EA199800024A1 - Синтез паклитаксела из соединений-предшественников и способы их получения - Google Patents

Синтез паклитаксела из соединений-предшественников и способы их получения

Info

Publication number
EA199800024A1
EA199800024A1 EA199800024A EA199800024A EA199800024A1 EA 199800024 A1 EA199800024 A1 EA 199800024A1 EA 199800024 A EA199800024 A EA 199800024A EA 199800024 A EA199800024 A EA 199800024A EA 199800024 A1 EA199800024 A1 EA 199800024A1
Authority
EA
Eurasian Patent Office
Prior art keywords
taxol
synthesis
analogs
predentional
packlite
Prior art date
Application number
EA199800024A
Other languages
English (en)
Other versions
EA000678B1 (ru
Inventor
Николас Дж. Систи
Чарльз С. Свинделл
Мадхави С. Чандер
Original Assignee
Напро Биотерапьютикс, Инк.
Брин Мор Колледж
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Напро Биотерапьютикс, Инк., Брин Мор Колледж filed Critical Напро Биотерапьютикс, Инк.
Publication of EA199800024A1 publication Critical patent/EA199800024A1/ru
Publication of EA000678B1 publication Critical patent/EA000678B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Настоящее изобретение относится к промежуточному соединению паклитаксела и способу его получения, включающему конденсацию кислоты с подходящей защищенной боковой цепью и производного баккатина III.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800024A 1995-06-07 1996-06-07 Промежуточное соединение для получения паклитаксела и способ получения промежуточного соединения EA000678B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/483,082 US5948919A (en) 1993-02-05 1995-06-07 Paclitaxel synthesis from precursor compounds and methods of producing the same
PCT/US1996/010024 WO1996040666A1 (en) 1995-06-07 1996-06-07 Paclitaxel synthesis from precursor compounds and methods of producing the same

Publications (2)

Publication Number Publication Date
EA199800024A1 true EA199800024A1 (ru) 1998-06-25
EA000678B1 EA000678B1 (ru) 2000-02-28

Family

ID=23918577

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800024A EA000678B1 (ru) 1995-06-07 1996-06-07 Промежуточное соединение для получения паклитаксела и способ получения промежуточного соединения

Country Status (10)

Country Link
US (1) US5948919A (ru)
EP (1) EP0847393B1 (ru)
JP (1) JP2001501578A (ru)
AT (1) ATE251147T1 (ru)
AU (1) AU706872B2 (ru)
CA (1) CA2222919A1 (ru)
DE (1) DE69630230T2 (ru)
EA (1) EA000678B1 (ru)
GE (1) GEP19991873B (ru)
WO (1) WO1996040666A1 (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100225535B1 (ko) * 1996-08-27 1999-10-15 정지석 파클리탁셀의 제조방법
US5750737A (en) * 1996-09-25 1998-05-12 Sisti; Nicholas J. Method for paclitaxel synthesis
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
US7167711B1 (en) 1997-12-23 2007-01-23 Openwave Systems Inc. System and method for controlling financial transactions over a wireless network
PT1082316E (pt) 1998-05-01 2004-11-30 Napro Biotherapeutics Inc Processos e intermediarios uteis para a sintese de paclitaxel a partir de c-7,c-10-di-cbz-bacatina iii
JP2003502401A (ja) * 1999-06-21 2003-01-21 ナプロ バイオセラピューティクス，インコーポレイテッド Ｃ−２ヒドロキシル保護−ｎ−アシル（２ｒ，３ｓ）−３−フェニルイソセリン活性化エステルおよびそれらの製造方法
JP4502338B2 (ja) * 1999-09-17 2010-07-14 株式会社横浜国際バイオ研究所 タキソイド化合物の製造法
US6414015B1 (en) 2000-01-28 2002-07-02 Utah State University Laulimalide microtubule stabilizing agents
US6358996B1 (en) 2000-06-09 2002-03-19 Napro Biotherapeutics, Inc. Stable isotope labeling of paclitaxel
CA2441484A1 (en) * 2001-03-23 2002-10-03 Napro Biotherapeutics, Inc. Molecular conjugates for use in treatment of cancer
US6653501B2 (en) 2001-06-27 2003-11-25 Napro Biotherapeutics, Inc. Chiral resolution method for producing compounds useful in the synthesis of taxanes
AU2005245396A1 (en) * 2004-05-14 2005-12-01 Immunogen, Inc. A facile method for synthesizing baccatin III compounds
CN102584632A (zh) * 2011-09-28 2012-07-18 北京东方协和医药生物技术有限公司 一种多西他赛手性侧链中间体的制备方法
KR20150132225A (ko) * 2013-03-15 2015-11-25 젠스페라, 아이엔씨. 암 조성물을 제조하는 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5399726A (en) * 1993-01-29 1995-03-21 Florida State University Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
FR2687150B1 (fr) * 1992-02-07 1995-04-28 Rhone Poulenc Rorer Sa Procede de preparation de derives du taxane.

Also Published As

Publication number Publication date
DE69630230T2 (de) 2004-07-29
JP2001501578A (ja) 2001-02-06
WO1996040666A1 (en) 1996-12-19
EA000678B1 (ru) 2000-02-28
ATE251147T1 (de) 2003-10-15
AU6170696A (en) 1996-12-30
EP0847393A4 (ru) 1998-07-08
EP0847393B1 (en) 2003-10-01
CA2222919A1 (en) 1996-12-19
EP0847393A1 (en) 1998-06-17
AU706872B2 (en) 1999-06-24
GEP19991873B (en) 1999-12-06
US5948919A (en) 1999-09-07
DE69630230D1 (de) 2003-11-06

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU