EP1066320A4 - Recepteur nucleaire orphelin - Google Patents
Recepteur nucleaire orphelinInfo
- Publication number
- EP1066320A4 EP1066320A4 EP99914221A EP99914221A EP1066320A4 EP 1066320 A4 EP1066320 A4 EP 1066320A4 EP 99914221 A EP99914221 A EP 99914221A EP 99914221 A EP99914221 A EP 99914221A EP 1066320 A4 EP1066320 A4 EP 1066320A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- nuclear receptor
- orphan nuclear
- orphan
- receptor
- nuclear
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- High Energy & Nuclear Physics (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7959398P | 1998-03-27 | 1998-03-27 | |
US79593P | 1998-03-27 | ||
PCT/US1999/006737 WO1999048915A1 (fr) | 1998-03-27 | 1999-03-26 | Recepteur nucleaire orphelin |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1066320A1 EP1066320A1 (fr) | 2001-01-10 |
EP1066320A4 true EP1066320A4 (fr) | 2005-03-16 |
Family
ID=22151520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99914221A Withdrawn EP1066320A4 (fr) | 1998-03-27 | 1999-03-26 | Recepteur nucleaire orphelin |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1066320A4 (fr) |
JP (1) | JP2002535241A (fr) |
AU (1) | AU3211699A (fr) |
WO (1) | WO1999048915A1 (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6984773B1 (en) * | 1998-01-09 | 2006-01-10 | The Salk Institute For Biological Studies | Transgenic mice expressing a human SXR receptor polypeptide |
US6756491B2 (en) | 1998-01-09 | 2004-06-29 | The Salk Institute For Biological Studies | Steroid-activated nuclear receptors and uses therefor |
AUPP135698A0 (en) | 1998-01-15 | 1998-02-05 | Commonwealth Scientific And Industrial Research Organisation | Insectical modalities |
US7238491B1 (en) | 1998-03-27 | 2007-07-03 | Smithkline Beecham Corporation | Pregnane X receptor method |
AUPP362898A0 (en) | 1998-05-21 | 1998-06-11 | University Of Sydney, The | Xenobiotic induction of gene expression |
WO2001002436A1 (fr) * | 1999-07-01 | 2001-01-11 | Commonwealth Scientific And Industrial Research Organisation | Nouvelles sequences genetiques codant les recepteurs de l'hormone steroide et de la neotinine et leurs utilisations |
EP1088900A1 (fr) | 1999-09-10 | 2001-04-04 | Epidauros Biotechnologie AG | Polymorphismes des gènes humaines CYP3A4, CYP3A7 et hPXR et leur utilisation pour des applications diagnostiques et thérapeutiques |
AU2006200258B2 (en) * | 1999-12-09 | 2009-04-09 | The Salk Institute For Biological Studies | Novel steroid-activated nuclear receptors and uses therefor |
EP1250432A2 (fr) * | 2000-01-28 | 2002-10-23 | Incyte Genomics, Inc. | Recepteurs nucleaires d'hormones |
NZ521806A (en) * | 2000-04-12 | 2004-07-30 | Puracyp | Compositions and methods for induction of proteins involved in xenobiotic metabolism |
AU2001284343A1 (en) * | 2000-06-21 | 2002-01-02 | Glaxo Group Limited | An orphan nuclear receptor |
AU2001285842A1 (en) * | 2000-07-25 | 2002-02-05 | Epidauros Biotechnologie Ag | Assay for screening compounds for inducing drug metabolizing enzymes |
WO2002018420A2 (fr) * | 2000-08-28 | 2002-03-07 | Lion Bioscience Ag | Nouveaux cofacteurs du recepteur du pregnane x et leurs methodes d'utilisation |
WO2002036784A1 (fr) * | 2000-11-01 | 2002-05-10 | The University Of Sydney | Animaux transgeniques utilises pour analyser la regulation du gene p450 du cytochrome cyp3a4 |
AUPR116100A0 (en) | 2000-11-01 | 2000-11-23 | University Of Sydney, The | P450 gene regulation |
EP1392725A1 (fr) * | 2001-05-24 | 2004-03-03 | SmithKline Beecham Corporation | Sequences du recepteur de pregnane-x non humaines a utiliser en pharmacologie comparative |
EP3209671B8 (fr) | 2014-10-21 | 2019-07-31 | Council of Scientific and Industrial Research | Esters de phosphonate d'alkylidène en tant qu'inducteurs de p-glycoprotéine |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999019354A1 (fr) * | 1997-10-14 | 1999-04-22 | Pharmacia & Upjohn Ab | Nouveaux polypeptides apparentes au recepteur de vitamine d, sequence d'acide nucleique codant ces polypeptides et utilisation de ces derniers |
WO1999031129A1 (fr) * | 1997-12-12 | 1999-06-24 | Merck & Co., Inc. | MOLECULES D'ADN CODANT DES PROTEINES RECEPTRICES NUCLEAIRES HUMAINES, nNR7 ET nNR7-1 |
WO1999035246A1 (fr) * | 1998-01-09 | 1999-07-15 | The Salk Institute For Biological Studies | Nouveaux recepteurs nucleaires actives par des steroides et leurs utilisations |
-
1999
- 1999-03-26 WO PCT/US1999/006737 patent/WO1999048915A1/fr not_active Application Discontinuation
- 1999-03-26 EP EP99914221A patent/EP1066320A4/fr not_active Withdrawn
- 1999-03-26 JP JP2000537897A patent/JP2002535241A/ja active Pending
- 1999-03-26 AU AU32116/99A patent/AU3211699A/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999019354A1 (fr) * | 1997-10-14 | 1999-04-22 | Pharmacia & Upjohn Ab | Nouveaux polypeptides apparentes au recepteur de vitamine d, sequence d'acide nucleique codant ces polypeptides et utilisation de ces derniers |
WO1999031129A1 (fr) * | 1997-12-12 | 1999-06-24 | Merck & Co., Inc. | MOLECULES D'ADN CODANT DES PROTEINES RECEPTRICES NUCLEAIRES HUMAINES, nNR7 ET nNR7-1 |
WO1999035246A1 (fr) * | 1998-01-09 | 1999-07-15 | The Salk Institute For Biological Studies | Nouveaux recepteurs nucleaires actives par des steroides et leurs utilisations |
Non-Patent Citations (3)
Title |
---|
KLIEWER S A ET AL: "AN ORPHAN NUCLEAR RECEPTOR ACTIVATED BY PREGNANES DEFINES A NOVEL STEROID SIGNALING PATHWAY", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 92, 9 January 1998 (1998-01-09), pages 73 - 82, XP000918927, ISSN: 0092-8674 * |
LEHMANN J M ET AL: "The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 102, no. 5, 1 September 1998 (1998-09-01), pages 1016 - 1023, XP000909297, ISSN: 0021-9738 * |
See also references of WO9948915A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP1066320A1 (fr) | 2001-01-10 |
JP2002535241A (ja) | 2002-10-22 |
WO1999048915A9 (fr) | 1999-11-18 |
WO1999048915A1 (fr) | 1999-09-30 |
AU3211699A (en) | 1999-10-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20000925 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20050131 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
18W | Application withdrawn |
Effective date: 20050418 |