AU759210B2 - HIV matrix protein tyrosine position 29 pocket binders - Google Patents

HIV matrix protein tyrosine position 29 pocket binders Download PDF

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Publication number
AU759210B2
AU759210B2 AU90201/98A AU9020198A AU759210B2 AU 759210 B2 AU759210 B2 AU 759210B2 AU 90201/98 A AU90201/98 A AU 90201/98A AU 9020198 A AU9020198 A AU 9020198A AU 759210 B2 AU759210 B2 AU 759210B2
Authority
AU
Australia
Prior art keywords
compound
hiv
straight
combination
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU90201/98A
Other languages
English (en)
Other versions
AU9020198A (en
Inventor
Michael Bukrinsky
David Callaway
Omar K Haffar
Senliang Pan
Peter Ulrich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferring BV
Original Assignee
Picower Institute for Medical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Picower Institute for Medical Research filed Critical Picower Institute for Medical Research
Publication of AU9020198A publication Critical patent/AU9020198A/en
Application granted granted Critical
Publication of AU759210B2 publication Critical patent/AU759210B2/en
Assigned to CYTOKINE PHARMASCIENCES, INC. reassignment CYTOKINE PHARMASCIENCES, INC. Alteration of Name(s) in Register under S187 Assignors: PICOWER INSTITUTE FOR MEDICAL RESEARCH, THE
Assigned to FERRING B.V. reassignment FERRING B.V. Alteration of Name(s) in Register under S187 Assignors: CYTOKINE PHARMASCIENCES, INC.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU90201/98A 1997-08-15 1998-08-14 HIV matrix protein tyrosine position 29 pocket binders Ceased AU759210B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/911883 1997-08-15
US08/911,883 US5849793A (en) 1997-08-15 1997-08-15 HIV matrix protein tyrosine position 29 pocket binders
PCT/US1998/016923 WO1999009005A1 (en) 1997-08-15 1998-08-14 Hiv matrix protein tyrosine position 29 pocket binders

Publications (2)

Publication Number Publication Date
AU9020198A AU9020198A (en) 1999-03-08
AU759210B2 true AU759210B2 (en) 2003-04-10

Family

ID=25431042

Family Applications (1)

Application Number Title Priority Date Filing Date
AU90201/98A Ceased AU759210B2 (en) 1997-08-15 1998-08-14 HIV matrix protein tyrosine position 29 pocket binders

Country Status (6)

Country Link
US (1) US5849793A (https=)
EP (1) EP1015422A4 (https=)
JP (1) JP2001515063A (https=)
AU (1) AU759210B2 (https=)
CA (1) CA2300876C (https=)
WO (1) WO1999009005A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6297253B1 (en) * 1996-10-15 2001-10-02 The Picower Institute For Medical Research Compounds and methods of use to treat infectious diseases
MXPA00012842A (es) * 1998-06-24 2004-06-22 Univ Emory Uso de 3'-azido-2',3'-didesoxiuridina en combinacion de drogas adicionales contra el vih para la manufactura de un medicamento para el tratamiento del vih.
US20050203150A1 (en) * 2004-03-09 2005-09-15 Haffar Omar K. Compounds, compositions and methods for inhibiting or treating HIV-1
ES2653855T3 (es) * 2007-09-26 2018-02-09 Indiana University Research And Technology Corporation Derivado de la benzoquinona e3330 en combinación con agentes quimioterapéuticos para el tratamiento del cáncer y la angiogénesis
US11331294B2 (en) 2007-09-26 2022-05-17 Indiana University Research And Technology Corporation Benzoquinone derivative E3330 in combination with chemotherapeutic agents for the treatment of bladder cancer
GB2476644B (en) 2009-12-23 2012-11-14 Haomamedica Ltd 1,4-Dihydro-1,4-dioxonaphtalene derivatives for the treatment of osteoporosis
US20140128398A1 (en) 2011-06-03 2014-05-08 Indiana University Research And Technology Corporation Compounds, compositions and methods for treating oxidative dna damage disorders
CN108341775B (zh) * 2017-01-25 2021-03-16 重庆常捷医药有限公司 一种瑞巴派特中间体的合成方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4229478A (en) * 1978-06-05 1980-10-21 Syntex (U.S.A.) Inc. Naphthaquinone anti-psoriatic agents
US4569943A (en) * 1982-10-20 1986-02-11 Takeda Chemical Industries, Ltd. Physiologically active substance P-23924, its production and use
US4628062A (en) * 1983-12-31 1986-12-09 Troponwerke Gmbh & Co., Kg 1,4-naphthoquinone derivatives having anti-inflammatory action

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2553647A (en) * 1946-03-20 1951-05-22 Research Corp Naphthoquinone antimalarials
US2572946A (en) * 1949-11-19 1951-10-30 Du Pont Composition comprising 2-aliphatic-3-hydroxy-1, 4 napthoquinone and method for controlling mites and aphids
JPS5010574B1 (https=) * 1970-07-30 1975-04-22
US3914264A (en) * 1975-01-30 1975-10-21 American Cyanamid Co 2-Lower alkoxy-3-(lower alkylthio)-1,4-naphthoquinone
US4053634A (en) * 1975-09-15 1977-10-11 E. I. Du Pont De Nemours And Company Miticidal and aphicidal method utilizing 2-higher alkyl-3-hydroxy-1,4-naphthoquinone carboxylic acid esters
JPS5829764B2 (ja) * 1976-02-10 1983-06-24 雄一 山村 免疫調整用水性剤
JPS60130515A (ja) * 1983-12-15 1985-07-12 Shiratori Seiyaku Kk 血中２，３−ジホスホグリセリン酸上昇剤
DE3431236A1 (de) * 1984-08-24 1986-02-27 Carnivora-Deutschland GmbH, 7109 Jagsthausen Verwendung von 1,4-naphthochinon-derivaten in niedrigen konzentrationen zur immunstimulation
DE3801743A1 (de) * 1987-07-03 1989-01-19 Bayer Ag Schaedlingsbekaempfungsmittel auf basis von substituierten 1,4-naphthochinonen und neue substituierte 1,4-naphthochinone

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4229478A (en) * 1978-06-05 1980-10-21 Syntex (U.S.A.) Inc. Naphthaquinone anti-psoriatic agents
US4569943A (en) * 1982-10-20 1986-02-11 Takeda Chemical Industries, Ltd. Physiologically active substance P-23924, its production and use
US4628062A (en) * 1983-12-31 1986-12-09 Troponwerke Gmbh & Co., Kg 1,4-naphthoquinone derivatives having anti-inflammatory action

Also Published As

Publication number Publication date
EP1015422A4 (en) 2004-12-08
AU9020198A (en) 1999-03-08
EP1015422A1 (en) 2000-07-05
WO1999009005A1 (en) 1999-02-25
JP2001515063A (ja) 2001-09-18
CA2300876A1 (en) 1999-02-25
CA2300876C (en) 2008-10-28
US5849793A (en) 1998-12-15

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Legal Events

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE INVENTORS TO INCLUDE DAVID CALLAWAY AND PETER ULRICH

FGA Letters patent sealed or granted (standard patent)