JP2001507243A - 強化された多孔性脊椎インプラント - Google Patents
強化された多孔性脊椎インプラントInfo
- Publication number
- JP2001507243A JP2001507243A JP50085297A JP50085297A JP2001507243A JP 2001507243 A JP2001507243 A JP 2001507243A JP 50085297 A JP50085297 A JP 50085297A JP 50085297 A JP50085297 A JP 50085297A JP 2001507243 A JP2001507243 A JP 2001507243A
- Authority
- JP
- Japan
- Prior art keywords
- implant
- spinal implant
- ceramic
- sleeve
- spinal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
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- A61F2/4465—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages having a circular or kidney shaped cross-section substantially perpendicular to the axis of the spine
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
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- A—HUMAN NECESSITIES
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- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00035—Other metals or alloys
- A61F2310/00125—Hafnium or Hf-based alloys
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
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- A61F2310/00005—The prosthesis being constructed from a particular material
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- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
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- A—HUMAN NECESSITIES
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- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.椎間の係合用の脊椎インプラントであって、 対向する2面と該2面の間に配設された外表面とを有する本体と、ここで、前 記本体は、前記本体を貫いて内方への成長を可能とする多孔質生体適合性材料を 含み、前記本体は、2個の椎間の係合用の寸法及び形状を有し、 上記本体の上記外表面の周りに配設され、かつ、圧縮加重下にて上記多孔質生 体適合性材料よりも相対的に強度のある第2の材料を含むスリーブと、 を備えることを特徴とする脊椎インプラント。 2.請求項1の脊椎インプラントであって、前記スリーブは、骨の内方への成長 のために、前記本体の前記外表面と連通するように貫通する複数の孔を画定する ことを特徴とする脊椎インプラント。 3.請求項2の脊椎インプラントであって、前記孔は、ほぼ円形であることを特 徴とする脊椎インプラント。 4.請求項2の脊椎インプラントであって、前記孔は、ほぼ長円形であることを 特徴とする脊椎インプラント。 5.請求項2の脊椎インプラントであって、前記孔は、ほぼ菱形であることを特 徴とする脊椎インプラント。 6.請求項2の脊椎インプラントであって、前記孔は、ほぼ矩形であることを特 徴とする脊椎インプラント。 7.請求項1の脊椎インプラントであって、 前記スリーブは、前記本体の前記外表面と接触する内表面を含み、上記スリー ブの内表面はチャンバを画定し、 前記スリーブは、温度応答性材料から形成されており、上記チャンバは、前記 スリーブが加熱された状態にあるとき前記本体を前記チャンバ内に摺動可能に受 け入れるように、前記本体の外形よりもわずかに大きな第1の内径を有し、 前記チャンバは、前記スリーブが冷却状態にあるとき、前記本体を内側に挟持 するように、前記本体よりもわずかに小さな第2の内径を有する ことを特徴とする脊椎インプラント。 8.請求項1の脊椎インプラントであって、前記スリーブは、前記インプラント が椎間に埋め込まれた場合に、対応する椎の終板と前記対向する2面とが接触可 能となるように、前記外表面の高さよりも低い高さを有することを特徴とする脊 椎インプラント。 9.請求項1の脊椎インプラントであって、前記スリーブは、 下端及び対向する上端と、 前記インプラントを前記椎体に係合させるための前記スリーブの上記下端及び 上端のそれぞれに配設された硬い歯と、 を含むことを特徴とする脊椎インプラント。 10.請求項1の脊椎インプラントであって、 前記スリーブは、下端と対向する上端とを含み、 上記スリーブの下端及び上端のそれぞれは、前記インプラントを前記椎体に係 合させるための凹凸表面を含む ことを特徴とする脊椎インプラント。 11.請求項1の脊椎インプラントであって、前記本体は円筒状で、前記スリー ブは中空円筒状であることを特徴とする脊椎インプラント。 12.請求項1の脊椎インプラントであって、前記本体の前記対向する2面は、 椎の終板の形態に対応する寸法及び形状を有することを特徴とする脊椎インプラ ント。 13.請求項1の脊椎インプラントであって、前記スリーブは、椎の終板の形状 に適合する外形を有することを特徴とする脊椎インプラント。 14.請求項1の脊椎インプラントであって、前記スリーブは、金属材料からな ることを特徴とする脊椎インプラント。 15.請求項14の脊椎インプラントであって、前記金属材料は、タンタル、ニ オブ、ハフニウム、タングステン及びこれらの合金からなる群より選ばれた金属 を含むことを特徴とする脊椎インプラント。 16.請求項15の脊椎インプラントであって、前記金属材料は、タンタル発泡 体であることを特徴とする脊椎インプラント。 17.請求項14の脊椎インプラントであって、前記スリーブは、チタン、チタ ン−バナジウム−アルミニウム合金、コバルト−クロム合金、コバルト−クロム −モリブデン合金、コバルト−ニッケル−クロム−モリブデン合金及び生体適合 性ステンレススチールからなる群より選ばれた金属材料を含むことを特徴とする 脊椎インプラント。 18.請求項17の脊椎インプラントであって、前記生体適合性ステンレススチ ールは、316LVMステンレススチールであることを特徴とする脊椎インプラ ント。 19.請求項17の脊椎インプラントであって、前記金属スリーブは、チタンを 含むことを特徴とする脊椎インプラント。 20.請求項1の脊椎インプラントであって、前記生体適合性材料は、セラミッ ク材料であることを特徴とする脊椎インプラント。 21.請求項20の脊椎インプラントであって、前記セラミックは、生体に作用 する骨伝導性(生体活性骨伝導性)セラミックであることを特徴とする脊椎イン プラント。 22.請求項20の脊椎インプラントであって、前記生体適合性材料は、コラー ゲン−セラミック複合材料であることを特徴とする脊椎インプラント。 23.請求項20の脊椎インプラントであって、前記生体適合性材料は、セラミ ック−成長因子複合材料であることを特徴とする脊椎インプラント。 24.請求項23の脊椎インプラントであって、前記生体適合性材料は、セラミ ック−骨形態形成プロテイン複合材料であることを特徴とする脊椎インプラント 。 25.請求項20の脊椎インプラントであって、前記セラミックはリン酸カルシ ウムセラミックであることを特徴とする脊椎インプラント。 26.請求項20の脊椎インプラントであって、前記生体適合性材料は、二相性 セラミックであることを特徴とする脊椎インプラント。 27.請求項20の脊椎インプラントであって、前記セラミック材料は、ヒドロ キシアパタイト、リン酸三カルシウム、リン酸四カルシウム、αリン酸カルシウ ム、βリン酸カルシウム及びこれらの混合物からなる群より選ばれることを特徴 とする脊椎インプラント。 28.請求項27の脊椎インプラントであって、前記セラミックは、二相性リン 酸カルシウムセラミックであることを特徴とする脊椎インプラント。 29.請求項28の脊椎インプラントであって、前記セラミックは、ヒドロキシ アパタイト/リン酸三カルシウムセラミックであることを特徴とする脊椎インプ ラント。 30.請求項29の脊椎インプラントであって、前記セラミックは、約90重量 %以下のヒドロキシアパタイトを含むことを特徴とする脊椎インプラント。 31.請求項30の脊椎インプラントであって、前記セラミックは、約75重量 %以下のヒドロキシアパタイトを含むことを特徴とする脊椎インプラント。 32.請求項31の脊椎インプラントであって、前記セラミックは、約50重量 %のヒドロキシアパタイトを含むことを特徴とする脊椎インプラント。 33.請求項32の脊椎インプラントであって、前記セラミックは、約25重量 %以下のヒドロキシアパタイトを含むことを特徴とする脊椎インプラント。 34.請求項1の脊椎インプラントであって、前記生体適合性材料は、少なくと も約30%の間隙率を有することを特徴とする脊椎インプラント。 35.請求項34の脊椎インプラントであって、前記生体適合性材料は、少なく とも約50%の間隙率を有することを特徴とする脊椎インプラント。 36.請求項35の脊椎インプラントであって、前記生体適合性材料は、少なく とも約70%の間隙率を有することを特徴とする脊椎インプラント。 37.請求項32の脊椎インプラントであって、前記セラミックは、少なくとも 約40%の間隙率を有することを特徴とする脊椎インプラント。 38.請求項37の脊椎インプラントであって、前記セラミックは、少なくとも 約50%の間隙率を有することを特徴とする脊椎インプラント。 39.請求項20の脊椎インプラントであって、前記セラミックは、約200ミ クロン〜約700ミクロンの平均孔寸法を有することを特徴とする脊椎インプラ ント。 40.請求項20の脊椎インプラントであって、前記セラミックは、約300ミ クロン〜約600ミクロンの平均孔寸法を有することを特徴とする脊椎インプラ ント。 41.請求項38の脊椎インプラントであって、前記セラミックは、約400ミ クロンの平均孔寸法を有することを特徴とする脊椎インプラント。 42.請求項1の脊椎インプラントであって、前記インプラントは、少なくとも 7.1MPaのASTM C-773圧縮強度を有することを特徴とする脊椎インプラント。 43.請求項41の脊椎インプラントであって、前記インプラントは、少なくと も20MPaの圧縮強度を有することを特徴とする脊椎インプラント。 44.請求項43の脊椎インプラントであって、前記インプラントは、少なくと も40MPaの圧縮強度を有することを特徴とする脊椎インプラント。 45.椎体間固定装置であって、 外表面と、ヒトの板の空隙の高さに適合する高さとを有する本体と、ここで、 前記本体は、前記本体を貫いて内方への成長を可能とする多孔質生体適合性材料 を含み、 上記本体の外表面と係合し、圧縮加重下にて、上記生体適合性材料よりも相対 的に強度のある材料を含むスリーブと、 を備えることを特徴とする椎体間固定装置。 46.請求項45の椎体間固定装置であって、さらに、 前記スリーブを隣接する椎体の終板に取り付けるための取り付け手段を備える ことを特徴とする椎体間固定装置。 47.請求項46の椎体間固定装置であって、 前記スリーブは、下端及び上端を含み、 前記取り付け手段は、上記スリーブの上端及び下端に配設された歯を含む ことを特徴とする椎体間固定装置。 48.請求項46の椎体間固定装置であって、 前記スリーブは、下端及び上端を含み、 前記取り付け手段は、上記スリーブの上端及び下端上に画定された凹凸表面を 含む ことを特徴とする椎体間固定装置。 49.請求項45の椎体間固定装置であって、前記スリーブは、骨の内方への成 長を促進するため、前記本体の外表面と連通する複数の孔を画定することを特徴 とする椎体間固定装置。 50.請求項45のインプラントであって、前記スリーブは、金属材料からなる ことを特徴とするインプラント。 51.請求項50のインプラントであって、前記金属材料は、タンタル、ニオブ 、ハフニウム、タングステン及びこれらの合金からなる群より選ばれた金属を含 むことを特徴とするインプラント。 52.請求項51のインプラントであって、前記金属材料は、タンタル発泡体で あることを特徴とするインプラント。 53.請求項50の椎体間固定装置であって、前記金属材料は、チタンを含むこ とを特徴とする椎体間固定装置。 54.請求項45の椎体間固定装置であって、前記本体は、椎の終板の形状に符 合する腎臓形状の横断面を有することを特徴とする椎体間固定装置。 55.請求項45の椎体間固定装置であって、前記本体の高さは、ヒトの板の空 隙の高さよりもわずかに高いことを特徴とする椎体間固定装置。 56.請求項45の椎体間固定装置であって、前記本体は、本来の椎間板の髄核 の寸法及び形状に適合する形態であることを特徴とする椎体間固定装置。 57.請求項45のインプラントであって、前記生体適合性材料は、セラミック 材料であることを特徴とするインプラント。 58.請求項57のインプラントであって、前記生体適合性材料は、二相性リン 酸カルシウムセラミックであることを特徴とするインプラント。 59.請求項58のインプラントであって、前記生体適合性材料は、ヒドロキシ アパタイト/リン酸三カルシウムセラミックであることを特徴とするインプラン ト。 60.請求項57のインプラントであって、前記セラミックは、少なくとも約5 0%の間隙率を有することを特徴とするインプラント。 61.請求項60のインプラントであって、前記セラミックは、少なくとも約7 0%の間隙率を有することを特徴とするインプラント。 62.請求項57のインプラントであって、前記セラミックは、約200ミクロ ン〜約700ミクロンの平均孔寸法を有することを特徴とするインプラント。 63.請求項62のインプラントであって、前記セラミックは、約300ミクロ ン〜約600ミクロンの平均孔寸法を有することを特徴とするインプラント。 64.請求項63のインプラントであって、前記セラミックは、約400ミクロ ンの平均孔寸法を有することを特徴とするインプラント。 65.隣接する健康な椎体間に位置する欠陥のある脊椎要素の除去によって残さ れた空隙を修復するために用いる椎体代替装置であって、 外表面を有し、隣接する椎体間の空隙内に配置可能な形態であり、かつ、多孔 質生体適合性材料を含む本体と、 上記本体の外表面の周りに設けられており、かつ、圧縮加重下にて上記生体適 合性材料よりも相対的に強度のある材料からなるスリーブと、 を備えることを特徴とする椎体代替装置。 66.請求項65の椎体代替装置であって、さらに、 前記隣接する椎体の終板に前記金属スリーブを取り付けるための取り付け手段 を備えることを特徴とする椎体代替装置。 67.請求項65の椎体代替装置であって、 前記スリーブは、下端と上端とを含み、 前記取り付け手段は、前記金属スリーブの上端及び下端に配設された歯を含む ことを特徴とする椎体代替装置。 68.請求項65の椎体代替装置であって、 前記スリーブは、下端と上端とを含み、 前記取り付け手段は、上記スリーブの上端及び下端上に画定された凹凸表面を 含む ことを特徴とする椎体代替装置。 69.請求項64の椎体代替装置であって、前記スリーブは、骨の内方への成長 を促進するため、前記本体の外表面と連通する複数の孔を画定することを特徴と する椎体代替装置。 70.請求項65のインプラントであって、前記スリーブは、金属材料からなる ことを特徴とするインプラント。 71.請求項70のインプラントであって、前記金属材料は、タンタル、ニオブ 、ハウニウム、タングステン及びこれらの合金からなる群より選ばれた金属を含 む ことを特徴とするインプラント。 72.請求項71のインプラントであって、前記金属材料はタンタル発泡体であ ることを特徴とするインプラント。 73.請求項70の椎体代替装置であって、前記金属材料は、チタンを含むこと を特徴とする椎体代替装置。 74.請求項65の椎体代替装置であって、前記本体は、終板及び隣接する椎体 の輪によって画定された空隙内にしっかりと嵌合する寸法と形状とを有すること を特徴とする椎体代替装置。 75.請求項65の椎体代替装置であって、前記生体適合性材料は、セラミック 材料であることを特徴とする椎体代替装置。 76.請求項75の椎体代替装置であって、前記生体適合性材料は、二相性リン 酸カルシウムセラミックであることを特徴とする椎体代替蔵置。 77.請求項76の椎体代替装置であって、前記生体適合性材料は、ヒドロキシ アパタイト/リン酸三カルシウムセラミックであることを特徴とする椎体代替装 置。 78.請求項75のインプラントであって、前記セラミックは、少なくとも約5 0%の間隙率を有することを特徴とするインプラント。 79.請求項78のインプラントであって、前記セラミックは、少なくとも約7 0%の間隙率を有することを特徴とするインプラント。 80.請求項75のインプラントであって、前記セラミックは、約200ミクロ ン〜約700ミクロンの平均孔寸法を有することを特徴とするインプラント。 81.請求項80のインプラントであって、前記セラミックは、約300ミクロ ン〜約600ミクロンの平均孔寸法を有することを特徴とするインプラント。 82.請求項81のインプラントであって、前記セラミックは、約400ミクロ ンの平均孔寸法を有することを特徴とするインプラント。 83.請求項45のインプラントであって、前記本体は、椎間板の寸法及び形状 に適合する形態であることを特徴とするインプラント。
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US08/485,842 | 1995-06-07 | ||
US08/485,842 US5702449A (en) | 1995-06-07 | 1995-06-07 | Reinforced porous spinal implants |
PCT/US1996/008035 WO1996040014A1 (en) | 1995-06-07 | 1996-05-30 | Reinforced porous spinal implants |
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JP3839055B2 JP3839055B2 (ja) | 2006-11-01 |
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JP50085297A Expired - Fee Related JP3839055B2 (ja) | 1995-06-07 | 1996-05-30 | 強化された多孔性脊椎インプラント |
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US (1) | US5702449A (ja) |
EP (1) | EP0836454B1 (ja) |
JP (1) | JP3839055B2 (ja) |
AT (1) | ATE293409T1 (ja) |
AU (1) | AU5954096A (ja) |
DE (1) | DE69634634T2 (ja) |
ES (1) | ES2240996T3 (ja) |
TW (1) | TW358733B (ja) |
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Also Published As
Publication number | Publication date |
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ES2240996T3 (es) | 2005-10-16 |
EP0836454A1 (en) | 1998-04-22 |
TW358733B (en) | 1999-05-21 |
AU5954096A (en) | 1996-12-30 |
US5702449A (en) | 1997-12-30 |
ZA964855B (en) | 1997-01-07 |
ATE293409T1 (de) | 2005-05-15 |
WO1996040014A1 (en) | 1996-12-19 |
DE69634634T2 (de) | 2006-03-02 |
EP0836454A4 (en) | 2000-09-20 |
EP0836454B1 (en) | 2005-04-20 |
DE69634634D1 (de) | 2005-05-25 |
JP3839055B2 (ja) | 2006-11-01 |
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