EP1066320A4 - Orphan nuclear receptor - Google Patents

Orphan nuclear receptor

Info

Publication number
EP1066320A4
EP1066320A4 EP99914221A EP99914221A EP1066320A4 EP 1066320 A4 EP1066320 A4 EP 1066320A4 EP 99914221 A EP99914221 A EP 99914221A EP 99914221 A EP99914221 A EP 99914221A EP 1066320 A4 EP1066320 A4 EP 1066320A4
Authority
EP
European Patent Office
Prior art keywords
nuclear receptor
orphan nuclear
orphan
receptor
nuclear
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99914221A
Other languages
German (de)
French (fr)
Other versions
EP1066320A1 (en
Inventor
Steven Anthony Kliewer
Timothy Mark Willson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of EP1066320A1 publication Critical patent/EP1066320A1/en
Publication of EP1066320A4 publication Critical patent/EP1066320A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
EP99914221A 1998-03-27 1999-03-26 Orphan nuclear receptor Withdrawn EP1066320A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7959398P 1998-03-27 1998-03-27
US79593P 1998-03-27
PCT/US1999/006737 WO1999048915A1 (en) 1998-03-27 1999-03-26 Orphan nuclear receptor

Publications (2)

Publication Number Publication Date
EP1066320A1 EP1066320A1 (en) 2001-01-10
EP1066320A4 true EP1066320A4 (en) 2005-03-16

Family

ID=22151520

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99914221A Withdrawn EP1066320A4 (en) 1998-03-27 1999-03-26 Orphan nuclear receptor

Country Status (4)

Country Link
EP (1) EP1066320A4 (en)
JP (1) JP2002535241A (en)
AU (1) AU3211699A (en)
WO (1) WO1999048915A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756491B2 (en) 1998-01-09 2004-06-29 The Salk Institute For Biological Studies Steroid-activated nuclear receptors and uses therefor
US6984773B1 (en) 1998-01-09 2006-01-10 The Salk Institute For Biological Studies Transgenic mice expressing a human SXR receptor polypeptide
AUPP135698A0 (en) 1998-01-15 1998-02-05 Commonwealth Scientific And Industrial Research Organisation Insectical modalities
US7238491B1 (en) 1998-03-27 2007-07-03 Smithkline Beecham Corporation Pregnane X receptor method
AUPP362898A0 (en) 1998-05-21 1998-06-11 University Of Sydney, The Xenobiotic induction of gene expression
WO2001002436A1 (en) * 1999-07-01 2001-01-11 Commonwealth Scientific And Industrial Research Organisation Novel genetic sequences encoding steroid and juvenile hormone receptor polypeptides and uses therefor
EP1088900A1 (en) 1999-09-10 2001-04-04 Epidauros Biotechnologie AG Polymorphisms in the human CYP3A4, CYP3A7 and hPXR genes and their use in diagnostic and therapeutic applications
AU2006200258B2 (en) * 1999-12-09 2009-04-09 The Salk Institute For Biological Studies Novel steroid-activated nuclear receptors and uses therefor
CA2398564A1 (en) * 2000-01-28 2001-08-02 Incyte Genomics, Inc. Nuclear hormone receptors
MXPA02009869A (en) * 2000-04-12 2005-02-17 Judy Raucy Compositions and methods for induction of proteins involved in xenobiotic metabolism.
JP2003535912A (en) * 2000-06-21 2003-12-02 グラクソ グループ リミテッド Nuclear orphan receptor
AU2001285842A1 (en) * 2000-07-25 2002-02-05 Epidauros Biotechnologie Ag Assay for screening compounds for inducing drug metabolizing enzymes
AU2001293778A1 (en) * 2000-08-28 2002-03-13 Lion Bioscience Ag Novel cofactors of the pregnane x receptor and methods of use
CA2426959C (en) * 2000-11-01 2011-10-04 The University Of Sydney Transgenic animals for analysing cyp3a4 cytochrome p450 gene regulation
AUPR116100A0 (en) 2000-11-01 2000-11-23 University Of Sydney, The P450 gene regulation
EP1392725A1 (en) * 2001-05-24 2004-03-03 SmithKline Beecham Corporation Nonhuman pregnane x receptor sequences for use in comparative pharmacology
CA2961166C (en) 2014-10-21 2021-04-13 Council Of Scientific And Industrial Research Alkylidene phosphonate esters as p-glycoprotein inducers

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999019354A1 (en) * 1997-10-14 1999-04-22 Pharmacia & Upjohn Ab Novel vitamin d receptor related polypeptides, nucleic acid sequence encoding the same and uses thereof
WO1999031129A1 (en) * 1997-12-12 1999-06-24 Merck & Co., Inc. DNA MOLECULES ENCODING HUMAN NUCLEAR RECEPTOR PROTEINS, nNR7 AND nNR7-1
WO1999035246A1 (en) * 1998-01-09 1999-07-15 The Salk Institute For Biological Studies Novel steroid-activated nuclear receptors and uses therefor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999019354A1 (en) * 1997-10-14 1999-04-22 Pharmacia & Upjohn Ab Novel vitamin d receptor related polypeptides, nucleic acid sequence encoding the same and uses thereof
WO1999031129A1 (en) * 1997-12-12 1999-06-24 Merck & Co., Inc. DNA MOLECULES ENCODING HUMAN NUCLEAR RECEPTOR PROTEINS, nNR7 AND nNR7-1
WO1999035246A1 (en) * 1998-01-09 1999-07-15 The Salk Institute For Biological Studies Novel steroid-activated nuclear receptors and uses therefor

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KLIEWER S A ET AL: "AN ORPHAN NUCLEAR RECEPTOR ACTIVATED BY PREGNANES DEFINES A NOVEL STEROID SIGNALING PATHWAY", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 92, 9 January 1998 (1998-01-09), pages 73 - 82, XP000918927, ISSN: 0092-8674 *
LEHMANN J M ET AL: "The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 102, no. 5, 1 September 1998 (1998-09-01), pages 1016 - 1023, XP000909297, ISSN: 0021-9738 *
See also references of WO9948915A1 *

Also Published As

Publication number Publication date
WO1999048915A1 (en) 1999-09-30
WO1999048915A9 (en) 1999-11-18
AU3211699A (en) 1999-10-18
JP2002535241A (en) 2002-10-22
EP1066320A1 (en) 2001-01-10

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Legal Events

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