JP2001501578A - パクリタクセルの前駆物質化合物からの合成及びその製造方法 - Google Patents

パクリタクセルの前駆物質化合物からの合成及びその製造方法

Info

Publication number
JP2001501578A
JP2001501578A JP09502161A JP50216197A JP2001501578A JP 2001501578 A JP2001501578 A JP 2001501578A JP 09502161 A JP09502161 A JP 09502161A JP 50216197 A JP50216197 A JP 50216197A JP 2001501578 A JP2001501578 A JP 2001501578A
Authority
JP
Japan
Prior art keywords
paclitaxel
iii
protected
protecting group
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP09502161A
Other languages
English (en)
Japanese (ja)
Inventor
ジェイ． システィ，ニコラス
エス． スウィンデル，チャールズ
シー． チャンダー，マッドハビ
Original Assignee
ナプロ バイオセラピューティクス，インコーポレイテッド
ブリン モーアー カレッジ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ナプロ バイオセラピューティクス，インコーポレイテッド, ブリン モーアー カレッジ filed Critical ナプロ バイオセラピューティクス，インコーポレイテッド
Publication of JP2001501578A publication Critical patent/JP2001501578A/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP09502161A 1995-06-07 1996-06-07 パクリタクセルの前駆物質化合物からの合成及びその製造方法 Ceased JP2001501578A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/483,082 US5948919A (en) 1993-02-05 1995-06-07 Paclitaxel synthesis from precursor compounds and methods of producing the same
US08/483,082 1995-06-07
PCT/US1996/010024 WO1996040666A1 (en) 1995-06-07 1996-06-07 Paclitaxel synthesis from precursor compounds and methods of producing the same

Publications (1)

Publication Number Publication Date
JP2001501578A true JP2001501578A (ja) 2001-02-06

Family

ID=23918577

Family Applications (1)

Application Number Title Priority Date Filing Date
JP09502161A Ceased JP2001501578A (ja) 1995-06-07 1996-06-07 パクリタクセルの前駆物質化合物からの合成及びその製造方法

Country Status (10)

Country Link
US (1) US5948919A (enExample)
EP (1) EP0847393B1 (enExample)
JP (1) JP2001501578A (enExample)
AT (1) ATE251147T1 (enExample)
AU (1) AU706872B2 (enExample)
CA (1) CA2222919A1 (enExample)
DE (1) DE69630230T2 (enExample)
EA (1) EA000678B1 (enExample)
GE (1) GEP19991873B (enExample)
WO (1) WO1996040666A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016518339A (ja) * 2013-03-15 2016-06-23 ジェンスペラ，インコーポレイテッド 癌組成物を作製する方法

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100225535B1 (ko) * 1996-08-27 1999-10-15 정지석 파클리탁셀의 제조방법
US5750737A (en) * 1996-09-25 1998-05-12 Sisti; Nicholas J. Method for paclitaxel synthesis
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
US7167711B1 (en) 1997-12-23 2007-01-23 Openwave Systems Inc. System and method for controlling financial transactions over a wireless network
DE69918300T2 (de) * 1998-05-01 2005-06-30 Napro Biotherapeutics, Inc., Boulder Verfahren und verwendbare zwischenprodukte für paclitaxel synthese von c-7,c-10 di-cbz baccatin iii
AU6051500A (en) * 1999-06-21 2001-01-09 Napro Biotherapeutics, Inc. C-2 hydroxyl protected-n-acyl(2r,3s)-3-phenylisoserine activated esters and methods for production thereof
JP4502338B2 (ja) * 1999-09-17 2010-07-14 株式会社横浜国際バイオ研究所 タキソイド化合物の製造法
US6414015B1 (en) 2000-01-28 2002-07-02 Utah State University Laulimalide microtubule stabilizing agents
US6358996B1 (en) 2000-06-09 2002-03-19 Napro Biotherapeutics, Inc. Stable isotope labeling of paclitaxel
WO2002076448A1 (en) * 2001-03-23 2002-10-03 Napro Biotherapeutics, Inc. Molecular conjugates for use in treatment of cancer
US6653501B2 (en) 2001-06-27 2003-11-25 Napro Biotherapeutics, Inc. Chiral resolution method for producing compounds useful in the synthesis of taxanes
WO2005113528A1 (en) * 2004-05-14 2005-12-01 Immunogen, Inc. A facile method for synthesizing baccatin iii compounds
CN102584632A (zh) * 2011-09-28 2012-07-18 北京东方协和医药生物技术有限公司 一种多西他赛手性侧链中间体的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5399726A (en) * 1993-01-29 1995-03-21 Florida State University Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
FR2687150B1 (fr) * 1992-02-07 1995-04-28 Rhone Poulenc Rorer Sa Procede de preparation de derives du taxane.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016518339A (ja) * 2013-03-15 2016-06-23 ジェンスペラ，インコーポレイテッド 癌組成物を作製する方法

Also Published As

Publication number Publication date
AU706872B2 (en) 1999-06-24
GEP19991873B (en) 1999-12-06
CA2222919A1 (en) 1996-12-19
EA199800024A1 (ru) 1998-06-25
EP0847393A4 (enExample) 1998-07-08
ATE251147T1 (de) 2003-10-15
WO1996040666A1 (en) 1996-12-19
EA000678B1 (ru) 2000-02-28
DE69630230D1 (de) 2003-11-06
EP0847393B1 (en) 2003-10-01
US5948919A (en) 1999-09-07
AU6170696A (en) 1996-12-30
DE69630230T2 (de) 2004-07-29
EP0847393A1 (en) 1998-06-17

Similar Documents

Publication Publication Date Title
JPH11513978A (ja) パクリタクセルの、その前駆物質化合物からの合成及びその製造方法
US5750737A (en) Method for paclitaxel synthesis
EP0847393B1 (en) Paclitaxel synthesis from precursor compounds and methods of producing the same
EP0837846B1 (en) C-2' hydroxyl-benzyl protected, n-carbamate protected (2r,3s)-3-phenylisoserine and production process therefor
EP0941219B1 (en) Intermediate for use in docetaxel synthesis and production method therefor
US6066749A (en) Method for conversion of C-2'-O-protected-10-hydroxy taxol to c-2'-O-protected taxol:useful intermediates in paclitaxel synthesis
US6048990A (en) Method for selective acylation of C-2'-O-protected-10-hydroxy-taxol at the C-10 position
US6136999A (en) C-2 hydroxyl protected-n-acyl (2R,3S)-3-phenylisoserine substituted phenyl activated esters and method for production thereof
US6143902A (en) C-2 hydroxyl protected-N-acyl (2R,3S)-3-phenylisoserine N-imido activated esters and method for production thereof
EP1082316B1 (en) Methods and useful intermediates for paclitaxel synthesis from c-7, c-10 di-cbz baccatin iii
CA2375343A1 (en) C-2 hydroxyl protected-n-acyl(2r,3s)-3-phenylisoserine activated esters and methods for production thereof

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20060905

A313 Final decision of rejection without a dissenting response from the applicant

Free format text: JAPANESE INTERMEDIATE CODE: A313

Effective date: 20070129

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20070227