JP2001515063A5 - - Google Patents
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- Publication number
- JP2001515063A5 JP2001515063A5 JP2000509689A JP2000509689A JP2001515063A5 JP 2001515063 A5 JP2001515063 A5 JP 2001515063A5 JP 2000509689 A JP2000509689 A JP 2000509689A JP 2000509689 A JP2000509689 A JP 2000509689A JP 2001515063 A5 JP2001515063 A5 JP 2001515063A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- straight
- branched chain
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 229940122440 HIV protease inhibitor Drugs 0.000 description 6
- 125000003545 alkoxy group Chemical group 0.000 description 6
- 125000000217 alkyl group Chemical group 0.000 description 6
- 239000004030 hiv protease inhibitor Substances 0.000 description 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 6
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 description 6
- 208000031886 HIV Infections Diseases 0.000 description 5
- 208000037357 HIV infectious disease Diseases 0.000 description 5
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 5
- QAGYKUNXZHXKMR-UHFFFAOYSA-N CPD000469186 Natural products CC1=C(O)C=CC=C1C(=O)NC(C(O)CN1C(CC2CCCCC2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 QAGYKUNXZHXKMR-UHFFFAOYSA-N 0.000 description 3
- NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 description 3
- 229960001936 indinavir Drugs 0.000 description 3
- CBVCZFGXHXORBI-PXQQMZJSSA-N indinavir Chemical compound C([C@H](N(CC1)C[C@@H](O)C[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H]2C3=CC=CC=C3C[C@H]2O)C(=O)NC(C)(C)C)N1CC1=CC=CN=C1 CBVCZFGXHXORBI-PXQQMZJSSA-N 0.000 description 3
- 229960000884 nelfinavir Drugs 0.000 description 3
- QAGYKUNXZHXKMR-HKWSIXNMSA-N nelfinavir Chemical compound CC1=C(O)C=CC=C1C(=O)N[C@H]([C@H](O)CN1[C@@H](C[C@@H]2CCCC[C@@H]2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 QAGYKUNXZHXKMR-HKWSIXNMSA-N 0.000 description 3
- 229960000311 ritonavir Drugs 0.000 description 3
- NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical group N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 description 3
- 229960001852 saquinavir Drugs 0.000 description 3
- QWAXKHKRTORLEM-UGJKXSETSA-N saquinavir Chemical compound C([C@@H]([C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)C=1N=C2C=CC=CC2=CC=1)C1=CC=CC=C1 QWAXKHKRTORLEM-UGJKXSETSA-N 0.000 description 3
- 238000002648 combination therapy Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/911,883 | 1997-08-15 | ||
| US08/911,883 US5849793A (en) | 1997-08-15 | 1997-08-15 | HIV matrix protein tyrosine position 29 pocket binders |
| PCT/US1998/016923 WO1999009005A1 (en) | 1997-08-15 | 1998-08-14 | Hiv matrix protein tyrosine position 29 pocket binders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001515063A JP2001515063A (ja) | 2001-09-18 |
| JP2001515063A5 true JP2001515063A5 (https=) | 2006-01-05 |
Family
ID=25431042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000509689A Pending JP2001515063A (ja) | 1997-08-15 | 1998-08-14 | Ｈｉｖマトリックスタンパク質チロシン２９位ポケットバインダー |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5849793A (https=) |
| EP (1) | EP1015422A4 (https=) |
| JP (1) | JP2001515063A (https=) |
| AU (1) | AU759210B2 (https=) |
| CA (1) | CA2300876C (https=) |
| WO (1) | WO1999009005A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6297253B1 (en) * | 1996-10-15 | 2001-10-02 | The Picower Institute For Medical Research | Compounds and methods of use to treat infectious diseases |
| MXPA00012842A (es) * | 1998-06-24 | 2004-06-22 | Univ Emory | Uso de 3'-azido-2',3'-didesoxiuridina en combinacion de drogas adicionales contra el vih para la manufactura de un medicamento para el tratamiento del vih. |
| US20050203150A1 (en) * | 2004-03-09 | 2005-09-15 | Haffar Omar K. | Compounds, compositions and methods for inhibiting or treating HIV-1 |
| ES2653855T3 (es) * | 2007-09-26 | 2018-02-09 | Indiana University Research And Technology Corporation | Derivado de la benzoquinona e3330 en combinación con agentes quimioterapéuticos para el tratamiento del cáncer y la angiogénesis |
| US11331294B2 (en) | 2007-09-26 | 2022-05-17 | Indiana University Research And Technology Corporation | Benzoquinone derivative E3330 in combination with chemotherapeutic agents for the treatment of bladder cancer |
| GB2476644B (en) | 2009-12-23 | 2012-11-14 | Haomamedica Ltd | 1,4-Dihydro-1,4-dioxonaphtalene derivatives for the treatment of osteoporosis |
| US20140128398A1 (en) | 2011-06-03 | 2014-05-08 | Indiana University Research And Technology Corporation | Compounds, compositions and methods for treating oxidative dna damage disorders |
| CN108341775B (zh) * | 2017-01-25 | 2021-03-16 | 重庆常捷医药有限公司 | 一种瑞巴派特中间体的合成方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2553647A (en) * | 1946-03-20 | 1951-05-22 | Research Corp | Naphthoquinone antimalarials |
| US2572946A (en) * | 1949-11-19 | 1951-10-30 | Du Pont | Composition comprising 2-aliphatic-3-hydroxy-1, 4 napthoquinone and method for controlling mites and aphids |
| JPS5010574B1 (https=) * | 1970-07-30 | 1975-04-22 | ||
| US3914264A (en) * | 1975-01-30 | 1975-10-21 | American Cyanamid Co | 2-Lower alkoxy-3-(lower alkylthio)-1,4-naphthoquinone |
| US4053634A (en) * | 1975-09-15 | 1977-10-11 | E. I. Du Pont De Nemours And Company | Miticidal and aphicidal method utilizing 2-higher alkyl-3-hydroxy-1,4-naphthoquinone carboxylic acid esters |
| JPS5829764B2 (ja) * | 1976-02-10 | 1983-06-24 | 雄一 山村 | 免疫調整用水性剤 |
| US4229478A (en) * | 1978-06-05 | 1980-10-21 | Syntex (U.S.A.) Inc. | Naphthaquinone anti-psoriatic agents |
| DE3378909D1 (en) * | 1982-10-20 | 1989-02-16 | Takeda Chemical Industries Ltd | Physiologically active substance p-23924, its production and use |
| JPS60130515A (ja) * | 1983-12-15 | 1985-07-12 | Shiratori Seiyaku Kk | 血中２，３−ジホスホグリセリン酸上昇剤 |
| DE3347658A1 (de) * | 1983-12-31 | 1985-07-11 | Troponwerke GmbH & Co KG, 5000 Köln | 1.4-naphthochinonderivate mit entzuendungshemmender wirkung |
| DE3431236A1 (de) * | 1984-08-24 | 1986-02-27 | Carnivora-Deutschland GmbH, 7109 Jagsthausen | Verwendung von 1,4-naphthochinon-derivaten in niedrigen konzentrationen zur immunstimulation |
| DE3801743A1 (de) * | 1987-07-03 | 1989-01-19 | Bayer Ag | Schaedlingsbekaempfungsmittel auf basis von substituierten 1,4-naphthochinonen und neue substituierte 1,4-naphthochinone |
-
1997
- 1997-08-15 US US08/911,883 patent/US5849793A/en not_active Expired - Lifetime
-
1998
- 1998-08-14 WO PCT/US1998/016923 patent/WO1999009005A1/en not_active Ceased
- 1998-08-14 EP EP98942068A patent/EP1015422A4/en not_active Withdrawn
- 1998-08-14 JP JP2000509689A patent/JP2001515063A/ja active Pending
- 1998-08-14 CA CA002300876A patent/CA2300876C/en not_active Expired - Fee Related
- 1998-08-14 AU AU90201/98A patent/AU759210B2/en not_active Ceased
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