JP2001151701A5 - - Google Patents
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- Publication number
- JP2001151701A5 JP2001151701A5 JP2000359325A JP2000359325A JP2001151701A5 JP 2001151701 A5 JP2001151701 A5 JP 2001151701A5 JP 2000359325 A JP2000359325 A JP 2000359325A JP 2000359325 A JP2000359325 A JP 2000359325A JP 2001151701 A5 JP2001151701 A5 JP 2001151701A5
- Authority
- JP
- Japan
- Prior art keywords
- acetylneuraminyl
- pharmaceutical composition
- substance
- acetyl
- keratoconjunctivitis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 description 9
- 239000000126 substance Substances 0.000 description 9
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 6
- 241000700605 Viruses Species 0.000 description 6
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 5
- 230000003993 interaction Effects 0.000 description 5
- 206010023332 keratitis Diseases 0.000 description 5
- 201000010666 keratoconjunctivitis Diseases 0.000 description 5
- 239000008101 lactose Substances 0.000 description 5
- 108010061514 sialic acid receptor Proteins 0.000 description 5
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 4
- 229920000669 heparin Polymers 0.000 description 4
- 229960002897 heparin Drugs 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 125000003047 N-acetyl group Chemical group 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- -1 dextran sulfate Chemical compound 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 229920002971 Heparan sulfate Polymers 0.000 description 2
- SQVRNKJHWKZAKO-PFQGKNLYSA-N N-acetyl-beta-neuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-PFQGKNLYSA-N 0.000 description 2
- SUHQNCLNRUAGOO-UHFFFAOYSA-N N-glycoloyl-neuraminic acid Natural products OCC(O)C(O)C(O)C(NC(=O)CO)C(O)CC(=O)C(O)=O SUHQNCLNRUAGOO-UHFFFAOYSA-N 0.000 description 2
- FDJKUWYYUZCUJX-UHFFFAOYSA-N N-glycolyl-beta-neuraminic acid Natural products OCC(O)C(O)C1OC(O)(C(O)=O)CC(O)C1NC(=O)CO FDJKUWYYUZCUJX-UHFFFAOYSA-N 0.000 description 2
- FDJKUWYYUZCUJX-KVNVFURPSA-N N-glycolylneuraminic acid Chemical compound OC[C@H](O)[C@H](O)[C@@H]1O[C@](O)(C(O)=O)C[C@H](O)[C@H]1NC(=O)CO FDJKUWYYUZCUJX-KVNVFURPSA-N 0.000 description 2
- 102000012404 Orosomucoid Human genes 0.000 description 2
- 108010061952 Orosomucoid Proteins 0.000 description 2
- 229960000633 dextran sulfate Drugs 0.000 description 2
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 2
- KFEUJDWYNGMDBV-UHFFFAOYSA-N (N-Acetyl)-glucosamin-4-beta-galaktosid Natural products OC1C(NC(=O)C)C(O)OC(CO)C1OC1C(O)C(O)C(O)C(CO)O1 KFEUJDWYNGMDBV-UHFFFAOYSA-N 0.000 description 1
- 206010001257 Adenoviral conjunctivitis Diseases 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- KFEUJDWYNGMDBV-LODBTCKLSA-N N-acetyllactosamine Chemical compound O[C@@H]1[C@@H](NC(=O)C)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KFEUJDWYNGMDBV-LODBTCKLSA-N 0.000 description 1
- HESSGHHCXGBPAJ-UHFFFAOYSA-N N-acetyllactosamine Natural products CC(=O)NC(C=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O HESSGHHCXGBPAJ-UHFFFAOYSA-N 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 208000021373 epidemic keratoconjunctivitis Diseases 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 201000006476 shipyard eye Diseases 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9904289-7 | 1999-11-26 | ||
| SE9904289A SE9904289D0 (sv) | 1999-11-26 | 1999-11-26 | Method and camposition for the treatment of adenovairal ocular infections |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001151701A JP2001151701A (ja) | 2001-06-05 |
| JP2001151701A5 true JP2001151701A5 (enExample) | 2010-01-28 |
| JP4559613B2 JP4559613B2 (ja) | 2010-10-13 |
Family
ID=20417870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000359325A Expired - Fee Related JP4559613B2 (ja) | 1999-11-26 | 2000-11-27 | アデノウイルス眼性感染の治療のための方法および組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7528113B2 (enExample) |
| EP (1) | EP1231925B1 (enExample) |
| JP (1) | JP4559613B2 (enExample) |
| CN (1) | CN100566722C (enExample) |
| AT (1) | ATE297211T1 (enExample) |
| AU (1) | AU1908601A (enExample) |
| DE (1) | DE60020729T2 (enExample) |
| HK (1) | HK1052139B (enExample) |
| SE (1) | SE9904289D0 (enExample) |
| WO (1) | WO2001037846A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2116140A1 (en) * | 2008-05-08 | 2009-11-11 | Nestec S.A. | Sialic acid to support the immune system in the elderly |
| KR101116868B1 (ko) * | 2008-10-20 | 2012-02-29 | 성균관대학교산학협력단 | 안질환의 예방 또는 치료용 조성물 |
| EP2364139A2 (en) | 2008-11-10 | 2011-09-14 | Life Science Nutrition AS | Ngna compositions and methods of use |
| RU2565593C2 (ru) * | 2009-07-07 | 2015-10-20 | Аденовир Фарма АБ | Новые противовирусные соединения, подходящие для лечения или предотвращения эпидемического кератоконъюнктивата |
| WO2015028548A1 (en) | 2013-08-28 | 2015-03-05 | Adenovir Pharma Ab | Multivalent sialic acid derivates |
| CN104586642A (zh) * | 2015-02-06 | 2015-05-06 | 武汉中科光谷绿色生物技术有限公司 | N-乙酰神经氨酸单体、n-乙酰神经氨酸水合物或n-乙酰神经氨酸盐在个人护理用品中的应用 |
| CN108904633A (zh) * | 2018-10-19 | 2018-11-30 | 长沙浩然医疗科技有限公司 | 一种改善视力的眼膏及其制备方法 |
| BR112022020881A2 (pt) * | 2020-04-15 | 2022-11-29 | Tx Medic Ab | Tratamento da sepse e hipercitocinemia |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522803A (en) * | 1983-02-04 | 1985-06-11 | The Liposome Company, Inc. | Stable plurilamellar vesicles, their preparation and use |
| AP249A (en) * | 1990-04-24 | 1993-03-17 | Biota Scient Management Pty Ltd | Anti-viral compounds. |
| ATE116546T1 (de) * | 1991-03-07 | 1995-01-15 | Kanto Ishi Pharma Co Ltd | Colominsäure und produkte einer teilweisen hydrolyse von colominsäure zur herstellung von arzneimitteln zur behandlung von hepatitis, nephritis und arthritis. |
| GB2261372A (en) * | 1991-11-15 | 1993-05-19 | Gregor Reid | Lactobacillus and skim milk compositions for prevention of urogenital infection |
| US6235313B1 (en) * | 1992-04-24 | 2001-05-22 | Brown University Research Foundation | Bioadhesive microspheres and their use as drug delivery and imaging systems |
| GB9312531D0 (en) * | 1993-06-17 | 1993-08-04 | Glaxo Group Ltd | Process |
| US5858698A (en) * | 1994-04-21 | 1999-01-12 | University Of Alberta | Methods for detection of enteropathogenic e. coli |
| AUPM623994A0 (en) * | 1994-06-15 | 1994-07-07 | Biomolecular Research Institute Limited | Antiviral dendrimers |
| JP3141693B2 (ja) * | 1994-08-16 | 2001-03-05 | ダイキン工業株式会社 | シアル酸の９位をフッ素で置換したガングリオシドｇｍ３類縁体及びその中間体 |
| US5962311A (en) * | 1994-09-08 | 1999-10-05 | Genvec, Inc. | Short-shafted adenoviral fiber and its use |
| DE19547972A1 (de) * | 1995-12-21 | 1997-07-10 | Weropharm Gmbh | Heparin zur Prophylaxe und akuten Therapie der allergischen Konjunktivitis |
| CN1211189A (zh) | 1996-02-14 | 1999-03-17 | 普罗克特和甘保尔公司 | 含衍自杜鹃花科植物的物质和乳酸菌生长因子的,用于泌尿生殖系统和肠道疾病的组合物 |
| ES2127110B1 (es) | 1996-05-24 | 1999-12-01 | Univ Valladolid | Procedimiento para variar las propiedades electricas del moco ocular humano y de sustitutos para uso oftalmico. |
| DE69709795T2 (de) * | 1996-07-22 | 2002-09-26 | Sankyo Co., Ltd. | Neuraminsäuredervate, ihre Herstellung und medizinische Verwendung |
| SE507028C2 (sv) * | 1996-08-06 | 1998-03-16 | Medicarb Ab | Ny medicinsk användning |
| US5719020A (en) * | 1996-09-25 | 1998-02-17 | Oklahoma Medical Research Foundation | 4,7-dialkoxy N-acetylneuraminic acid derivatives and methods for detection of influenza type A and B viruses in clinical specimens |
| AU7277798A (en) | 1997-05-01 | 1998-11-24 | Cytel Corporation | Use of sialyl galactosides and related compounds as anti-angiogenic agents |
| US20050201952A1 (en) * | 1998-01-29 | 2005-09-15 | Yash Sharma | Treatment and prevention of viral hepatitis infections |
| AT408946B (de) | 1999-02-18 | 2002-04-25 | Immuno Ag | Verwendung von orosomucoid zur herstellung einer pharmazeutischen präparation |
-
1999
- 1999-11-26 SE SE9904289A patent/SE9904289D0/xx unknown
-
2000
- 2000-11-23 AT AT00982008T patent/ATE297211T1/de not_active IP Right Cessation
- 2000-11-23 CN CNB008161739A patent/CN100566722C/zh not_active Expired - Fee Related
- 2000-11-23 EP EP00982008A patent/EP1231925B1/en not_active Expired - Lifetime
- 2000-11-23 HK HK03104387.0A patent/HK1052139B/zh not_active IP Right Cessation
- 2000-11-23 WO PCT/SE2000/002313 patent/WO2001037846A1/en not_active Ceased
- 2000-11-23 AU AU19086/01A patent/AU1908601A/en not_active Abandoned
- 2000-11-23 DE DE60020729T patent/DE60020729T2/de not_active Expired - Lifetime
- 2000-11-27 JP JP2000359325A patent/JP4559613B2/ja not_active Expired - Fee Related
-
2004
- 2004-11-29 US US10/997,955 patent/US7528113B2/en not_active Expired - Fee Related
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