JP2002167397A5 - - Google Patents
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- Publication number
- JP2002167397A5 JP2002167397A5 JP2001084010A JP2001084010A JP2002167397A5 JP 2002167397 A5 JP2002167397 A5 JP 2002167397A5 JP 2001084010 A JP2001084010 A JP 2001084010A JP 2001084010 A JP2001084010 A JP 2001084010A JP 2002167397 A5 JP2002167397 A5 JP 2002167397A5
- Authority
- JP
- Japan
- Prior art keywords
- arg
- pro
- phe
- gly
- leu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Chemical group 0.000 description 21
- 125000000539 amino acid group Chemical group 0.000 description 18
- 150000003839 salts Chemical class 0.000 description 18
- 150000001408 amides Chemical class 0.000 description 17
- 150000002148 esters Chemical class 0.000 description 17
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 6
- 230000007935 neutral effect Effects 0.000 description 5
- 150000001413 amino acids Chemical class 0.000 description 4
- 210000004899 c-terminal region Anatomy 0.000 description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 3
- MUXONAMCEUBVGA-DCAQKATOSA-N Arg-Arg-Gln Chemical compound NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(O)=O MUXONAMCEUBVGA-DCAQKATOSA-N 0.000 description 3
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 3
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 3
- HJVGMOYJDDXLMI-AVGNSLFASA-N Arg-Arg-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCCNC(N)=N HJVGMOYJDDXLMI-AVGNSLFASA-N 0.000 description 2
- 108010016626 Dipeptides Proteins 0.000 description 2
- 150000003862 amino acid derivatives Chemical class 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 1
- FVBZXNSRIDVYJS-AVGNSLFASA-N Arg-Pro-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N FVBZXNSRIDVYJS-AVGNSLFASA-N 0.000 description 1
- 208000031886 HIV Infections Diseases 0.000 description 1
- 208000037357 HIV infectious disease Diseases 0.000 description 1
- HGCNKOLVKRAVHD-UHFFFAOYSA-N L-Met-L-Phe Natural products CSCCC(N)C(=O)NC(C(O)=O)CC1=CC=CC=C1 HGCNKOLVKRAVHD-UHFFFAOYSA-N 0.000 description 1
- HGCNKOLVKRAVHD-RYUDHWBXSA-N Met-Phe Chemical compound CSCC[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 HGCNKOLVKRAVHD-RYUDHWBXSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 108010068488 methionylphenylalanine Proteins 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001084010A JP4786047B2 (ja) | 2000-03-23 | 2001-03-23 | ペプチド誘導体 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000087114 | 2000-03-23 | ||
| JP2000-87114 | 2000-03-23 | ||
| JP2000087114 | 2000-03-23 | ||
| JP2000288891 | 2000-09-19 | ||
| JP2000288891 | 2000-09-19 | ||
| JP2000-288891 | 2000-09-19 | ||
| JP2001084010A JP4786047B2 (ja) | 2000-03-23 | 2001-03-23 | ペプチド誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002167397A JP2002167397A (ja) | 2002-06-11 |
| JP2002167397A5 true JP2002167397A5 (https=) | 2008-04-17 |
| JP4786047B2 JP4786047B2 (ja) | 2011-10-05 |
Family
ID=26588465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001084010A Expired - Fee Related JP4786047B2 (ja) | 2000-03-23 | 2001-03-23 | ペプチド誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7635751B2 (https=) |
| EP (1) | EP1270585B1 (https=) |
| JP (1) | JP4786047B2 (https=) |
| KR (1) | KR20020081466A (https=) |
| CN (1) | CN1419563A (https=) |
| AT (1) | ATE326478T1 (https=) |
| AU (1) | AU2001242749A1 (https=) |
| CA (1) | CA2403447A1 (https=) |
| DE (1) | DE60119714T2 (https=) |
| WO (1) | WO2001070769A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003063892A1 (en) * | 2002-01-29 | 2003-08-07 | Takeda Chemical Industries, Ltd. | Use of apelin |
| US8673848B2 (en) | 2012-01-27 | 2014-03-18 | Novartis Ag | Synthetic apelin mimetics for the treatment of heart failure |
| WO2007072980A1 (ja) | 2005-12-20 | 2007-06-28 | Takeda Pharmaceutical Company Limited | アペリンの新規用途 |
| RU2303454C1 (ru) * | 2006-06-22 | 2007-07-27 | Общество С Ограниченной Ответственностью "Сиа Пептайдс" | Средство, нормализующее репродуктивную функцию у женщин, и способ его получения |
| EP1903052A3 (en) * | 2006-07-28 | 2008-04-02 | Faust Pharmaceuticals SA | APJ receptor ligands and uses thereof |
| WO2013050441A1 (en) | 2011-10-05 | 2013-04-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for inhibiting or preventing platelet aggregation |
| US9381229B2 (en) | 2011-11-28 | 2016-07-05 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Pharmaceutical composition for use in the treatment of dysfunction associated with aging |
| CN104254540A (zh) * | 2012-01-09 | 2014-12-31 | 安科治疗公司 | Apj受体化合物 |
| US8921307B2 (en) | 2012-11-20 | 2014-12-30 | Novartis Ag | Synthetic linear apelin mimetics for the treatment of heart failure |
| UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
| US20160067347A1 (en) | 2012-12-20 | 2016-03-10 | Amgen Inc. | Apj receptor agonists and uses thereof |
| KR20160031551A (ko) | 2013-07-25 | 2016-03-22 | 노파르티스 아게 | 심부전의 치료를 위한 시클릭 폴리펩티드 |
| HK1218252A1 (zh) | 2013-07-25 | 2017-02-10 | Novartis Ag | 合成apelin多肽之生物结合物 |
| CN104436158A (zh) * | 2013-09-22 | 2015-03-25 | 华中科技大学 | Apelin-13在治疗糖尿病肾病中的应用 |
| GB201407532D0 (en) * | 2014-04-29 | 2014-06-11 | Univ Ulster | Apelin analogues |
| MA41580A (fr) | 2015-01-23 | 2017-11-29 | Novartis Ag | Conjugués d'acides gras de l'apeline synthétique présentant une demi-vie améliorée |
| US10426818B2 (en) | 2015-03-24 | 2019-10-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Method and pharmaceutical composition for use in the treatment of diabetes |
| HUE050317T2 (hu) | 2015-05-20 | 2020-11-30 | Amgen Inc | APJ receptor triazol agonistái |
| ES2930077T3 (es) | 2016-02-15 | 2022-12-07 | Inst Nat Sante Rech Med | Apelina para su uso en el tratamiento de la disfunción cognitiva posoperatoria |
| US9988369B2 (en) | 2016-05-03 | 2018-06-05 | Amgen Inc. | Heterocyclic triazole compounds as agonists of the APJ receptor |
| US11046680B1 (en) | 2016-11-16 | 2021-06-29 | Amgen Inc. | Heteroaryl-substituted triazoles as APJ receptor agonists |
| WO2018093579A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Triazole phenyl compounds as agonists of the apj receptor |
| US10736883B2 (en) | 2016-11-16 | 2020-08-11 | Amgen Inc. | Triazole furan compounds as agonists of the APJ receptor |
| WO2018093576A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Alkyl substituted triazole compounds as agonists of the apj receptor |
| WO2018093577A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Cycloalkyl substituted triazole compounds as agonists of the apj receptor |
| EP3541803B1 (en) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Triazole pyridyl compounds as agonists of the apj receptor |
| MA50509A (fr) | 2017-11-03 | 2021-06-02 | Amgen Inc | Agonistes de triazole fusionnés du récepteur apj |
| US11807624B2 (en) | 2018-05-01 | 2023-11-07 | Amgen Inc. | Substituted pyrimidinones as agonists of the APJ receptor |
| WO2026007692A1 (zh) * | 2024-07-05 | 2026-01-08 | 浙江大学 | Apelin-13多肽突变体 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2118372T3 (es) * | 1992-11-17 | 1998-09-16 | Icos Corp | Nuevos receptores siete transmembrana v28. |
| KR20010033601A (ko) * | 1997-12-24 | 2001-04-25 | 다케다 야쿠힌 고교 가부시키가이샤 | 폴리펩티드, 그의 제법 및 용도 |
| US6475718B2 (en) * | 1998-09-08 | 2002-11-05 | Schering Aktiengesellschaft | Methods and compositions for modulating the interaction between the APJ receptor and the HIV virus |
| AU5759399A (en) * | 1998-09-25 | 2000-04-17 | Takeda Chemical Industries Ltd. | Peptide derivative |
-
2001
- 2001-03-22 EP EP01915695A patent/EP1270585B1/en not_active Expired - Lifetime
- 2001-03-22 WO PCT/JP2001/002278 patent/WO2001070769A1/ja not_active Ceased
- 2001-03-22 US US10/239,321 patent/US7635751B2/en not_active Expired - Fee Related
- 2001-03-22 AU AU2001242749A patent/AU2001242749A1/en not_active Abandoned
- 2001-03-22 KR KR1020027012331A patent/KR20020081466A/ko not_active Withdrawn
- 2001-03-22 CN CN01807077A patent/CN1419563A/zh active Pending
- 2001-03-22 DE DE60119714T patent/DE60119714T2/de not_active Expired - Lifetime
- 2001-03-22 AT AT01915695T patent/ATE326478T1/de not_active IP Right Cessation
- 2001-03-22 CA CA002403447A patent/CA2403447A1/en not_active Abandoned
- 2001-03-23 JP JP2001084010A patent/JP4786047B2/ja not_active Expired - Fee Related
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