JP2001501975A - 亢進した細胞取り込みを有する結合ペプチド核酸 - Google Patents
亢進した細胞取り込みを有する結合ペプチド核酸Info
- Publication number
- JP2001501975A JP2001501975A JP11500871A JP50087199A JP2001501975A JP 2001501975 A JP2001501975 A JP 2001501975A JP 11500871 A JP11500871 A JP 11500871A JP 50087199 A JP50087199 A JP 50087199A JP 2001501975 A JP2001501975 A JP 2001501975A
- Authority
- JP
- Japan
- Prior art keywords
- naturally occurring
- amino acid
- side chain
- peptide nucleic
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dispersion Chemistry (AREA)
- AIDS & HIV (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86476597A | 1997-05-28 | 1997-05-28 | |
US08/864,765 | 1997-05-28 | ||
PCT/US1998/010804 WO1998053801A1 (en) | 1997-05-28 | 1998-05-28 | Conjugated peptide nucleic acids having enhanced cellular uptake |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2001501975A true JP2001501975A (ja) | 2001-02-13 |
Family
ID=25344022
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11500871A Pending JP2001501975A (ja) | 1997-05-28 | 1998-05-28 | 亢進した細胞取り込みを有する結合ペプチド核酸 |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1003480A4 (de) |
JP (1) | JP2001501975A (de) |
AU (1) | AU745309B2 (de) |
CA (1) | CA2291839A1 (de) |
IL (1) | IL133087A0 (de) |
NZ (1) | NZ501289A (de) |
WO (1) | WO1998053801A1 (de) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017518363A (ja) * | 2014-05-16 | 2017-07-06 | ウギゼンゼ アーゲーUgisense Ag | ペプチド核酸モノマー及びオリゴマー |
JP2017520563A (ja) * | 2014-06-24 | 2017-07-27 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | 核酸の送達のための立体化学的に濃縮した組成物 |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6472209B1 (en) | 1997-10-17 | 2002-10-29 | Mayo Foundation For Medical Education And Research | Using polyamide nucleic acid oligomers to engender a biological response |
US6723560B2 (en) | 1998-10-08 | 2004-04-20 | Mayo Foundation For Medical Education And Research | Using polyamide nucleic acid oligomers to engender a biological response |
US6989270B1 (en) | 1997-10-17 | 2006-01-24 | Mayo Foundation For Medical Education And Research | Using polyamide nucleic acid oligomers to engender a biological response |
DE19909373A1 (de) * | 1999-03-03 | 2000-10-05 | Ugichem | Neue PNA-Monomere, daraus resultierende PNA-Oligomere und deren Verwendung |
DE10038169A1 (de) * | 2000-08-04 | 2002-03-07 | November Ag Molekulare Medizin | Synthetisches Partikel zur Markierung einer Substanz |
AU2003260289A1 (en) * | 2002-09-11 | 2004-04-30 | Santaris Pharma A/S | Modified pna molecules |
JP5645840B2 (ja) | 2008-12-02 | 2014-12-24 | 株式会社Wave Life Sciences Japan | リン原子修飾核酸の合成方法 |
CN102596204B (zh) | 2009-07-06 | 2016-11-23 | 波涛生命科学有限公司 | 新的核酸前药及其使用方法 |
EP2620428B1 (de) | 2010-09-24 | 2019-05-22 | Wave Life Sciences Ltd. | Asymmetrische hilfsgruppe |
JP6128529B2 (ja) | 2011-07-19 | 2017-05-17 | ウェイブ ライフ サイエンシズ リミテッドWave Life Sciences Ltd. | 官能化核酸の合成のための方法 |
AU2013287630B2 (en) | 2012-07-13 | 2017-05-25 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant |
WO2014012081A2 (en) | 2012-07-13 | 2014-01-16 | Ontorii, Inc. | Chiral control |
PL2872485T3 (pl) | 2012-07-13 | 2021-05-31 | Wave Life Sciences Ltd. | Asymetryczna grupa pomocnicza |
WO2015108047A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
EP3095460A4 (de) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chirales nukleinsäureadjuvans mit antiallergischer wirkung und antiallergikum |
JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
US10160969B2 (en) | 2014-01-16 | 2018-12-25 | Wave Life Sciences Ltd. | Chiral design |
AU2020315947A1 (en) * | 2019-07-24 | 2022-03-10 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for treating cancer using peptide nucleic acid-based agents |
CN114315835B (zh) * | 2021-11-30 | 2023-03-03 | 华南农业大学 | 一种6-苯甲基腺嘌呤半抗原、人工抗原、抗体及其制备方法和应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK51092D0 (da) * | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
US5539082A (en) * | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
US5705333A (en) * | 1994-08-05 | 1998-01-06 | The Regents Of The University Of California | Peptide-based nucleic acid mimics(PENAMS) |
ATE222589T1 (de) * | 1994-10-06 | 2002-09-15 | Isis Pharmaceuticals Inc | Peptid-nukleinsäure-konjugate |
AU4344696A (en) * | 1994-12-21 | 1996-07-10 | Novartis Ag | Oligonucleotide-dendrimer conjugates |
EP0870055B1 (de) * | 1995-10-12 | 2007-05-16 | LANSDORP, Peter, M. | Verfahren zum nachweis von mehrfachkopien einer wiederholungssequenz in einem nukleinsäuremolekül |
-
1998
- 1998-05-28 NZ NZ501289A patent/NZ501289A/en not_active IP Right Cessation
- 1998-05-28 EP EP98923819A patent/EP1003480A4/de not_active Withdrawn
- 1998-05-28 IL IL13308798A patent/IL133087A0/xx unknown
- 1998-05-28 AU AU76021/98A patent/AU745309B2/en not_active Ceased
- 1998-05-28 JP JP11500871A patent/JP2001501975A/ja active Pending
- 1998-05-28 WO PCT/US1998/010804 patent/WO1998053801A1/en not_active Application Discontinuation
- 1998-05-28 CA CA002291839A patent/CA2291839A1/en not_active Abandoned
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017518363A (ja) * | 2014-05-16 | 2017-07-06 | ウギゼンゼ アーゲーUgisense Ag | ペプチド核酸モノマー及びオリゴマー |
JP2017520563A (ja) * | 2014-06-24 | 2017-07-27 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | 核酸の送達のための立体化学的に濃縮した組成物 |
Also Published As
Publication number | Publication date |
---|---|
IL133087A0 (en) | 2001-03-19 |
EP1003480A1 (de) | 2000-05-31 |
EP1003480A4 (de) | 2002-04-17 |
NZ501289A (en) | 2001-06-29 |
WO1998053801A1 (en) | 1998-12-03 |
CA2291839A1 (en) | 1998-12-03 |
AU7602198A (en) | 1998-12-30 |
AU745309B2 (en) | 2002-03-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6686442B2 (en) | Conjugated peptide nucleic acids having enhanced cellular uptake | |
JP2001501975A (ja) | 亢進した細胞取り込みを有する結合ペプチド核酸 | |
EP1709195B1 (de) | Zelltransfektionsformulierungen von kleiner interferierender rna, verwandte zusammensetzungen und herstellungsverfahren und verwendung | |
US5777153A (en) | Cationic lipids | |
JP5042863B2 (ja) | 生物学的に活性な分子をデリバリーするための脂質ナノ粒子系組成物および方法 | |
JP3941854B2 (ja) | 核酸送達用の脂質−ポリアミド結合体および組成物 | |
US20030073640A1 (en) | Novel compositions for the delivery of negatively charged molecules | |
US20030119725A1 (en) | Peptide-mediated transfection agents and methods of use | |
US20030207804A1 (en) | Modified peptide nucleic acids | |
HU223263B1 (hu) | Nukleinsavak transzfekciójára alkalmas gyógyászati kompozíciók és alkalmazásuk | |
JPH11506795A (ja) | 脂質及び例えばリポソーム中でのその使用 | |
JP2001517061A (ja) | 活性複合体の分離 | |
JP2004501211A (ja) | ポリアミド核酸誘導体および薬剤、ならびにその調製方法 | |
MXPA01013114A (es) | Conjugados y metodos para la produccion de los mismos, y su uso poara transportar moleculas a traves de membranas biologicas. | |
EP2596102A2 (de) | Sequenzspezifische doppelsträngige dna/rna-bindende verbindungen und ihre verwendung | |
EP1067969B1 (de) | Polyen-makrolidderivate, verwendung zur vektorisierung von molekülen | |
JP2002510706A (ja) | Dnaトランスフェクションのための新規化合物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20040212 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20040329 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20040511 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20060425 |