HUP0402570A2 - Fertőző és más betegségek megelőzése és terápiás kezelése immuneffektor gyűrűs amino-alkil-glükozaminid-foszfát (gyűrűs A 6P) vegyületekkel - Google Patents
Fertőző és más betegségek megelőzése és terápiás kezelése immuneffektor gyűrűs amino-alkil-glükozaminid-foszfát (gyűrűs A 6P) vegyületekkelInfo
- Publication number
- HUP0402570A2 HUP0402570A2 HU0402570A HUP0402570A HUP0402570A2 HU P0402570 A2 HUP0402570 A2 HU P0402570A2 HU 0402570 A HU0402570 A HU 0402570A HU P0402570 A HUP0402570 A HU P0402570A HU P0402570 A2 HUP0402570 A2 HU P0402570A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- hydrogen atom
- independently
- atom
- subject
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 208000015181 infectious disease Diseases 0.000 title abstract 2
- 229910019142 PO4 Inorganic materials 0.000 title 1
- 125000004103 aminoalkyl group Chemical group 0.000 title 1
- 125000004122 cyclic group Chemical group 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 150000008271 glucosaminides Chemical class 0.000 title 1
- 230000002458 infectious effect Effects 0.000 title 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title 1
- 239000010452 phosphate Substances 0.000 title 1
- 230000000069 prophylactic effect Effects 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 125000001931 aliphatic group Chemical group 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 206010027654 Allergic conditions Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány tárgya eljárás fertőző betegség, autoimmun betegség vagyallergiás állapot enyhítésére vagy lényegében megelőzésére valamilyenalanyban, oly módon, hogy az alanyt egy vagy több (I) általánosképletű vegyület vagy gyógyászatilag elfogadható sójának hatásosmennyiségével hozzák érintkezésbe ahol a képletben X jelentése -O-vagy -NH-csoport és Y jelentése oxigénatom vagy kénatom, R1, R2, és R3jelentése egymástól függetlenül 2-20 szénatomos acilcsoport, R4jelentése hidrogénatom vagy -PO3R7R8 csoport, ahol R7 és R8 jelentéseegymástól függetlenül hidrogénatom vagy 1-4 szénatomos alifás csoport,R5 jelentése hidrogénatom, -CH3 vagy -PO3R9R10 csoport, ahol R9 és R10jelentése egymástól függetlenül hidrogénatom vagy 1-4 szénatomosalifás csoport, R6 jelentése hidrogénatom, -OH; 1-4 szénatomosoxialifás csoport, -PO3R11R12, -OPO3R11R12, -SO3R11; -OSO3R11, -NR11R12, -SR11, -CN, -NO2, -CHO, -CO2R11 vagy CONR11R12 csoport, aholR11 és R12 jelentése egymástól függetlenül hidrogénatom vagy 1-4szénatomos alifás csoport, azzal a feltétellel, hogy az R4 és R5csoportok egyikének jelentése foszfortartalmú csoport, és amikor R4jelentése -PO3R7R8 csoport, R5 jelentése -PO3R9R10 csoporttól eltérő,ahol <*1<< <*2<< <*3< és <**<< királis központokat jelöl, n, m, p és qjelentése egymástól függetlenül 0-tól 6-ig terjedő egész szám, azzal afeltétellel, hogy p és m értékének összege 0-6. A találmány tárgyátképezik a fenti (I) általános képletű vegyületeket vagy azokgyógyászatilag elfogadható sóját tartalmazó gyógyászati készítményekis.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2002/003581 WO2003066065A1 (en) | 2002-02-04 | 2002-02-04 | Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0402570A2 true HUP0402570A2 (hu) | 2005-10-28 |
| HUP0402570A3 HUP0402570A3 (en) | 2006-02-28 |
Family
ID=27732076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0402570A HUP0402570A3 (en) | 2002-02-04 | 2002-02-04 | Prophylactic and therapeutic treatment of infectious and other diseases with aminoalkyl glucosaminide phosphate (cyclic a 6p) immunoeffector compounds |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1482955B1 (hu) |
| JP (1) | JP2005523902A (hu) |
| KR (1) | KR100858947B1 (hu) |
| CN (2) | CN1622812A (hu) |
| AU (1) | AU2002255513B2 (hu) |
| BR (1) | BR0215583A (hu) |
| CA (1) | CA2474402C (hu) |
| CZ (1) | CZ2004861A3 (hu) |
| ES (1) | ES2453903T3 (hu) |
| HU (1) | HUP0402570A3 (hu) |
| IL (1) | IL163305A (hu) |
| MX (1) | MXPA04007491A (hu) |
| NO (1) | NO20043693L (hu) |
| NZ (1) | NZ534592A (hu) |
| WO (1) | WO2003066065A1 (hu) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002253909B2 (en) * | 2002-02-04 | 2008-06-05 | Corixa Corporation | New immunoeffector compounds |
| US6911434B2 (en) | 2002-02-04 | 2005-06-28 | Corixa Corporation | Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds |
| US8173608B2 (en) | 2005-03-04 | 2012-05-08 | Riken | Compound having cyclic structure and use thereof |
| CA2764374C (en) | 2009-06-05 | 2019-11-19 | Infectious Disease Research Institute | Synthetic glucopyranosyl lipid adjuvants |
| GB201101331D0 (en) | 2011-01-26 | 2011-03-09 | Glaxosmithkline Biolog Sa | Compositions and uses |
| GB201113570D0 (en) | 2011-08-05 | 2011-09-21 | Glaxosmithkline Biolog Sa | Vaccine |
| MX2022000879A (es) | 2019-07-21 | 2022-05-02 | Glaxosmithkline Biologicals Sa | Vacuna viral terapeutica. |
| US20230234992A1 (en) | 2020-06-05 | 2023-07-27 | Glaxosmithkline Biologicals Sa | Modified betacoronavirus spike proteins |
| EP4032547A1 (en) | 2021-01-20 | 2022-07-27 | GlaxoSmithKline Biologicals S.A. | Hsv1 fce derived fragements for the treatment of hsv |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6113918A (en) * | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| MXPA02011486A (es) | 2000-05-19 | 2004-01-26 | Corixa Corp | Tratamiento profilactico y terapeutico de enfermedades infecciosas, autoinmunes y alergicas con compuestos a base de mono y disacarido. |
| JP4843181B2 (ja) | 2000-08-04 | 2011-12-21 | コリクサ コーポレイション | 免疫エフェクター化合物 |
| AU2002253909B2 (en) * | 2002-02-04 | 2008-06-05 | Corixa Corporation | New immunoeffector compounds |
-
2002
- 2002-02-04 JP JP2003565489A patent/JP2005523902A/ja not_active Withdrawn
- 2002-02-04 CN CNA028284356A patent/CN1622812A/zh active Pending
- 2002-02-04 HU HU0402570A patent/HUP0402570A3/hu unknown
- 2002-02-04 BR BR0215583-4A patent/BR0215583A/pt not_active Application Discontinuation
- 2002-02-04 CZ CZ2004861A patent/CZ2004861A3/cs unknown
- 2002-02-04 WO PCT/US2002/003581 patent/WO2003066065A1/en active Application Filing
- 2002-02-04 AU AU2002255513A patent/AU2002255513B2/en not_active Expired
- 2002-02-04 MX MXPA04007491A patent/MXPA04007491A/es active IP Right Grant
- 2002-02-04 EP EP02724914.3A patent/EP1482955B1/en not_active Expired - Lifetime
- 2002-02-04 CA CA2474402A patent/CA2474402C/en not_active Expired - Lifetime
- 2002-02-04 NZ NZ534592A patent/NZ534592A/en not_active IP Right Cessation
- 2002-02-04 ES ES02724914.3T patent/ES2453903T3/es not_active Expired - Lifetime
- 2002-02-04 IL IL16330502A patent/IL163305A/xx unknown
- 2002-02-04 KR KR1020047011969A patent/KR100858947B1/ko active IP Right Grant
- 2002-02-04 CN CN200710161297XA patent/CN101138566B/zh not_active Expired - Lifetime
-
2004
- 2004-09-03 NO NO20043693A patent/NO20043693L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BR0215583A (pt) | 2004-12-21 |
| KR20040081174A (ko) | 2004-09-20 |
| NZ534592A (en) | 2006-06-30 |
| CA2474402A1 (en) | 2003-08-14 |
| AU2002255513A1 (en) | 2003-09-02 |
| EP1482955A4 (en) | 2008-08-06 |
| CN101138566A (zh) | 2008-03-12 |
| JP2005523902A (ja) | 2005-08-11 |
| CN1622812A (zh) | 2005-06-01 |
| HUP0402570A3 (en) | 2006-02-28 |
| NO20043693L (no) | 2004-09-03 |
| CZ2004861A3 (cs) | 2004-12-15 |
| CN101138566B (zh) | 2012-05-23 |
| ES2453903T3 (es) | 2014-04-08 |
| WO2003066065A1 (en) | 2003-08-14 |
| AU2002255513B2 (en) | 2008-03-06 |
| KR100858947B1 (ko) | 2008-09-17 |
| EP1482955A1 (en) | 2004-12-08 |
| IL163305A (en) | 2010-10-31 |
| EP1482955B1 (en) | 2013-12-25 |
| MXPA04007491A (es) | 2004-11-10 |
| CA2474402C (en) | 2012-09-11 |
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