JP4851513B2 - 脊椎インプラントに有用な荷重支持用の合成コラーゲン−ミネラル複合体およびその製造方法 - Google Patents
脊椎インプラントに有用な荷重支持用の合成コラーゲン−ミネラル複合体およびその製造方法 Download PDFInfo
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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Description
別の実施形態では、本発明は、椎骨間の脊椎インプラントを作製する方法を提供する。この方法は、再構成された原線維コラーゲンおよびミネラル粒子を含む組成物を成型して、望ましくはぬれ圧縮強度が少なくとも約200N/cm2である荷重支持複合材料を提供するステップを含む。この複合材料を整形して、隣接する第1椎骨と第2椎骨の間に導入するための本体が提供される。前記本体上には、第1椎骨および前記第2椎骨と摩擦係合するように構成された表面突起が形成される。有利な実施形態では、成型手順中にこの本体を整形し、かつ/または突起を形成する。さらに、成型操作中に、またはその他の方法で、貫通穴および/または器具係合開口または他のアダプタ部を本体に設けることができる。この成型操作は圧縮下で行うことができ、それによって、本発明の複合材料および得られるスペーサの強度および密度が高められる。
本発明の追加の実施形態ならびに特徴および利点は、本明細書の説明から明らかになるであろう。
本発明のインプラントにおける荷重支持体の側壁は、アーチ形、平面、またはこれらの組合せとし得る。本発明のある種の実施形態では、脊椎スペーサに少なくとも1つの湾曲した側壁部分を設ける。この湾曲した側壁部分は、隣接する椎体の湾曲にほぼ対応するように構成される。
Claims (14)
- 椎骨間の脊椎インプラントであって、
骨由来の粒子を含まない、生体適合性のある荷重支持複合体を備え、前記荷重支持複合体は、0.5mmから10mmの間の平均長を有する再構成された原線維コラーゲンを含み、前記荷重支持複合体は他の源からのコラーゲンを含まず、前記荷重支持複合体は、粒子状ミネラルを含み、前記粒子状ミネラルは湾曲した表面特徴を有する材料を形成し、前記荷重支持複合体は、ぬれ圧縮強度が少なくとも200N/cm2であり、隣接する椎骨間に移植されるように寸法設定され構成された本体を提供し、前記本体は、前記椎骨の一方に摩擦係合するように構成された上部表面と、前記椎骨の他方に摩擦係合するように構成された下部表面と、前記本体の少なくとも1つの開口とを含み、前記開口は骨形成材料を受けるように構成され、前記荷重支持複合体は圧縮されず、前記荷重支持複合体は少なくとも15:1のミネラルとコラーゲンの重量比を有し、また、少なくとも1g/cm 3 のかさ密度を有する、脊椎インプラント。 - 前記粒子状ミネラルは合成セラミックを含む、請求項1に記載の脊椎インプラント。
- 前記合成セラミックはリン酸三カルシウムを含む、請求項2に記載の脊椎インプラント。
- 前記合成セラミックは二相性リン酸カルシウムを含む、請求項3に記載の脊椎インプラント。
- 前記二相性リン酸カルシウムは、リン酸三カルシウムとヒドロキシアパタイトの重量比が50:50〜95:5である、請求項4に記載の脊椎インプラント。
- リン酸三カルシウムとヒドロキシアパタイトの前記比が80:20〜90:10である、請求項5に記載の脊椎インプラント。
- リン酸三カルシウムとヒドロキシアパタイトの前記比が85:15である、請求項6に記載の脊椎インプラント。
- 前記上部表面および下部表面は、隣接する椎骨と摩擦係合するように前記複合体に形成された突起を含む、請求項1に記載の脊椎インプラント。
- 前記突起は、歯、鋸歯、および/または溝を含む、請求項8に記載の脊椎インプラント。
- 前記複合体は、200N/cm2 〜2000N/cm2の圧縮強度を示す、請求項1に記載の脊椎インプラント。
- 前記複合体は強化フィラメントも含む、請求項1に記載の脊椎インプラント。
- 前記強化フィラメントはコラーゲン糸を含む、請求項11に記載の脊椎インプラント。
- 前記本体は、医用送達器具に取り付けられるように構成された少なくとも1つの開口を含む、請求項1に記載の脊椎インプラント。
- 前記複合体のかさ密度は少なくとも1g/cm3 から2g/cm 3 である、請求項1に記載の脊椎インプラント。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/118,082 | 2005-04-29 | ||
US11/118,082 US7857853B2 (en) | 2005-04-29 | 2005-04-29 | Synthetic loadbearing collagen-mineral composites useful for spinal implants, and methods of manufacture |
PCT/US2006/014812 WO2006118803A2 (en) | 2005-04-29 | 2006-04-19 | Synthetic loadbearing collagen-mineral composites for spinal implants |
Publications (2)
Publication Number | Publication Date |
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JP4851513B2 true JP4851513B2 (ja) | 2012-01-11 |
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US (2) | US7857853B2 (ja) |
EP (2) | EP1883377B1 (ja) |
JP (1) | JP4851513B2 (ja) |
CN (1) | CN101166486B (ja) |
AU (1) | AU2006242649B2 (ja) |
ES (1) | ES2456949T3 (ja) |
WO (1) | WO2006118803A2 (ja) |
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Also Published As
Publication number | Publication date |
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CN101166486B (zh) | 2010-10-06 |
WO2006118803A2 (en) | 2006-11-09 |
AU2006242649B2 (en) | 2011-08-04 |
US20060247772A1 (en) | 2006-11-02 |
US7857853B2 (en) | 2010-12-28 |
US8252055B2 (en) | 2012-08-28 |
US20100320647A1 (en) | 2010-12-23 |
CN101166486A (zh) | 2008-04-23 |
EP2272470A2 (en) | 2011-01-12 |
ES2456949T3 (es) | 2014-04-24 |
AU2006242649A1 (en) | 2006-11-09 |
JP2008539001A (ja) | 2008-11-13 |
EP2272470A3 (en) | 2011-01-26 |
EP1883377B1 (en) | 2014-03-12 |
EP1883377A2 (en) | 2008-02-06 |
WO2006118803A3 (en) | 2007-07-26 |
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