JP2000516585A - 血管新生阻害物質による雌生殖系の調節方法 - Google Patents
血管新生阻害物質による雌生殖系の調節方法Info
- Publication number
- JP2000516585A JP2000516585A JP10508217A JP50821798A JP2000516585A JP 2000516585 A JP2000516585 A JP 2000516585A JP 10508217 A JP10508217 A JP 10508217A JP 50821798 A JP50821798 A JP 50821798A JP 2000516585 A JP2000516585 A JP 2000516585A
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- angiogenesis
- agm
- mice
- inhibiting
- female
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2338596P | 1996-08-02 | 1996-08-02 | |
| US60/023,385 | 1996-08-02 | ||
| PCT/US1997/013882 WO1998005323A2 (en) | 1996-08-02 | 1997-08-01 | Method of regulating the female reproductive system through angiogenesis inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000516585A true JP2000516585A (ja) | 2000-12-12 |
| JP2000516585A5 JP2000516585A5 (OSRAM) | 2005-04-07 |
Family
ID=21814780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10508217A Pending JP2000516585A (ja) | 1996-08-02 | 1997-08-01 | 血管新生阻害物質による雌生殖系の調節方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US6017949A (OSRAM) |
| EP (1) | EP0957910A2 (OSRAM) |
| JP (1) | JP2000516585A (OSRAM) |
| AU (2) | AU3968597A (OSRAM) |
| CA (1) | CA2262535A1 (OSRAM) |
| WO (2) | WO1998005293A2 (OSRAM) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011526609A (ja) * | 2008-07-03 | 2011-10-13 | バイエル オイ | 避妊のための子宮内用送達システム |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU224028B1 (hu) * | 1995-03-27 | 2005-05-30 | Assistance Publique-Hopitaux De Paris | Fumagillol és származékai alkalmazása bélfertőzések kezelésére szolgáló gyógyszerek előállítására |
| US6440445B1 (en) * | 1996-09-30 | 2002-08-27 | Brigham & Women's Hospital | Methods and compounds for treatment of abnormal uterine bleeding |
| AU3352799A (en) * | 1997-10-31 | 1999-08-23 | Children's Medical Center Corporation | Method for regulating size and growth of vascularized normal tissue |
| JP4841724B2 (ja) * | 1998-10-09 | 2011-12-21 | ベジェニクス ピーティーワイ リミテッド | 腫瘍イメージングおよび抗腫瘍治療の標的としてのＦｌｔ４（ＶＥＲＧ−３） |
| US7141607B1 (en) * | 2000-03-10 | 2006-11-28 | Insite Vision Incorporated | Methods and compositions for treating and inhibiting retinal neovascularization |
| JPWO2004022082A1 (ja) * | 2002-09-04 | 2005-12-22 | 株式会社プロテイン・エクスプレス | 胚着床制御剤 |
| WO2004103159A2 (en) * | 2003-05-14 | 2004-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for modulating endometrium |
| EP1648575A4 (en) * | 2003-07-14 | 2009-09-16 | Fusion Sport Internat Pty Ltd | METHOD, DEVICE AND SYSTEM FOR SPORT TRAINING AND TESTING |
| US7524811B2 (en) * | 2003-08-29 | 2009-04-28 | Children's Medical Center Corporation | Anti-angiogenic peptides from the N-terminus of endostatin |
| CA2537179A1 (en) * | 2003-08-29 | 2005-03-10 | Children's Medical Center Corporation | Anti-angiogenic peptides from the n-terminus of endostatin |
| CA2724231A1 (en) | 2008-05-15 | 2009-11-19 | The University Of North Carolina At Chapel Hill | Novel targets for regulation of angiogenesis |
| CA2731020A1 (en) * | 2008-07-18 | 2010-01-21 | Zafgen, Inc. | Use of antiangiogenic fumagillins in the treatment of obesity |
| US20100159506A1 (en) * | 2008-07-25 | 2010-06-24 | Cellscape Corporation | Methods and systems for genetic analysis of fetal nucleated red blood cells |
| US20120004162A1 (en) | 2008-12-04 | 2012-01-05 | Vath James E | Methods of Treating an Overweight or Obese Subject |
| WO2010065883A2 (en) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Method of treating an overweight or obese subject |
| JP5890312B2 (ja) | 2009-10-09 | 2016-03-22 | ザフゲン，インコーポレイテッド | 肥満治療に用いられるスルホン化合物 |
| US8815309B2 (en) | 2010-01-08 | 2014-08-26 | Zafgen, Inc. | Methods of treating a subject with benign prostate hyperplasia |
| EP2521719B1 (en) | 2010-01-08 | 2015-07-29 | Zafgen, Inc. | Fumagillol type compounds and methods of making and using same |
| RU2427325C1 (ru) * | 2010-01-29 | 2011-08-27 | Государственное образовательное учреждение высшего профессионального образования "Астраханская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО АГМА Росздрава) | Способ оценки эффективности лечения хронической плацентарной недостаточности в эксперименте |
| US8774488B2 (en) | 2010-03-11 | 2014-07-08 | Cellscape Corporation | Method and device for identification of nucleated red blood cells from a maternal blood sample |
| US20130266578A1 (en) | 2010-04-07 | 2013-10-10 | Thomas E. Hughes | Methods of treating an overweight subject |
| WO2011130728A1 (en) | 2010-04-17 | 2011-10-20 | Bayer Healthcare Llc | Synthetic metabolites of fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention diseases and conditions |
| JP2013531067A (ja) | 2010-07-19 | 2013-08-01 | バイエル ヘルスケア リミティド ライアビリティ カンパニー | 疾病及び状態の処置及び予防のためのフルオロ置換オメガ−カルボキシアリールジフェニル尿素を用いた組み合わせ薬 |
| US9266896B2 (en) | 2010-07-22 | 2016-02-23 | Zafgen, Inc. | Tricyclic compounds and methods of making and using same |
| PH12013500934A1 (en) | 2010-11-09 | 2022-10-24 | Zafgen Inc | Crystalline solids of a metap-2 inhibitor and methods of making and using same |
| AU2011336785A1 (en) | 2010-11-29 | 2013-06-20 | Zafgen, Inc | Treatment of obesity using non-daily administration of 6-0-(4 - dimethylaminoethoxy) cinnamoyl fumagillol |
| JP6058557B2 (ja) | 2011-01-26 | 2017-01-11 | ザフゲン，インコーポレイテッド | テトラゾール化合物ならびにその作製方法および使用方法 |
| KR101875988B1 (ko) | 2011-03-08 | 2018-07-06 | 자프겐 인크. | 옥사스피로[2.5]옥탄 유도체 및 유사체 |
| CA2835261C (en) | 2011-05-06 | 2019-06-04 | Zafgen, Inc. | Partially saturated tricyclic compounds and methods of making and using same |
| EP2705036B1 (en) | 2011-05-06 | 2015-08-12 | Zafgen Inc. | Tricyclic sulfonamide compounds and methods of making and using same |
| CN103764652B (zh) | 2011-05-06 | 2016-03-23 | 扎夫根股份有限公司 | 三环吡唑磺酰胺化合物及其制备和使用方法 |
| EP2763671A2 (en) | 2011-10-03 | 2014-08-13 | Zafgen, Inc. | Methods of treating age related disorders |
| CA2861381A1 (en) | 2012-01-18 | 2013-07-25 | Zafgen, Inc. | Tricyclic sulfone compounds and methods of making and using same |
| AU2013209723B2 (en) | 2012-01-18 | 2016-11-24 | Zafgen, Inc. | Tricyclic sulfonamide compounds and methods of making and using same |
| US9260419B2 (en) | 2012-05-07 | 2016-02-16 | Zafgen, Inc. | Polymorphic salt of a metap-2 inhibitor and methods of making and using same |
| US9839622B2 (en) | 2012-05-08 | 2017-12-12 | Zafgen, Inc. | Methods of treating hypothalamic obesity |
| BR112014027981A2 (pt) | 2012-05-09 | 2017-06-27 | Zafgen Inc | compostos do tipo fumagilol e métodos de produção e utilização dos mesmos |
| EA028367B1 (ru) | 2012-11-05 | 2017-11-30 | Зафджен, Инк. | Способы лечения заболеваний печени |
| AU2013337282A1 (en) | 2012-11-05 | 2015-05-21 | Zafgen, Inc. | Tricyclic compounds and methods of making and using same |
| WO2014071369A1 (en) | 2012-11-05 | 2014-05-08 | Zafgen, Inc. | Tricyclic compounds for use in the treatment and/or control of obesity |
| BR112015023390A2 (pt) | 2013-03-14 | 2017-07-18 | Zafgen Inc | métodos para tratar de doença renal e outros distúrbios |
| CN106432255A (zh) | 2015-08-11 | 2017-02-22 | 扎夫根公司 | 烟曲霉素醇螺环化合物和制备和使用其的方法 |
| AR105671A1 (es) | 2015-08-11 | 2017-10-25 | Zafgen Inc | Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1226816A (en) * | 1982-12-20 | 1987-09-15 | Moses J. Folkman | Inhibition of angiogenesis |
| DE3344797A1 (de) * | 1983-12-10 | 1985-06-20 | Th. Kieserling & Albrecht Gmbh & Co, 5650 Solingen | Transportvorrichtung fuer felgenrohlinge |
| US4599331A (en) * | 1984-12-24 | 1986-07-08 | Syntex (U.S.A.) Inc. | Etianic acids as antiangiogenics |
| DE68915900T2 (de) * | 1988-09-01 | 1994-11-24 | Childrens Medical Center | Angiogenese hemmendes Mittel. |
| US5086164A (en) * | 1989-01-10 | 1992-02-04 | Repligen Corporation | Novel methods and compositions for treatment of angiogenic diseases |
| WO1991019731A1 (en) * | 1990-06-11 | 1991-12-26 | The Upjohn Company | Steroids which inhibit angiogenesis |
| FR2672801B1 (fr) * | 1991-02-14 | 1995-03-03 | Sanofi Sa | Utilisation de derives de tetrahydrothienopyridine comme inhibiteurs de l'angiogenese. |
| GB9225475D0 (en) * | 1992-12-05 | 1993-01-27 | Imp Cancer Res Tech | Compounds to combat angiogenesis |
| JPH08509703A (ja) * | 1993-03-12 | 1996-10-15 | ゾーマ コーポレイション | 殺菌／透過性増加タンパク質産物の治療用途 |
| EP0658342B1 (en) * | 1993-09-24 | 1999-03-17 | Takeda Chemical Industries, Ltd. | Antineoplastic pharmaceutical composition containing a fumagillol derivative and a platinum complex |
| GB9410533D0 (en) | 1994-05-26 | 1994-07-13 | Lynxvale Ltd | In situ hybridisation and immuno-Chemical localisation of a growth factor |
| GB9410534D0 (en) * | 1994-05-26 | 1994-07-13 | Lynxvale Ltd | Improvements in or relating to growth factor inhibitors |
| ATE248912T1 (de) * | 1995-10-23 | 2003-09-15 | Childrens Medical Center | Therapeutische antiangiogenische zusammensetzungen und verfahren |
-
1997
- 1997-07-31 WO PCT/US1997/013522 patent/WO1998005293A2/en not_active Ceased
- 1997-07-31 AU AU39685/97A patent/AU3968597A/en not_active Withdrawn
- 1997-08-01 AU AU39107/97A patent/AU3910797A/en not_active Abandoned
- 1997-08-01 US US08/904,708 patent/US6017949A/en not_active Expired - Fee Related
- 1997-08-01 CA CA002262535A patent/CA2262535A1/en not_active Abandoned
- 1997-08-01 EP EP97936441A patent/EP0957910A2/en not_active Withdrawn
- 1997-08-01 JP JP10508217A patent/JP2000516585A/ja active Pending
- 1997-08-01 WO PCT/US1997/013882 patent/WO1998005323A2/en not_active Ceased
-
1999
- 1999-05-17 US US09/313,528 patent/US6441027B1/en not_active Expired - Lifetime
-
2001
- 2001-11-21 US US09/990,646 patent/US20020156055A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011526609A (ja) * | 2008-07-03 | 2011-10-13 | バイエル オイ | 避妊のための子宮内用送達システム |
Also Published As
| Publication number | Publication date |
|---|---|
| US6441027B1 (en) | 2002-08-27 |
| CA2262535A1 (en) | 1998-02-12 |
| WO1998005323A2 (en) | 1998-02-12 |
| AU3968597A (en) | 1998-02-25 |
| US20020156055A1 (en) | 2002-10-24 |
| US6017949A (en) | 2000-01-25 |
| WO1998005293A2 (en) | 1998-02-12 |
| AU3910797A (en) | 1998-02-25 |
| EP0957910A2 (en) | 1999-11-24 |
| WO1998005323A3 (en) | 1998-05-07 |
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