhan Plimas Rock, Oshamo, Shamo, Okinachabo, Okinawahigeocho, Okazawa-nakedo Brown Cocktail, Katsura Chabo, Kawachi Yakko, Goshiki Kawachi Yakko, Kinza Saurazao, Kinza Sajitokko, Kimpa, Gifujidori, Ginsuzunamichabo, Kumamotosh, Crekodori, Kuroshiwa, Genpeichabo, Cochin, Koeikoshoku Black-tailed giant moth, black-tailed moth, black-tailed duckweed,
Black-tailed Chabo, Black-Eyed Marsh, Koshamo, Koshori, Golden Sebright Bantam, Goishizurao, Goishikoshamo, Goishishabo, Sakagechabo, Makigechabo, Satsumadori, Sadhigejidori, Shibashido, Shokokoku, Shojoshokudo, Shoshojona Uminohiki, Shirafujia Nagatori, Shirafujihiki, Shirafujishokoku, Silver Sebright Bantam, Shirosasaoshamo, Shirozasasasumadori, Shirozasagitoko, Sorozasaminohiki, Shirozasaminohikibo, Tosazido,
Nagoya, Nankinshamo, Outrigger, Outrigger, Outrigger, Outrigger, Outrigger, Outrigger, Outrigger, Outer Coach Bantham, Outer Shark, Outer Shooter , Hakushomininiki, hakushokreghorn, bantam, whiskered, higochabo, hinadotori, bramar, plymouth rock, pekinbantam, polish,
Eggs of any kind, such as Minohiki, Minohikichabo, Miyazakidori, Yamatogunkei, Rhode Island Red, and eggs of any of these hybrids can be used.

The "flavonoid" of the component (B) used in the present invention means that two benzene rings are linked by three carbons.
Is based on C ₆ -C is ₃ -C ₆ compounds Phenylchromane,
It is a generic term for compounds including their oxidation or reduction products, and is classified into flavone, flavonol, chalcone, flavanone, dihydroflavonol, isoflavone, anthocyanidin, neoflavanoid, and auron. Representative examples include acacetin, alpinenetin, apigenin, baicalein, butein, chalcone, chrysin, cyanidin, daidzein, diosmetin, echinatine, eriodictyol, eupatorin, galangin, genistein, hesperetin, hinoki flavone, isoquercetin, isoramnetin, isoramnetin Isovitexin, kaempferol, luteolin, malvidin, morin, myricetin, naringenin, narirutin, neoeriocitrin, neohesperidin, procyanidin, puerarin, quercetin, rhamnetin, leupholin, rutin, saponalin, scutellarein, sinensetin, spiraeoside, vitexin, etc. Can be Further, these glycosides and derivatives may be used.

The term "coumarin" used in the present invention means 2H-1-benzopyran-2-on in which an α-pyrone ring is fused to a benzene ring.
A compound having e as a basic skeleton and including an oxidized or reduced product thereof is intended. Coumarin is classified into monocyclic α-pyrone, coumarin, isocoumarin, and phthalide.
Representative examples include angelicin, bergapten, bergaptor, citropten, coumarin, dalbergine, daphnetin, esculetin, esculin, imperatrine, quinmelosine, psoralen, scopoletin, umbelliferone, xanthoxin, hispidine, ostol, alkangericin, xanthi Retin, bisnadine, capillarin, artemidine, phyllodurtine and the like. Further, these glycosides and derivatives may be used.

"Phenylpropanoid" used in the present invention is a substance in which three straight carbon atoms are bonded to a benzene nucleus,
That is, it is a compound having a C ₆ -C ₃ compound as a basic skeleton, and a compound containing an oxidized or reduced product thereof is intended.
It is classified into phenylpropanoid, coumarin, lignan, neolignan, sesquilignan, dilignan, lignin and others. Representative examples include ferulate, chlorogenic acid, cinnamic aldehyde, coniphenyl alcohol, syringenin, dihydroconiferyl alcohol,
Examples include anethole, eugenol, safrole, myristicin, steganacin, gomisin, magnolol, hinokiol, lysospermic acid, kazullenone, gingolide, asaton, rappaol, and the like. Further, these glycosides and derivatives may be used.

The "tannin" used in the present invention is a plant-based polyphenol, and is a compound containing an oxidized or reduced product thereof, and is a hydrolyzable tannin (pyrogallol tannin) or a condensed tannin (catechol tannin). )are categorized. Representative examples include gallotannin, quintuple tannin, gallic tannin, tannic acid, asatannin, hamamelitannin, ellagitannin, ellagic acid, geraniin, corirazine, tubrazic acid, agglymonin, caffeic acid, chlorogenic acid, rosmarinic acid, labdocin, Catechin, epicatechin, leucoanthocyanidin, proanthocyanidin, procyanidin, prodelphinidin, profisetinidine, epigallocatechin gallate, epicatechin gallate, theaflavin, thearvidin epigallocatechin, epicatechin and the like. Further, these glycosides and derivatives may be used.

The "extracts from crude drugs, plants, fungi, microorganisms and other natural products containing polyphenol derivatives" used in the present invention are exemplified by the following extracts from natural products. can do. That is, Sa
Yeast or culture thereof belonging to ccharomyces, Acacia elegans, Ashitaba, adzuki bean, asparasa linenalis, assamcha, anise, avocado, amacha, amachaworu, arabica coffee tree, arnica, almond, almond, aloe, ansokko, squid, mussel, izayoibara, itadori , Ginkgo, rice, grasses of the family Poaceae (genus Harugaya, Anemone spp., Sparrows), nettle, fennel, turmeric, umebasaisin, keirinsaishin, usbnia oyster, prunus, unshrewed orange, elephantia , Erabu sea snake, pea, spinach, milk thistle, Pseudomonas persicae, barley, okra, panax ginseng, edulis, ononis, Dutch mustard, watercress, Dutch jelly ( Seri), Netherlands Mitsuba (celery), orange, Bombyx mori, Diospyros kaki, valerian, chamomile, oat, ramie, Karin, Artemisia capillaris, licorice, Uncaria Gambir, raspberry, kiwi, yellowfin tuna, cucumber, Kinanoki, debris, gardenia,
Kumazasa, cumin, clara, grapefruit, chlorella, gentiana, gennoshoko, kenponashi, kousuiminka (lemon balm), red algae, kohone, koganebana, kobateishi, burdock, wheat, rice bran, saffron, sabonsou, hawthorn, shitake, shita, shita, shii Perilla, peonies, scabbard, jasmine, ginger, ginger, scab, shirovanairis, honeysuckle (goldfish, gentian), horsetail, stevia, red pine, hypericum perforatum, hypericum perforatum, euphorbia sylvestris, euphorbia serrata Sambucus nigra, Atlantic mouse, Achillea millefolium, Common mint,
Rose, sage (salvia), senkyu, assembly, soybean, natto or its culture, daidai,
Aspergillus japonicus, antelope, clove, choreimaitake, camellia, camellia, teuchiwa walnut, touga, touki, tokinsenka (marigold), eucalyptus (larva such as insects of bat family), corn, dokudami, tomato, swordfish, fresh seaweed Carrot, garlic, noibara, nobara, hakukayumato,
Adlay, Hamanashi, Hamamelis, Hikikoshi, Kurobana Hikikoshi, Cypress, Himakuma, Sandalwood, Hillflower, Belowroad Oy (Usubenitachioi), Loquat, Fukitanpopo, Grapes, Beech, Fuyudaidai, Loofah, Safflower, Hosobarengi
Hong apricot, apricot, magaki, magwa, matsuhodo, matsurika, quince, mannenrow, mannshugurumi, onigumi, mannentake, euglena (euglena),
Skull, purple, purple flower, purple flower, melilot, peach, cornflower, eucalyptus, eucalyptus similis, yukinoshita, yuzu, lily, European birch, propolis, royal jelly, honey, pollen, mugwort, sagebrush, lavender, lavender
Mung bean, apple, lettuce, lemon, astragalus, roman chamomile, waremokou, cyanobacteria, cloococcus and microcystis and julemo, spirulina and formimidium, brown algae, red algae, green algae, brown seaweed kelp and reddish Algiaceae belonging to algae, sweet tonsil, barley, aloe vera, kidachi aloe, orange luffy, cape aloe, Aloe africana Miller, Aloe spica
ta Baker, Kobotol, Sinanikei, linden tree, medusa, serpirum, duke,
Tormentilla, Parietaria, Kyounin, Lactococcus,
Lactic acid bacteria, Lactococcus lactis, Lactobacillus, Western-type lacquer and the like. Regarding plants, flowers, spikes, pericarp, fruits,
Stems, leaves, branches, branches and leaves, stems, bark, rhizomes, root bark, roots, seeds or whole plants can be used.

As the component (A), directly or directly from pig, equine ligament, skin tissue and umbilical cord, chicken egg,
After hydrolysis using an acid, an alkali or an enzyme, extraction is performed using water or a water-soluble solvent. Nominal ligaments, skin tissue, and umbilical cord as raw materials are subjected to blood removal or freezing for aseptic purposes,
Processing such as melting or heating, or removal of oil-soluble components for removing hormones may be performed.

The extraction solvent may be water, physiological saline, alcohols (for example, lower alcohols such as methanol, anhydrous ethanol and ethanol, or propylene glycol,
An organic solvent such as polyhydric alcohol such as 1,3-butylene glycol) or acetone can be used alone or as a mixture of two or more kinds.

The production method is usually carried out in the range of the boiling point of the solvent at normal temperature to normal pressure, and after extraction, filtration and, if necessary,
Sterilization, pH adjustment, ion exchange resin, activated carbon column,
Purification treatment such as deodorization, decolorization, and removal of allergen components is performed using a dialysis membrane or the like. The extract thus obtained can be used as it is as the component (A), but it may be concentrated and dried to be used as a paste or powder.

As the component (B), a synthetic compound or an extract from the natural product is used. When a natural product is used, the raw material is mainly extracted using water, ethanol, propylene glycol, 1,3-butylene glycol, or a mixture thereof as a solvent at room temperature to the boiling point of the solvent. A liquid or a concentrate or a dried product thereof can be suitably used.

In the cosmetic composition according to the present invention, the component (A) contains 0.0001 to 20% by weight (preferably,
0.001 to 10% by weight). In the case of an extract, it is used in this dry conversion amount.

In the cosmetic composition according to the present invention, the component (B) is usually desirably contained in a concentration of 0.0001 to 5% by weight as a solid content of a single substance or a mixture.

The cosmetic composition according to the present invention includes 1) topical or systemic skin cleansing or skin cosmetics, 2) medicinal and / or cosmetic preparations applied to the scalp and hair, 3) baths Bath agent used in hot water, 4) Deodorant and deodorant for human body, 5) Sheet for skin application, cosmetic sheet, cosmetic cotton, sanitary goods, sanitary cotton, wet tissue, etc., ampule , Capsules, powders (powder), granules, solids, solutions, gels, air bubbles, emulsions, sheets, mist, sprays, and the like.

Specifically, basic cosmetics such as lotion, milky lotion, cream, ointment, gel, lotion, oil, pack, mist, facial cosmetic sheet, shaving agent, facial cleanser, skin cleanser, Hair cosmetics such as shampoos, rinses, hair treatments, hair styling products, perming agents, hair tonics, hair dyes, hair growth and hair growth, makeup cosmetics such as foundation, lipstick, blusher, eyeshadow, eyeliner, mascara, and perfumes Kind, skin deodorant,
Antiperspirants, bath additives, etc. are raised.

The cosmetic composition of the present invention may contain, in addition to the above essential components (A) and (B), if necessary, components and additives exemplified below as long as the effects of the present invention are not impaired. It can be arbitrarily selected and added.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea butter, soybean oil, camellia oil, corn oil, rapeseed Oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, or hydrogenated products of these oils (hardened oil, etc.) )Such.

(2) waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, squalene, squalane, pristane, etc.

(3) Mineral oil Liquid paraffin, vaseline, paraffin, ozokeride, ceresin, microcrystalline wax and the like.

(4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid Synthetic fatty acids such as, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

(5) alcohols ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterols, 2-hexyldecanol,
Synthetic alcohols such as isostearyl alcohol and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters: Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose or its ester, trehalose or its derivative, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or alkylene such as chitosan, ethylene oxide (C2-C4)
Hydroxyalkyl to which an oxide is added (C2-C
4) chitin or chitosan, low molecular weight chitin or chitosan,
Chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or a salt thereof, hyaluronic acid or a salt thereof, chondroitin sulfate or a salt thereof, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose , Hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide or polypropylene oxide or a crosslinked polymer thereof, carboxyvinyl polymer, Polyethyleneimine and the like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate type amphoteric surfactant, nonionic surfactant (ether type nonionic) Surfactants, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing nonionic surfactants), other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactants, surfactants containing titanium and silicon,
Fluorocarbon-based surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: vitamin C acid or its derivative, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxelol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K
2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U Such.

(12) Various amino acids: valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine and the like, and their sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a conventional manner according to the type and form of the product to be added (for example, grinding, milling, washing, hydrolysis, Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decoloration, etc. Can be selected for use. In particular, plants can also be used as the component (B) according to the present invention.

The solvent used for the extraction may be appropriately selected in consideration of the purpose and type of the product to be produced, and the processing to be performed later. Usually, water and a water-soluble organic solvent (for example, , Ethanol, propylene glycol, 1,3-butylene glycol, etc.)
It is desirable to use a mixture of two or more species. However, when the content of the organic solvent is not preferable depending on the application, it is sufficient to use only water or ethanol which is easy to remove after extraction, and it is only necessary to use any mixed solution alone or with water, and to exploit. It may be something.

In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical cosmetics, including protection of skin and hair, moisturizing, whitening, improving feel and texture, imparting flexibility, relieving irritation, relieving stress by fragrance,
Cell activation (prevention of cell aging), suppression of inflammation, suppression of allergy, improvement of skin and hair quality, prevention and improvement of rough skin, hair growth, hair growth, prevention of hair loss, gloss imparting, cleaning effect, relief of fatigue, blood In addition to cosmetic effects such as flow promotion and warm bath effects, addition or enhancement of effects such as fragrance, deodorization, thickening, preservation, and buffering can be expected.

As a specific plant (crude) used as a raw material,
For example, almonds (herring peach), eyes (blue leaves), blue berries
(Seifu Fuji), Aoki (Aoki), Aokiri or Kenasia Ogiri
(Otogi), Aotsurafuji (Kibo), Acacia, Akashoma (Akasho), Akasuri `` Fruit '', Red clover, Red grape, Akaminoki (Logwood), Red acacia (Red bud), Akane (Akane grass root), Red acacia or Jio ( Ground yellow), Agi (Awei), Aki larch, Akinire (Lauyu skin),
Aguay Guacu, Aguahe (Omitengu palm),
Akebi (Kidori), Asa (John Asako), Malva Asagao or Asagao (Toshibushi), Hydrangea (hydrangea), Ashitaba (Asahi),
Azuki (red azuki bean), acerola, asenyaku (Asenyaku), acira (shokuyoukanna), anise, abiu, abiurana, rape, avemaki `` fruit '', avocado, ama, amacha (sweet tea), amachaworu, amadocoro (tamatake), Amana (Kikomiko), Amaranthus (Amaranthus, Barnyardbean, Himagotoi, Senninkoku, Sugimorigeito, Hosoaoigaito, Aogateto, Haribiyu, Amaranthus hippochondriacus), Amigasa lily or Bimo (shellfish),
Aristolomeria (Yurizisen), Arcana (Alcanna), Argarrobo (Cabbage), Altea, Arnica, Alpinia or Katsumadai (Souduq), Aloe (Length), Aloe Vera, Angelica, Apricot or Hong apricot (Anjin), Ansokkou (Azusa), Yellow Sapote , Ikakozorina (ground bile head), Epimedium or Epimedium
(Inyokaku), Igusa (Wicked grass), Knotweed (Tiger root),
Strawberry (first place), strawberry, fig (Fig.
Leaf)), Ichihatsu (first time), Ichibi (Aoi-ko), Ichiyakuso (one medicinal herb), Ginkgo (Ginkgo `` seed, leaf ''), Itohimemehagi (Enshi), Carob, Inu-zuna (Telelexi), Inuyuyu (Sonagainubiyu), Rice `` seed, seed coat '', Inondo `` seed '', Ibuki-kusou-so, nettle, ylang-ylang, iwa-tobacco (Iwazuchi-chi), iwahiba or iwa-matsu (makikashiwa), oolong tea, wikyo (fenka), wheat (tibusanoki), ukiyagara (Miyako) ), Uguisukagura "fruit"
Himeuikyo, Turmeric (Utsukin), Duckweed (Buoying), Usubasaishin or Keirinsaishin or Shousaisaishin (spicy), Usvenia oi, Usvenitai oi, Utsubogusa (summer hay), Udo or Shishiudo (Qangji, Independent, Tang Independent) ), Unyadegato (Unkaria, Cat's claw), Uba tea, Ume (Ume `` seed, pulp ''), Urajirogashi, Uwaurushi (Kusakokomomo), Unshu mandarin (Chen skin), Estragon, Ezocogi (Ezogoka), Echinashi (Hosobamurasakikirengiku) , Enishida, Enokitake (Enokitake), Ebisugusa or Cassia Tola (Keiko), Elcampre, Elderberry `` fruit '', Elemi, Elingii or Prelotus elinge, Endu (Gossip, Sophoraceae rice), Ogi or Kibanaugi (yellow) Hoki), Ousei (Naruco Yuri, Kagi Kurumabanaruko Yuri), OuHisasa Yuki or Sasanoyuki, Coptis (Coptis), Oogatahouken, giant Karasuuri (Karokon), Ooguruma (civil engineering incense), giant Tsudzurafuji
(Self-defense), psyllium (car forehead, care forehead), toucan (haruko), toucan cactus, Obanana okera or okera
(White jujube), large-leaf crab (banaba), large-leafed beetle "fruit", large-leaf grass (grain sperm), large-flowered catechu, large-leaved hawthorn or hawthorn (barley), barley
(Barley), oka, okazeri (snake bed), okra `` fruit '', ogulma (turnover), panax ginseng or ginseng (carrot), hypericum or hypericum perforatum or perforated periwinkle (brother cutting), dragonfly (continuous), onamimi Ears), Onigurimi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyagara (Tenma), Oniyuri or Sasasayuri or Hakatayuri (Yuri), Ononis, Halibut
(Hihayu), Ominaeshi (defeated soybean), Oyuco, Dutch mustard (Watercress), Dutch jelly, Dutch honeywort, olive "fruit, seed, leaf", oregano, orange "fruit, pericarp", silkworm (ripened yellow) , Cocoa "fruit, peel,
Seeds '', oysters (persimmons `` leaves ''), kagi kazura (fishing hooks), oysters or kantosou (rensensou), gaku hydrangea, cassia, casino ki (crops fruit `` fruits ''), gajutsu (shadotsutsu), Kashiwa
(Kazuki, Kazaha), Cascarilla, Cascara sagrada, Gypsophila, Kanixa (Kin Sato), Kaniwa, Carnation,
Valerian (valerian root), birch or weeping birch (white birch), gerbera, pumpkin, kapokki `` seed '', kahokusansho (pepper), gama (bamboo yellow), chamomile or roman chamomile, chamomile (weed), camu cam (duckling),
Color, Karaku salmon, Calla uri or Chinese iris cucumber (Our gourd), Callas bishaku (Midsummer), Oats wheat, Guarana `` seed '', Calla pho (Pop), Karaya, Galyu, Karin
(Gourd melon), Garcinia, Kawamidori, Kawara Psycho (Koryosai, Hakuboshi), Kawazusha, Kawaratake, Kawaranadeshiko (Ishitake) or Ezokawaranadeshiko (Qumugi, Quumiko), Kawarangin (Blue Mustard), Kawamuragi (Inchinchinko) , Kansui
(Sweet), licorice (licorice), cantaraasa, candelilla,
Kanto, Canna, Raspberry (Ezo strawberry, Dutch strawberry, Shrimp strawberry, Nawashiro strawberry, Maple strawberry, European strawberry), Kiwi `` Fruits, leaves '', Kikarasuuri (Urorone), Kikyo (Kikyo, Kikyo root), Kiku (Chrysanthemum flower, Shimakaniku, Artemisia japonica, Kikutanagiku, Catalpa (Azumitsu), Rigid ridge (Yotei root), Pheasant (Kikomi), Kizuta, Kidachi aloe, Kidachiha, Kina, Kinoki (Shincona, Akaki linoki), Quinoa (Kinoa),
Yellowfin, yellow sylvesta, kimmenkaku, cabbage, cabbage "immature fruit", cucumber, gyoryu
(Nishikawayanagi, Ichiyanagi), Kiraja Saponaria, Kiraya, Kiranso (Gold Acne Herb), Kumquat `` Fruits '', Ginseki,
Kimbusen, betel, golden hibiscus (Sesame crane), guapeba vermelha, guava `` fruit '', guayule, quelux infectria (gallicate), kukuinuts,
Wolfberry (Gugi, gugiko, gugi leaf, ground skin), cedar
(Tenmen winter), Kudzu (Kakkon), camphor tree, gooseberry `` fruit '', ginseng (yellow flower), cutiti river, gardenia (garden garden), kunugi (bokuso), kupuasu, kumazasa,
Black pine (horse whip grass), Clara (bitter butter), cranberry `` fruit '', chestnut `` seed, fruit, astringent skin '', curculigo latifolia `` fruit '', grapefruit `` fruit / leaf '', buckthorn, black squirrel, rescuer Or Hikiokoshi (extended lifegrass), cloves (cloves, cloves), gumbinazuna (sekimei, sekimeishi), kaigai (infestation, infestation), celosia (corolla, rooster), gekkavidin, bayberry (laurel), kenashisarutoribara (soil) (Bukuryo, mountain return), gentian, genoshoko (old treasured grass), kemponashi (kigushi), koukisekoku, kishumikan (kouji, tachibana, ovenimikan, fukuremikan, sagamikouji, ponkan, santara (tachibana skin)), koshinbara (monthly flower) , Kosui mint, Kozo "fruit", Kocha (tea), Kouhone (river bone), Koho (Straw and kara straw), Koryang, Koryokyo (Kora Kyo), Cilantro `` fruit '', Kouren (Kohren), Koganebana (yellow Gon), bilberry (Koshibachi), coconut `` fruit '',
Goshuyu (goshuyu), goshoichigo (covered bonko), pepper
(Pepper), cosmos, copaiba balsam, coffee `` seed, leaves '', kobushi or magnolia (hot spring), burdock (burdock,
(Burdock), kobotdur, sesame (sesame), sesame seeds (spotted ginseng), beetle (gomiko), Sanekazura or binankazura or pine bush, wheat (wheat), rice or rice bran "red bran, white bran", rice oil, cola acuminata " Seeds ", Cola
Vera “seed”, colony lya, fenugreek “fruit”, colombo, kondurango, kelp, konjac, comfrey
(Final barn grass), sisal (sisal asa), saxima button or syna button or cinnamon
Sakura (Oshimazakura, Yamazakura, Oyamazakura, Edhigashi, Mamezakura, Miyayamazakura, Yoshino cherry tree, Takanezakura, Kasumizakura, Chojizakura,
Kohigan, Satozakura, Kanzakura `` leaves, flowers, fruits, bark (cherry bark) ''), cherries, pomegranate, sasa, sasanqua,
Sadomodaka (Sawaka), Sweet potato, Sugarcane, Sugar beet, Sun jujube (Satsuma jujube), Saffron (Bamboo safflower, West safflower), Sapodilla, Sapotea marillo, Pomelo `` Fruit '', Savonso, Salmon berry `` Fruit '', Sarasinuma (Masahima) , Salvia (sage), Sawagikyo (Sankyona), Sawagumi (Sanguo), Sankaku cactus, Sangre degrad (Croton), Sansouyousou, Sanshin ginseng (San carrot), Sanshuyu (sanshuyu), Sanshoyu (sanshoyu) ), Sandscon (Yamazone), Shea (Karite), Cyano (fruit), Shiitake (Shitake), Shion (Shion), Dikitaris, Shikunshi (Kimiko), Perilla or Aodiso or Chirimendiso or Kamenendoso (Shiyo leaf, Shiso) ), Rosewood, linden, Chinese pine, Chinese forsythia, shimeji
(Hinshimeji, Shakashimeji, Hatakeshimeji, Oshiroishimeji, Bunashimeji, Honjimeshi, Shirotamogitake),
Shimokren (hot spring), sycamore, potato, peonies (shakuyaku), shajin (shasan), jasmine (matsurika), janohige (wheat gate winter), gypsophila paniculata, sycamore (sandy sand, compact sand), juzdama, palm Fruits, ginger (ginger), ginseng hydrangea (Tsuneyama), shobu (irises, iris roots), shojiku (fruits), shirakashi (seed), shirogoshi butterfly (seed), white clover (clover), white adzuki (chicken bone grass), Shirobanairisu (Small iris), Shirobanatsuta "flower", Shirominanten (Minamitenmi), Cinchonasakusylbra, Jinkoge (Mizuka, Mizuka, Sinking flower), Cinnamon, Cinnammum cassia (cinnamon bark), Watermelon (watermelon), Honeysuckle (gold and silver) Flower, Shinobi winter),
Sorrel (acid model), swimberry `` fruit '', star apple, stevia, strawberry `` fruit '', suzu psycho (Xu Chang Lord), horsetail (Qing Ting), purslane (horse tongue, horse tooth kenko), plum `` fruit '', pear Japanese red pine “cone”, larch, vegetative, walnut, walnut, hawthorn, dandelion, horse chestnut
(Marronnier), pear `` fruits '', snowy pears, Atlantic elderberry, elderberry, elder tree (juniper, juniper), yellow millet (milfoil), yellow rose, yellow balsam, yellow mistletoe, yellow crow,
Horseradish, Sekisho (Iris), Sekkoku (Ishimusu), Cedron (Bowshuboku), Zeniaoi, Hirohase Nega, Senega, Seri, Celery, Sengyu (Kawakyu), Sengshinren (Shinshinren), Sengdan, Senninsaboten, Senna , Leaves '', senninso (great tate), senburi (drug), squid (vegetables), elephant, buckwheat `` seed '', soybean potato, rhubarb (daioh), radish, soybean, daidai (orange peel, kimi), takasaburo ( Drengsou), Takatodai (Daigei), Takawarabi (Inu spine), Dark sweet cherry "fruit", Tachiaoi, Tachijakoso (thyme,
Hyakurika), Tachidokoro (Hikai), Tachiyanagi, Tamarind `` seed '', onion, tamshiba (spicy), Taranoki `` fruit, leaf, root bark '', dahlia (tenjikubotan), tarwi,
Tanshiniwa, Tanjin (Dan ginseng), Dandelion (Gankoei) or Shirobana dandelion or Moko dandelion, Dammar, Cherry `` fruit '', Tigaya `` fruit, root, bud '', Chixet carrot (Bamboo ginseng), Chicory, Chancapiedra (Kidachiko Mikansou) , Datura (Rhuanghuang), Daffodilium (Wuyi), Artemisia (Aiba), Choreimaitake (Irei), Chorogi, Tsukimisou, Tsukuritake (Mushroom), Camellia, Camellia, Tsumexa (lacquer grass), Camellia Ducklings), Azuki bean (red azuki bean), Tsurukudami
(Hanshu crow), Tsuruna (Ban apricot), Ginseng (four-leaf ginseng), Tsuwabuki, Deiko, Teuchigurumi, Duberry `` Fruit '', Tulip, Chocolate stay, Tengusa, Tencha (Tencha), Tendaiyaku (Wood medicine), Touga (Winter urach) ), Squash, capsicum (pepper), squid (return), calendula (marigold), tonabena (river cut), corn or corn hair (southern barbed hair), scutellaria (female child), torindo or kosen Gentian,
Tokusa (wood pirates), dokudami (jujutsu), konkon (sore root), sashimi or beetle or scutellaria, eucommia (mushroom `` bark, leaves, roots ''), ash (qin bark), tomato, tragacanth, triacanthos `` seed '', Turkey Kikyo, Tormentilla, Dronoki, Trolo-mallow, Niseria berry "fruit", Chinese yam or Yamanoimo (Yamayaku),
(Bucher Bloom), Naginata Kouju, Nazuna, Rapeseed, Natsume Bean or Hatehaki (Sword Bean), Natsumikan, Jujube (Dajutsu), Naniwaibara (Kanakurako), Navena (intermittent), Nameko, Narco Lily (Yoshimi), Peanut (Peanut) ), Nanten (Minami Tenmi), Nanban Karamushi (ramie), Niois violet,
Nigaki (bitter), bitter mugwort (bitter), nutmeg, kei or nikkei or Ceylon nikkei or yabnikkei (cinnamon bark)
Or Keishi (Keishi), Chinese chive (Niriko), elderberry (bone-bearing tree `` fruit, flower, stem, leaf ''), garlic (garlic), nulde (fivefold child), leek, nemoki or nebu or nebi or nemulinoki or zigokubana ( Healing), Noa thistle (Ohi), Noibara (Fruit), Yarrow, Nodake (Maehu), Nobara, Nomomo,
Pineapple `` fruit '', Hibiscus (Bussouge, Furin Bussouge, Roselle), Hi-Gindou, Hauchiwa, Pau Dosse, Haka-Muraboshi (Bone Crushing), Hachsen
(Ringworm skin), huckleberry `` fruit '', chickweed (reddish), hazel (haruko), hasiridokoro (roth root), basil, lotus
(Lotus, lotus meat, Renko), parsley (Netherland jelly), naked mussels, batata, bees or medakes (bamboo-boiled), patchouli, mint (lightly-loaded, lightly-leaved leaves), pearl barley (yokuninin), hanasuge
(Chimo), Banana, Hanamint, Hanabishi (Siturishi, Shisitsuri), Vanillabins, Papaya, Scotch (Rice koji), Pahalobobo, Hub `` Whole grass, stem, leaves '', paprika,
Hamago or Mitsuba Hamago (vine thorns), Hamazuge (Katsukishi), Hamabishi (Satsuriko), Hamanas (maikai flower), Hamabou (beach storm), Hamamelis, palm, rose (rose), balata, balata rubber tree, agaric (haratake,
White agaricus, Usukimori no kasa), Haran, Pariurus (Pleurotus japonicus), Parietaria, Balsamina (Tsurureishi, Nigauri), Harunile (Yellow, Yu white skin, Yuba), Barbasco, Harindou, Handaikai
(Giant Sea), Breadfruit, Hiogi (Ranking), Lycopodium Carrot (Party), Pecan Nut, Giganbana (Shirubi, Jinjusha Hana), Higul Madaria, Hishi (Ryomi), Pistachio, Beet, Hitotsuba (Ishire) , Aedes fern, daisies
(Daisy), Hinata Kozuchi (cow knee), Hinoki, Hiba,
Castor, Sunflower, Bell Pepper, Himeuzu (Tenoi), Himegama (Kaba), Himematsutake (Kawariharatake, Hiromatsutake), Pimenta `` Fruit '', Juniper, Bjakuyu, Hiyu `` Fruit '', Belowudooi, Hirohiro Okinagusa (Hakutooka), Loquat Fruits, leaves, stems '', betel wax (large clothing skin, betel nut), puerh tea (Pulse tea), sprout kazura (southern rattan), butterflies, coltsfoot (populations of winter flowers, copulations of winter leaves), fujibakama (rice grass), fujimame (flat beans) ), Grape "fruit, peel, seeds,
Leaf '', beech, sycamore (caterpillar), Brazilian liquorice, Brazilian carrot, black currant `` fruit '', blackberry, blagnen, plum `` fruit '', flucellaria, blueberry (Prunus avium), prune, floral blanka, Blond psyllium, bundou (mung beans), hazelnut, loofah, safflower (safflower), henneken, belladonna, berry `` fruit '',
Persea, Perbianberg, Pereschia grandifolia, Benikea or duckweed (Keiten), Boysenberry `` fruit '', Broomweed or Elderweed or Nendou or Hawakigi Kokia (Skinkoshi), Baldwink (Fengxian, Acute child, Perforated grass) , Potteria sapota, potteria lukuma, spinach, boufu (windbreak), spinach, physalis (toron), honoki (wakopoku, park), bokeh (gourd), hosovanaokera (blue jitsu), hosobanokirinsou (geitensan) Seven), Hosobabarengiku, Bodaiju (bodai tree), button (peony "flower, leaf, stem, bark"), buttonpi (peony skin), hops,
Jojoba, Bolizi (Ruriichisha), Bordeaux, Whittle berry `` fruit '', Hong Onik (meat porcelain, Daigei), Hong Sekkok (iron bark stone, sparrow mountain stone masum), misurutennanshaw
(Tennan star), Maitake (Maitake), Ephedra (Maoh), Maca, Macadamia nut, Margaret (Mokshungiku), Macri
(Sea grass), maguwa (mulberry white bark `` bark, leaves ''),
Splengeli, Masaranpouba, Masaransububa do
Ceara, Masheira de Boi, Mashua (Tamanouzenhallen, Kyukonkinrenka), Matabi (Mokuten Tate), Matsukasa, Pine `` leaves, bark, roots '', Matta Olho, Matsuhodo (Bukuryo), Matico (Cordon Sillo) ), Mayorum (Hanaminka), Malvanojazine (Difficult), Mulberry `` Fruit '', Quince, Malein (Birudomouzumizu), Mango, Mangosteen, Mansagna (Andesca Mitzle), Mansugurumi, Mandarin `` Fruit '',
Mannentake (Lingzhi), Pheasant (Kikomi `` fruit ''), Mishimasaiko (Saiko), Mizuobako or Mizuasagao (Ryugoshi),
Mizokukushi (half-edge lotus), Misohagi (Chisatsuna), Mizunagi or Shiroyanagi (Henryoku), Mitsugashiwa, Mitsuba, Midorisapote, Midorihakka, Mimosa, Myoga, Miracle fruit `` Fruits '', Myrrh, Milobaran, Wheatwaragiku, Mukuge (Mokuge) , Mukunoki, Mukuroji (prolonged skin), Munya, Purple (purple root), Purple or purple
(Purple beads), purple corn, purple purple (Kunming chicken blood wisteria), megakanza opuntica, mehajiki (mother grass), red eel, mela loica, melissa, melilot,
Melon `` fruit '', sagebrush, moso bamboo, moku giraffe, moje (koshoboku), mock berry (wood incense), maple blossom, peach (peach `` leaves, seeds, flowers, fruits ''), bean sprouts, morello cherry `` fruits '', moroheiya (Burlap), yakawa murasaki potato, yakuchi (masuti), cornflower mackerel (cornflower), cornflower mint, yacon, yashabushi (arrow wheel) or himeyashabushi or giant yashabushi `` fruit,
`` Peel, kaho '', willow willow, Japanese yade (octagonal gilded), mistletoe (parasitic willow), willow (kawayanagi, tachiyanagi, weeping willow, red willow, pussy willow, dogwood willow,
(Sweet willow, koreanagi, unryuyanagi, yamayamayanagi, palm, yamayanagi, giant willow, tyrichkinuyanagi, fox willow, bonsai), willow `` leaf,
Stalks ''
(Tsurusui, Tenmeisei), pokeweed (commercial land), yamanoki (yamaharu), yamamomo (yangmei), yamamugi, eucalyptus, yukinoshita (tiger ear grass), yucca or flevifolia, yuzu `` fruit '', lily, yorigusa , Mugwort (Aiba), reigan (Rainuma), lime "fruit", rye, lakanka "fruit",
Raspberry `` leaves, fruits '', latania (Clameria), Rakkyo or shallots (Shiroi), lavender, longan (longan meat), agave (Aono agave,
Fukurin agave), Ryokucha (green tea), apple `` fruit, seeds, leaves, roots '', gentian, rubus or suavisimus (sweeten), litchi (lichi, lichi nucleus), lettuce (chisha), red currant `` fruit '', Red pitaya, lemon `` fruit '', lemongrass, forsythia or Chinese forsythia (forsythia), astragalus, coconut palm, locust (reed), loganberry `` fruit '', rosemary (mannan wax), rosehip (nobara), wasabi, Waremokou (chiyu) and the like.

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usubaonori, Susiaonori, Hiraaonori, Bowaoonori, Hosoedaoonori), Anaaousa (Aosaa) and the seaweed [Aosa] Kinds: Kombu (macomb, rishikonbu, hosomekombu, mishitsembo), wakame, hirome, blue seaweed, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitys luetokeana), hijiki, hibamata, umiuchiwa, usubaumiwiwa Klebanoumi prickly pear, Akaba prickly pear, Konau prickly pear, Okina prickly pear, Usuki prickly pear, Echinoki prickly pear], seaweed [Red algae: Hijirimen, Maxa (Tengusa), Hirakusa, Oniku , Obakusa, Kataobakusa,
Yatabegusa, Yuikiri, Shimatengusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Byaksinkirinsai, Tsunomata, Obatsunomata, Tochaka (Yahatsutsunomata), Ezotsunomata, Togetsunomata, Hirakotonogi, Kotobino, Kotobino , Hyus banori, Akamomininori] and the like.

Other algae, for example, green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kwanomimo: Kwanomimo, Volvox: Ohiokawawari, Volvox, Palmera, Yotsumemo, Spirogyra: Hizaori, Spirogyra, Tsurugimidro, Hibimidro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asamidori gusa, kawashiogusa, marimo, baronia genus: tamagobaronia, tamabaronia, tamagatamo: tamatamamo, iwata: husaiwata, surichogita, heraiwata, crocodile, crocus Sakibutimiru, Nagamir, Hiramil, and Casanori:
Casanori, Juzumo: Futtuzumo, Tamazumi,
Species of the genus Mizudzumo, Genus genus, Colecaet, Genus genus, Species of the genus Rosa: Rosa spp.

Cyanobacteria (Genus Lynch: L., L., L.), Genus: L., mushrooms,
(Hassay, Yuremo, Racenmo (Spirulina) genus: Spirulina, Trichodesmium (Aiakashio), etc.).

Brown algae (Piraella spp .: Piraella spp., Spirogyra spp.
Isogawara genus: Isogawara, Kuroshira genus: Gunsenkurogashira, Kashirazaki genus: Kashirazaki, Muchimo genus: Muchimo, Hiramutimo, Kebelligsa, Amidigusa genus: Amidigusa, Sakibiroamiji, Sanadagusa: Sanadagusa, Fukurinamiji, Common genus, Common genus Artemisia spp.
Genus genus: genus pine, genus genus: genus genus: genus genus, genus okinawa, genus okinawa mozuku, genus nov. Ishige, Irolo, Icmegasa: Ichimegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Ursigsa,
Betula serrata, Betula serrata, Laminaria spp. Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakuganusa: Shakuganusa,
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Genus: Genus Genus: Fennel, Turmo Genus: Turmo, Aname Genus: Anana, Sinus Genus: Sujime, Genus Missiscoma: Genus Ligustrum, Genus L. , Oni-kombu, Gohei-kombu, Naga-kombu, Pea-kombu, Ochimitsu-kombu, Toro-kombu genus: Toro-kombu, Antokume genus: Antokume, Kajime genus: Kajime, Tsuruarame, Kurome, Kikuishicombe genus: Kikuishikombu, Nejirekombu: Nekorecome genus, Kuroshiomeko genus : Nekoshikambu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yabanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Hokumokumo, Tamamomaku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametarawara, Tatsukuri, Yasumatamoku, Umitoranoo, Oobamoku, Fushizushimoku, Hahakimoku, Togemoku, Jolemoku, Saw-momiku, Obanomigomi, Genus Genus
Bulukimo, genus cynomolgus: cynomolgus etc.).

Red algae (Russia genus: Bovine genus, Funori bonus, Amanori genus: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Larvae, Larvae, Larva : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: Sodegarami, rattle genus: rattle, hiragaragara, hirohatamatamaki genus: hirohatamaitadaki, tamamaidaki genus: tamaitadaki, swordfish genus: swordfish, swordfish, tengusa, swordfish, swordfish, swordfish, swordfish, swordfish, swordfish, and swordfish Genus: hibiroudo, himehibiroudo,
Genus Isomomedogi: Genus Isomomedo, Genus genus genus: Genus medusa, Ryumonsou: genus Ryumonsou, Hera Ryumon, Nisekarekigusa: Genus Nisekaregusa, Okitsubara: Obaokitsubara, Akaba: Akaba, Malvaacana, Naminohanana
Naminohana, coral genus: rattlespotter, shiogosagoromo genus: shiogosagoromo, iwanokawa genus: etsukiiwanokawa, kainokawa genus: kainokawa, kaninote genus: kanote, coral genus: coralberry, coral mosquito, mosquito mosquito , Tambanori, slippery,
Genus Isonohana: Nuracusa, Cronulla, Stinging genus, Hirakintoki: Hirakintoki, Matagawa: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Komenori, Tosakamatsu, Aedes pine, Kakrait: Otonafuri, Itofunori Nagaobane, Funori genus: Hanafunori, Fukuronori, Makhunori, Karekunusa genus: Kalexigusa, Tosakamomoki genus: Hosobanotokamaki, Hirohanotosakamakiki, Yatsudegataokamoku, Kurosakamoka, Nezashinosakada : Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honooka: Honoo, Hikagenoito: Hikagenoito, Usuginu, Nikuhono: Nikuho Noo, Benisunago genera: Benisunago, Susukakebeni genera: Susukakebeni, Okamuragusa genera:
Yamadagusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagiibanodan, Kijinoio genus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurushiramo, Shiramo, Ogogonori, Mizookonori, Kabanori, Tengusamodo: Hachijotengusamodoki, Fushikenori: Fushikenori, Namiiwatake: Namiiwatake, Spiraea:
Sponge and genus: ssp.
Genus: crocodile, saimi, crocodile, lotus spp .: lotus spp. The genus Taogosou: Taoyanagisou, Hanasakura, Shirotsunagi: Skullweed, Shirokonori, Hananoeda: Hanaeda, Hirata Goat: Hirata Goat, Darusus: Dars, Masagoshibari, Anadars, Weedbugsa: Webaguroni, Benifukuronori
Genus Fushigusa: Fushitsugi, Himefushiguni, Hirohafushiguni, Watsunagisou: Hirawagatsugiso, Usubawagatsugiso, Igis genus: Eggis, Keigisu, Kariegisu, Haneigisu, Amixa, Egonori, Chrysanthemum genus, Chinosidae Family: Habutaenori, Konohanori, Suzushironori, Usbeni genus: Usbeni, Hasujiginu: Hasujiginu, Nagakonohanori: Nagakonohanori, Suzuginu: Suzuginu, Abasibaginu, Hyusbanori: Kagisubanori, Jaureusbanori, Jaureusbanori, Jaureusbanori
Genus Ayanishi: Genus Ayanishi, Genus Ayaginu: Genus Ayaginu, Genus Dasia: Enashidazia, Genus Shimadada: Genus Isohagi, Genus Shimadada, Genus Dazimodoki: Genus Dazimomodoki, Genus Itogusa: Moletogusa, Genus Genus: Macri, Yanagina, Hana, Rana Salix japonicus, Mosayanagi, Sasabayanaginori, Soso genus: Closozo, Kobusozo, Hanesozo, Sozonohana, Hanegusa genus: Hanegusa, Kaneegusa, Kozanemo genus: Kozanemo, Isomurasaki, Hosokozanemo, Himegogoke genus, Himegoshiogoshio, Himegohoshikuo, Himegohokeo genus Genus Isomegus: Isomegusa, Aspergillus: Aspera, Asparagus: Isobashi, Aspera spp. Rihiba, Kawamozuku genera: Kawamozuku, Aokawamozuku, Himekawamozuku, Ideyukogome genera: Ideyukogome, Okichimozuku genera: Okichimozuku,
Genus genus, genus chinorimo: chinorimo, genus thysinori: chisinori).

The axle algae (Charium spp.
L. genus: L. genus, Lichnotumnus, L. genus: L., L., L., etc., Yellow algae (L. genus: L.).

Materials derived from animal raw materials include cockscomb extract, swine or horse stomach, duodenum, intestine, spleen extract or its degradation product, swine or bovine brain tissue extract, keratin and its extract. Degradation products or their derivatives, silk proteins and their degradation products or their derivatives, swine or bovine blood cell protein degradation products (globin peptides), milk, casein and its degradation products or their derivatives, skim milk powder and their degradation products or Derivatives thereof, lactoferrin or its decomposition products, fish meat decomposition products, and the like.

(14) Microbial culture metabolite Yeast metabolite, yeast extract, natto metabolite, natto extract, rice fermented extract, rice bran (red bran, white bran) fermented extract, euglena extract or its decomposition product or These water-soluble derivatives, lactic acid fermentation products of raw milk or skim milk powder, trehalose or derivatives thereof.

(15) α-Hydroxy acids glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(17) UV absorber / blocker Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), p-
Aminobenzoic acid derivatives (e.g., paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate), methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, Octyl paramethoxycinnamate, paramethoxycinnamic acid
2-ethoxyethyl, sodium paramethoxycinnamate, potassium paramethoxycinnamate, monodiparamethoxycinnamate
Glyceryl-2-ethylhexanoate), salicylic acid derivatives (octyl salicylate, salicylphenyl, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanin Acid derivatives (such as urocanic acid and ethyl urocanate), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, Nicotinic acid derivatives, vitamin B6 derivatives, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, Kishibenzon, Okutabenzon, sulisobenzone, benzo resorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, Neo Heliopan, ESKA roll,
Zinc oxide, talc, kaolin, etc.

(18) Turnover promoting action / cell activator hydroquinone, lactic acid bacteria extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (aloe,
Ogon, horsetail, gentian, burdock, radish, carrot, hamamelis, hop, yokinin, odoranthus, assembly, touki, tokinsenka, amacha, hypericum, cucumber, tachikuso, rosemary, parsley) and the like.

(19) Astringent Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, aluminum potassium sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound) Such.

(20) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(21) Antioxidant stearic acid ester, vitamin E or a derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA),
Hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol, sesamolin, gossypol and the like.

(22) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hypericum, Hamamelis, Clover, Melissa, Emmeso, Birch, Sage, Rosemary, Minami Amami,
Ages, ginkgo, green tea) etc.

(23) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof, licorice extract, sicon extract, age extract and the like.

(24) Antibacterial, bactericidal and disinfecting agents acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyl diaminoethyl glycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, salad powder, iodine compound,
Iodoform, sorbic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, chloro Butanol, isopropylmethylphenol, nonionic surfactants (polyoxyethylene lauryl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene Lenoctyl phenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethyl ammonium bromide, benzalkonium chloride, benzethonium chloride, methyl rosaniline chloride), Formaldehyde, hexamine, brilliant green, malachite green,
Crystal Violet, Jamal, Photosensitizer 101
No. 201, No. 201, No. 401, N-long-chain acyl-basic amino acid derivatives and their acid addition salts, zinc oxide, hinokitiol, kudin and the like.

(25) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or a salt thereof, polyethylene glycol, chondroitin sulfate or a salt thereof, a water-soluble chitin derivative or chitosan derivative, pyrrolidone carboxylic acid or a salt thereof, Sodium lactate, mini sasanishiki extract, natto metabolite, natto extract, etc.

(26) Inhibitors of elastase activity diisopropyl fluorophosphate, plant extracts (Ougon, Hypericum perforatum, Clara, mulberry leaves, calyx, gennoshoko, comfrey, sage, elderberry, bollige, buttonpi), seaweed extract and the like.

(27) Hair preparations Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid and the like.

(28) Antiandrogens Estrogen (eg, estrone, estradiol, ethinylestradiol), isoflavones, oxendrones and the like.

(29) Peripheral vascular blood flow promoter Vitamin E or a derivative thereof, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(30) Stimulants Pepper tincture, vanylamide nonylate, tincture tincture, tincture tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(31) Metabolic activator Photosensitizer No. 301, hinokitiol, pantothenic acid or a derivative thereof, allantoin, placental extract, biotin, glyceride pentadecanoate and the like.

(32) Antiseborrheic agents pyridoxine or its derivatives, sulfur, vitamin B6 and the like.

(33) Keratolytic agent Resorcin, salicylic acid, lactic acid, urea and the like.

(34) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium acid, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, etc.

(35) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide; thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.

(36) Hair swelling agent Ethanolamine, urea, guanidine and the like.

(37) Dyes 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium piclamate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonic acid sodium salt, hematein and the like.

(38) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guayakwood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Great Fenxiang essential oil, Tuberose essential oil, T-shaped essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batturi essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, Camphor essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaloe essential oil, Lemon grass essential oil, Lemon essential oil, Rosemary Vegetable flavors such as essential oils and Japanese peppermint essential oils, and other synthetic flavors.

(39) Dyes / colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

(40) Marine components Seawater such as deep water, for example, seawater salts, dried seawater, inorganic salts obtained from the Dead Sea or the Atlantic or Pacific Ocean (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud Or mud (Fango) s, for example, sea mud or mud in various places such as Italian Fango, German Fango, Eifel Fango, Freiburg Fango (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, iron oxide, manganese oxide, sodium oxide, Potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium,
Iron, copper, nickel, zinc, lead, manganese, arsenic, water),
Shotokuishi etc.

(41) Others Hormones, sequestering agents, pH adjusters, chelating agents, preservatives / anti-binders, cooling agents, stabilizers, emulsifiers,
Vegetable proteins and their degradation products, animal and vegetable polysaccharides and their degradation products, animal and vegetable glycoproteins and their degradation products, blood flow enhancers, antiallergic agents, wound healing agents, foaming agents, thickeners ,
Enzymes, electronic water, small clustered water, and the like are raised, and when these are used in combination to form a cosmetic composition, an additive or synergistic improvement in the effects of the present invention or other cosmetic effects can be expected.

[0079]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described in more detail with reference to examples. However, the present invention is not limited to these.

[0080]

[Example] [Production Example 1] Production method of water-soluble elastin Fresh porcine or equine ligament (1 kg) was washed with water, cut into small pieces, and placed in an aqueous solution of sodium hydroxide adjusted to pH 10.5. Boil for 2 hours. Next, this is centrifuged to collect the residue, and the mixture is boiled with a dilute sulfuric acid aqueous solution adjusted to pH 2 for 1 to 2 hours. After centrifuging again to collect the residue and washing it sufficiently with water, the residue was placed in a proteolytic enzyme solution at 55 to 60 ° C for 6 to 6 hours.
The mixture was hydrolyzed for 8 hours, then heated to around 100 ° C. to inactivate the enzyme, and filtered to obtain a water-soluble elastin solution (3 L).

[0081]

[Production Example 2] Production Example 1 of Water-Soluble Collagen Fresh pig or horse skin tissue (10 kg) was washed with water, purified water (20 L) was added, and the pH was adjusted to an acidic side with dilute hydrochloric acid and aqueous sodium hydroxide solution. , And finally neutralized and filtered to remove insolubles. Next, lactic acid (0.2% amount) was added as a stabilizer to obtain a water-soluble collagen solution (about 20 kg).

[0082]

[Example 3] [Production Example 3] Production Example 2 of water-soluble collagen After washing fresh pig or horse skin tissue (10 kg) with water, adding purified water (20 L), adjusting the pH to 4 to 5 with hydrochloric acid, and extracting with stirring. I do. This is centrifuged to remove insolubles. Next, lactic acid (0.2% amount) was added as a stabilizer to obtain a water-soluble collagen solution (about 20 kg).

[0083]

EXAMPLES [Production Example 4] Production example 1 of water-soluble umbilical cord extract Normal umbilical cord (1 kg) of healthy pigs or horses was washed with water and all blood was removed. Stored frozen for several months. The frozen umbilical cord was thawed, cut into small pieces, ethanol was added, and the mixture was stirred for 48 hours. Then, the ethanol was completely removed. Then, a chloroform solution (1 L) was added thereto, and the mixture was left at 4 ° C. for 48 hours. Further, add the same amount of chloroform solution and mix at 4 ° C until uniform, then add 10% aqueous sodium chloride solution (5 L), shake vigorously for 3 hours, separate into aqueous layer and chloroform layer, and recover collected aqueous layer. After the chloroform was completely removed from the solution, the pH of the system was adjusted to 5.0 to obtain a solution of a mucopolysaccharide-containing water-soluble umbilical cord extract.

[0084]

[Example] [Production Example 5] Production example 2 of water-soluble umbilical cord extract Normal umbilical cord (1 kg) of healthy pig or horse was washed with water, cut into small pieces, and 0.22 w / v% hydroxylated. A sodium aqueous solution (5 L) was added and extracted with stirring. Next, the mixture was neutralized with trichloroacetic acid, and trichloroacetic acid was added (deproteinization) to a concentration of 5%, followed by filtration and the solution was neutralized with a sodium hydroxide solution. The solution thus obtained was dialyzed in running water for 24 hours, and then dried to obtain a mucopolysaccharide-containing water-soluble umbilical cord extract (about 13 g).

[0085]

[Production Example 6] Production Example 1 of Water-Soluble Chicken Egg Extract Fresh chicken eggs (150 g) were completely solidified in a warm water bath (90 ° C.), then the yolk portion was removed and the mixture was mixed with a mixer. Crushed. Water (800 g) was added thereto, and the mixture was extracted by heating at 80 ° C. for 1 hour. After standing overnight, ethanol (20% amount) was added, activated carbon was added thereto, and the mixture was filtered.
0g).

[0086]

[Example 7] [Production Example 7] Production example 2 of water-soluble chicken egg extract After completely solidifying fresh chicken eggs (150g) in a warm water bath (90 ° C), the yolk portion was removed and the mixture was mixed with a mixer. Crushed. 1N-hydrochloric acid (800 g) was added thereto, and the mixture was hydrolyzed at 40 to 60 ° C. for about 1 hour, neutralized with sodium hydroxide solution, activated carbon was added thereto, and the mixture was filtered. A water-soluble chicken egg extract (about 500 g) was obtained.

[0087]

Example 1 Moisturizing test 1 The change over time of the water content of the stratum corneum by a monitor was determined by measuring the electric conductivity. (Measuring instrument) IMPEDANCE METER SKICON-200; manufactured by IBS Corporation (Monitor) 20-year-old woman, 26-year-old woman, 29-year-old woman, 31-year-old woman (Test environment) 24 ° C, 50% RH (Sample solution) Water-soluble elastin , Water-soluble collagen, water-soluble umbilical cord extract, and water-soluble hen egg extract were adjusted to an aqueous solution concentration of 0.0001% on a dry matter basis, and an aqueous solution of aloe vera polysaccharide adjusted to a solids concentration of 0.0001% (Comparative Example) (Method) Test One hour before, the monitor enters the constant temperature and humidity room adjusted to the test environment and is stabilized. afterwards,
Apply 1mL of each sample solution to the forearm flexion side of the monitor,
After seconds, excess water is removed and the electrical conductivity of the stratum corneum is measured over time.

FIGS. 1 to 4 show the results. It has been found that the component (A) according to the present invention has a higher moisturizing effect and is maintained for a longer time than an aqueous solution of an aloe vera polysaccharide having the same solid content (comparative example).

[0089]

Example 2 Moisturizing Action Test 2 The change over time of the transepidermal water loss was measured by a monitor. (Measuring instrument) TEWAMETER TM210; COURAGE + KHAZAKA Elect
Made by ronic Gmbh (monitor) 20-year-old woman, 26-year-old woman, 29-year-old woman, 30-year-old man, 35-year-old man (sample solution) Water-soluble elastin, water-soluble collagen, water-soluble umbilical cord extract, and water-soluble egg extract An aqueous solution adjusted to a dry matter concentration of 0.0001% and an aqueous solution of a glutamate / proline mixture adjusted to a solid concentration of 0.0001% (Comparative Example) (Method) Each sample solution (1
mL) three times a day. After the third application, after stabilizing for 1 hour in a constant temperature and humidity chamber (24 ° C., 50% RH), measurement of transepidermal water loss is started. The measurement is performed at intervals of 2 seconds for 3 minutes, and the average value of all numerical values is defined as the TEWL value of the test site. still,
Each blank was measured under the same conditions before sample application.

Table 1 shows the results of the average water change of the five monitors. It has been found that the component (A) used in the present invention suppresses transepidermal water evaporation and exhibits a water retention effect.

[0091]

[Table 1]

[0092]

[Example] Tyrosinase activity inhibitory test (Test method) Tyrosine solution (L-tyrosine 0.3 mg / mL) 1.0
mL, 2.0 mL of McClubine buffer (pH 6.5) and 0.2 mL of the sample solution were mixed, and allowed to stand in a thermostat at 37 ° C. for about 10 minutes. Then, a tyrosinase solution (mushroom-derived, 2500 unit / mL) After adding 0.1 mL, the absorbance at 475 nm was measured (A), and then the reaction solution was placed in a 37 ° C constant temperature bath.
After standing for 20 minutes, the absorbance at 475 nm is measured in the same manner (A ′). At the same time, as a blank, absorbance was measured by the same operation using purified water instead of the sample solution (a),
(A ′), and the tyrosinase activity inhibition rate was determined by Equation 1. Table 2 shows the results.

<Equation 1> Inhibition rate (%) = (a′−a) − (A′−A) / (a′−)
a) x 100

[0094]

[Table 2]

[0095]

Example: Preparation of skin roughening and pigmentation model by UV irradiation Irradiation of UV-B (Toshiba Corporation) after shaving the back skin of a test animal (A-1 type guinea pig (female), 7 weeks old, manufactured by Kiwa Experimental Animal Laboratories) While irradiating 0.12 J once a day with FL20S-E lamp (manufactured by FL20S-E), rough breeding accompanied by erythema and desquamation and pigmentation were confirmed (normally 4 days). Then 3 animals
Divided into three groups ((a) sample cream administration group, (b) control cream administration group, (c) untreated group with ultraviolet irradiation only, 3 animals in each group), rough skin confirmed in (a) and (b) The next day (approximately day 5), about 0.5 mg of the sample cream (Table 3) or the control cream (Table 4) was applied to the rough skin site once a day. At this time, care was taken not to induce rough skin due to physical stimulation. In addition, about (c), normal breeding was continued until the end of the test (30 days from the start of cream application).

[0096]

[Table 3]

[0097]

[Table 4]

[0098]

[Examples] Skin roughness improvement effect by ultraviolet irradiation (1) Skin elasticity improvement test Skin elasticity of a test animal at a skin roughness site was measured with a skin viscoelasticity meter (CUTOMETER SEM474 manufactured by Eurotech Japan). The test site was shaved as needed. As the measurement conditions, Mode-1, an operation of applying a negative pressure of 300 mb for 2 seconds at 2 second intervals was repeated twice. The measurement of skin viscoelasticity was performed before ultraviolet irradiation and 30 days after the start of cream application.

The principle of measurement is as follows. The skin at the measurement site is aspirated and subsequently the negative pressure is released. The return of the skin that occurs at this time is subjected to waveform processing. Figure 5 shows CUTOMETER SEM474
5 shows a general waveform measured in. The ascending waveform is when negative pressure is applied, and the descending waveform is when negative pressure is released. Uv value is the plastic part of skin viscoelasticity, in case of high elastic body,
The value is extremely small with almost no plastic part. Uv values in middle-aged skin are extremely high. The degree of plasticity was determined from the following equation.

<Equation 1> Plasticity = Uv value / Ue value

The Uf value indicates the maximum suction value. The Ur value shows a waveform after the negative pressure is released and the suction returns. Uf value for highly elastic materials
= Ur value. In the case of a highly viscous material, two waveforms are observed.
A vertically extending elastic part Ur and a horizontally viscoelastic plastic part Ua are provided. If the skin is rich in elasticity, Uf value = Ur value. The elasticity was determined from the following equation.

<Equation 2> Elasticity = Ur value / Uf value

Table 5 shows the results. As is clear from Table 5, the cosmetic composition according to the present invention is excellent in improving skin elasticity. Therefore, the effect of preventing skin aging due to ultraviolet rays can be expected.

[0104]

[Table 5]

(2) Wrinkle improvement test The test site of the test animal was subjected to shaving treatment as necessary, and a skin shape replica at the rough skin site was collected (SILFLO manufactured by FLEXICO). One month later, a skin shape replica was similarly collected. The measurement of wrinkles is performed by irradiating the collected replica with light from a fixed direction (at an angle of 25 ° C.), analyzing the shadows of the wrinkles with image processing software (ImageHyper II manufactured by Interquest), and determining the wrinkle depth and the wrinkle area ratio occupying the measurement site. Was calculated.
Incidentally, the test method and the measurement of the wrinkle area ratio were performed according to the method of the Japan Cosmetic Engineers Association, Vol. 27, No. 3, pp. 355-373 (1993).

Table 6 shows the results. As is clear from Table 6, the cosmetic composition according to the present invention has an effect of improving wrinkles. Therefore, the effect of preventing skin aging due to ultraviolet rays can be expected.

[0107]

[Table 6]

(3) Pigmentation Improvement Test The test site of the test animal was shaved as necessary, and the L value (lightness) was measured using a color difference meter (CR-200 manufactured by Minolta). The L value was measured five times per test site. The average of each individual was calculated and the average of each group was compared.

Table 7 shows the results. As is clear from Table 7, the cosmetic composition according to the present invention is excellent in the effect of preventing pigmentation due to ultraviolet rays.

[0110]

[Table 7]

[0111]

EXAMPLES Preparation of Sample Hair Tonic In order to confirm the effect of the cosmetic composition of the present invention on hair, sample hair tonics shown in Tables 8 to 9 were prepared and used to evaluate the hair restoring effect.

[0112]

[Table 8]

[0113]

[Table 9]

[0114]

[Example] Hair-growth action test About 8 cm ² (length 2 cm, width 4 cm) of the back of a C3H mouse was hair-removed with an electric clipper and an electric shaver. Next, a sample hair tonic once a day on the depilated back, about 0.2 mL 5 days a week,
The test hair was applied for 20 days (the test animals consisted of 8 animals per group, the back was divided into the left side and the right side, and the sample hair tonic was applied, respectively). On the 12th and 20th days after the application, the area ratio (%) at which the regeneration of the hair was recognized relative to the area from which the hair had been removed was measured with an image analyzer, and compared with the control group. FIG. 6 shows the results. "Test method by Ogawa et al. (Fragrance Journal,
Vol.17, No.5, pp.20-29 (1989)) "

As experimental animals, 8-week-old male C3H mice were used. These animals were housed in an environment of room temperature of 20 to 24 ° C., humidity of 35 to 65%, all-fresh ventilation 15 times / hour, and lighting of 9 hours / day. Animals had free access to solid feed MF (Oriental Yeast Industry) and tap water.

As shown in FIG. 6, the cosmetic composition of the present invention exhibited a more remarkable hair-growth effect by applying the sample hair tonic.

[0117]

EXAMPLES Use Test In order to evaluate the feeling of use of the cosmetic composition of the present invention, panelists (10 genders) were used using the sample hair tonics prepared in the examples.
), And a questionnaire survey was conducted.
The results were as shown in Table 10.

[0118]

[Table 10]

[0119]

EXAMPLES Production of Various Formulations Various cosmetic compositions according to the present invention were produced. The formulation examples are shown below, but the invention is not limited thereto.

1) Production Example of Lotion A whitening lotion was produced according to the following formulation. % By weight Sorbit 2 2.1,3-butylene glycol 2 3. Polyethylene glycol 1000 1 4. Polyoxyethylene oleyl ether (25E.O.) 25. Ethanol 10 6. 6. Water-soluble umbilical cord extract of pig (dry matter concentration: 1.4%) Saxifraga extract (containing 0.8% of polyphenol) 28. Sodium lactate 0.2 9. pH adjuster qs 10 Preservative appropriate amount 11. Purified water 100 residue

2) Production Example of Emulsion An emollient emulsion was produced according to the following formulation. % By weight Squalane 3 2. Vaseline 1 3. Stearyl alcohol 0.3 4. Sorbitan monostearate 1.55. Polyoxyethylene (20) sorbitan monooleate 3 6.1,3-butylene glycol 5 7. 7. Porcine water-soluble elastin (dry matter concentration: 1.2%) Quercetin 0.002 9. Glycolic acid 0.110. 10. Ascorbic acid phosphate magnesium salt 0.1 Preservative appropriate amount 12. Purified water 100 residue

3) Production Example of Cream A cream was produced according to the following formulation. % By weight Squalane 20 2. Beeswax 5 3. Refined jojoba oil 5 4. Glycerin monostearate 25 5. Sorbitan monostearate 2 6 Polyoxyethylene (20) sorbitan monostearate 2 7. Glycerin 5 8. 8. Porcine water-soluble collagen (dry matter concentration: 1.4%) 9. Water-soluble elastin in horses (1.7% dry matter concentration) N-acetyltyrosine sodium 1111. Tannic acid 0.001 12. 12. Glutathione-containing yeast extract 0.01 Sodium citrate 0.2 14. Preservative appropriate amount 15. Purified water 100 residue

4) Production Example of Shampoo A shampoo was produced according to the following formulation. % By weight Triethanolamine lauryl sulfate 5 2. 3. Polyoxyethylene lauryl ether sulfate Na 12 3.1,3-butylene glycol 4 Lauric acid diethanolamide 2 5. Disodium edetate 0.16. 6. Water-soluble egg extract solution (dry matter concentration: 1.4%) Hop extract (containing 0.4% of polyphenol) 1 8 Clara extract (containing 0.6% polyphenol) 0.5 9. Korean carrot extract (containing 0.3% of polyphenol) 110. Sodium tartrate 0.2 11. Preservative appropriate amount 12. Purified water 100 residue

5) Production Example of Body Soap A body soap was produced according to the following formulation. % By weight Potassium laurate 15 2. Potassium myristate 5 3. Propylene glycol 5 4. Horse water-soluble collagen (1.8% dry matter concentration) 2 5. Fujibakama extract (containing 0.6% of polyphenol) 1 6 Sodium citrate 0.17. Sodium lactate 0.18. pH adjuster qs 9. Preservative appropriate amount 10. Purified water 100 residue

6) Preparation Example of Bath Agent A bath agent was manufactured according to the following formulation. % By weight Sodium bicarbonate 50 2. Anhydrous sodium sulfate 35 3. Borax 2 4. 4. Water-soluble porcine elastin (dry matter) Touki extract (dried powder) 5 6. Sodium lactate 2 7 Sodium glycolate 1

[0126]

EFFECT OF THE INVENTION The cosmetic composition according to the present invention comprises physiologically effective skin and hair by water-soluble elastin, water-soluble collagen, water-soluble umbilical cord extract, or water-soluble chicken egg extract, which are essential components. Functions such as sound effects and skin conditioning effects improve the condition of the skin and hair, increase the permeability of the other essential component, a polyphenol derivative, and make the beneficial cosmetic effects on the skin and hair more effective Acts in a way. In addition, by using an anti-inflammatory component, an anti-allergic component, an anti-acne component, an anti-skin roughening component, an anti-wrinkle component, etc., it is also possible to obtain a cosmetic composition having more excellent functions and effects than conventional products. It is possible.

[Brief description of the drawings]

FIG. 1 shows the change over time in the electrical conductivity of a 20-year-old woman's component (A) -containing sample solution application site according to the example (moisturizing action 1).

FIG. 2 shows the change over time in the electrical conductivity of a 26-year-old female component (A) -containing sample solution application site according to the example (moisturizing action 1).

FIG. 3 shows the change over time in the electrical conductivity of the site of application of the component solution containing the component (A) of a 29-year-old woman according to the example (moisturizing action 1).

FIG. 4 shows the change over time in the electrical conductivity of a 31-year-old female component (A) -containing sample solution application site according to the example (moisturizing action 1).

FIG. 5 shows a general waveform measured by a skin viscoelasticity meter used in an example (skin elasticity improvement test).

FIG. 6 shows the hair regeneration area ratio (%) of the dehaired C3H mice according to the example (hair growth effect).

[Procedure amendment]

[Submission date] February 22, 2001 (2001.2.2)
2)

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] 0027

[Correction method] Change

[Correction contents]

The cosmetic composition of the present invention may further comprise the following essential components (A) and (B), if necessary, as long as the effects of the present invention are not impaired. Can be arbitrarily selected and used in combination, and the content in the preparation is not particularly limited, but is usually preferably 0.0001 to 50%.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/00 A61K 7/00 N 7/075 7/075 7/50 7/50 F-term (Reference) 4C083 AA021 AA031 AA071 AA082 AA112 AA122 AB152 AB312 AB352 AC012 AC022 AC072 AC122 AC132 AC182 AC242 AC302 AC422 AC442 AC471 AC472 AC532 AC642 AC782 AC792 AC841 AC842 AD042 AD332 AD352 AD411 AD412 AD642 CC01 CC04 CC05 CC23 CC25 EE13 EE EE DD DD EE29

Claims (3)

[Claims] 1. A cosmetic composition comprising the following components (A) and (B). (A) a) water-soluble elastin extracted from swine or equine nodal ligament or hydrolyzate thereof b) water-soluble collagen extracted from swine or equine skin tissue or hydrolyzate thereof c) pig or horse Water-soluble umbilical cord extract extracted from umbilical cord or a hydrolyzate thereof d) Any one or more water-soluble components selected from water-soluble hen egg extract extracted from chicken egg or its hydrolyzate (B ) Polyphenol derivatives 2. Component (B) is a flavonoid, coumarin,
2. The cosmetic composition according to claim 1, which is at least one polyphenol derivative selected from phenylpropanoids and tannins. 3. The cosmetic composition according to claim 1, wherein the component (B) is an extract from crude drugs, plants, fungi, microorganisms, and other natural products containing a polyphenol derivative.