JP2001521549A - 強力なβ−ラクタマーゼ阻害剤としての２−オキソ−１−アゼチジンスルホン酸誘導体 - Google Patents

強力なβ−ラクタマーゼ阻害剤としての２−オキソ−１−アゼチジンスルホン酸誘導体

Info

Publication number
JP2001521549A
JP2001521549A JP54535898A JP54535898A JP2001521549A JP 2001521549 A JP2001521549 A JP 2001521549A JP 54535898 A JP54535898 A JP 54535898A JP 54535898 A JP54535898 A JP 54535898A JP 2001521549 A JP2001521549 A JP 2001521549A
Authority
JP
Japan
Prior art keywords
compound
pharmaceutically acceptable
acceptable salt
group
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP54535898A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001521549A5 (https=
Inventor
マイチ，サマレンドラ，エヌ．
セッティ，エジュアルド，エル．
フィリップス，オルドタン，エー．
レッディー，アンディー，ヴィ．，ナレンダー
ミセティック，ロナルド，ジー．
シン，ラッジェッシュワー
房広 東谷
千恵子 欅田
幸一 西田
達哉 宇治
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of JP2001521549A publication Critical patent/JP2001521549A/ja
Publication of JP2001521549A5 publication Critical patent/JP2001521549A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP54535898A 1997-04-24 1998-04-23 強力なβ−ラクタマーゼ阻害剤としての２−オキソ−１−アゼチジンスルホン酸誘導体 Ceased JP2001521549A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/840,608 1997-04-24
US08/840,608 US5888998A (en) 1997-04-24 1997-04-24 2-oxo-1-azetidine sulfonic acid derivatives as potent β-lactamase inhibitors
PCT/IB1998/000622 WO1998047895A1 (en) 1997-04-24 1998-04-23 2-OXO-1-AZETIDINE SULFONIC ACID DERIVATIVES AS POTENT β-LACTAMASE INHIBITORS

Publications (2)

Publication Number Publication Date
JP2001521549A true JP2001521549A (ja) 2001-11-06
JP2001521549A5 JP2001521549A5 (https=) 2005-12-02

Family

ID=25282793

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54535898A Ceased JP2001521549A (ja) 1997-04-24 1998-04-23 強力なβ−ラクタマーゼ阻害剤としての２−オキソ−１−アゼチジンスルホン酸誘導体

Country Status (10)

Country Link
US (1) US5888998A (https=)
EP (1) EP0979229B1 (https=)
JP (1) JP2001521549A (https=)
KR (1) KR20010020181A (https=)
AU (1) AU740446B2 (https=)
CA (1) CA2287219C (https=)
DE (1) DE69808901T2 (https=)
HU (1) HUP0001269A3 (https=)
NO (1) NO995108L (https=)
WO (1) WO1998047895A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010521517A (ja) * 2007-03-23 2010-06-24 バジリア ファルマスーチカ アーゲー 細菌感染症を処置するための組合せ薬
JP2019521173A (ja) * 2016-07-21 2019-07-25 シャンハイ インスティチュート オブ マテリア メディカ，チャイニーズ アカデミー オブ サイエンシーズ 単環式β−ラクタム−親鉄剤抱合体並びにその製造方法及び使用

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010002705A (ko) * 1999-06-17 2001-01-15 고두모 신규 티아졸 초산의 반응성 포스페이트 유도체의 제조방법
US6916803B2 (en) * 2000-09-14 2005-07-12 Pantherix, Ltd. 3-(Heteroaryl acetamido)-2-oxo-azetidine-1-sulfonic acids derivatives as antibacterial agents
WO2007065288A2 (en) 2005-12-07 2007-06-14 Basilea Pharmaceutica Ag Useful combinations of monobactam antibiotics with beta-lactamase inhibitors
CA2807546C (en) 2010-08-10 2022-08-23 Rempex Pharmaceuticals, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
US8806158B2 (en) 2010-09-22 2014-08-12 International Business Machines Corporation Intelligent computer memory management
WO2013033461A1 (en) 2011-08-31 2013-03-07 Rempex Pharmaceuticals, Inc. Heterocyclic boronic acid ester derivatives and therapeutic uses thereof
US9156858B2 (en) 2012-05-23 2015-10-13 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US10561675B2 (en) 2012-06-06 2020-02-18 Rempex Pharmaceuticals, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
CN103435650B (zh) * 2012-12-28 2015-12-02 南京海融医药科技有限公司 单环β-内酰胺类化合物、制备方法及其制药用途
KR20150103269A (ko) 2013-01-04 2015-09-09 렘펙스 파머수티클스 인코퍼레이티드 보론산 유도체 및 그의 치료적 용도
MX2015008627A (es) 2013-01-04 2015-09-23 Rempex Pharmaceuticals Inc Derivados de acido boronico y usos terapeuticos de los mismos.
US9101638B2 (en) 2013-01-04 2015-08-11 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US9241947B2 (en) 2013-01-04 2016-01-26 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
ES2750805T3 (es) 2014-05-05 2020-03-27 Rempex Pharmaceuticals Inc Síntesis de sales de boronato y usos de las mismas
EP3139930B1 (en) 2014-05-05 2024-08-14 Melinta Therapeutics, Inc. Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof
AU2015264418A1 (en) 2014-05-19 2016-11-10 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
WO2016003929A1 (en) 2014-07-01 2016-01-07 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US10662205B2 (en) 2014-11-18 2020-05-26 Qpex Biopharma, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
EP3233869B1 (en) 2014-12-19 2019-09-25 Rempex Pharmaceuticals, Inc. Apparatus and continuous flow process for production of boronic acid derivatives
US20180051041A1 (en) 2015-03-17 2018-02-22 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
RU2618433C2 (ru) * 2015-08-10 2017-05-03 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный университет" (СПбГУ) Антимикробная комбинация в отношении устойчивых к карбапенемам грамотрицательных бактерий вида pseudomonas aeruginosa, продуцирующих металло-β-лактамазу
MX389349B (es) 2016-06-30 2025-03-20 Qpex Biopharma Inc Derivados de ácido borónico y usos terapéuticos de los mismos.
RU2664434C2 (ru) * 2016-12-01 2018-08-17 Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный университет" (СПбГУ) АНТИМИКРОБНАЯ КОМБИНАЦИЯ В ОТНОШЕНИИ УСТОЙЧИВЫХ К КАРБАПЕНЕМАМ ГРАМОТРИЦАТЕЛЬНЫХ БАКТЕРИЙ ВИДА KLEBSIELLA PNEUMONIAE, ПРОДУЦИРУЮЩИХ МЕТАЛЛО-β-ЛАКТАМАЗУ
RU2666619C2 (ru) * 2016-12-01 2018-09-11 Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный университет" (СПбГУ) АНТИМИКРОБНАЯ КОМБИНАЦИЯ В ОТНОШЕНИИ УСТОЙЧИВЫХ К КАРБАПЕНЕМАМ ГРАМОТРИЦАТЕЛЬНЫХ БАКТЕРИЙ ВИДА ACINETOBACTER BAUMANNII, ПРОДУЦИРУЮЩИХ МЕТАЛЛО-β-ЛАКТАМАЗУ
US11286270B2 (en) 2017-10-11 2022-03-29 Qpex Biopharma, Inc. Boronic acid derivatives and synthesis thereof
EP3781576B1 (en) 2018-04-20 2024-06-12 Qpex Biopharma, Inc. Boronic acid derivatives and therapeutic uses thereof
AU2021266715A1 (en) 2020-05-05 2022-11-17 Qpex Biopharma, Inc. Boronic acid derivatives and synthesis, polymorphic forms, and therapeutic uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775670A (en) * 1980-09-29 1988-10-04 E. R. Squibb & Sons, Inc. 2-oxo-1-azetidinesulfonic acid salts
US4632985A (en) * 1985-06-03 1986-12-30 E. R. Squibb & Sons, Inc. 3-acylamino-2-oxo-1-azetidinesulfonic acids
US5006650A (en) * 1987-02-11 1991-04-09 The Upjohn Company Novel N-1 substituted beta-lactams as antibiotics
JPH02502455A (ja) * 1987-02-27 1990-08-09 ジ・アップジョン・カンパニー ピリドンカルボン酸または酸誘導体を含有する抗生物質β‐ラクタム
US5112968A (en) * 1989-07-28 1992-05-12 E. R. Squibb & Sons, Inc. Monobactam hydrazide derivatives
CA2024282A1 (en) * 1989-09-21 1991-03-22 Peter H. Ermann Heterocyclic hydrazide derivatives of monocyclic beta-lactam antibiotics
ZA918014B (en) * 1990-11-05 1992-07-29 Squibb & Sons Inc Heteroaroyl derivatives of monocyclic beta-lactam antibiotics

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010521517A (ja) * 2007-03-23 2010-06-24 バジリア ファルマスーチカ アーゲー 細菌感染症を処置するための組合せ薬
JP2019521173A (ja) * 2016-07-21 2019-07-25 シャンハイ インスティチュート オブ マテリア メディカ，チャイニーズ アカデミー オブ サイエンシーズ 単環式β−ラクタム−親鉄剤抱合体並びにその製造方法及び使用

Also Published As

Publication number Publication date
NO995108D0 (no) 1999-10-20
US5888998A (en) 1999-03-30
NO995108L (no) 1999-10-20
EP0979229B1 (en) 2002-10-23
AU6931498A (en) 1998-11-13
AU740446B2 (en) 2001-11-01
DE69808901D1 (de) 2002-11-28
KR20010020181A (ko) 2001-03-15
HUP0001269A3 (en) 2001-11-28
CA2287219C (en) 2010-01-12
CA2287219A1 (en) 1998-10-29
WO1998047895A1 (en) 1998-10-29
EP0979229A1 (en) 2000-02-16
DE69808901T2 (de) 2003-07-31
HUP0001269A2 (hu) 2001-05-28

Similar Documents

Publication Publication Date Title
JP2001521549A (ja) 強力なβ−ラクタマーゼ阻害剤としての２−オキソ−１−アゼチジンスルホン酸誘導体
JP5180836B2 (ja) モノバクタム系抗生物質とβ−ラクタマーゼ系阻害剤との有用な組み合わせ
EP1012139B1 (en) Azetidinone derivatives as beta-lactamase inhibitors
KR102667828B1 (ko) 베타-락타마제 억제제 화합물
JPH05509089A (ja) セファロスポリンおよび同族体、製法および医薬組成物
RU2143435C1 (ru) β-ЛАКТАМЫ
EP2046802A2 (en) Novel 2-substituted methyl penam derivatives
JPH11513670A (ja) セファロスポリン抗生物質
CS232735B2 (en) Method of making cephalosporine derivatives
WO1997045429A1 (en) Beta-lactams
EP0209751A2 (en) Cephalosporin derivatives and bactericides containing the same
EP0842180B1 (en) Penam sulfones as beta-lactamase inhibitors
EP0349340A2 (en) Novel cephem compound, method for producing the same and anti-bacterial agent
CA1237427A (en) Cephem compounds
KR830001593B1 (ko) 세팔로스포린 항생제의 제조방법
JPH0613529B2 (ja) 新規セフアロスポリン誘導体及び抗菌剤
US20040260084A1 (en) Novel c-3 s/o-and s/n formaldehe acetal derivatives of cephalosporins and their use as antibotics
JP2020105148A (ja) 非アリールヘテロ環置換芳香族化合物
AU2002351821A1 (en) Novel C-3 S/O- and S/N formaldehe acetal derivatives of cephalosporins and their use as antibiotics
JPH064644B2 (ja) 新規セフアロスポリン誘導体及び抗菌剤
JPS61134391A (ja) 新規セフアロスポリン化合物及びそれを有効成分とする抗菌剤

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050425

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050425

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090203

A313 Final decision of rejection without a dissenting response from the applicant

Free format text: JAPANESE INTERMEDIATE CODE: A313

Effective date: 20090525

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20090630