JP2001513754A - Ｔｎｆ媒介疾患を処置するためのｔｎｆ結合タンパク質を使用する組み合わせ治療 - Google Patents
Ｔｎｆ媒介疾患を処置するためのｔｎｆ結合タンパク質を使用する組み合わせ治療Info
- Publication number
- JP2001513754A JP2001513754A JP52589398A JP52589398A JP2001513754A JP 2001513754 A JP2001513754 A JP 2001513754A JP 52589398 A JP52589398 A JP 52589398A JP 52589398 A JP52589398 A JP 52589398A JP 2001513754 A JP2001513754 A JP 2001513754A
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- Prior art keywords
- stnfr
- tnf
- methotrexate
- tnfbp
- treatment
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- Ceased
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3258796P | 1996-12-06 | 1996-12-06 | |
| US60/032,587 | 1996-12-06 | ||
| US3635597P | 1997-01-23 | 1997-01-23 | |
| US60/036,355 | 1997-01-23 | ||
| US3931597P | 1997-02-07 | 1997-02-07 | |
| US60/039,315 | 1997-02-07 | ||
| US5202397P | 1997-07-09 | 1997-07-09 | |
| US60/052,023 | 1997-07-09 | ||
| PCT/US1997/022733 WO1998024463A2 (en) | 1996-12-06 | 1997-12-08 | Combination therapy using a tnf binding protein for treating tnf-mediated diseases |
Publications (2)
| Publication Number | Publication Date |
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| JP2001513754A true JP2001513754A (ja) | 2001-09-04 |
| JP2001513754A5 JP2001513754A5 (enExample) | 2005-08-11 |
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| Country | Link |
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| EP (1) | EP0942740B1 (enExample) |
| JP (1) | JP2001513754A (enExample) |
| AT (1) | ATE247974T1 (enExample) |
| AU (1) | AU5696198A (enExample) |
| CA (1) | CA2273850A1 (enExample) |
| DE (1) | DE69724451T2 (enExample) |
| DK (1) | DK0942740T3 (enExample) |
| ES (1) | ES2207759T3 (enExample) |
| PT (1) | PT942740E (enExample) |
| WO (1) | WO1998024463A2 (enExample) |
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| JPH10510540A (ja) | 1994-12-12 | 1998-10-13 | オメロス メディカル システムズ，インコーポレーテッド | 灌注用溶液並びに疼痛、炎症及びけいれんの抑制法 |
| US20020028798A1 (en) * | 1995-12-12 | 2002-03-07 | Omeros Medical Systems | Irrigation solution and method for inhibition of pain and inflammation |
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| US8119127B2 (en) * | 1999-02-24 | 2012-02-21 | Tact Ip, Llc | Cytokine antagonists for neurological and neuropsychiatric disorders |
| US6982089B2 (en) * | 1999-02-24 | 2006-01-03 | Tact Ip, Llc | Cytokine antagonists for neurological and neuropsychiatric disorders |
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| CA2366785C (en) * | 1999-04-19 | 2012-02-07 | Immunex Corporation | Soluble tumor necrosis factor receptor treatment of medical disorders |
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| EP1200127B1 (en) * | 1999-07-21 | 2008-06-25 | Omeros Corporation | Solutions and methods for inhibition of pain, inflammation and cartilage degradation |
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| US7244823B2 (en) * | 2000-03-02 | 2007-07-17 | Xencor | TNF-alpha variants proteins for the treatment of TNF-alpha related disorders |
| CN100494182C (zh) | 2000-05-12 | 2009-06-03 | 基酶有限公司 | 肿瘤坏死α因子信号的调节因子 |
| MXPA02012879A (es) * | 2000-06-20 | 2004-07-30 | Herbst Arthur L | Inhibidores de ciclooxigenasa-2 y la prevencion de los efectos secundarios de terapia por radiacion. |
| US20060018907A1 (en) * | 2000-08-07 | 2006-01-26 | Centocor, Inc. | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| WO2002017853A2 (en) * | 2000-08-31 | 2002-03-07 | Genzyme Biosurgery Corporation | Hyaluronan-based antiadhesion compositions, their preparation and use |
| US7087224B2 (en) * | 2000-10-31 | 2006-08-08 | Amgen Inc. | Method of treating anemia by administering IL-1ra |
| PL222211B1 (pl) | 2001-06-26 | 2016-07-29 | Amgen Fremont Inc | Przeciwciało przeciwko OPGL, kompozycja je zawierająca, jego zastosowanie i sposób jego wytwarzania, sposób wykrywania poziomu OPGL, kompozycja obejmująca polinukleotydy i komórka gosodarza |
| DE10132308A1 (de) * | 2001-07-06 | 2003-01-30 | Aventis Behring Gmbh | Kombinationspräparat zur Therapie von immunologischen Erkrankungen |
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| JP4928079B2 (ja) * | 2002-11-21 | 2012-05-09 | ジェンザイム・コーポレーション | 慢性組織移植片拒絶を阻害するためのジアミド誘導体の使用 |
| PT1562571E (pt) * | 2002-11-21 | 2011-11-25 | Genzyme Corp | Combinação de derivados de diamina e agentes imunossupressores para a indução da tolerância imunológica |
| RS51041B (sr) * | 2003-02-28 | 2010-10-31 | Ares Trading S.A. | Tečne formulacije tbp-1 proteina koji vezuju faktor tumorske nekroze |
| US20080025986A1 (en) * | 2003-06-06 | 2008-01-31 | Ozes Osman N | Methods of Treating Tnf-Mediated Disorders |
| CN1968700A (zh) * | 2004-04-15 | 2007-05-23 | 阿尔克姆斯有限公司 | 聚合物基的持续释放装置 |
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| US8236306B2 (en) * | 2004-12-18 | 2012-08-07 | Edward Lewis Tobinick | Methods to facilitate transmission of large molecules across the blood-brain, blood-eye, and blood-nerve barriers |
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| CA2782320A1 (en) * | 2009-12-02 | 2011-06-09 | Acceleron Pharma Inc. | Compositions and methods for increasing serum half-life of fc fusion proteins |
| WO2012170938A1 (en) | 2011-06-08 | 2012-12-13 | Acceleron Pharma Inc. | Compositions and methods for increasing serum half-life |
| CN103965357B (zh) | 2013-12-31 | 2016-08-17 | 嘉和生物药业有限公司 | 一种抗人rankl抗体 |
| EP3085709B1 (en) | 2014-12-28 | 2019-08-21 | Genor Biopharma Co., Ltd | Humanized anti-human rankl antibody, pharmaceutical composition and use thereof |
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| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| IN150740B (enExample) | 1978-11-24 | 1982-12-04 | Hoffmann La Roche | |
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| IL98078A0 (en) | 1991-05-07 | 1992-06-21 | Yeda Res & Dev | Pharmaceutical compositions comprising an anticytokyne |
| IL90339A (en) | 1989-05-18 | 1996-10-16 | Yeda Res & Dev | Anti-cytotoxic protein and its purification |
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| EP1132471A3 (de) | 1989-09-12 | 2001-11-28 | F. Hoffmann-La Roche Ag | TNF-bindende Proteine |
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| US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
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| CA2106079C (en) | 1991-03-15 | 2000-04-25 | Robert C. Thompson | Pegylation of polypeptides |
| DE69213240T2 (de) | 1991-07-04 | 1997-04-24 | Immunodex K/S, Glostrup | Wasserlösliche reagenzien und konjugate auf polymerbasis, die vom divinylsulfon abgeleitete reste enthalten |
| IL99120A0 (en) | 1991-08-07 | 1992-07-15 | Yeda Res & Dev | Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them |
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-
1997
- 1997-12-08 DK DK97953156T patent/DK0942740T3/da active
- 1997-12-08 WO PCT/US1997/022733 patent/WO1998024463A2/en not_active Ceased
- 1997-12-08 AT AT97953156T patent/ATE247974T1/de active
- 1997-12-08 AU AU56961/98A patent/AU5696198A/en not_active Abandoned
- 1997-12-08 JP JP52589398A patent/JP2001513754A/ja not_active Ceased
- 1997-12-08 PT PT97953156T patent/PT942740E/pt unknown
- 1997-12-08 ES ES97953156T patent/ES2207759T3/es not_active Expired - Lifetime
- 1997-12-08 DE DE69724451T patent/DE69724451T2/de not_active Expired - Lifetime
- 1997-12-08 EP EP97953156A patent/EP0942740B1/en not_active Expired - Lifetime
- 1997-12-08 CA CA002273850A patent/CA2273850A1/en not_active Abandoned
-
1999
- 1999-06-04 US US09/326,394 patent/US6306820B1/en not_active Expired - Fee Related
-
2001
- 2001-07-17 US US09/907,263 patent/US20020119924A1/en not_active Abandoned
-
2003
- 2003-07-16 US US10/622,383 patent/US20040048799A1/en not_active Abandoned
- 2003-07-16 US US10/621,783 patent/US20040047863A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0942740B1 (en) | 2003-08-27 |
| CA2273850A1 (en) | 1998-06-11 |
| WO1998024463A2 (en) | 1998-06-11 |
| DE69724451T2 (de) | 2004-03-18 |
| AU5696198A (en) | 1998-06-29 |
| ES2207759T3 (es) | 2004-06-01 |
| ATE247974T1 (de) | 2003-09-15 |
| DK0942740T3 (da) | 2003-12-15 |
| US20040048799A1 (en) | 2004-03-11 |
| US20020119924A1 (en) | 2002-08-29 |
| EP0942740A2 (en) | 1999-09-22 |
| HK1022440A1 (en) | 2000-08-11 |
| US6306820B1 (en) | 2001-10-23 |
| PT942740E (pt) | 2004-01-30 |
| US20040047863A1 (en) | 2004-03-11 |
| WO1998024463A3 (en) | 1998-07-16 |
| DE69724451D1 (de) | 2003-10-02 |
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