JP2001500477A - インドリシジンのアナログを用いて感染を処置するための組成物および方法 - Google Patents

インドリシジンのアナログを用いて感染を処置するための組成物および方法

Info

Publication number
JP2001500477A
JP2001500477A JP10510994A JP51099498A JP2001500477A JP 2001500477 A JP2001500477 A JP 2001500477A JP 10510994 A JP10510994 A JP 10510994A JP 51099498 A JP51099498 A JP 51099498A JP 2001500477 A JP2001500477 A JP 2001500477A
Authority
JP
Japan
Prior art keywords
analog
peptide
spp
indolicidin
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10510994A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001500477A5 (enExample
Inventor
アール． フレイサー，ジャネット
エイチ．ピー． ウエスト，マイケル
ジェイ． クリーガー，ティモシー
テイラー，ロバート
アーフル，ダグラス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JP2001500477A publication Critical patent/JP2001500477A/ja
Publication of JP2001500477A5 publication Critical patent/JP2001500477A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP10510994A 1996-08-21 1997-08-21 インドリシジンのアナログを用いて感染を処置するための組成物および方法 Pending JP2001500477A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2475496P 1996-08-21 1996-08-21
US3494997P 1997-01-13 1997-01-13
US60/034,949 1997-01-13
US60/024,754 1997-01-13
PCT/US1997/014779 WO1998007745A2 (en) 1996-08-21 1997-08-21 Compositions and methods for treating infections using analogues of indolicidin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2004242925A Division JP4073900B2 (ja) 1996-08-21 2004-08-23 インドリシジンのアナログを用いて感染を処置するための組成物および方法

Publications (2)

Publication Number Publication Date
JP2001500477A true JP2001500477A (ja) 2001-01-16
JP2001500477A5 JP2001500477A5 (enExample) 2005-04-07

Family

ID=26698836

Family Applications (2)

Application Number Title Priority Date Filing Date
JP10510994A Pending JP2001500477A (ja) 1996-08-21 1997-08-21 インドリシジンのアナログを用いて感染を処置するための組成物および方法
JP2004242925A Expired - Fee Related JP4073900B2 (ja) 1996-08-21 2004-08-23 インドリシジンのアナログを用いて感染を処置するための組成物および方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2004242925A Expired - Fee Related JP4073900B2 (ja) 1996-08-21 2004-08-23 インドリシジンのアナログを用いて感染を処置するための組成物および方法

Country Status (9)

Country Link
US (4) US6180604B1 (enExample)
EP (1) EP0925308B1 (enExample)
JP (2) JP2001500477A (enExample)
AT (2) ATE410441T1 (enExample)
CA (1) CA2263799A1 (enExample)
DE (2) DE69739035D1 (enExample)
ES (2) ES2315252T3 (enExample)
HK (1) HK1043475B (enExample)
WO (1) WO1998007745A2 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005504769A (ja) * 2001-08-21 2005-02-17 マイクロロジックス　バイオテック，インコーポレイテッド 抗菌性カチオン性ペプチドおよびそれらの処方物
JP2005516889A (ja) * 2001-08-24 2005-06-09 マイクロロジックス バイオテック， インコーポレイテッド 抗菌性および抗炎症性ペプチド
WO2009154264A1 (ja) * 2008-06-20 2009-12-23 学校法人福岡大学 ペプチド
US8697639B2 (en) 2005-07-28 2014-04-15 Biosynexus Incorporated Compositions and methods for treating bacteria
JP2016530315A (ja) * 2013-09-12 2016-09-29 アリオス バイオファーマ インク． ピリダジノン化合物およびその用途

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE20000918A1 (en) * 1990-03-22 2001-05-30 Sloan Kettering Inst Cancer GP75 As a Tumor Vaccine for Melanoma
US6180604B1 (en) 1996-08-21 2001-01-30 Micrologix Biotech Inc. Compositions and methods for treating infections using analogues of indolicidin
US6503881B2 (en) * 1996-08-21 2003-01-07 Micrologix Biotech Inc. Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
WO1999043357A1 (en) * 1998-02-25 1999-09-02 Micrologix Biotech Inc. Indolicidin and cationic peptides conjugated with polymers
US6303575B1 (en) * 1998-05-12 2001-10-16 The Regents Of The University Of California Indolicidin analogs and methods of using same
WO1999065506A2 (en) * 1998-06-12 1999-12-23 Micrologix Biotech Inc. Cancer therapy with indolicidin or cationic peptides and their polymer conjugates
US6444645B1 (en) * 1998-06-18 2002-09-03 The Regents Of The University Of California Crosslink-stabilized indolicidin analogs
US6288212B1 (en) * 1998-08-28 2001-09-11 The University Of British Columbia Anti-endotoxic, antimicrobial cationic peptides and methods of use therefor
WO2000026344A1 (en) * 1998-10-30 2000-05-11 Interlink Biotechnologies Llc Peptides with enhanced stability to protease degradation
US6946261B1 (en) 1998-11-20 2005-09-20 Migenix Inc. Efficient methods for producing anti-microbial cationic peptides in host cells
EP1185623A4 (en) * 1999-03-03 2005-03-23 Regents Board Of Genetic and epigenetic manipulation of abc transporters and ecto-phosphatases for the conference of drug resistance and for the loss of drug resistance in biological systems and methods for the detection of ecto-phosphatase inhibitors
US6309633B1 (en) * 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US6576224B1 (en) 1999-07-06 2003-06-10 Sinuspharma, Inc. Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
US6429211B1 (en) * 2000-05-23 2002-08-06 Bayer Corporation Praziquantel compounds for treating diseases due to Sarcocystis Neospora Toxoplasma and Isospora
PL363153A1 (en) * 2000-06-16 2004-11-15 Hercules Incorporated Chemically-modified antimicrobial peptides, compositions and methods of production and use
KR20090089922A (ko) 2000-10-18 2009-08-24 파마셋 인코포레이티드 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드
US7214364B2 (en) 2000-12-27 2007-05-08 Corus Pharma, Inc. Inhalable aztreonam lysinate formulation for treatment and prevention of pulmonary bacterial infections
DK2301524T3 (da) 2000-12-27 2013-07-15 Gilead Sciences Inc Inhalerbar aztreonam uden arginin til behandling og forebyggelse af bakterielle lungeinfektioner
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7060675B2 (en) 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US7115572B2 (en) * 2001-03-29 2006-10-03 Council Of Scientific And Industrial Research Indolicidin analogs with anti-microbial activity
US6759058B1 (en) * 2001-04-25 2004-07-06 Western Center For Drug Development College Of Pharmacy Western University Of Health Sciences Enteric-coated proliposomal formulations for poorly water soluble drugs
US8658202B2 (en) 2001-04-25 2014-02-25 Western University Of Health Sciences Coated drug delivery formulations
US6858580B2 (en) 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
EP1401478A2 (en) * 2001-06-22 2004-03-31 The Hospital for Sick Children Antimicrobial peptides
US6734165B2 (en) * 2001-08-23 2004-05-11 The Trustees Of Columbia University In The City Of New York Method for re-sensitizing vancomycin resistant bacteria which selectively cleave a cell wall depsipeptide
US7166571B2 (en) 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7312192B2 (en) 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US20030219854A1 (en) * 2002-03-21 2003-11-27 Micrologix Biotech Inc. Methods for producing modified anti-infective peptides
US7399583B2 (en) * 2002-04-17 2008-07-15 Novartis Ag Method for the identification of inhibitors of the binding of ARE-containing mRNA and a HuR protein
AU2003231471A1 (en) * 2002-04-25 2003-11-10 Toagosei Co., Ltd. Antimicrobial polypeptide and utizliation thereof
US7345018B2 (en) 2002-04-25 2008-03-18 Reception Aps Method of treating side effects induced by therapeutic agents
WO2003105768A2 (en) 2002-06-13 2003-12-24 Nobex Corporation Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
IL150907A (en) * 2002-07-25 2007-07-04 Stephan Cherkez Process for the preparation of stable amorphous calcium pseudomonate
SE0202613D0 (sv) 2002-09-04 2002-09-04 Innate Pharmaceuticals Ab Förfarande och prob för identifiering av ämnen som modifierar bakteriers virulens, som sådana identifierade ämnen samt deras användning
US7238669B2 (en) * 2002-09-11 2007-07-03 The Curators Of The University Of Missouri Phage-display peptides as novel antimicrobial agents against Haemophilus influenzae
US20050245582A1 (en) * 2002-09-12 2005-11-03 The Hartz Mountain Corporation High concentration topical insecticides containing pyrethroids
WO2005014777A2 (en) * 2002-10-16 2005-02-17 Board Of Regents, The University Of Texas System Methods and compositions for increasing the efficacy of biologically-active ingredients
KR20110079783A (ko) 2003-02-19 2011-07-07 예일 유니버시티 항-바이러스 뉴클레오시드 유사체 및 바이러스 감염, 특히 에이치아이브이 감염의 치료방법
US20040260454A1 (en) * 2003-06-11 2004-12-23 Basir Otman A. Vibro-acoustic engine diagnostic system
US7189403B2 (en) * 2003-06-30 2007-03-13 Institut Pasteur Attenuated flavivirus strains containing a mutated M-ectodomain and their applications
US20050171063A1 (en) * 2003-10-20 2005-08-04 Pawan Malhotra Use of phosphono derivatives as anti-malarials
WO2005039557A1 (en) * 2003-10-22 2005-05-06 Council Of Scientific And Industrial Research Use of selected amino acid-zinc complexes as anti-malarial
US7674771B2 (en) * 2003-10-29 2010-03-09 Toagosei Co., Ltd Antimicrobial peptides and utilization of the same
CA2559208A1 (en) * 2004-03-17 2005-09-29 Mpex Pharmaceuticals, Inc. Use and administration of bacterial efflux pump inhibitors
US7994225B2 (en) * 2004-03-17 2011-08-09 Rempex Pharmaceuticals, Inc. Bacterial efflux pump inhibitors for the treatment of ophthalmic and otic infections
WO2005090385A2 (en) * 2004-03-18 2005-09-29 Ansata Therapeutics, Inc. Compositions having antimicrobial activity and uses thereof
CN101027318B (zh) 2004-07-19 2016-05-25 比奥孔有限公司 胰岛素-低聚物共轭物，制剂及其用途
JP4507080B2 (ja) * 2004-07-30 2010-07-21 東亞合成株式会社 抗菌ペプチド及びその利用
US7588885B2 (en) * 2004-08-06 2009-09-15 Chung Yuan Christian University Use of biocistronic DNA constructs for identifying compounds that inhibit IRES-dependent translation
US20060068020A1 (en) * 2004-09-24 2006-03-30 Cottrell Ian W Encapsulated pharmaceutical agents
JP4730584B2 (ja) * 2004-12-06 2011-07-20 東亞合成株式会社 抗菌ペプチド及びその利用
EP1849474B1 (en) * 2005-02-15 2016-09-07 Toagosei Co., Ltd. Antimicrobial peptide and use thereof
US20090099062A1 (en) * 2007-05-31 2009-04-16 Ethan Lee Pyrvinium For The Treatment of Cancer
US9241908B2 (en) 2007-10-16 2016-01-26 Biocon Limited Orally administrable solid pharmaceutical composition and a process thereof
ES2559840T3 (es) * 2008-06-04 2016-02-16 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
US8773662B2 (en) * 2010-07-22 2014-07-08 Vuv Analytics, Inc. Methods and apparatus for vacuum ultraviolet (VUV) or shorter wavelength circular dichroism spectroscopy
WO2012017215A1 (en) * 2010-08-05 2012-02-09 Helperby Therapeutics Limited Combination of a pyrroloquinoline compound and a beta-lactam antimicrobial agent, mupirocin or chlorhexidine
CN102167731B (zh) * 2011-02-10 2013-01-23 周逸明 一种固相多肽合成奥米加南的制备方法
WO2013056003A2 (en) 2011-10-12 2013-04-18 Yale University Catechol diethers as potent anti-hiv agents
WO2015077057A1 (en) * 2013-11-20 2015-05-28 Texas Southern University Methionine aminopeptidase inhibitors for treating infectious diseases
RU2678985C2 (ru) * 2017-02-06 2019-02-05 Общество с ограниченной ответственностью "Научно-производственная фирма ВЕРТА" Биоцидный пептид и препарат на его основе
CN108721292B (zh) * 2018-05-04 2022-04-01 中国疾病预防控制中心病毒病预防控制所 扑蛲灵在制备广谱抗冠状病毒药物中的应用
US12702790B2 (en) 2019-06-13 2026-08-11 Hollister Incorporated Reusable urinary catheter kits
LT3952973T (lt) 2019-06-13 2023-07-10 Hollister Incorporated Daugkartinio naudojimo šlapimo kateterio produktai
WO2020263859A1 (en) 2019-06-25 2020-12-30 Hollister Incorporated Reusable urinary catheter products
KR102433665B1 (ko) * 2021-11-17 2022-08-19 주식회사 씨위드 인돌리시딘 유래 항균 펩타이드 및 이의 용도

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2128617A (en) 1982-10-06 1984-05-02 Martti Vaara Polypeptides for use in antibacterial therapy
NZ237202A (en) 1990-02-23 1994-01-26 Bristol Myers Squibb Co Composition containing beta-lactam antibiotic and cationic oligopeptide
US5547939A (en) 1991-06-14 1996-08-20 The Regents Of The University Of California Broad spectrum antimicrobial compounds and methods of use
US5324716A (en) 1991-06-14 1994-06-28 Regents Of The University Of California Broad spectrum antimicrobial compounds and methods of use
US5593866A (en) 1992-08-21 1997-01-14 The University Of British Columbia Cationic peptides and method for production
US5359030A (en) 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
US5681811A (en) 1993-05-10 1997-10-28 Protein Delivery, Inc. Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same
DK0759774T3 (da) 1993-09-22 2002-10-07 Xoma Technology Ltd Fremgangsmåde til behandling af gram-negativ bakteriel infektion ved indgivelse af baktericidt/permeabilitet-forøgende (BPI) proteinprodukt og antibiotikum
DE69424680T2 (de) * 1993-10-25 2000-09-28 The Liposome Co.,Inc. Liposomale defensine
CA2181164C (en) 1994-01-14 2008-01-08 Arnold Horwitz Anti-gram-positive bacterial methods and materials
US5574017A (en) * 1994-07-05 1996-11-12 Gutheil; William G. Antibacterial agents
US5877274A (en) 1995-06-02 1999-03-02 University Of British Columbia Antimicrobial cationic peptides
DE69637731D1 (de) 1995-08-23 2008-12-11 Univ British Columbia Antimikrobielle kationische peptide und methoden zu ihrer identifizierung
US5994308A (en) 1996-02-28 1999-11-30 Board Of Trustees Of Southern Illinois University Broad spectrum antimicrobial peptides containing a tryptophan triplet and methods of use
US6503881B2 (en) * 1996-08-21 2003-01-07 Micrologix Biotech Inc. Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
US6180604B1 (en) * 1996-08-21 2001-01-30 Micrologix Biotech Inc. Compositions and methods for treating infections using analogues of indolicidin
US6551994B1 (en) 1997-04-10 2003-04-22 Mcgill University Compounds and methods for inhibiting the interaction between α-catenin and β-catenin
WO1999043357A1 (en) 1998-02-25 1999-09-02 Micrologix Biotech Inc. Indolicidin and cationic peptides conjugated with polymers

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005504769A (ja) * 2001-08-21 2005-02-17 マイクロロジックス　バイオテック，インコーポレイテッド 抗菌性カチオン性ペプチドおよびそれらの処方物
JP2012041367A (ja) * 2001-08-21 2012-03-01 Carrus Capital Corp 抗菌性カチオン性ペプチドおよびそれらの処方物
JP4932136B2 (ja) * 2001-08-21 2012-05-16 カーラス キャピタル コーポレイション 抗菌性カチオン性ペプチドおよびそれらの処方物
JP2005516889A (ja) * 2001-08-24 2005-06-09 マイクロロジックス バイオテック， インコーポレイテッド 抗菌性および抗炎症性ペプチド
US8697639B2 (en) 2005-07-28 2014-04-15 Biosynexus Incorporated Compositions and methods for treating bacteria
WO2009154264A1 (ja) * 2008-06-20 2009-12-23 学校法人福岡大学 ペプチド
JP2016530315A (ja) * 2013-09-12 2016-09-29 アリオス バイオファーマ インク． ピリダジノン化合物およびその用途
US10364226B2 (en) 2013-09-12 2019-07-30 Alios Biopharma, Inc. Pyridazinone compounds and uses thereof

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US20040009910A1 (en) 2004-01-15
EP0925308B1 (en) 2002-06-05
ATE410441T1 (de) 2008-10-15
JP2005225857A (ja) 2005-08-25
US6180604B1 (en) 2001-01-30
WO1998007745A2 (en) 1998-02-26
US20080242614A1 (en) 2008-10-02
DE69713112T2 (de) 2003-01-30
WO1998007745A3 (en) 1998-07-09
US7390787B2 (en) 2008-06-24
EP0925308A2 (en) 1999-06-30
DE69713112D1 (de) 2002-07-11
HK1043475A1 (en) 2002-09-13
US6538106B1 (en) 2003-03-25
CA2263799A1 (en) 1998-02-26
HK1021824A1 (en) 2000-07-07
ES2315252T3 (es) 2009-04-01
HK1043475B (en) 2009-07-03
ATE218579T1 (de) 2002-06-15
JP4073900B2 (ja) 2008-04-09
DE69739035D1 (de) 2008-11-20

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