DE69713112T2 - Zusammensetzungen und methoden zur behandlung von infektionen unter verwendung von indolicidin-analogen - Google Patents
Zusammensetzungen und methoden zur behandlung von infektionen unter verwendung von indolicidin-analogenInfo
- Publication number
- DE69713112T2 DE69713112T2 DE69713112T DE69713112T DE69713112T2 DE 69713112 T2 DE69713112 T2 DE 69713112T2 DE 69713112 T DE69713112 T DE 69713112T DE 69713112 T DE69713112 T DE 69713112T DE 69713112 T2 DE69713112 T2 DE 69713112T2
- Authority
- DE
- Germany
- Prior art keywords
- peptide
- spp
- analogue
- mbi
- peptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 78
- 208000015181 infectious disease Diseases 0.000 title claims abstract description 56
- 238000000034 method Methods 0.000 title abstract description 50
- 150000001413 amino acids Chemical class 0.000 claims abstract description 27
- USSYUMHVHQSYNA-SLDJZXPVSA-N indolicidin Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)CC1=CNC2=CC=CC=C12 USSYUMHVHQSYNA-SLDJZXPVSA-N 0.000 claims abstract description 7
- 238000002347 injection Methods 0.000 claims description 50
- 239000007924 injection Substances 0.000 claims description 50
- HAJKHJOABGFIGP-UHFFFAOYSA-N indolizidine Chemical class C1CCCN2CCCC21 HAJKHJOABGFIGP-UHFFFAOYSA-N 0.000 claims description 49
- 241000894006 Bacteria Species 0.000 claims description 35
- 210000004027 cell Anatomy 0.000 claims description 27
- 239000003242 anti bacterial agent Substances 0.000 claims description 26
- 239000000872 buffer Substances 0.000 claims description 23
- 239000002502 liposome Substances 0.000 claims description 23
- 229940088710 antibiotic agent Drugs 0.000 claims description 21
- 230000003115 biocidal effect Effects 0.000 claims description 19
- 244000005700 microbiome Species 0.000 claims description 17
- 239000008194 pharmaceutical composition Substances 0.000 claims description 17
- 241000588724 Escherichia coli Species 0.000 claims description 15
- -1 co-amoxiclavulanate Chemical compound 0.000 claims description 13
- 239000013604 expression vector Substances 0.000 claims description 13
- 238000010253 intravenous injection Methods 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 239000003981 vehicle Substances 0.000 claims description 10
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims description 9
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 claims description 9
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims description 9
- 241000233866 Fungi Species 0.000 claims description 8
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- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims description 7
- 238000002513 implantation Methods 0.000 claims description 7
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- 150000008574 D-amino acids Chemical class 0.000 claims description 6
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- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 claims description 6
- 229960002518 gentamicin Drugs 0.000 claims description 6
- IVBHGBMCVLDMKU-GXNBUGAJSA-N piperacillin Chemical compound O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 IVBHGBMCVLDMKU-GXNBUGAJSA-N 0.000 claims description 6
- 229920001515 polyalkylene glycol Polymers 0.000 claims description 6
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- 150000003522 tetracyclines Chemical class 0.000 claims description 6
- MINDHVHHQZYEEK-UHFFFAOYSA-N (E)-(2S,3R,4R,5S)-5-[(2S,3S,4S,5S)-2,3-epoxy-5-hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy-(beta)-methyl-2H-pyran-2-crotonic acid ester with 9-hydroxynonanoic acid Natural products CC(O)C(C)C1OC1CC1C(O)C(O)C(CC(C)=CC(=O)OCCCCCCCCC(O)=O)OC1 MINDHVHHQZYEEK-UHFFFAOYSA-N 0.000 claims description 5
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims description 5
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims description 5
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims description 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 5
- 229960005091 chloramphenicol Drugs 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 229960003128 mupirocin Drugs 0.000 claims description 5
- 229930187697 mupirocin Natural products 0.000 claims description 5
- DDHVILIIHBIMQU-YJGQQKNPSA-L mupirocin calcium hydrate Chemical compound O.O.[Ca+2].C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)OC1.C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)OC1 DDHVILIIHBIMQU-YJGQQKNPSA-L 0.000 claims description 5
- 150000007523 nucleic acids Chemical class 0.000 claims description 5
- 229960002292 piperacillin Drugs 0.000 claims description 5
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 claims description 5
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 claims description 4
- UKAUYVFTDYCKQA-UHFFFAOYSA-N -2-Amino-4-hydroxybutanoic acid Natural products OC(=O)C(N)CCO UKAUYVFTDYCKQA-UHFFFAOYSA-N 0.000 claims description 4
- 229930186147 Cephalosporin Natural products 0.000 claims description 4
- UKAUYVFTDYCKQA-VKHMYHEASA-N L-homoserine Chemical compound OC(=O)[C@@H](N)CCO UKAUYVFTDYCKQA-VKHMYHEASA-N 0.000 claims description 4
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 4
- 229930182555 Penicillin Natural products 0.000 claims description 4
- 108010059993 Vancomycin Proteins 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 claims description 4
- 229940126575 aminoglycoside Drugs 0.000 claims description 4
- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 claims description 4
- WZOZEZRFJCJXNZ-ZBFHGGJFSA-N cefoxitin Chemical compound N([C@]1(OC)C(N2C(=C(COC(N)=O)CS[C@@H]21)C(O)=O)=O)C(=O)CC1=CC=CS1 WZOZEZRFJCJXNZ-ZBFHGGJFSA-N 0.000 claims description 4
- VAAUVRVFOQPIGI-SPQHTLEESA-N ceftriaxone Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC1=NC(=O)C(=O)NN1C VAAUVRVFOQPIGI-SPQHTLEESA-N 0.000 claims description 4
- 229940124587 cephalosporin Drugs 0.000 claims description 4
- 150000001780 cephalosporins Chemical class 0.000 claims description 4
- 229960003405 ciprofloxacin Drugs 0.000 claims description 4
- 229940124307 fluoroquinolone Drugs 0.000 claims description 4
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 claims description 4
- 239000003120 macrolide antibiotic agent Substances 0.000 claims description 4
- 229940041033 macrolides Drugs 0.000 claims description 4
- 229960003085 meticillin Drugs 0.000 claims description 4
- 229940041009 monobactams Drugs 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 244000045947 parasite Species 0.000 claims description 4
- 150000002960 penicillins Chemical class 0.000 claims description 4
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 claims description 4
- 229960003165 vancomycin Drugs 0.000 claims description 4
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims description 4
- NNRXCKZMQLFUPL-WBMZRJHASA-N (3r,4s,5s,6r,7r,9r,11r,12r,13s,14r)-6-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione;(2r,3 Chemical compound OC(=O)[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O.O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 NNRXCKZMQLFUPL-WBMZRJHASA-N 0.000 claims description 3
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- RXZBMPWDPOLZGW-XMRMVWPWSA-N (E)-roxithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N/OCOCCOC)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 RXZBMPWDPOLZGW-XMRMVWPWSA-N 0.000 claims description 3
- GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 claims description 3
- 241000194032 Enterococcus faecalis Species 0.000 claims description 3
- YAVZHCFFUATPRK-YZPBMOCRSA-N Erythromycin stearate Chemical compound CCCCCCCCCCCCCCCCCC(O)=O.O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 YAVZHCFFUATPRK-YZPBMOCRSA-N 0.000 claims description 3
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- GPRBEKHLDVQUJE-VINNURBNSA-N cefotaxime Chemical compound N([C@@H]1C(N2C(=C(COC(C)=O)CS[C@@H]21)C(O)=O)=O)C(=O)/C(=N/OC)C1=CSC(N)=N1 GPRBEKHLDVQUJE-VINNURBNSA-N 0.000 claims description 3
- SRZNHPXWXCNNDU-RHBCBLIFSA-N cefotetan Chemical compound N([C@]1(OC)C(N2C(=C(CSC=3N(N=NN=3)C)CS[C@@H]21)C(O)=O)=O)C(=O)C1SC(=C(C(N)=O)C(O)=O)S1 SRZNHPXWXCNNDU-RHBCBLIFSA-N 0.000 claims description 3
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2475496P | 1996-08-21 | 1996-08-21 | |
| US3494997P | 1997-01-13 | 1997-01-13 | |
| PCT/US1997/014779 WO1998007745A2 (en) | 1996-08-21 | 1997-08-21 | Compositions and methods for treating infections using analogues of indolicidin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69713112D1 DE69713112D1 (de) | 2002-07-11 |
| DE69713112T2 true DE69713112T2 (de) | 2003-01-30 |
Family
ID=26698836
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69713112T Expired - Lifetime DE69713112T2 (de) | 1996-08-21 | 1997-08-21 | Zusammensetzungen und methoden zur behandlung von infektionen unter verwendung von indolicidin-analogen |
| DE69739035T Expired - Lifetime DE69739035D1 (de) | 1996-08-21 | 1997-08-21 | Zusammensetzungen und Methoden zur Behandlung von Infektionen unter Verwendung von Indolicidinanalogen |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69739035T Expired - Lifetime DE69739035D1 (de) | 1996-08-21 | 1997-08-21 | Zusammensetzungen und Methoden zur Behandlung von Infektionen unter Verwendung von Indolicidinanalogen |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US6180604B1 (enExample) |
| EP (1) | EP0925308B1 (enExample) |
| JP (2) | JP2001500477A (enExample) |
| AT (2) | ATE410441T1 (enExample) |
| CA (1) | CA2263799A1 (enExample) |
| DE (2) | DE69713112T2 (enExample) |
| ES (2) | ES2178000T3 (enExample) |
| HK (1) | HK1043475B (enExample) |
| WO (1) | WO1998007745A2 (enExample) |
Families Citing this family (76)
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|---|---|---|---|---|
| IE910820A1 (en) * | 1990-03-22 | 1991-09-25 | Sloan Kettering Inst Cancer | Gp75 as a tumor vaccine for melanoma |
| US6180604B1 (en) * | 1996-08-21 | 2001-01-30 | Micrologix Biotech Inc. | Compositions and methods for treating infections using analogues of indolicidin |
| US6503881B2 (en) * | 1996-08-21 | 2003-01-07 | Micrologix Biotech Inc. | Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics |
| WO1999043357A1 (en) * | 1998-02-25 | 1999-09-02 | Micrologix Biotech Inc. | Indolicidin and cationic peptides conjugated with polymers |
| US6303575B1 (en) * | 1998-05-12 | 2001-10-16 | The Regents Of The University Of California | Indolicidin analogs and methods of using same |
| AU4253799A (en) * | 1998-06-12 | 2000-01-05 | Micrologix Biotech, Inc. | Cancer therapy with cationic peptides |
| US6444645B1 (en) * | 1998-06-18 | 2002-09-03 | The Regents Of The University Of California | Crosslink-stabilized indolicidin analogs |
| US6288212B1 (en) * | 1998-08-28 | 2001-09-11 | The University Of British Columbia | Anti-endotoxic, antimicrobial cationic peptides and methods of use therefor |
| WO2000026344A1 (en) * | 1998-10-30 | 2000-05-11 | Interlink Biotechnologies Llc | Peptides with enhanced stability to protease degradation |
| US6946261B1 (en) * | 1998-11-20 | 2005-09-20 | Migenix Inc. | Efficient methods for producing anti-microbial cationic peptides in host cells |
| AU782306B2 (en) * | 1999-03-03 | 2005-07-21 | Board Of Regents, The University Of Texas System | Genetic and epigenetic manipulation of ABC transporters and ecto-phosphatases for the conference of drug resistance and for the loss of drug resistance in biological systems and methods for the detection of ecto-phosphatase inhibitors |
| US7169889B1 (en) | 1999-06-19 | 2007-01-30 | Biocon Limited | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin |
| US6309633B1 (en) * | 1999-06-19 | 2001-10-30 | Nobex Corporation | Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same |
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| US6429211B1 (en) * | 2000-05-23 | 2002-08-06 | Bayer Corporation | Praziquantel compounds for treating diseases due to Sarcocystis Neospora Toxoplasma and Isospora |
| CA2412011A1 (en) | 2000-06-16 | 2001-12-27 | Hercules Incorporated | Chemically-modified antimicrobial peptides, compositions and methods of production and use |
| CA2426187C (en) | 2000-10-18 | 2011-08-16 | Pharmasset Limited | Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation |
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| US7115572B2 (en) * | 2001-03-29 | 2006-10-03 | Council Of Scientific And Industrial Research | Indolicidin analogs with anti-microbial activity |
| US8658202B2 (en) | 2001-04-25 | 2014-02-25 | Western University Of Health Sciences | Coated drug delivery formulations |
| US6759058B1 (en) * | 2001-04-25 | 2004-07-06 | Western Center For Drug Development College Of Pharmacy Western University Of Health Sciences | Enteric-coated proliposomal formulations for poorly water soluble drugs |
| US6713452B2 (en) | 2001-06-04 | 2004-03-30 | Nobex Corporation | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US6828297B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US6858580B2 (en) | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| EP1401478A2 (en) * | 2001-06-22 | 2004-03-31 | The Hospital for Sick Children | Antimicrobial peptides |
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| US6734165B2 (en) * | 2001-08-23 | 2004-05-11 | The Trustees Of Columbia University In The City Of New York | Method for re-sensitizing vancomycin resistant bacteria which selectively cleave a cell wall depsipeptide |
| CA2457885A1 (en) * | 2001-08-24 | 2003-03-06 | Micrologix Biotech Inc. | Antimicrobial and anti-inflammatory peptides |
| US7196059B2 (en) | 2001-09-07 | 2007-03-27 | Biocon Limited | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
| US7312192B2 (en) | 2001-09-07 | 2007-12-25 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
| US6913903B2 (en) | 2001-09-07 | 2005-07-05 | Nobex Corporation | Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
| US7166571B2 (en) | 2001-09-07 | 2007-01-23 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
| US20030219854A1 (en) * | 2002-03-21 | 2003-11-27 | Micrologix Biotech Inc. | Methods for producing modified anti-infective peptides |
| EP1497327A2 (en) * | 2002-04-17 | 2005-01-19 | Novartis AG | Method for the identification of inhibitors of the binding of are-containing mrna and an hur protein |
| US7345018B2 (en) | 2002-04-25 | 2008-03-18 | Reception Aps | Method of treating side effects induced by therapeutic agents |
| AU2003231471A1 (en) * | 2002-04-25 | 2003-11-10 | Toagosei Co., Ltd. | Antimicrobial polypeptide and utizliation thereof |
| US7601688B2 (en) | 2002-06-13 | 2009-10-13 | Biocon Limited | Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus |
| IL150907A (en) * | 2002-07-25 | 2007-07-04 | Stephan Cherkez | Process for the preparation of stable amorphous calcium pseudomonate |
| SE0202613D0 (sv) * | 2002-09-04 | 2002-09-04 | Innate Pharmaceuticals Ab | Förfarande och prob för identifiering av ämnen som modifierar bakteriers virulens, som sådana identifierade ämnen samt deras användning |
| US7238669B2 (en) * | 2002-09-11 | 2007-07-03 | The Curators Of The University Of Missouri | Phage-display peptides as novel antimicrobial agents against Haemophilus influenzae |
| US20050245582A1 (en) * | 2002-09-12 | 2005-11-03 | The Hartz Mountain Corporation | High concentration topical insecticides containing pyrethroids |
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| CA2514466C (en) | 2003-02-19 | 2015-05-26 | Yale University | Anti-viral nucleoside analogs and methods for treating viral infections, especially hiv infections |
| US20040260454A1 (en) * | 2003-06-11 | 2004-12-23 | Basir Otman A. | Vibro-acoustic engine diagnostic system |
| US7189403B2 (en) * | 2003-06-30 | 2007-03-13 | Institut Pasteur | Attenuated flavivirus strains containing a mutated M-ectodomain and their applications |
| US20050171063A1 (en) * | 2003-10-20 | 2005-08-04 | Pawan Malhotra | Use of phosphono derivatives as anti-malarials |
| WO2005039557A1 (en) * | 2003-10-22 | 2005-05-06 | Council Of Scientific And Industrial Research | Use of selected amino acid-zinc complexes as anti-malarial |
| EP1688486B1 (en) * | 2003-10-29 | 2016-12-14 | Toagosei Co., Ltd. | Antibacterial peptide and utilization of the same |
| JP2008500965A (ja) * | 2004-03-17 | 2008-01-17 | エムペックス・ファーマシューティカルズ・インコーポレーテッド | 細菌の排出ポンプ阻害剤の使用および投与 |
| US7994225B2 (en) * | 2004-03-17 | 2011-08-09 | Rempex Pharmaceuticals, Inc. | Bacterial efflux pump inhibitors for the treatment of ophthalmic and otic infections |
| US20050282755A1 (en) * | 2004-03-18 | 2005-12-22 | Ansata Therapeutics, Inc. | Compositions having antimicrobial activity and uses thereof |
| PT1773878E (pt) | 2004-07-19 | 2015-06-05 | Biocon Ltd | Conjugados de insulina-oligómero, formulaçôes e usos dos mesmos |
| JP4507080B2 (ja) * | 2004-07-30 | 2010-07-21 | 東亞合成株式会社 | 抗菌ペプチド及びその利用 |
| US7588885B2 (en) * | 2004-08-06 | 2009-09-15 | Chung Yuan Christian University | Use of biocistronic DNA constructs for identifying compounds that inhibit IRES-dependent translation |
| US20060068020A1 (en) * | 2004-09-24 | 2006-03-30 | Cottrell Ian W | Encapsulated pharmaceutical agents |
| JP4730584B2 (ja) | 2004-12-06 | 2011-07-20 | 東亞合成株式会社 | 抗菌ペプチド及びその利用 |
| US20090030179A1 (en) * | 2005-02-15 | 2009-01-29 | Toagosei Co., Ltd | Antimicrobial peptide and use thereof |
| WO2007014372A2 (en) | 2005-07-28 | 2007-02-01 | Biosynexus Incorporated | Compositions and methods for treating bacteria |
| WO2008150845A1 (en) * | 2007-05-31 | 2008-12-11 | Vanderbilt University | Screening for wnt pathway modulators and pyrvinium for the treatment of cance |
| US8207295B2 (en) * | 2008-06-04 | 2012-06-26 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
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| JP2011195451A (ja) * | 2008-06-20 | 2011-10-06 | Fukuoka Univ | ペプチド |
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| DK2600869T3 (da) * | 2010-08-05 | 2020-11-16 | Helperby Therapeutics Ltd | Kombination af en pyrroloquinolinforbindelse og et beta-lactam-antimikrobielt middel, mupirocin eller chlorhexidin |
| CN102167731B (zh) * | 2011-02-10 | 2013-01-23 | 周逸明 | 一种固相多肽合成奥米加南的制备方法 |
| WO2013056003A2 (en) | 2011-10-12 | 2013-04-18 | Yale University | Catechol diethers as potent anti-hiv agents |
| WO2015038660A1 (en) | 2013-09-12 | 2015-03-19 | Alios Biopharma, Inc. | Pyridazinone compounds and uses thereof |
| WO2015077057A1 (en) * | 2013-11-20 | 2015-05-28 | Texas Southern University | Methionine aminopeptidase inhibitors for treating infectious diseases |
| RU2678985C2 (ru) * | 2017-02-06 | 2019-02-05 | Общество с ограниченной ответственностью "Научно-производственная фирма ВЕРТА" | Биоцидный пептид и препарат на его основе |
| CN108721292B (zh) * | 2018-05-04 | 2022-04-01 | 中国疾病预防控制中心病毒病预防控制所 | 扑蛲灵在制备广谱抗冠状病毒药物中的应用 |
| US12383700B2 (en) | 2019-06-13 | 2025-08-12 | Hollister Incorporated | Reusable urinary catheter products |
| EP4628107A3 (en) | 2019-06-25 | 2025-12-17 | Hollister Incorporated | Reusable urinary catheter products |
| KR102433665B1 (ko) * | 2021-11-17 | 2022-08-19 | 주식회사 씨위드 | 인돌리시딘 유래 항균 펩타이드 및 이의 용도 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB2128617A (en) | 1982-10-06 | 1984-05-02 | Martti Vaara | Polypeptides for use in antibacterial therapy |
| NZ237202A (en) | 1990-02-23 | 1994-01-26 | Bristol Myers Squibb Co | Composition containing beta-lactam antibiotic and cationic oligopeptide |
| US5547939A (en) | 1991-06-14 | 1996-08-20 | The Regents Of The University Of California | Broad spectrum antimicrobial compounds and methods of use |
| US5324716A (en) | 1991-06-14 | 1994-06-28 | Regents Of The University Of California | Broad spectrum antimicrobial compounds and methods of use |
| US5593866A (en) | 1992-08-21 | 1997-01-14 | The University Of British Columbia | Cationic peptides and method for production |
| US5359030A (en) | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
| US5681811A (en) | 1993-05-10 | 1997-10-28 | Protein Delivery, Inc. | Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same |
| NZ275205A (en) | 1993-09-22 | 1998-03-25 | Xoma Corp | Use of bactericidal/permeability-increasing protein in treating gram-negative bacterial infection |
| JP4076026B2 (ja) * | 1993-10-25 | 2008-04-16 | トランセイヴ，インコーポレイテッド | リポソームディフェンシン |
| DK0754050T3 (da) | 1994-01-14 | 2002-10-21 | Xoma Technology Ltd | Anti-gram-positive bakterielle fremgangsmåder og materialer |
| US5574017A (en) * | 1994-07-05 | 1996-11-12 | Gutheil; William G. | Antibacterial agents |
| US5877274A (en) | 1995-06-02 | 1999-03-02 | University Of British Columbia | Antimicrobial cationic peptides |
| AU6940796A (en) | 1995-08-23 | 1997-03-19 | University Of British Columbia, The | Antimicrobial cationic peptides and methods of screening for the same |
| US5994308A (en) | 1996-02-28 | 1999-11-30 | Board Of Trustees Of Southern Illinois University | Broad spectrum antimicrobial peptides containing a tryptophan triplet and methods of use |
| US6180604B1 (en) | 1996-08-21 | 2001-01-30 | Micrologix Biotech Inc. | Compositions and methods for treating infections using analogues of indolicidin |
| US6503881B2 (en) * | 1996-08-21 | 2003-01-07 | Micrologix Biotech Inc. | Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics |
| US6551994B1 (en) | 1997-04-10 | 2003-04-22 | Mcgill University | Compounds and methods for inhibiting the interaction between α-catenin and β-catenin |
| WO1999043357A1 (en) | 1998-02-25 | 1999-09-02 | Micrologix Biotech Inc. | Indolicidin and cationic peptides conjugated with polymers |
-
1997
- 1997-08-20 US US08/915,314 patent/US6180604B1/en not_active Expired - Lifetime
- 1997-08-21 JP JP10510994A patent/JP2001500477A/ja active Pending
- 1997-08-21 ES ES97941352T patent/ES2178000T3/es not_active Expired - Lifetime
- 1997-08-21 ES ES01119148T patent/ES2315252T3/es not_active Expired - Lifetime
- 1997-08-21 DE DE69713112T patent/DE69713112T2/de not_active Expired - Lifetime
- 1997-08-21 WO PCT/US1997/014779 patent/WO1998007745A2/en not_active Ceased
- 1997-08-21 CA CA002263799A patent/CA2263799A1/en not_active Abandoned
- 1997-08-21 EP EP97941352A patent/EP0925308B1/en not_active Expired - Lifetime
- 1997-08-21 AT AT01119148T patent/ATE410441T1/de not_active IP Right Cessation
- 1997-08-21 AT AT97941352T patent/ATE218579T1/de active
- 1997-08-21 DE DE69739035T patent/DE69739035D1/de not_active Expired - Lifetime
-
2000
- 2000-09-22 US US09/667,486 patent/US6538106B1/en not_active Expired - Fee Related
-
2002
- 2002-07-08 HK HK02105059.5A patent/HK1043475B/en not_active IP Right Cessation
-
2003
- 2003-01-24 US US10/351,985 patent/US7390787B2/en not_active Expired - Fee Related
-
2004
- 2004-08-23 JP JP2004242925A patent/JP4073900B2/ja not_active Expired - Fee Related
-
2008
- 2008-03-28 US US12/058,500 patent/US20080242614A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2263799A1 (en) | 1998-02-26 |
| HK1021824A1 (en) | 2000-07-07 |
| EP0925308B1 (en) | 2002-06-05 |
| HK1043475A1 (en) | 2002-09-13 |
| JP2005225857A (ja) | 2005-08-25 |
| US6180604B1 (en) | 2001-01-30 |
| US20080242614A1 (en) | 2008-10-02 |
| US20040009910A1 (en) | 2004-01-15 |
| DE69739035D1 (de) | 2008-11-20 |
| JP4073900B2 (ja) | 2008-04-09 |
| ES2178000T3 (es) | 2002-12-16 |
| ATE218579T1 (de) | 2002-06-15 |
| WO1998007745A2 (en) | 1998-02-26 |
| WO1998007745A3 (en) | 1998-07-09 |
| DE69713112D1 (de) | 2002-07-11 |
| US7390787B2 (en) | 2008-06-24 |
| HK1043475B (en) | 2009-07-03 |
| US6538106B1 (en) | 2003-03-25 |
| ATE410441T1 (de) | 2008-10-15 |
| EP0925308A2 (en) | 1999-06-30 |
| JP2001500477A (ja) | 2001-01-16 |
| ES2315252T3 (es) | 2009-04-01 |
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| 8364 | No opposition during term of opposition |