JP2001501929A - コロストリニン、およびその使用方法 - Google Patents

コロストリニン、およびその使用方法

Info

Publication number
JP2001501929A
JP2001501929A JP10516329A JP51632998A JP2001501929A JP 2001501929 A JP2001501929 A JP 2001501929A JP 10516329 A JP10516329 A JP 10516329A JP 51632998 A JP51632998 A JP 51632998A JP 2001501929 A JP2001501929 A JP 2001501929A
Authority
JP
Japan
Prior art keywords
colostrinin
corostrinin
composition
treating
immune system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10516329A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001501929A5 (enExample
Inventor
ヤヌス、マリン
リゾフスキィ、ヨーゼフ
デュボフスカ―イングロット、アンナ
Original Assignee
ルートヴィック ヒルシフェルト インスティテュト オブ イミュノロジー アンド エクスペリメンタル セラピー ポゥリッシュ アカデミー オブ サイエンシズ
ジョージアディス バイオテック リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ルートヴィック ヒルシフェルト インスティテュト オブ イミュノロジー アンド エクスペリメンタル セラピー ポゥリッシュ アカデミー オブ サイエンシズ, ジョージアディス バイオテック リミテッド filed Critical ルートヴィック ヒルシフェルト インスティテュト オブ イミュノロジー アンド エクスペリメンタル セラピー ポゥリッシュ アカデミー オブ サイエンシズ
Publication of JP2001501929A publication Critical patent/JP2001501929A/ja
Publication of JP2001501929A5 publication Critical patent/JP2001501929A5/ja
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/18Peptides; Protein hydrolysates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/19Dairy proteins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00Function of food ingredients
    • A23V2200/30Foods, ingredients or supplements having a functional effect on health
    • A23V2200/324Foods, ingredients or supplements having a functional effect on health having an effect on the immune system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Nutrition Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
JP10516329A 1996-10-03 1997-10-03 コロストリニン、およびその使用方法 Pending JP2001501929A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PL96316416A PL185442B1 (pl) 1996-10-03 1996-10-03 Środek farmaceutyczny o działaniu immunologicznym i psychotropowym, jego postać terapeutyczna oraz zastosowanie
PL316416 1996-10-03
PCT/GB1997/002721 WO1998014473A1 (en) 1996-10-03 1997-10-03 Colostrinin, and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008031513A Division JP2008174561A (ja) 1996-10-03 2008-02-13 コロストリニン、およびその使用方法

Publications (2)

Publication Number Publication Date
JP2001501929A true JP2001501929A (ja) 2001-02-13
JP2001501929A5 JP2001501929A5 (enExample) 2005-05-12

Family

ID=20068412

Family Applications (2)

Application Number Title Priority Date Filing Date
JP10516329A Pending JP2001501929A (ja) 1996-10-03 1997-10-03 コロストリニン、およびその使用方法
JP2008031513A Pending JP2008174561A (ja) 1996-10-03 2008-02-13 コロストリニン、およびその使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008031513A Pending JP2008174561A (ja) 1996-10-03 2008-02-13 コロストリニン、およびその使用方法

Country Status (18)

Country Link
US (2) US6852700B1 (enExample)
EP (1) EP0932623A1 (enExample)
JP (2) JP2001501929A (enExample)
KR (2) KR100508764B1 (enExample)
CN (2) CN1131712C (enExample)
AR (1) AR013612A1 (enExample)
AU (1) AU4565197A (enExample)
BR (1) BR9712259A (enExample)
CA (1) CA2266859C (enExample)
CZ (1) CZ298215B6 (enExample)
GB (1) GB2333453B (enExample)
HU (1) HUP9904368A3 (enExample)
IL (1) IL129211A (enExample)
PL (1) PL185442B1 (enExample)
RU (1) RU2217152C2 (enExample)
TR (1) TR199901022T2 (enExample)
WO (1) WO1998014473A1 (enExample)
ZA (1) ZA978885B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008536914A (ja) * 2005-04-21 2008-09-11 エヌ.ブイ.・ヌートリシア Hiv患者における腸の機能不全の治療
JP2018500284A (ja) * 2014-11-04 2018-01-11 ゲオ−ポーランド スプウカ・ス・オルガニザツィーノン・オトゥポビエジャルノシチョン Bdnf依存性疾患の治療に使用されるプロリンリッチポリペプチド複合体

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL185442B1 (pl) 1996-10-03 2003-05-30 Georgiades Biotech Ltd Środek farmaceutyczny o działaniu immunologicznym i psychotropowym, jego postać terapeutyczna oraz zastosowanie
ID26730A (id) 1998-05-27 2001-02-01 Gemma Biotechnology Ltd Induksi protein-protein dan peptida-peptida antibiotik oleh lait/scd14-protein
MXPA00012399A (es) * 1998-06-10 2003-07-14 Albert B Crum Complememnto nutricional profilactico y terapeutico para la creacion y mantenimiento de microflora intestinal protectora de la salud y mejoramiento del sistema inmunologico.
GB9813031D0 (en) * 1998-06-16 1998-08-12 Regen Biotech Limited Dietary supplement
GB9912852D0 (en) * 1999-06-02 1999-08-04 Regen Therapeutics Plc Peptides
US6852685B1 (en) * 1999-08-17 2005-02-08 Board Of Regents, The University Of Texas System Use of colostrinin, constituent peptides thereof, and analogs thereof to promote neuronal cell differentiation
WO2001012650A2 (en) 1999-08-17 2001-02-22 The University Of Texas System Use of colostrinin, constituent peptides thereof, and analogs thereof as oxidative stress regulators
DE60036638T2 (de) * 1999-08-17 2008-02-21 The University Of Texas System, Austin Verwendung von colostrinin, dessen peptidbestandteile und deren analoga zur förderung der neuronalen zelldifferenzierung
US7119064B2 (en) * 1999-08-17 2006-10-10 Board Of Regents, The University Of Texas System Use of colostrinin, constituent peptides thereof, and analogs thereof as modulators of intracellular signaling molecules
EP1224217A4 (en) * 1999-08-17 2006-05-24 Univ Texas USE OF COLOSTRININE, ITS CONSTITUENT PEPTIDES AND ITS ANALOGUES FOR ACTIVATING CYTOKINES
US6903068B1 (en) * 1999-08-17 2005-06-07 Board Of Regents, The University Of Texas System Use of colostrinin, constituent peptides thereof, and analogs thereof for inducing cytokines
GB0001825D0 (en) * 2000-01-26 2000-03-22 Regen Therapeutics Plc Peptides
WO2002013849A1 (en) * 2000-08-17 2002-02-21 The University Of Texas System Use of colostrinin, constituent peptides thereof, and analogs thereof for inducing cytokines
WO2002013850A1 (en) * 2000-08-17 2002-02-21 The University Of Texas System Use of colostrinin, constituent peptides thereof, and analogs thereof as oxidative stress regulators
WO2002013851A1 (en) * 2000-08-17 2002-02-21 The University Of Texas System Use of colostrinin, constituent peptides thereof, and analogs thereof to promote neural cell differentiation
GB0029777D0 (en) 2000-12-06 2001-01-17 Regen Therapeutics Plc Peptides
HUP0200172A2 (hu) * 2002-01-15 2003-11-28 András Bertha Eljárás tumorellenes hatóanyag kinyerésére
EP1567551A4 (en) * 2002-10-22 2008-03-12 Univ Texas COLOSTRININE AND PEPTIDES THEREOF AS MODULATORS OF INTRACELLULAR SIGNALING MOLECULES AND INHIBITORS OF APOPTOSIS
US20070161780A1 (en) * 2003-03-11 2007-07-12 Regen Therapeutics Plc Purification of peptides from colostrum
CN1313487C (zh) * 2003-06-10 2007-05-02 天津商学院 具有抗菌作用的免疫活性肽(Trpi)
WO2005041680A2 (en) * 2003-11-03 2005-05-12 Advanced Protein Systems A novel colostral fractionation process
US20070212367A1 (en) * 2006-03-13 2007-09-13 Keech Andrew M Novel immunologically active peptide fragments of a proline-rich polypeptide isolated from colostral mammalian fluids for treatment of viral and non-viral diseases or diseased conditions
GB2436328A (en) * 2006-03-22 2007-09-26 Regen Therapeutics Plc Peptide derived from colostrinin
US20110098216A1 (en) * 2009-10-22 2011-04-28 Regen Therapeutics Plc Therapeutic uses of colostrinin
ITMI20111460A1 (it) * 2011-07-29 2013-01-30 Bionest Ltd Composizioni per la terapia adiuvante dell'anoressia comprendenti anticorpi, fattori di crescita e citochine isolati dal colostro dei mammiferi
DK2797609T3 (en) 2011-12-30 2017-01-09 Innomed S A COMBINING growth factors, cytokines, anti-bacterial / ANTIVIRALS FACTORS STEM CELL-STIMULATING FACTORS, complement C3A / C4A, immunoglobulins, and chemotactic factors
RU2645082C2 (ru) 2011-12-30 2018-02-15 Инномед С.А. Комбинация факторов роста, цитокинов, антибактериальных/антивирусных факторов, факторов стволовых клеток, белков комплемента с3а/с4а и хемотаксических факторов
ITMI20112433A1 (it) * 2011-12-30 2013-07-01 Bionest Ltd Composizioni per la terapia orale adiuvante dell'anoressia comprendenti anticorpi, antibatterici, fattori di crescita e citochine
GB201205856D0 (en) 2012-04-02 2012-05-16 Randall Jeremy A P Food supplement to support brain function
CN107408214B (zh) 2015-01-30 2021-07-09 惠普发展公司,有限责任合伙企业 M进制循环编码
WO2020176637A1 (en) 2019-02-26 2020-09-03 Pantheryx, Inc. Compositions for management of disorders of the gastrointestinal tract

Family Cites Families (11)

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ATE90569T1 (de) 1988-04-19 1993-07-15 Biotest Pharma Gmbh Praeparat mit antikoerperaktivitaet und breitem wirkungsspektrum, daraus bestehende oder diese enthaltende mittel und deren verwendung zur behandlung von bakteriell oder toxin-bedingten erkrankungen und zur bekaempfung von protozoen.
JPH05163160A (ja) * 1991-12-13 1993-06-29 Snow Brand Milk Prod Co Ltd 免疫低下に伴う感染症の予防及び治療用栄養剤
JP3174611B2 (ja) * 1992-02-28 2001-06-11 明治乳業株式会社 免疫賦活組成物
US5645834A (en) 1992-08-28 1997-07-08 Immuno-Dynamics, Inc. Method and product for treating failure of passive transfer and improving milk production in bovine species
GB9318611D0 (en) * 1993-09-08 1993-10-27 Sandoz Nutrition Ltd Improvements in or relating to organic compounds
DE4337654C2 (de) 1993-11-04 1996-08-08 Biotest Pharma Gmbh Verwendung boviner Kolostralmilch von nicht mit Viren hyperimmunisierten Tieren als Leberschutzpräparat
JP4112021B2 (ja) * 1994-02-16 2008-07-02 明治乳業株式会社 乳酸菌を用いた免疫賦活剤
RU2062109C1 (ru) * 1994-11-28 1996-06-20 Товарищество с ограниченной ответственностью "Старк" Способ получения иммунного препарата
WO1997005884A1 (en) 1995-08-07 1997-02-20 New England Medical Center Hospitals, Inc. Infant formula and infant formula additives
DE19619990A1 (de) 1996-05-17 1997-11-20 Charlotte Adler Verfahren zur Herstellung von Kolostralmilchprodukten sowie deren Verwendung
PL185442B1 (pl) 1996-10-03 2003-05-30 Georgiades Biotech Ltd Środek farmaceutyczny o działaniu immunologicznym i psychotropowym, jego postać terapeutyczna oraz zastosowanie

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008536914A (ja) * 2005-04-21 2008-09-11 エヌ.ブイ.・ヌートリシア Hiv患者における腸の機能不全の治療
JP2018500284A (ja) * 2014-11-04 2018-01-11 ゲオ−ポーランド スプウカ・ス・オルガニザツィーノン・オトゥポビエジャルノシチョン Bdnf依存性疾患の治療に使用されるプロリンリッチポリペプチド複合体
JP2021054837A (ja) * 2014-11-04 2021-04-08 ゲオ−ポーランド スプウカ・ス・オルガニザツィーノン・オトゥポビエジャルノシチョン Bdnf依存性疾患の治療に使用されるプロリンリッチポリペプチド複合体

Also Published As

Publication number Publication date
JP2008174561A (ja) 2008-07-31
KR100508764B1 (ko) 2005-08-17
CZ298215B6 (cs) 2007-07-25
RU2217152C2 (ru) 2003-11-27
GB9908331D0 (en) 1999-06-09
GB2333453B (en) 2001-05-30
CN1535722A (zh) 2004-10-13
EP0932623A1 (en) 1999-08-04
KR20000048886A (ko) 2000-07-25
PL185442B1 (pl) 2003-05-30
GB2333453A (en) 1999-07-28
IL129211A0 (en) 2000-02-17
ZA978885B (en) 1999-07-26
PL316416A1 (en) 1998-04-14
CA2266859C (en) 2012-05-08
WO1998014473A1 (en) 1998-04-09
GB2333453A8 (en) 2000-11-27
KR20050046766A (ko) 2005-05-18
TR199901022T2 (xx) 1999-07-21
US6852700B1 (en) 2005-02-08
BR9712259A (pt) 2000-01-25
HUP9904368A2 (hu) 2000-06-28
AR013612A1 (es) 2001-01-10
CN1238782A (zh) 1999-12-15
CA2266859A1 (en) 1998-04-09
IL129211A (en) 2004-08-31
AU4565197A (en) 1998-04-24
US20050152985A1 (en) 2005-07-14
HUP9904368A3 (en) 2000-07-28
CN1131712C (zh) 2003-12-24
CZ114999A3 (cs) 2000-06-14

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