JP2001505872A - α―ヒドロキシ酸リンカーを含むペプチドプロドラッグ - Google Patents
α―ヒドロキシ酸リンカーを含むペプチドプロドラッグInfo
- Publication number
- JP2001505872A JP2001505872A JP51316798A JP51316798A JP2001505872A JP 2001505872 A JP2001505872 A JP 2001505872A JP 51316798 A JP51316798 A JP 51316798A JP 51316798 A JP51316798 A JP 51316798A JP 2001505872 A JP2001505872 A JP 2001505872A
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- alkyl
- amino
- prodrug
- bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK0972/96 | 1996-09-09 | ||
DK97296 | 1996-09-09 | ||
PCT/DK1997/000376 WO1998011126A1 (fr) | 1996-09-09 | 1997-09-09 | Promedicaments peptidiques contenant une sequence de liaison alpha-hydroxyacide |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2001505872A true JP2001505872A (ja) | 2001-05-08 |
Family
ID=8099572
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51316798A Pending JP2001505872A (ja) | 1996-09-09 | 1997-09-09 | α―ヒドロキシ酸リンカーを含むペプチドプロドラッグ |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0932614A1 (fr) |
JP (1) | JP2001505872A (fr) |
KR (1) | KR20000036015A (fr) |
AU (1) | AU724326B2 (fr) |
CA (1) | CA2265454A1 (fr) |
IL (1) | IL128828A0 (fr) |
NZ (1) | NZ334595A (fr) |
WO (1) | WO1998011126A1 (fr) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014084110A1 (fr) * | 2012-11-30 | 2014-06-05 | 株式会社糖鎖工学研究所 | Lieur à chaîne glucidique liée, composé contenant un lieur à chaîne glucidique liée et substance physiologiquement active ou son sel, et son procédé de production |
JP2016519134A (ja) * | 2013-05-07 | 2016-06-30 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | 腎薬物標的化のためのペプチドおよびペプチド−活性成分の接合体 |
JP2016523825A (ja) * | 2013-05-07 | 2016-08-12 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | 腎毒性活性物質からの保護のための接合体 |
JP2021503481A (ja) * | 2017-11-17 | 2021-02-12 | サイトジェル ファーマ リミテッド ライアビリティ カンパニー | μオピオイド受容体のポリマーアゴニスト |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6278298A (en) * | 1997-02-14 | 1998-09-08 | Salk Institute For Biological Studies, The | Methods and compositions for delivery of therapeutic agents to bone tissue employing conjugates of negatively charged peptide oligomers with therapeutic agents |
IL138214A0 (en) * | 1998-03-09 | 2001-10-31 | Zealand Pharmaceuticals As | Pharmacolgically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis |
US6528486B1 (en) | 1999-07-12 | 2003-03-04 | Zealand Pharma A/S | Peptide agonists of GLP-1 activity |
EP1076066A1 (fr) * | 1999-07-12 | 2001-02-14 | Zealand Pharmaceuticals A/S | Peptides abaissant le taux de glucose sanguin |
US7671029B2 (en) | 1999-08-06 | 2010-03-02 | Immupharma Sa | Compositions and methods for enhanced pharmacological activity of compositions comprising peptide drug substances |
US6908900B2 (en) | 2001-01-17 | 2005-06-21 | Zimmer & Associates Ag | Compositions and methods for enhanced pharmacological activity through oral and parenteral administration of compositions comprising polypeptide drug substances and other poorly absorbed active ingredients |
CA2389233A1 (fr) * | 1999-10-29 | 2001-05-10 | Paul K. S. Nam | Oligomeres et segments oligomeres d'acides .alpha.-hydroxycarboxyliques et d'acides .alpha.-amines |
US6939693B2 (en) | 1999-10-29 | 2005-09-06 | Novus International, Inc. | Enantioselective oligomerization of α-hydroxy carboxylic acids and α-amino acids |
DE10018617A1 (de) * | 2000-01-13 | 2001-10-31 | Joerg G Moser | Cyclodextrin-Dimere mit Peptid-Spacerstrukturen zur Entgiftung von pharmazeutischen Wirkstoffen hohen Nebenwirkungspotentials |
AU2001293995B2 (en) | 2000-10-09 | 2005-10-13 | Cytomx Therapeutics, Inc. | Therapeutic antibodies |
US6881829B2 (en) * | 2002-04-26 | 2005-04-19 | Chimeracom, L.L.C. | Chimeric hybrid analgesics |
AU2005337116A1 (en) | 2005-09-21 | 2007-04-12 | 7Tm Pharma A/S | Y4 selective receptor agonists for therapeutic interventions |
JP2009508886A (ja) | 2005-09-21 | 2009-03-05 | 7ティーエム ファーマ エイ/エス | 治療的介入のためのy2選択性レセプターアゴニスト |
ES2572952T3 (es) | 2005-11-07 | 2016-06-03 | Indiana University Research And Technology Corporation | Análogos de glucagón que muestran solubilidad y estabilidad fisiológicas |
ES2628063T3 (es) | 2007-01-05 | 2017-08-01 | Indiana University Research And Technology Corporation | Análogos de glucagón que muestran una mayor solubilidad en tampones de pH fisiológicos |
KR20090119876A (ko) | 2007-02-15 | 2009-11-20 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 | 글루카곤/glp-1 수용체 공동-항진물질 |
EP3492488A1 (fr) | 2007-08-22 | 2019-06-05 | The Regents of The University of California | Polypeptides de liaison activables et procédés d'identification et utilisation de ceux-ci |
WO2009058662A2 (fr) | 2007-10-30 | 2009-05-07 | Indiana University Research And Technology Corporation | Antagonistes du glucagon |
ES2558155T3 (es) | 2007-10-30 | 2016-02-02 | Indiana University Research And Technology Corporation | Compuestos que muestran actividad antagonista de glucacón y agonista de GLP-1 |
JP2011511778A (ja) | 2008-01-30 | 2011-04-14 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション | エステルに基づいたペプチドプロドラッグ |
KR20110040760A (ko) | 2008-06-17 | 2011-04-20 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 | 대사 질환 및 비만 치료용 gip-기초된 혼합형 항진제 |
CN103641907A (zh) | 2008-06-17 | 2014-03-19 | 印第安纳大学研究及科技有限公司 | 胰高血糖素/glp-1受体共激动剂 |
CN104447980A (zh) | 2008-06-17 | 2015-03-25 | 印第安纳大学研究及科技有限公司 | 在生理pH缓冲液中具有增强的溶解性和稳定性的胰高血糖素类似物 |
JP5635532B2 (ja) | 2008-12-15 | 2014-12-03 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン類似体 |
CA2747155A1 (fr) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Analogues du glucagon |
WO2010070251A1 (fr) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Analogues du glucagon |
BRPI0823376A2 (pt) | 2008-12-15 | 2015-06-16 | Zealand Pharma As | Análagos de glucagon |
EP2376521B1 (fr) | 2008-12-19 | 2016-04-13 | Indiana University Research and Technology Corporation | Promédicaments insuliniques à base d'amide |
EP2376097A4 (fr) * | 2008-12-19 | 2012-10-03 | Univ Indiana Res & Tech Corp | Promédicaments peptidiques de la superfamille du glucagon à base d'amide |
EP2376520B1 (fr) | 2008-12-19 | 2014-02-12 | Indiana University Research&Technology Corporation | Analogues d'insuline |
CN102482347B (zh) | 2009-01-12 | 2017-04-26 | 希托马克斯医疗有限责任公司 | 修饰抗体组合物及其制备和使用方法 |
MX2011013625A (es) | 2009-06-16 | 2012-01-20 | Univ Indiana Res & Tech Corp | Compuestos glucagon activo de receptor de gip. |
AU2010272944B2 (en) | 2009-07-13 | 2015-11-19 | Zealand Pharma A/S | Acylated glucagon analogues |
US8703701B2 (en) | 2009-12-18 | 2014-04-22 | Indiana University Research And Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
BR112012018585A2 (pt) | 2010-01-27 | 2017-01-10 | Univ Indiana Res & Tech Corp | conjungados e composições de glucagon antagonista-gip agonista para o tratamento de distúrbios metabólicos e de obesidade |
CA2797133C (fr) | 2010-04-27 | 2019-08-06 | Zealand Pharma A/S | Conjugues peptidiques d'antagonistes du recepteur de glp-1 et de gastrine, et leur utilisation |
CA2797095A1 (fr) | 2010-05-13 | 2011-11-17 | Indiana University Research And Technology Corporation | Peptides de la superfamille des glucagons presentant une activite de recepteur nucleaire d'hormone |
BR112012028707A2 (pt) | 2010-05-13 | 2019-09-24 | Univ Indiana Res & Tech Corp | composto de glucagon da superfamília de peptídeos exibindo atividade do receptor g com proteína acoplada, pró farmaco, dímero ou multímro, composição farmacêutica que o compreendem e método de administração do mesmo. |
WO2011159895A2 (fr) | 2010-06-16 | 2011-12-22 | Indiana University Research And Technology Corporation | Agonistes de l'insuline à une seule chaîne très actifs au niveau du récepteur à l'insuline |
UY33462A (es) | 2010-06-23 | 2012-01-31 | Zealand Pharma As | Analogos de glucagon |
CA2803164C (fr) | 2010-06-24 | 2018-08-21 | Indiana University Research And Technology Corporation | Promedicaments insuliniques a base d'amide |
CA2802897A1 (fr) | 2010-06-24 | 2011-12-29 | Zealand Pharma A/S | Analogues de glucagon |
JP2013540102A (ja) | 2010-06-24 | 2013-10-31 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション | アミド結合を介して修飾されたグルカゴンスーパーファミリーのペプチドプロドラッグ |
JP6086067B2 (ja) | 2010-12-22 | 2017-03-01 | インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション | Gipレセプター活性を示すグルカゴンアナローグ |
PT2723367T (pt) | 2011-06-22 | 2017-08-11 | Univ Indiana Res & Tech Corp | Co-agonistas do recetor da glucagina/glp-1 |
AU2012273365A1 (en) | 2011-06-22 | 2014-01-16 | Indiana University Research And Technology Corporation | Glucagon/glp-1 receptor co-agonists |
EP3643306A3 (fr) * | 2011-08-12 | 2020-08-26 | Ascendis Pharma A/S | Promédicaments liés à un support dotés de liaisons ester carboxylique réversibles |
TW201326194A (zh) | 2011-11-03 | 2013-07-01 | Zealand Pharma As | Glp-1胃泌素受體促效劑肽結合物 |
RU2014117678A (ru) | 2011-11-17 | 2015-12-27 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Пептиды глюкагонового суперсемейства, обладающие глюкокортикоидной рецепторной активностью |
CN104114183A (zh) | 2011-12-20 | 2014-10-22 | 印第安纳大学研究及科技有限公司 | 用于治疗糖尿病的基于ctp的胰岛素类似物 |
SG11201406943XA (en) | 2012-04-27 | 2014-12-30 | Cytomx Therapeutics Inc | Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof |
TR201815338T4 (tr) | 2012-05-03 | 2018-11-21 | Zealand Pharma As | Gıp-glp-1 dual agonist bileşikleri ve yöntemler. |
CN104583232B (zh) | 2012-06-21 | 2018-04-13 | 印第安纳大学研究及科技有限公司 | 展现gip受体活性的胰高血糖素类似物 |
MY170671A (en) | 2012-07-23 | 2019-08-26 | Zealand Pharma As | Glucagon analogues |
TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
JP6387008B2 (ja) | 2012-09-26 | 2018-09-05 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation | インスリンアナローグダイマー |
RU2678134C2 (ru) | 2013-03-14 | 2019-01-23 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Конъюгаты инсулин-инкретин |
HUE034308T2 (en) | 2013-03-21 | 2018-02-28 | Sanofi Aventis Deutschland | Preparation of hydantoin-containing peptide products |
MX365465B (es) | 2013-03-21 | 2019-06-04 | Sanofi Aventis Deutschland | Sintesis de productos peptidicos que contienen imida ciclica. |
HUE039616T2 (hu) | 2013-10-17 | 2019-01-28 | Zealand Pharma As | Acilezett glükagon analógok |
US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
WO2015066279A2 (fr) | 2013-10-30 | 2015-05-07 | Cytomx Therapeutics, Inc. | Anticorps activables se liant au récepteur du facteur de croissance épidermique et méthodes d'utilisation de ceux-ci |
JP2017503474A (ja) | 2013-11-06 | 2017-02-02 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン−glp−1−gipトリプルアゴニスト化合物 |
US10093713B2 (en) | 2013-11-06 | 2018-10-09 | Zealand Pharma A/S | GIP-GLP-1 dual agonist compounds and methods |
WO2015089283A1 (fr) | 2013-12-11 | 2015-06-18 | Cytomx Therapeutics, Inc. | Anticorps qui se lient à des anticorps activables et leurs procédés d'utilisation |
ES2822994T3 (es) | 2014-09-24 | 2021-05-05 | Univ Indiana Res & Tech Corp | Conjugados de incretina-insulina |
WO2016049174A1 (fr) | 2014-09-24 | 2016-03-31 | Indiana University Research And Technology Corporation | Promédicaments insuliniques à base d'amide lipidique |
BR112017008659A2 (pt) | 2014-10-29 | 2018-01-30 | Zealand Pharma As | ?métodos e compostos de agonista de gip? |
US10336802B2 (en) | 2015-04-16 | 2019-07-02 | Zealand Pharma A/S | Acylated glucagon analogue |
JP6563614B1 (ja) | 2016-12-09 | 2019-08-21 | ジーランド・ファーマ・ア/エス | アシル化glp−1/glp−2二重アゴニスト |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5589356A (en) * | 1993-06-21 | 1996-12-31 | Vanderbilt University | Litigation of sidechain unprotected peptides via a masked glycoaldehyde ester and O,N-acyl rearrangement |
-
1997
- 1997-09-09 WO PCT/DK1997/000376 patent/WO1998011126A1/fr active Search and Examination
- 1997-09-09 JP JP51316798A patent/JP2001505872A/ja active Pending
- 1997-09-09 EP EP97939975A patent/EP0932614A1/fr not_active Withdrawn
- 1997-09-09 KR KR1019997001982A patent/KR20000036015A/ko not_active Application Discontinuation
- 1997-09-09 CA CA002265454A patent/CA2265454A1/fr not_active Abandoned
- 1997-09-09 IL IL12882897A patent/IL128828A0/xx unknown
- 1997-09-09 AU AU41994/97A patent/AU724326B2/en not_active Ceased
- 1997-09-09 NZ NZ334595A patent/NZ334595A/xx unknown
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014084110A1 (fr) * | 2012-11-30 | 2014-06-05 | 株式会社糖鎖工学研究所 | Lieur à chaîne glucidique liée, composé contenant un lieur à chaîne glucidique liée et substance physiologiquement active ou son sel, et son procédé de production |
US10202469B2 (en) | 2012-11-30 | 2019-02-12 | Glytech, Inc. | Sugar chain-attached linker, compound containing sugar chain-attached linker and physiologically active substance or salt thereof, and method for producing same |
JP2016519134A (ja) * | 2013-05-07 | 2016-06-30 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | 腎薬物標的化のためのペプチドおよびペプチド−活性成分の接合体 |
JP2016523825A (ja) * | 2013-05-07 | 2016-08-12 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | 腎毒性活性物質からの保護のための接合体 |
JP2021503481A (ja) * | 2017-11-17 | 2021-02-12 | サイトジェル ファーマ リミテッド ライアビリティ カンパニー | μオピオイド受容体のポリマーアゴニスト |
Also Published As
Publication number | Publication date |
---|---|
CA2265454A1 (fr) | 1998-03-19 |
WO1998011126A1 (fr) | 1998-03-19 |
AU724326B2 (en) | 2000-09-14 |
AU4199497A (en) | 1998-04-02 |
KR20000036015A (ko) | 2000-06-26 |
IL128828A0 (en) | 2000-01-31 |
EP0932614A1 (fr) | 1999-08-04 |
NZ334595A (en) | 2000-08-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2001505872A (ja) | α―ヒドロキシ酸リンカーを含むペプチドプロドラッグ | |
US7414107B2 (en) | Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis | |
AU741216B2 (en) | Phenethylamine derivatives | |
CA2618494A1 (fr) | Procede destine a la production de bivalirudine | |
CS204011B2 (en) | Process for preparing substituted pentapeptides | |
EP1179537B1 (fr) | Procede de synthese de peptides en phase solide | |
HU208324B (en) | Process for producing bradykinin-antagonist peptides and pharmaceutical compositions comprising same | |
JPH06508126A (ja) | ボンベシン類似体類 | |
JPS62116595A (ja) | 新規化合物、その製法及びそれを含む医薬組成物 | |
CA2267084C (fr) | Procede a une phase de resalage et de purification d'oligopeptides | |
HU182866B (en) | Process for preparing new tetrapeptide derivatives | |
JP2011507821A (ja) | ペプチド修飾の方法 | |
Escher et al. | Synthesis and biological activities of photoaffinity labeling analogs of substance P | |
JPH1160598A (ja) | オピオイド様ペプチド | |
MXPA99002149A (en) | Peptide prodrugs containing an alpha-hydroxyacid linker | |
WO1986003495A2 (fr) | Derives des substances p et de leurs fragments | |
JPS61103898A (ja) | 生物学的に活性なペンタペプチド類及びヘプタペプチド類 | |
CA1180006A (fr) | Pseudopeptides a action therapeutique, composes les contenant et methode de preparation et d'utilisation | |
CA2588590A1 (fr) | Conjugues peptidiques pharmacologiquement actifs ayant une tendance reduite a l'hydrolyse enzymatique | |
MXPA00008723A (en) | Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis | |
JPH05506250A (ja) | エンドテリン形成の阻害 | |
JPH07149793A (ja) | 新規ペプチド | |
JPH1160597A (ja) | 神経関連ペプチド |