|
US5880116A
(en)
*
|
1996-12-13 |
1999-03-09 |
Neurocal International |
Use of celastrol to treat alzheimer's disease
|
|
KR20010012822A
(ko)
*
|
1997-05-23 |
2001-02-26 |
게리 디. 스트리트 |
자가 면역 질환의 치료에 유용한 신규의 트리프톨라이드유도체
|
|
EP0983256B1
(en)
*
|
1997-05-23 |
2004-03-10 |
Aventis Pharmaceuticals Inc. |
Triptolide derivatives useful in the treatment of autoimmune diseases
|
|
US6004999A
(en)
*
|
1997-05-23 |
1999-12-21 |
Hoechst Marion Roussel, Inc. |
Triptolide derivatives useful in the treatment of autoimmune diseases
|
|
US5972998A
(en)
*
|
1997-05-23 |
1999-10-26 |
Hoechst Marion Roussel, Inc. |
Triptolide derivatives useful in the treatment of autoimmune diseases
|
|
US6548537B1
(en)
|
1998-09-02 |
2003-04-15 |
Pharmagenesis, Inc. |
Triptolide prodrugs having high aqueous solubility
|
|
JP2002523495A
(ja)
*
|
1998-09-02 |
2002-07-30 |
ファーマジェネシス， インコーポレイテッド |
高い水溶性を有するトリプトリドプロドラッグ
|
|
EP1375488B1
(en)
*
|
1998-09-02 |
2006-08-02 |
Pharmagenesis, Inc. |
Triptolide prodrugs having high aqueous solubility
|
|
EP1187615A2
(en)
*
|
1999-02-02 |
2002-03-20 |
K.U. Leuven Research & Development |
Immunosurpressive effects of pteridine derivatives
|
|
US6329148B1
(en)
|
1999-02-16 |
2001-12-11 |
The Board Of Trustees Of The Leland Stanford University |
Combined therapy of diterpenoid triepoxides and death domain receptor ligands for synergistic killing of tumor cells
|
|
AU5368699A
(en)
*
|
1999-04-16 |
2000-11-02 |
Chengdu Diao Pharmaceutical Group Company Limited |
Derivatives of triptolide, and preparation and uses thereof
|
|
US7323471B1
(en)
*
|
1999-08-13 |
2008-01-29 |
Dor Biopharma, Inc. |
Topical azathioprine for the treatment of oral autoimmune diseases
|
|
US6294546B1
(en)
*
|
1999-08-30 |
2001-09-25 |
The Broad Of Trustees Of The Leland Stanford Junior University |
Uses of diterpenoid triepoxides as an anti-proliferative agent
|
|
US6620843B2
(en)
*
|
2001-01-19 |
2003-09-16 |
Pharmagenesis |
Anticancer treatment using triptolide prodrugs
|
|
EP1390358A4
(en)
*
|
2001-03-15 |
2004-06-16 |
Pharmagenesis Inc |
AMINO ACID DERIVATIVES OF TRIPTOLIDE COMPOUNDS AS IMMUNOMODULATORS AND ANTICROPHES
|
|
AU2003243351B2
(en)
*
|
2002-05-31 |
2009-04-30 |
Pharmagenesis, Inc. |
Triptolide derivatives for modulation of apoptosis and immunosuppression
|
|
CN100398544C
(zh)
*
|
2002-09-18 |
2008-07-02 |
成都达远药物有限公司 |
高免疫抑制活性的水溶性雷公藤内酯醇衍生物及其应用
|
|
WO2004058246A1
(en)
*
|
2002-12-17 |
2004-07-15 |
Pharmagenesis, Inc. |
Triptolide derivatives as immunomodulator and anticancer agents
|
|
CN1223595C
(zh)
*
|
2002-12-27 |
2005-10-19 |
中国科学院上海药物研究所 |
雷公藤内酯醇衍生物及其应用
|
|
CN100408583C
(zh)
*
|
2003-02-25 |
2008-08-06 |
美国泛华医药公司 |
用作免疫调节剂和抗癌药的卤代雷公藤内酯醇衍生物
|
|
US6943259B2
(en)
*
|
2003-02-25 |
2005-09-13 |
Pharmagenesis, Inc. |
Halogenated triptolide derivatives as immunomodulators and anticancer agents
|
|
US7820834B2
(en)
*
|
2003-12-24 |
2010-10-26 |
Pharmagenesis, Inc. |
Triptolide 5,6-derivatives as immunomodulators and anticancer agents
|
|
WO2005077008A2
(en)
*
|
2004-02-09 |
2005-08-25 |
Pharmagenesis, Inc. |
Methods for isolation of triptolide compounds from tripterygium wilfordii
|
|
ES2385716T3
(es)
*
|
2004-03-02 |
2012-07-30 |
Pharmagenesis, Inc. |
Derivados en el anillo de lactona de triptolida como inmunomoduladores y agentes anticáncer
|
|
US20070244080A1
(en)
*
|
2004-06-25 |
2007-10-18 |
Pharmagenesis, Inc. |
Method for Treatment of Inflammatory Disorders Using Triptolide Compounds
|
|
US8617906B2
(en)
|
2004-10-13 |
2013-12-31 |
Pharmagenesis, Inc. |
Identification and screening of triptolide target molecules
|
|
WO2007009055A2
(en)
|
2005-07-13 |
2007-01-18 |
Salvia Sciences, Inc. |
Ester prodrugs of prostratin and related phorbol compounds
|
|
WO2008009079A2
(en)
|
2006-07-20 |
2008-01-24 |
Gilead Sciences, Inc. |
Substituted pteridines useful for the treatment and prevention of viral infections
|
|
WO2008009078A2
(en)
|
2006-07-20 |
2008-01-24 |
Gilead Sciences, Inc. |
4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
|
|
US8067632B2
(en)
|
2007-07-26 |
2011-11-29 |
The Board Of Trustees Of The Leland Stanford Junior University |
Process to produce prostratin and structural or functional analogs thereof
|
|
CN101235041B
(zh)
*
|
2007-10-26 |
2013-05-29 |
北京美迪克斯生物技术有限公司 |
四种雷公藤甲素衍生物及其制剂的制备方法
|
|
JP5653939B2
(ja)
*
|
2009-02-05 |
2015-01-14 |
ファーマジェネシス， インコーポレイテッド |
抗癌剤および免疫調節因子としてのトリプトリドｃ環誘導体
|
|
CN102596977B
(zh)
|
2009-05-07 |
2016-06-29 |
明尼苏达大学评议会 |
雷公藤内酯前药
|
|
US9150600B2
(en)
|
2009-05-07 |
2015-10-06 |
Regents Of The University Of Minnesota |
Triptolide prodrugs
|
|
CN102286065B
(zh)
*
|
2010-06-18 |
2012-11-14 |
中国科学院上海药物研究所 |
松香烷型二萜衍生物、其制备方法和应用
|
|
ES2902651T3
(es)
*
|
2012-08-23 |
2022-03-29 |
Senestech Inc |
Reducción de la capacidad reproductiva de mamíferos
|
|
SG11201606876RA
(en)
|
2015-03-04 |
2016-10-28 |
Gilead Sciences Inc |
Toll like receptor modulator compounds
|
|
WO2016205539A1
(en)
*
|
2015-06-16 |
2016-12-22 |
Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada, Reno |
Non-hormonal male contraceptive agents and methods using same
|
|
KR102452412B1
(ko)
*
|
2015-10-29 |
2022-10-06 |
항조우 웨벤 파마슈티컬스 인크 |
트리프톨리드의 c14-히드록실 에스테르화 아미노산 유도체, 및 그의 제조 방법 및 용도
|
|
SI3507276T1
(sl)
|
2016-09-02 |
2022-01-31 |
Gilead Sciences, Inc. |
Spojine modulatorja toličnih receptorjev
|
|
WO2018045150A1
(en)
|
2016-09-02 |
2018-03-08 |
Gilead Sciences, Inc. |
4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
|
|
CN106890187A
(zh)
*
|
2017-02-22 |
2017-06-27 |
中山大学附属第三医院 |
雷公藤甲素及其修饰物在抑制b细胞产生抗体中的应用
|
|
CN109021061B
(zh)
*
|
2018-09-29 |
2019-07-12 |
郭可点 |
雷公藤甲素靶向前药及其制备方法和应用
|
|
TWI751517B
(zh)
|
2019-04-17 |
2022-01-01 |
美商基利科學股份有限公司 |
類鐸受體調節劑之固體形式
|
|
TW202210480A
(zh)
|
2019-04-17 |
2022-03-16 |
美商基利科學股份有限公司 |
類鐸受體調節劑之固體形式
|
|
TWI879779B
(zh)
|
2019-06-28 |
2025-04-11 |
美商基利科學股份有限公司 |
類鐸受體調節劑化合物的製備方法
|
|
CN111440185B
(zh)
*
|
2020-03-31 |
2021-05-14 |
中国农业科学院蜜蜂研究所 |
一种半抗原及其在检测雷公藤乙素和雷公藤甲素方面的应用
|
|
CN115466269A
(zh)
*
|
2021-06-11 |
2022-12-13 |
复旦大学 |
一种胆碱碳酸酯类前药及其制备方法和应用
|
|
CN114478684B
(zh)
*
|
2022-01-21 |
2023-10-31 |
南京中医药大学 |
一类雷公藤甲素前药、其制备方法及其医药用途
|