JP2001515063A - Ｈｉｖマトリックスタンパク質チロシン２９位ポケットバインダー - Google Patents
Ｈｉｖマトリックスタンパク質チロシン２９位ポケットバインダーInfo
- Publication number
- JP2001515063A JP2001515063A JP2000509689A JP2000509689A JP2001515063A JP 2001515063 A JP2001515063 A JP 2001515063A JP 2000509689 A JP2000509689 A JP 2000509689A JP 2000509689 A JP2000509689 A JP 2000509689A JP 2001515063 A JP2001515063 A JP 2001515063A
- Authority
- JP
- Japan
- Prior art keywords
- hiv
- compound
- straight
- branched chain
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 238000004393 prognosis Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000012439 solid excipient Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229940100611 topical cream Drugs 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 230000017613 viral reproduction Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/911,883 | 1997-08-15 | ||
| US08/911,883 US5849793A (en) | 1997-08-15 | 1997-08-15 | HIV matrix protein tyrosine position 29 pocket binders |
| PCT/US1998/016923 WO1999009005A1 (en) | 1997-08-15 | 1998-08-14 | Hiv matrix protein tyrosine position 29 pocket binders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001515063A true JP2001515063A (ja) | 2001-09-18 |
| JP2001515063A5 JP2001515063A5 (https=) | 2006-01-05 |
Family
ID=25431042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000509689A Pending JP2001515063A (ja) | 1997-08-15 | 1998-08-14 | Ｈｉｖマトリックスタンパク質チロシン２９位ポケットバインダー |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5849793A (https=) |
| EP (1) | EP1015422A4 (https=) |
| JP (1) | JP2001515063A (https=) |
| AU (1) | AU759210B2 (https=) |
| CA (1) | CA2300876C (https=) |
| WO (1) | WO1999009005A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010540545A (ja) * | 2007-09-26 | 2010-12-24 | インディアナ・ユニバーシティ・リサーチ・アンド・テクノロジー・コーポレーション | キノン誘導体、医薬組成物、およびそれらの使用 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6297253B1 (en) * | 1996-10-15 | 2001-10-02 | The Picower Institute For Medical Research | Compounds and methods of use to treat infectious diseases |
| MXPA00012842A (es) * | 1998-06-24 | 2004-06-22 | Univ Emory | Uso de 3'-azido-2',3'-didesoxiuridina en combinacion de drogas adicionales contra el vih para la manufactura de un medicamento para el tratamiento del vih. |
| US20050203150A1 (en) * | 2004-03-09 | 2005-09-15 | Haffar Omar K. | Compounds, compositions and methods for inhibiting or treating HIV-1 |
| US11331294B2 (en) | 2007-09-26 | 2022-05-17 | Indiana University Research And Technology Corporation | Benzoquinone derivative E3330 in combination with chemotherapeutic agents for the treatment of bladder cancer |
| GB2476644B (en) | 2009-12-23 | 2012-11-14 | Haomamedica Ltd | 1,4-Dihydro-1,4-dioxonaphtalene derivatives for the treatment of osteoporosis |
| US20140128398A1 (en) | 2011-06-03 | 2014-05-08 | Indiana University Research And Technology Corporation | Compounds, compositions and methods for treating oxidative dna damage disorders |
| CN108341775B (zh) * | 2017-01-25 | 2021-03-16 | 重庆常捷医药有限公司 | 一种瑞巴派特中间体的合成方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5010574B1 (https=) * | 1970-07-30 | 1975-04-22 | ||
| JPS5296745A (en) * | 1976-02-10 | 1977-08-13 | Yuichi Yamamura | Aqueous agent for immunity control |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2553647A (en) * | 1946-03-20 | 1951-05-22 | Research Corp | Naphthoquinone antimalarials |
| US2572946A (en) * | 1949-11-19 | 1951-10-30 | Du Pont | Composition comprising 2-aliphatic-3-hydroxy-1, 4 napthoquinone and method for controlling mites and aphids |
| US3914264A (en) * | 1975-01-30 | 1975-10-21 | American Cyanamid Co | 2-Lower alkoxy-3-(lower alkylthio)-1,4-naphthoquinone |
| US4053634A (en) * | 1975-09-15 | 1977-10-11 | E. I. Du Pont De Nemours And Company | Miticidal and aphicidal method utilizing 2-higher alkyl-3-hydroxy-1,4-naphthoquinone carboxylic acid esters |
| US4229478A (en) * | 1978-06-05 | 1980-10-21 | Syntex (U.S.A.) Inc. | Naphthaquinone anti-psoriatic agents |
| DE3378909D1 (en) * | 1982-10-20 | 1989-02-16 | Takeda Chemical Industries Ltd | Physiologically active substance p-23924, its production and use |
| JPS60130515A (ja) * | 1983-12-15 | 1985-07-12 | Shiratori Seiyaku Kk | 血中２，３−ジホスホグリセリン酸上昇剤 |
| DE3347658A1 (de) * | 1983-12-31 | 1985-07-11 | Troponwerke GmbH & Co KG, 5000 Köln | 1.4-naphthochinonderivate mit entzuendungshemmender wirkung |
| DE3431236A1 (de) * | 1984-08-24 | 1986-02-27 | Carnivora-Deutschland GmbH, 7109 Jagsthausen | Verwendung von 1,4-naphthochinon-derivaten in niedrigen konzentrationen zur immunstimulation |
| DE3801743A1 (de) * | 1987-07-03 | 1989-01-19 | Bayer Ag | Schaedlingsbekaempfungsmittel auf basis von substituierten 1,4-naphthochinonen und neue substituierte 1,4-naphthochinone |
-
1997
- 1997-08-15 US US08/911,883 patent/US5849793A/en not_active Expired - Lifetime
-
1998
- 1998-08-14 WO PCT/US1998/016923 patent/WO1999009005A1/en not_active Ceased
- 1998-08-14 EP EP98942068A patent/EP1015422A4/en not_active Withdrawn
- 1998-08-14 JP JP2000509689A patent/JP2001515063A/ja active Pending
- 1998-08-14 CA CA002300876A patent/CA2300876C/en not_active Expired - Fee Related
- 1998-08-14 AU AU90201/98A patent/AU759210B2/en not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5010574B1 (https=) * | 1970-07-30 | 1975-04-22 | ||
| JPS5296745A (en) * | 1976-02-10 | 1977-08-13 | Yuichi Yamamura | Aqueous agent for immunity control |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010540545A (ja) * | 2007-09-26 | 2010-12-24 | インディアナ・ユニバーシティ・リサーチ・アンド・テクノロジー・コーポレーション | キノン誘導体、医薬組成物、およびそれらの使用 |
| JP2015017091A (ja) * | 2007-09-26 | 2015-01-29 | インディアナ・ユニバーシティ・リサーチ・アンド・テクノロジー・コーポレーション | キノン誘導体、医薬組成物、およびそれらの使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1015422A4 (en) | 2004-12-08 |
| AU9020198A (en) | 1999-03-08 |
| EP1015422A1 (en) | 2000-07-05 |
| WO1999009005A1 (en) | 1999-02-25 |
| CA2300876A1 (en) | 1999-02-25 |
| CA2300876C (en) | 2008-10-28 |
| US5849793A (en) | 1998-12-15 |
| AU759210B2 (en) | 2003-04-10 |
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