DE69808901T2 - 2-oxo-1-azetidinsulfonicsaure- derivative als potent ss-lactamase hemmer - Google Patents

2-oxo-1-azetidinsulfonicsaure- derivative als potent ss-lactamase hemmer

Info

Publication number
DE69808901T2
DE69808901T2 DE69808901T DE69808901T DE69808901T2 DE 69808901 T2 DE69808901 T2 DE 69808901T2 DE 69808901 T DE69808901 T DE 69808901T DE 69808901 T DE69808901 T DE 69808901T DE 69808901 T2 DE69808901 T2 DE 69808901T2
Authority
DE
Germany
Prior art keywords
compound
pharmaceutical composition
pharmaceutically acceptable
formula
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69808901T
Other languages
German (de)
English (en)
Other versions
DE69808901D1 (de
Inventor
Fusahiro Higashitani
Chieko Kunugita
N. Maiti
G. Micetich
Koichi Nishida
A. Phillips
V. Reddy
L. Setti
Rajeshwar Singh
Tatsuya Uji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Naeja Pharmaceutical Inc
Taiho Pharmaceutical Co Ltd
Original Assignee
Naeja Pharmaceutical Inc
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Naeja Pharmaceutical Inc, Taiho Pharmaceutical Co Ltd filed Critical Naeja Pharmaceutical Inc
Publication of DE69808901D1 publication Critical patent/DE69808901D1/de
Application granted granted Critical
Publication of DE69808901T2 publication Critical patent/DE69808901T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69808901T 1997-04-24 1998-04-23 2-oxo-1-azetidinsulfonicsaure- derivative als potent ss-lactamase hemmer Expired - Fee Related DE69808901T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/840,608 US5888998A (en) 1997-04-24 1997-04-24 2-oxo-1-azetidine sulfonic acid derivatives as potent β-lactamase inhibitors
PCT/IB1998/000622 WO1998047895A1 (en) 1997-04-24 1998-04-23 2-OXO-1-AZETIDINE SULFONIC ACID DERIVATIVES AS POTENT β-LACTAMASE INHIBITORS

Publications (2)

Publication Number Publication Date
DE69808901D1 DE69808901D1 (de) 2002-11-28
DE69808901T2 true DE69808901T2 (de) 2003-07-31

Family

ID=25282793

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69808901T Expired - Fee Related DE69808901T2 (de) 1997-04-24 1998-04-23 2-oxo-1-azetidinsulfonicsaure- derivative als potent ss-lactamase hemmer

Country Status (10)

Country Link
US (1) US5888998A (https=)
EP (1) EP0979229B1 (https=)
JP (1) JP2001521549A (https=)
KR (1) KR20010020181A (https=)
AU (1) AU740446B2 (https=)
CA (1) CA2287219C (https=)
DE (1) DE69808901T2 (https=)
HU (1) HUP0001269A3 (https=)
NO (1) NO995108L (https=)
WO (1) WO1998047895A1 (https=)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010002705A (ko) * 1999-06-17 2001-01-15 고두모 신규 티아졸 초산의 반응성 포스페이트 유도체의 제조방법
US6916803B2 (en) * 2000-09-14 2005-07-12 Pantherix, Ltd. 3-(Heteroaryl acetamido)-2-oxo-azetidine-1-sulfonic acids derivatives as antibacterial agents
WO2007065288A2 (en) 2005-12-07 2007-06-14 Basilea Pharmaceutica Ag Useful combinations of monobactam antibiotics with beta-lactamase inhibitors
EP2124942B1 (en) * 2007-03-23 2016-04-27 Basilea Pharmaceutica AG Combination medicaments for treating bacterial infections
CA2807546C (en) 2010-08-10 2022-08-23 Rempex Pharmaceuticals, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
US8806158B2 (en) 2010-09-22 2014-08-12 International Business Machines Corporation Intelligent computer memory management
WO2013033461A1 (en) 2011-08-31 2013-03-07 Rempex Pharmaceuticals, Inc. Heterocyclic boronic acid ester derivatives and therapeutic uses thereof
US9156858B2 (en) 2012-05-23 2015-10-13 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US10561675B2 (en) 2012-06-06 2020-02-18 Rempex Pharmaceuticals, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
CN103435650B (zh) * 2012-12-28 2015-12-02 南京海融医药科技有限公司 单环β-内酰胺类化合物、制备方法及其制药用途
KR20150103269A (ko) 2013-01-04 2015-09-09 렘펙스 파머수티클스 인코퍼레이티드 보론산 유도체 및 그의 치료적 용도
MX2015008627A (es) 2013-01-04 2015-09-23 Rempex Pharmaceuticals Inc Derivados de acido boronico y usos terapeuticos de los mismos.
US9101638B2 (en) 2013-01-04 2015-08-11 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US9241947B2 (en) 2013-01-04 2016-01-26 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
ES2750805T3 (es) 2014-05-05 2020-03-27 Rempex Pharmaceuticals Inc Síntesis de sales de boronato y usos de las mismas
EP3139930B1 (en) 2014-05-05 2024-08-14 Melinta Therapeutics, Inc. Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof
AU2015264418A1 (en) 2014-05-19 2016-11-10 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
WO2016003929A1 (en) 2014-07-01 2016-01-07 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US10662205B2 (en) 2014-11-18 2020-05-26 Qpex Biopharma, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
EP3233869B1 (en) 2014-12-19 2019-09-25 Rempex Pharmaceuticals, Inc. Apparatus and continuous flow process for production of boronic acid derivatives
US20180051041A1 (en) 2015-03-17 2018-02-22 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
RU2618433C2 (ru) * 2015-08-10 2017-05-03 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный университет" (СПбГУ) Антимикробная комбинация в отношении устойчивых к карбапенемам грамотрицательных бактерий вида pseudomonas aeruginosa, продуцирующих металло-β-лактамазу
MX389349B (es) 2016-06-30 2025-03-20 Qpex Biopharma Inc Derivados de ácido borónico y usos terapéuticos de los mismos.
CN107641119B (zh) * 2016-07-21 2019-11-08 中国科学院上海药物研究所 单环β-内酰胺-铁载体轭合物及其制备方法和用途
RU2664434C2 (ru) * 2016-12-01 2018-08-17 Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный университет" (СПбГУ) АНТИМИКРОБНАЯ КОМБИНАЦИЯ В ОТНОШЕНИИ УСТОЙЧИВЫХ К КАРБАПЕНЕМАМ ГРАМОТРИЦАТЕЛЬНЫХ БАКТЕРИЙ ВИДА KLEBSIELLA PNEUMONIAE, ПРОДУЦИРУЮЩИХ МЕТАЛЛО-β-ЛАКТАМАЗУ
RU2666619C2 (ru) * 2016-12-01 2018-09-11 Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный университет" (СПбГУ) АНТИМИКРОБНАЯ КОМБИНАЦИЯ В ОТНОШЕНИИ УСТОЙЧИВЫХ К КАРБАПЕНЕМАМ ГРАМОТРИЦАТЕЛЬНЫХ БАКТЕРИЙ ВИДА ACINETOBACTER BAUMANNII, ПРОДУЦИРУЮЩИХ МЕТАЛЛО-β-ЛАКТАМАЗУ
US11286270B2 (en) 2017-10-11 2022-03-29 Qpex Biopharma, Inc. Boronic acid derivatives and synthesis thereof
EP3781576B1 (en) 2018-04-20 2024-06-12 Qpex Biopharma, Inc. Boronic acid derivatives and therapeutic uses thereof
AU2021266715A1 (en) 2020-05-05 2022-11-17 Qpex Biopharma, Inc. Boronic acid derivatives and synthesis, polymorphic forms, and therapeutic uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775670A (en) * 1980-09-29 1988-10-04 E. R. Squibb & Sons, Inc. 2-oxo-1-azetidinesulfonic acid salts
US4632985A (en) * 1985-06-03 1986-12-30 E. R. Squibb & Sons, Inc. 3-acylamino-2-oxo-1-azetidinesulfonic acids
US5006650A (en) * 1987-02-11 1991-04-09 The Upjohn Company Novel N-1 substituted beta-lactams as antibiotics
JPH02502455A (ja) * 1987-02-27 1990-08-09 ジ・アップジョン・カンパニー ピリドンカルボン酸または酸誘導体を含有する抗生物質β‐ラクタム
US5112968A (en) * 1989-07-28 1992-05-12 E. R. Squibb & Sons, Inc. Monobactam hydrazide derivatives
CA2024282A1 (en) * 1989-09-21 1991-03-22 Peter H. Ermann Heterocyclic hydrazide derivatives of monocyclic beta-lactam antibiotics
ZA918014B (en) * 1990-11-05 1992-07-29 Squibb & Sons Inc Heteroaroyl derivatives of monocyclic beta-lactam antibiotics

Also Published As

Publication number Publication date
NO995108D0 (no) 1999-10-20
US5888998A (en) 1999-03-30
NO995108L (no) 1999-10-20
EP0979229B1 (en) 2002-10-23
AU6931498A (en) 1998-11-13
AU740446B2 (en) 2001-11-01
DE69808901D1 (de) 2002-11-28
KR20010020181A (ko) 2001-03-15
HUP0001269A3 (en) 2001-11-28
CA2287219C (en) 2010-01-12
CA2287219A1 (en) 1998-10-29
WO1998047895A1 (en) 1998-10-29
EP0979229A1 (en) 2000-02-16
JP2001521549A (ja) 2001-11-06
HUP0001269A2 (hu) 2001-05-28

Similar Documents

Publication Publication Date Title
DE69808901T2 (de) 2-oxo-1-azetidinsulfonicsaure- derivative als potent ss-lactamase hemmer
DE69809446T2 (de) Azetidinonderivate als beta-lactamase-inhibitoren
US20110288063A1 (en) Novel fused bridged bicyclic heteroaryl substituted 6-alkylidene penems as potent beta-lactamase inhibitors
NL8105470A (nl) 1-sulfo 2-oxoazetidinederivaten, alsmede bereiding en toepassing daarvan.
CN107260729B (zh) β-内酰胺化合物及其用途
DE2837264A1 (de) 7 beta -arylmalonamido-7 alpha -methoxy-3-thiadiazolylthio-1-oxadethiacephalosporine, ihre ester und salze, sowie verfahren zu deren herstellung
EP0335297B1 (de) Cephalosporinderivate
EP0671401A1 (de) Beta-Lactame
IE76147B1 (en) Beta-Lactames
CH626370A5 (en) Process for the preparation of the syn isomer or of a mixture of syn and anti isomers of 7beta-acylamidoceph-3-em-4-carboxylic acids with antibiotic activity
DE69625910T2 (de) Penamsulfone als beta-laktamase inhibitoren
DE3851906T2 (de) Cephalosporinverbindungen und antibakterielle Mittel.
DE3424780A1 (de) In 7ss-stellung durch eine carbonamidogruppe, welche einen eine oxogruppe aufweisenden gesaettigten heterocyclischen ring enthaelt, substituierte 3-cephem-4-carbonsaeure-derivate
FR2531711A1 (fr) Nouveaux derives de la cephalosporine, leur preparation et les medicaments qui les contiennent
DE69033952T2 (de) Antibakterielle Cephalosporin-Derivate
EP0362622A1 (de) Verwendung stabiler Oxapenem-3-carbonsäuren zur Herstellung Beta-Lactamase hemmender Arzneimittel
US5811419A (en) Isooxacephem-derivatives
CA1237427A (en) Cephem compounds
US4912214A (en) Isothiazolyl beta-lactam antibacterial agents
US4343807A (en) Derivatives of clavulanic acid, a process for their preparation and their use
EP0201459A1 (de) Acylaminomethylpenemverbindungen, ihre Herstellung und sie enthaltende pharmazeutische Präparate
HUT61558A (en) Process for producing new heterocyclic carboxylic acid esters and pharmaceutical compositions comprising same
JPH0613529B2 (ja) 新規セフアロスポリン誘導体及び抗菌剤
CH642664A5 (de) 7alpha-methoxycephalosporine und verfahren zur herstellung derselben.
DE2449863A1 (de) Penamderivate und verfahren zu deren herstellung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee