JP2001504437A5 - - Google Patents

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Publication number
JP2001504437A5
JP2001504437A5 JP1997531172A JP53117297A JP2001504437A5 JP 2001504437 A5 JP2001504437 A5 JP 2001504437A5 JP 1997531172 A JP1997531172 A JP 1997531172A JP 53117297 A JP53117297 A JP 53117297A JP 2001504437 A5 JP2001504437 A5 JP 2001504437A5
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JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP1997531172A
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English (en)
Japanese (ja)
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JP4267697B2 (ja
JP2001504437A (ja
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Publication date
Priority claimed from US08/609,277 external-priority patent/US5663335A/en
Application filed filed Critical
Publication of JP2001504437A publication Critical patent/JP2001504437A/ja
Publication of JP2001504437A5 publication Critical patent/JP2001504437A5/ja
Application granted granted Critical
Publication of JP4267697B2 publication Critical patent/JP4267697B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP53117297A 1996-03-01 1997-02-28 免疫抑制性化合物および方法 Expired - Fee Related JP4267697B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/609,277 1996-03-01
US08/609,277 US5663335A (en) 1996-03-01 1996-03-01 Immunosuppressive compounds and methods
PCT/US1997/003202 WO1997031921A1 (en) 1996-03-01 1997-02-28 Immunosuppressive compounds and methods

Publications (3)

Publication Number Publication Date
JP2001504437A JP2001504437A (ja) 2001-04-03
JP2001504437A5 true JP2001504437A5 (enExample) 2004-11-11
JP4267697B2 JP4267697B2 (ja) 2009-05-27

Family

ID=24440096

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53117297A Expired - Fee Related JP4267697B2 (ja) 1996-03-01 1997-02-28 免疫抑制性化合物および方法

Country Status (12)

Country Link
US (1) US5663335A (enExample)
EP (1) EP0907652B1 (enExample)
JP (1) JP4267697B2 (enExample)
CN (1) CN1133637C (enExample)
AT (1) ATE296304T1 (enExample)
AU (2) AU2125897A (enExample)
CA (1) CA2248266C (enExample)
DE (1) DE69733353T2 (enExample)
DK (1) DK0907652T3 (enExample)
ES (1) ES2242214T3 (enExample)
PT (1) PT907652E (enExample)
WO (2) WO1997031920A1 (enExample)

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US5972998A (en) * 1997-05-23 1999-10-26 Hoechst Marion Roussel, Inc. Triptolide derivatives useful in the treatment of autoimmune diseases
ES2213279T3 (es) * 1997-05-23 2004-08-16 Aventis Pharmaceuticals Inc. Derivados de triptolida utiles en el tratamiento de enfermedades autoinmunes.
US6004999A (en) * 1997-05-23 1999-12-21 Hoechst Marion Roussel, Inc. Triptolide derivatives useful in the treatment of autoimmune diseases
DE69932649T2 (de) * 1998-09-02 2007-08-09 Pharmagenesis, Inc., Palo Alto Triptolid-Prodrugs mit hoher Wasserlöslichkeit
EP1375488B1 (en) * 1998-09-02 2006-08-02 Pharmagenesis, Inc. Triptolide prodrugs having high aqueous solubility
US6548537B1 (en) 1998-09-02 2003-04-15 Pharmagenesis, Inc. Triptolide prodrugs having high aqueous solubility
JP2002536320A (ja) * 1999-02-02 2002-10-29 カー・イュー・ルーベン・リサーチ・アンド・ディベロップメント プテリジン誘導体の免疫抑制作用
US6329148B1 (en) 1999-02-16 2001-12-11 The Board Of Trustees Of The Leland Stanford University Combined therapy of diterpenoid triepoxides and death domain receptor ligands for synergistic killing of tumor cells
AU5368699A (en) * 1999-04-16 2000-11-02 Chengdu Diao Pharmaceutical Group Company Limited Derivatives of triptolide, and preparation and uses thereof
US7323471B1 (en) * 1999-08-13 2008-01-29 Dor Biopharma, Inc. Topical azathioprine for the treatment of oral autoimmune diseases
US6294546B1 (en) * 1999-08-30 2001-09-25 The Broad Of Trustees Of The Leland Stanford Junior University Uses of diterpenoid triepoxides as an anti-proliferative agent
US6620843B2 (en) * 2001-01-19 2003-09-16 Pharmagenesis Anticancer treatment using triptolide prodrugs
US6569893B2 (en) * 2001-03-15 2003-05-27 Pharmagenesis, Inc. Amino acid derivatives of triptolide compounds as immune modulators and anticancer agents
JP4680589B2 (ja) * 2002-05-31 2011-05-11 ファーマジェネシス, インコーポレイテッド アポトーシスおよび免疫抑制の調節のためのトリプトリド誘導体
CN100398544C (zh) * 2002-09-18 2008-07-02 成都达远药物有限公司 高免疫抑制活性的水溶性雷公藤内酯醇衍生物及其应用
JP2006513209A (ja) * 2002-12-17 2006-04-20 ファーマジェネシス, インコーポレイテッド 免疫調節因子および抗癌剤としてのトリプトライド誘導体
CN1223595C (zh) 2002-12-27 2005-10-19 中国科学院上海药物研究所 雷公藤内酯醇衍生物及其应用
US6943259B2 (en) * 2003-02-25 2005-09-13 Pharmagenesis, Inc. Halogenated triptolide derivatives as immunomodulators and anticancer agents
CN100408583C (zh) * 2003-02-25 2008-08-06 美国泛华医药公司 用作免疫调节剂和抗癌药的卤代雷公藤内酯醇衍生物
US7820834B2 (en) * 2003-12-24 2010-10-26 Pharmagenesis, Inc. Triptolide 5,6-derivatives as immunomodulators and anticancer agents
EP1722806A4 (en) * 2004-02-09 2009-09-16 Pharmagenesis Inc METHOD OF ISOLATING TRIPTOLIDE COMPOUNDS FROM TRIPTERYGIUM WILFORDII
ES2385716T3 (es) * 2004-03-02 2012-07-30 Pharmagenesis, Inc. Derivados en el anillo de lactona de triptolida como inmunomoduladores y agentes anticáncer
WO2006012204A2 (en) * 2004-06-25 2006-02-02 Pharmagenesis, Inc. Method for treatment of inflammatory disorders using triptolide compounds
US8617906B2 (en) 2004-10-13 2013-12-31 Pharmagenesis, Inc. Identification and screening of triptolide target molecules
EP1924548B1 (en) 2005-07-13 2018-03-28 Salvia Sciences, Inc. Ester prodrugs of prostratin and related phorbol compounds
US10144736B2 (en) 2006-07-20 2018-12-04 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
US9259426B2 (en) 2006-07-20 2016-02-16 Gilead Sciences, Inc. 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
US8067632B2 (en) * 2007-07-26 2011-11-29 The Board Of Trustees Of The Leland Stanford Junior University Process to produce prostratin and structural or functional analogs thereof
CN101235041B (zh) * 2007-10-26 2013-05-29 北京美迪克斯生物技术有限公司 四种雷公藤甲素衍生物及其制剂的制备方法
AU2010210594B2 (en) * 2009-02-05 2015-02-12 Pharmagenesis, Inc. Triptolide C-ring derivatives as anticancer agents and immune modulators
MY160392A (en) 2009-05-07 2017-03-15 Univ Minnesota Triptolide prodrugs
US9150600B2 (en) 2009-05-07 2015-10-06 Regents Of The University Of Minnesota Triptolide prodrugs
CN102286065B (zh) * 2010-06-18 2012-11-14 中国科学院上海药物研究所 松香烷型二萜衍生物、其制备方法和应用
MX368417B (es) 2012-08-23 2019-10-02 Senestech Inc Reduccion de la capacidad reproductiva de mamiferos.
PL3097102T3 (pl) 2015-03-04 2018-04-30 Gilead Sciences Inc Związki 4,6-diamino-pirydo[3,2-d]pirymidyny modulujące działanie receptora toll-podobnego
WO2016205539A1 (en) * 2015-06-16 2016-12-22 Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada, Reno Non-hormonal male contraceptive agents and methods using same
CN107207525B (zh) * 2015-10-29 2018-11-27 杭州卫本药业有限公司 C14-位羟基酯化的雷公藤甲素氨基酸衍生物、及其制备方法和应用
KR102268448B1 (ko) 2016-09-02 2021-06-22 길리애드 사이언시즈, 인코포레이티드 톨 유사 수용체 조정제 화합물
ES2826748T3 (es) 2016-09-02 2021-05-19 Gilead Sciences Inc Derivados de 4,6-diamino-pirido[3,2-d]pirimidina como moduladores de receptores de tipo Toll
CN106890187A (zh) * 2017-02-22 2017-06-27 中山大学附属第三医院 雷公藤甲素及其修饰物在抑制b细胞产生抗体中的应用
CN109021061B (zh) * 2018-09-29 2019-07-12 郭可点 雷公藤甲素靶向前药及其制备方法和应用
TWI751517B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI879779B (zh) 2019-06-28 2025-04-11 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法
CN111440185B (zh) * 2020-03-31 2021-05-14 中国农业科学院蜜蜂研究所 一种半抗原及其在检测雷公藤乙素和雷公藤甲素方面的应用
CN115466269A (zh) * 2021-06-11 2022-12-13 复旦大学 一种胆碱碳酸酯类前药及其制备方法和应用
CN114478684B (zh) * 2022-01-21 2023-10-31 南京中医药大学 一类雷公藤甲素前药、其制备方法及其医药用途

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US4005108A (en) * 1973-04-03 1977-01-25 Research Corporation Novel anti-leukemic diterpenoid triepoxides
CA1310009C (en) * 1984-03-28 1992-11-10 John Mark Braughler Ester prodrugs of steroids
CN1027371C (zh) * 1989-09-08 1995-01-11 中国医学科学院皮肤病研究所 二萜内酯化合物的合成方法
CN1052860A (zh) * 1989-12-22 1991-07-10 中国医学科学院皮肤病研究所 雷藤氯内酯醇的制备方法及抗生育用途
CN1052861A (zh) * 1989-12-22 1991-07-10 中国医学科学院皮肤病研究所 雷醇内酯的制备方法及抗生育用途
US5430054A (en) * 1989-12-22 1995-07-04 Jiangsu Family Planning Institute Preparation methods of diterpene lactone compounds and application of the same to antifertility
CN1052859A (zh) * 1989-12-22 1991-07-10 中国医学科学院皮肤病研究所 17-羟基雷藤内酯醇及类似物的结构与制备方法
AU7570191A (en) * 1990-03-14 1991-10-10 Board Of Regents, The University Of Texas System Tripterygium wilfordii hook f extracts and components thereof for immunosuppression

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