JP2001512107A - 融合ヘテロ環式化合物及びそのキヌレニン−３−ヒドロキシラーゼ阻害剤としての使用 - Google Patents

融合ヘテロ環式化合物及びそのキヌレニン−３−ヒドロキシラーゼ阻害剤としての使用

Info

Publication number
JP2001512107A
JP2001512107A JP2000505134A JP2000505134A JP2001512107A JP 2001512107 A JP2001512107 A JP 2001512107A JP 2000505134 A JP2000505134 A JP 2000505134A JP 2000505134 A JP2000505134 A JP 2000505134A JP 2001512107 A JP2001512107 A JP 2001512107A
Authority
JP
Japan
Prior art keywords
oxo
cyano
propanamide
methyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000505134A
Other languages
English (en)
Japanese (ja)
Inventor
ペバレツロ，パオロ
バラジ，マリオ
エイデンペルゲル，フランコ
グレコ，フエリチタ
スペチヤーレ，カーメラ
Original Assignee
フアルマシア・エ・アツプジヨン・エツセ・ピー・アー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by フアルマシア・エ・アツプジヨン・エツセ・ピー・アー filed Critical フアルマシア・エ・アツプジヨン・エツセ・ピー・アー
Publication of JP2001512107A publication Critical patent/JP2001512107A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2000505134A 1997-07-30 1998-07-02 融合ヘテロ環式化合物及びそのキヌレニン−３−ヒドロキシラーゼ阻害剤としての使用 Pending JP2001512107A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9716101.2A GB9716101D0 (en) 1997-07-30 1997-07-30 Fused heterocyclic compounds
GB9716101.2 1997-07-30
PCT/EP1998/004218 WO1999006375A1 (fr) 1997-07-30 1998-07-02 Composes heterocycliques fondus et utilisation de ces composes comme inhibiteurs de la kynurenine-3-hydroxylase

Publications (1)

Publication Number Publication Date
JP2001512107A true JP2001512107A (ja) 2001-08-21

Family

ID=10816708

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000505134A Pending JP2001512107A (ja) 1997-07-30 1998-07-02 融合ヘテロ環式化合物及びそのキヌレニン−３−ヒドロキシラーゼ阻害剤としての使用

Country Status (6)

Country Link
EP (1) EP1001941A1 (fr)
JP (1) JP2001512107A (fr)
AU (1) AU8731798A (fr)
CA (1) CA2296606A1 (fr)
GB (1) GB9716101D0 (fr)
WO (1) WO1999006375A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007500700A (ja) * 2003-07-29 2007-01-18 スミスクライン ビーチャム コーポレーション 化合物

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102458990B1 (ko) 2014-04-23 2022-10-25 미쓰비시 타나베 파마 코퍼레이션 신규한 바이시클릭 또는 트리시클릭 헤테로시클릭 화합물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143923B1 (en) * 1991-04-29 1993-11-02 Hoechst-Roussel Pharmaceuticals Incorporated Benzoisothiazole-and benzisoxazole-3-carboxamides
GB9521486D0 (en) * 1995-10-20 1995-12-20 Pharmacia Spa Fluoro-substituted benzoylpropionic acid derivatives
GB9522617D0 (en) * 1995-11-03 1996-01-03 Pharmacia Spa 4-Phenyl-4-oxo-butenoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007500700A (ja) * 2003-07-29 2007-01-18 スミスクライン ビーチャム コーポレーション 化合物

Also Published As

Publication number Publication date
EP1001941A1 (fr) 2000-05-24
CA2296606A1 (fr) 1999-02-11
GB9716101D0 (en) 1997-10-01
WO1999006375A1 (fr) 1999-02-11
AU8731798A (en) 1999-02-22

Similar Documents

Publication Publication Date Title
US4943587A (en) Hydroxamate derivatives of selected nonsteroidal antiinflammatory acyl residues and their use for cyclooxygenase and 5-lipoxygenase inhibition
JP4357004B2 (ja) ピラゾール誘導体およびそれを含有するｃｏｘ阻害剤
IL101663A (en) Phenyl pyrazolidinones
EP0934290B1 (fr) Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
JP2002509536A (ja) ２−（４−ブロモ又は４−ヨードフェニルアミノ）安息香酸誘導体及びｍｅｋ阻害物質としてのそれらの使用
WO2000046209A1 (fr) Derives d'acide pyrazolecarboxylique, leur preparation, les compositions pharmaceutiques en contenant
NO330011B1 (no) Acylerte heteroarylkondenserte sykloalkenylaminer og deres anvendelse for fremstilling av farmasoytiske midler,samt farmasoytisk preparat inneholdende minst en slik forbindelse
EP0833822A1 (fr) Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
FR2701708A1 (fr) Dérivés de 2-amido-4-phénylthiazoles polysubstitués, procédé de préparation, composition pharmaceutique et utilisation de ces dérivés pour la préparation d'un médicament.
JP2006510728A (ja) 糖尿病の処置に有用なアニリノピラゾール誘導体
US8129372B2 (en) Compounds having NPY Y5 receptor antagonistic activity
RU2109735C1 (ru) Оксопропаннитрильные производные конденсированного пиразола или их фармацевтически приемлемые соли, проявляющие иммуностимулирующую активность, и фармацевтическая композиция
US5534530A (en) 5-acylamino-1,2,4-thiadiazoles, their preparation and pharmaceutical compositions containing them
CA2365419A1 (fr) Nouveaux derives de thiazolobenzimidazole
JP2002531501A (ja) Ｇｌｐ−１受容体の非ペプチド拮抗薬及び使用方法
JP2007523873A (ja) 新規化合物
KR100248643B1 (ko) 아릴 및 헤테로아릴 알콕시나프탈렌 유도체
JP2001524546A (ja) ベンゼンスルンアミド組成物
JP2001512107A (ja) 融合ヘテロ環式化合物及びそのキヌレニン−３−ヒドロキシラーゼ阻害剤としての使用
JP2005533857A (ja) 新規アリールイミダゾール誘導体、その製造方法及びその医薬用途
US6133302A (en) 5-(3-Phenyl-3-oxo-propyl)-1H-tetrazole derivatives
JP2001524547A (ja) Ｋｙｎ−ｏｈ阻害剤としての１，３，４−チアジアゾール誘導体
JPH06128227A (ja) ロイコトリエン拮抗薬としてのインドールカルバミン酸類
JP2001518473A (ja) 縮合ベンゾチオピラン化合物
JP2001524551A (ja) チオフェン−スルホンアミド組成物