JP2001503253A5 - - Google Patents

Download PDF

Info

Publication number
JP2001503253A5
JP2001503253A5 JP1998518402A JP51840298A JP2001503253A5 JP 2001503253 A5 JP2001503253 A5 JP 2001503253A5 JP 1998518402 A JP1998518402 A JP 1998518402A JP 51840298 A JP51840298 A JP 51840298A JP 2001503253 A5 JP2001503253 A5 JP 2001503253A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1998518402A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001503253A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1997/017924 external-priority patent/WO1998016254A1/en
Publication of JP2001503253A publication Critical patent/JP2001503253A/ja
Publication of JP2001503253A5 publication Critical patent/JP2001503253A5/ja
Pending legal-status Critical Current

Links

JP51840298A 1996-10-17 1997-10-14 非抗原性即素複合体およびインターナライジング受容体システムの融合タンパク Pending JP2001503253A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2843096P 1996-10-17 1996-10-17
US60/028,430 1996-10-17
PCT/US1997/017924 WO1998016254A1 (en) 1996-10-17 1997-10-14 Non-antigenic toxin-conjugate and fusion protein of internalizing receptor system

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2005292358A Division JP4056543B2 (ja) 1996-10-17 2005-10-05 非抗原性即素複合体およびインターナライジング受容体システムの融合タンパク

Publications (2)

Publication Number Publication Date
JP2001503253A JP2001503253A (ja) 2001-03-13
JP2001503253A5 true JP2001503253A5 (https=) 2004-09-02

Family

ID=21843399

Family Applications (2)

Application Number Title Priority Date Filing Date
JP51840298A Pending JP2001503253A (ja) 1996-10-17 1997-10-14 非抗原性即素複合体およびインターナライジング受容体システムの融合タンパク
JP2005292358A Expired - Fee Related JP4056543B2 (ja) 1996-10-17 2005-10-05 非抗原性即素複合体およびインターナライジング受容体システムの融合タンパク

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2005292358A Expired - Fee Related JP4056543B2 (ja) 1996-10-17 2005-10-05 非抗原性即素複合体およびインターナライジング受容体システムの融合タンパク

Country Status (11)

Country Link
US (4) US6083477A (https=)
EP (1) EP0932417B1 (https=)
JP (2) JP2001503253A (https=)
AT (1) ATE233573T1 (https=)
AU (1) AU729515B2 (https=)
CA (1) CA2269060C (https=)
DE (1) DE69719529T2 (https=)
DK (1) DK0932417T3 (https=)
ES (1) ES2191827T3 (https=)
PT (1) PT932417E (https=)
WO (1) WO1998016254A1 (https=)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8771694B2 (en) * 1994-08-12 2014-07-08 Immunomedics, Inc. Immunoconjugates and humanized antibodies specific for B-cell lymphoma and leukemia cells
ES2251723T3 (es) * 1994-08-12 2006-05-01 Immunomedics, Inc. Inmunoconjugados y anticuerpos humanizados especificos para linfoma de celulas b y celulas de leucemia.
US6136311A (en) 1996-05-06 2000-10-24 Cornell Research Foundation, Inc. Treatment and diagnosis of cancer
US6653104B2 (en) * 1996-10-17 2003-11-25 Immunomedics, Inc. Immunotoxins, comprising an internalizing antibody, directed against malignant and normal cells
WO1998016254A1 (en) * 1996-10-17 1998-04-23 Immunomedics, Inc. Non-antigenic toxin-conjugate and fusion protein of internalizing receptor system
ES2248898T3 (es) * 1997-05-02 2006-03-16 The Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services Inmunotoxinas que comprenden una proteina onc dirigida contra celulas malignas.
US6187284B1 (en) * 1997-09-03 2001-02-13 Immunomedics, Inc. Fluorination of proteins and peptides for F-18 positron emission tomography
ES2322975T3 (es) * 1998-01-15 2009-07-02 Center For Molecular Medicine And Immunology Componente direccionador biespecifico que comprende un anticuerpo contra el antigeno carcinoembrionario (cea) y la region de union a ligando de la subunidad alfa del receptor de il-13.
US6703488B1 (en) 1998-01-15 2004-03-09 Center For Molecular Medicine And Immunology Antibody/receptor targeting moiety for enhanced delivery of armed ligand
US6869604B1 (en) * 1998-03-27 2005-03-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Recombinant anti-tumor RNAse
MXPA01011279A (es) 1999-05-07 2002-07-02 Genentech Inc Tratamiento de enfermedades autoinmunes con antagonistas que se unene a los marcadores de superficie, de celulas b.
US6949520B1 (en) 1999-09-27 2005-09-27 Coley Pharmaceutical Group, Inc. Methods related to immunostimulatory nucleic acid-induced interferon
US7045283B2 (en) * 2000-10-18 2006-05-16 The Regents Of The University Of California Methods of high-throughput screening for internalizing antibodies
US7329405B2 (en) * 2001-08-23 2008-02-12 Genmab A/S Human antibodies specific for interleukin 15 (IL-15)
US7247304B2 (en) * 2001-08-23 2007-07-24 Genmab A/S Methods of treating using anti-IL-15 antibodies
IL160358A0 (en) * 2001-08-23 2004-07-25 Genmab As Human antibodies specific for interleukin 15 (il-15)
CA2513287A1 (en) * 2002-01-14 2003-07-17 William Herman Multispecific binding molecules
US8877901B2 (en) 2002-12-13 2014-11-04 Immunomedics, Inc. Camptothecin-binding moiety conjugates
US7591994B2 (en) 2002-12-13 2009-09-22 Immunomedics, Inc. Camptothecin-binding moiety conjugates
US9701754B1 (en) 2002-10-23 2017-07-11 City Of Hope Covalent disulfide-linked diabodies and uses thereof
GB0308731D0 (en) * 2003-04-15 2003-05-21 Anticancer Therapeutic Inv Sa Method of radiotherapy
AU2005207026A1 (en) * 2004-01-22 2005-08-04 Immunomedics, Inc. Folate conjugates and complexes
WO2005115477A2 (en) 2004-04-13 2005-12-08 Quintessence Biosciences, Inc. Non-natural ribonuclease conjugates as cytotoxic agents
JP2008515896A (ja) * 2004-10-05 2008-05-15 オクスナー クリニック ファウンデーション Il−15によるb細胞増殖の増強
EP2567976B1 (en) 2005-03-23 2017-07-19 Genmab A/S Antibodies against CD38 for treatment of multiple myeloma
CA2619941C (en) 2005-08-31 2014-04-01 Immunomedics, Inc. F-18 peptides for pre targeted positron emission tomography imaging
WO2007109321A2 (en) 2006-03-20 2007-09-27 The Regents Of The University Of California Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting
EP2044097A4 (en) * 2006-06-23 2010-10-06 Quintessence Biosciences Inc Modified ribonucleases
US8298801B2 (en) 2006-07-17 2012-10-30 Quintessence Biosciences, Inc. Methods and compositions for the treatment of cancer
EP3569245A1 (en) 2006-09-26 2019-11-20 Genmab A/S Combination treatment of cd38-expressing tumors
WO2008133141A1 (ja) * 2007-04-24 2008-11-06 Toyo Boseki Kabushiki Kaisha オスモチン組換えタンパク質およびその製造方法、並びにその利用
US8940298B2 (en) 2007-09-04 2015-01-27 The Regents Of The University Of California High affinity anti-prostate stem cell antigen (PSCA) antibodies for cancer targeting and detection
EP2205271B1 (en) * 2007-10-08 2014-05-21 Quintessence Biosciences, Inc. Compositions and methods for ribonuclease-based therapies
US11072655B2 (en) 2008-01-15 2021-07-27 The Board Of Trustees Of The Leland Stanford Junior University Markers of acute myeloid leukemia stem cells
CA2965198C (en) 2008-01-15 2021-02-16 The Board Of Trustees Of The Leland Stanford Junior University Markers of acute myeloid leukemia stem cells
AU2009205665B2 (en) 2008-01-15 2013-12-05 The Board Of Trustees Of The Leland Stanford Junior University Methods for manipulating phagocytosis mediated by CD47
US20100069616A1 (en) * 2008-08-06 2010-03-18 The Regents Of The University Of California Engineered antibody-nanoparticle conjugates
US8029782B2 (en) 2008-10-01 2011-10-04 Quintessence Biosciences, Inc. Therapeutic ribonucleases
EP3912643B8 (en) 2009-02-13 2023-08-23 Immunomedics, Inc. Immunoconjugates with an intracellularly-cleavable linkage
EP2398504B1 (en) 2009-02-17 2018-11-28 Cornell Research Foundation, Inc. Methods and kits for diagnosis of cancer and prediction of therapeutic value
GB0905438D0 (en) * 2009-03-30 2009-05-13 Ge Healthcare Ltd Radiolabelling reagents and methods
JP5863115B2 (ja) * 2009-04-16 2016-02-16 シャリテ−ウニヴェルズィテートメディツィーン ベルリン 疾患の処置方法に使用するためのbリンパ球ターゲティング剤
KR101934923B1 (ko) 2009-11-02 2019-04-10 유니버시티 오브 워싱톤 스루 이츠 센터 포 커머셜리제이션 치료학적 뉴클레아제 조성물 및 방법
CA2782333C (en) 2009-12-02 2019-06-04 Imaginab, Inc. J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen (psma) and methods for their use
GB201002508D0 (en) 2010-02-12 2010-03-31 Algeta As Product
DK2580243T3 (da) 2010-06-09 2020-01-13 Genmab As Antibodies against human cd38
PH12013502441B1 (en) 2011-04-29 2019-02-08 Univ Washington Therapeutic nuclease compositions and methods
AU2012250924B2 (en) 2011-05-02 2017-05-25 Immunomedics, Inc. Ultrafiltration concentration of allotype selected antibodies for small-volume administration
MX361875B (es) 2012-03-14 2018-12-18 Regeneron Pharma Moléculas de unión de antígeno multiespecifícas y usos de las mismas.
JP2015521602A (ja) 2012-06-14 2015-07-30 アンブルックス, インコーポレイテッドAmbrx, Inc. 核受容体リガンドポリペプチドに対して複合化されている抗psma抗体
SI2900277T1 (sl) 2012-12-13 2022-05-31 Immunomedics, Inc. Odmerki imunokonjugatov protiteles in SN-38 za boljšo učinkovitost in zmanjšano toksičnost
US11559580B1 (en) 2013-09-17 2023-01-24 Blaze Bioscience, Inc. Tissue-homing peptide conjugates and methods of use thereof
PL3063275T3 (pl) 2013-10-31 2020-03-31 Resolve Therapeutics, Llc Terapeutyczne fuzje nukleaza-albumina i sposoby
US9139649B2 (en) 2014-02-25 2015-09-22 Immunomedics, Inc. Humanized anti-CD22 antibody
US9603927B2 (en) 2014-02-28 2017-03-28 Janssen Biotech, Inc. Combination therapies with anti-CD38 antibodies
US9732154B2 (en) 2014-02-28 2017-08-15 Janssen Biotech, Inc. Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia
MX386886B (es) 2014-09-09 2025-03-12 Janssen Biotech Inc Combinación de anticuerpos anti-cd38 y ácido todo-trans retinoico para usarse en terapias.
CN117138060A (zh) 2014-10-07 2023-12-01 免疫医疗公司 抗体-药物缀合物的新辅助剂用途
AU2015358615B2 (en) 2014-12-04 2021-08-05 Janssen Biotech, Inc. Anti-CD38 antibodies for treatment of acute myeloid leukemia
WO2016172427A1 (en) 2015-04-22 2016-10-27 Immunomedics, Inc. Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells
MX389805B (es) 2015-05-20 2025-03-11 Janssen Biotech Inc Anticuerpos anti-cd38 para el tratamiento de amiloidosis de cadena ligera y otras enfermedades malignas hematológicas positivas para cd38.
AU2016282674B2 (en) 2015-06-22 2022-01-13 Janssen Biotech, Inc. Combination therapies for heme malignancies with anti-CD38 antibodies and survivin inhibitors
US20170044265A1 (en) 2015-06-24 2017-02-16 Janssen Biotech, Inc. Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38
EP4257134A3 (en) 2015-06-25 2024-01-24 Immunomedics, Inc. Combining anti-hla-dr or anti-trop-2 antibodies with microtubule inhibitors, parp inhibitors, bruton kinase inhibitors or phosphoinositide 3-kinase inhibitors significantly improves therapeutic outcome in cancer
PL3316885T3 (pl) 2015-07-01 2021-12-06 Immunomedics, Inc. Immunokoniugaty przeciwciało-sn-38 z linkerem cl2a
MY189159A (en) 2015-07-06 2022-01-29 Regeneron Pharma Multispecific antigen-binding molecules and uses thereof
WO2017027325A1 (en) 2015-08-07 2017-02-16 Imaginab, Inc. Antigen binding constructs to target molecules
US11090358B2 (en) 2015-09-09 2021-08-17 Fred Hutchinson Cancer Research Center Cartilage-homing peptides
US10781261B2 (en) 2015-11-03 2020-09-22 Janssen Biotech, Inc. Subcutaneous formulations of anti-CD38 antibodies and their uses
DK3827845T3 (da) 2015-11-03 2022-05-23 Janssen Biotech Inc Subkutane formuleringer af anti-cd38-antistoffer og anvendelser deraf
WO2017190079A1 (en) 2016-04-28 2017-11-02 Regeneron Pharmaceuticals, Inc. Methods of making multispecific antigen-binding molecules
JP2019527678A (ja) 2016-06-28 2019-10-03 ユーエムセー・ユトレヒト・ホールディング・ベー・フェー CD38に特異的に結合する抗体によるIgE媒介疾患の治療
JP7308034B2 (ja) 2016-07-01 2023-07-13 リゾルブ セラピューティクス, エルエルシー 最適化二重ヌクレアーゼ融合物および方法
AU2018210157B2 (en) 2017-01-18 2022-10-06 Fred Hutchinson Cancer Center Peptide compositions and methods of use thereof for disrupting TEAD interactions
WO2018147960A1 (en) 2017-02-08 2018-08-16 Imaginab, Inc. Extension sequences for diabodies
EP3595699A4 (en) 2017-03-16 2020-12-23 Blaze Bioscience, Inc. PEPTIDIC CONJUGATES OF CARTILAGE ECOTROPISM AND THEIR METHODS OF USE
US11655307B2 (en) 2017-05-30 2023-05-23 The Board Of Regents Of The University Of Oklahoma Anti-doublecortin-like kinase 1 antibodies and methods of use
FI3635009T3 (fi) 2017-06-07 2026-04-07 Regeneron Pharma Koostumuksia ja menetelmiä entsyymien internalisoimiseksi
AU2018283161A1 (en) 2017-06-15 2020-01-02 Blaze Bioscience, Inc. Renal-homing peptide conjugates and methods of use thereof
BR112020003670A2 (pt) 2017-08-22 2020-09-01 Sanabio, Llc receptores de interferon solúveis e usos dos mesmos
JP2021502961A (ja) 2017-10-31 2021-02-04 ヤンセン バイオテツク,インコーポレーテツド 高リスク多発性骨髄腫の治療方法
EP3727146A4 (en) * 2017-12-19 2021-10-06 Blaze Bioscience, Inc. TUMOR HOMING AND CELL-PENETANT PEPTIDE IMMUNO-ONCOLOGY AGENT COMPLEX AND METHOD OF USE
JP7779653B2 (ja) 2018-02-07 2025-12-03 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 治療用タンパク質送達のための方法および組成物
EP3793591A1 (en) 2018-05-17 2021-03-24 Regeneron Pharmaceuticals, Inc. Anti-cd63 antibodies, conjugates, and uses thereof
CA3150224A1 (en) 2019-09-10 2021-03-18 Obsidian Therapeutics, Inc. Ca2 compositions and methods for tunable regulation
WO2022265912A1 (en) 2021-06-16 2022-12-22 Gundersen Lutheran Medical Foundation, Inc. Antibodies targeting an amphiregulin-derived cell surface neo-epitope

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837003A (en) * 1984-09-13 1989-06-06 Mallinckrodt, Inc. Radiolabeled antibody fragments
US5541297A (en) * 1988-04-01 1996-07-30 Immunomedics, Inc. Therapeutic conjugates of toxins and drugs
WO1992000762A1 (en) * 1990-07-05 1992-01-23 Akzo N.V. Receptor directed-toxin conjugates
US5346686A (en) * 1992-10-05 1994-09-13 Mallinckrodt Medical, Inc. Labelled interleukin-8 and medical uses thereof
US5591630A (en) * 1994-05-06 1997-01-07 Immunex Corporation Monoclonal antibodies that bind interleukin-15 receptors
US5795966A (en) * 1995-02-22 1998-08-18 Immunex Corp Antagonists of interleukin-15
WO1998016254A1 (en) * 1996-10-17 1998-04-23 Immunomedics, Inc. Non-antigenic toxin-conjugate and fusion protein of internalizing receptor system
TW581136U (en) * 2002-10-08 2004-03-21 Nien Made Entpr Co Ltd Structure of wooden blind window

Similar Documents

Publication Publication Date Title
JP2001509286A5 (https=)
JP2001501216A5 (https=)
JP2000501599A5 (https=)
JP2000509282A5 (https=)
JP2000501018A5 (https=)
JP2001503253A5 (https=)
JP2000501324A5 (https=)
JP2001510377A5 (https=)
JP2000500055A5 (https=)
JP2000510696A5 (https=)
JP2001501388A5 (https=)
JP2000501338A5 (https=)
JP2001508605A5 (https=)
JP2000500874A5 (https=)
JP2000515517A5 (https=)
JP2000502485A5 (https=)
JP2000517167A5 (https=)
JP2000502568A5 (https=)
JP2000500912A5 (https=)
JP2000502570A5 (https=)
JP2001503413A5 (https=)
JP2000501229A5 (https=)
JP2000514801A5 (https=)
JP2000502714A5 (https=)
JP2000500184A5 (https=)