JP2001519441A - 新規ビタミンｄ受容体関連ポリペプチド、かかるポリペプチドをコードする核酸配列及びその使用 - Google Patents
新規ビタミンｄ受容体関連ポリペプチド、かかるポリペプチドをコードする核酸配列及びその使用Info
- Publication number
- JP2001519441A JP2001519441A JP2000515925A JP2000515925A JP2001519441A JP 2001519441 A JP2001519441 A JP 2001519441A JP 2000515925 A JP2000515925 A JP 2000515925A JP 2000515925 A JP2000515925 A JP 2000515925A JP 2001519441 A JP2001519441 A JP 2001519441A
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- vdrr
- polypeptide
- nucleic acid
- acid sequence
- amino acid
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- Pending
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- 229960001445 alitretinoin Drugs 0.000 description 1
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- 210000004556 brain Anatomy 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 229910001628 calcium chloride Inorganic materials 0.000 description 1
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- 238000011260 co-administration Methods 0.000 description 1
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- 208000029742 colonic neoplasm Diseases 0.000 description 1
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- 239000004030 hiv protease inhibitor Substances 0.000 description 1
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- 239000000203 mixture Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229940077150 progesterone and estrogen Drugs 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- XXPDBLUZJRXNNZ-UHFFFAOYSA-N promethazine hydrochloride Chemical compound Cl.C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 XXPDBLUZJRXNNZ-UHFFFAOYSA-N 0.000 description 1
- 229940127293 prostanoid Drugs 0.000 description 1
- 150000003814 prostanoids Chemical class 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 230000009711 regulatory function Effects 0.000 description 1
- 238000003571 reporter gene assay Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 210000001995 reticulocyte Anatomy 0.000 description 1
- 229930002330 retinoic acid Natural products 0.000 description 1
- 108091008726 retinoic acid receptors α Proteins 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 208000014680 small intestine neoplasm Diseases 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
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- 239000008223 sterile water Substances 0.000 description 1
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- 229960004793 sucrose Drugs 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 229940037128 systemic glucocorticoids Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
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- 229960001727 tretinoin Drugs 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Pain & Pain Management (AREA)
- Nutrition Science (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9703745-1 | 1997-10-14 | ||
| SE9703745A SE9703745D0 (sv) | 1997-10-14 | 1997-10-14 | New receptors |
| SE9801148A SE9801148D0 (sv) | 1997-10-14 | 1998-03-31 | New receptors |
| SE9801148-9 | 1998-03-31 | ||
| PCT/SE1998/001548 WO1999019354A1 (en) | 1997-10-14 | 1998-08-31 | Novel vitamin d receptor related polypeptides, nucleic acid sequence encoding the same and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001519441A true JP2001519441A (ja) | 2001-10-23 |
| JP2001519441A5 JP2001519441A5 (sk) | 2006-01-05 |
Family
ID=26663102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000515925A Pending JP2001519441A (ja) | 1997-10-14 | 1998-08-31 | 新規ビタミンｄ受容体関連ポリペプチド、かかるポリペプチドをコードする核酸配列及びその使用 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1023323A1 (sk) |
| JP (1) | JP2001519441A (sk) |
| KR (1) | KR20010031120A (sk) |
| CN (1) | CN1134452C (sk) |
| AU (1) | AU732079B2 (sk) |
| CA (1) | CA2306453A1 (sk) |
| NZ (1) | NZ504025A (sk) |
| SE (1) | SE9801148D0 (sk) |
| WO (1) | WO1999019354A1 (sk) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007082550A (ja) * | 1998-01-09 | 2007-04-05 | Salk Inst For Biological Studies | 新規なステロイド活性化核受容体とその利用法 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002508393A (ja) * | 1997-12-12 | 2002-03-19 | メルク エンド カムパニー インコーポレーテッド | ヒト核内受容体タンパク質ｎＮＲ７およびｎＮＲ７−１をコードするＤＮＡ分子 |
| US6911537B2 (en) * | 1998-01-09 | 2005-06-28 | The Salk Institute For Biological Studies | Xenobiotic compound modulated expression systems and uses therefor |
| AU2003200641B2 (en) * | 1998-01-09 | 2008-04-03 | The Salk Institute For Biological Studies | Novel Steroid-activated Nuclear Receptors and Uses therefor |
| US6984773B1 (en) | 1998-01-09 | 2006-01-10 | The Salk Institute For Biological Studies | Transgenic mice expressing a human SXR receptor polypeptide |
| EP1066320A4 (en) * | 1998-03-27 | 2005-03-16 | Glaxo Group Ltd | ORPHAN NUCLEAR RECEPTOR |
| US7238491B1 (en) | 1998-03-27 | 2007-07-03 | Smithkline Beecham Corporation | Pregnane X receptor method |
| FR2801311B1 (fr) | 1999-11-22 | 2005-08-26 | Centre Nat Rech Scient | Polypeptides derives du recepteur nucleaire de la vitamine d, et leurs utilisations notamment dans le cadre du criblage d'analogues de la vitamine d |
| AU2006200258B2 (en) * | 1999-12-09 | 2009-04-09 | The Salk Institute For Biological Studies | Novel steroid-activated nuclear receptors and uses therefor |
| US6514941B1 (en) | 1999-12-10 | 2003-02-04 | Campina Melkunie B.V. | Method of preparing a casein hydrolysate enriched in anti-hypertensive peptides |
| US20040053866A1 (en) * | 2002-08-21 | 2004-03-18 | The Regents Of The University Of California | Tumor suppressor genes and their uses |
| SE0400489D0 (sv) * | 2004-02-27 | 2004-02-27 | Biovitrum Ab | Therapeutic proteins |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03504438A (ja) * | 1988-03-30 | 1991-10-03 | アーチ デベロプメント コーポレイション | アンドロジェンレセプターを含むｄｎａ結合蛋白質 |
| ATE215601T1 (de) * | 1991-09-17 | 2002-04-15 | Salk Inst For Biological Studi | Rezeptoren der steroid/thyroid superfamilie von rezeptoren |
| US5756448A (en) * | 1992-02-26 | 1998-05-26 | The General Hospital Corporation | Constitute activator of retinoid (CAR) receptor polypeptides |
| AU711041B2 (en) * | 1995-01-17 | 1999-10-07 | Salk Institute For Biological Studies, The | Methods, polypeptides, nucleotide sequence of XOR-6, a vitamin D-like receptor from xenopus |
| WO1996036230A1 (en) * | 1995-05-16 | 1996-11-21 | The Salk Institute For Biological Studies | Modulators for new members of the steroid/thyroid superfamily of receptors |
-
1998
- 1998-03-31 SE SE9801148A patent/SE9801148D0/xx unknown
- 1998-08-31 WO PCT/SE1998/001548 patent/WO1999019354A1/en not_active Application Discontinuation
- 1998-08-31 AU AU90131/98A patent/AU732079B2/en not_active Ceased
- 1998-08-31 KR KR1020007004011A patent/KR20010031120A/ko not_active Application Discontinuation
- 1998-08-31 NZ NZ504025A patent/NZ504025A/xx unknown
- 1998-08-31 EP EP98941985A patent/EP1023323A1/en not_active Withdrawn
- 1998-08-31 CA CA002306453A patent/CA2306453A1/en not_active Abandoned
- 1998-08-31 CN CNB988112264A patent/CN1134452C/zh not_active Expired - Fee Related
- 1998-08-31 JP JP2000515925A patent/JP2001519441A/ja active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007082550A (ja) * | 1998-01-09 | 2007-04-05 | Salk Inst For Biological Studies | 新規なステロイド活性化核受容体とその利用法 |
| JP2010029211A (ja) * | 1998-01-09 | 2010-02-12 | Salk Inst For Biological Studies | 新規なステロイド活性化核受容体とその利用法 |
| JP4586005B2 (ja) * | 1998-01-09 | 2010-11-24 | ザ ソールク インスチチュート フォア バイオロジカル スタディズ | 新規なステロイド活性化核受容体とその利用法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2306453A1 (en) | 1999-04-22 |
| KR20010031120A (ko) | 2001-04-16 |
| WO1999019354A9 (en) | 1999-12-02 |
| NZ504025A (en) | 2003-04-29 |
| CN1134452C (zh) | 2004-01-14 |
| AU732079B2 (en) | 2001-04-12 |
| AU9013198A (en) | 1999-05-03 |
| SE9801148D0 (sv) | 1998-03-31 |
| WO1999019354A1 (en) | 1999-04-22 |
| CN1279689A (zh) | 2001-01-10 |
| EP1023323A1 (en) | 2000-08-02 |
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