JP2000511549A - 細胞移動阻害剤としての１―（１ｈ―ピロール―２―イルメチル）―２―ピペリドン - Google Patents

細胞移動阻害剤としての１―（１ｈ―ピロール―２―イルメチル）―２―ピペリドン

Info

Publication number
JP2000511549A
JP2000511549A JP10500202A JP50020298A JP2000511549A JP 2000511549 A JP2000511549 A JP 2000511549A JP 10500202 A JP10500202 A JP 10500202A JP 50020298 A JP50020298 A JP 50020298A JP 2000511549 A JP2000511549 A JP 2000511549A
Authority
JP
Japan
Prior art keywords
compound
piperidone
ylmethyl
pyrrol
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10500202A
Other languages
English (en)
Japanese (ja)
Inventor
ゲールツ，フーゴ・アルフオンス・ガブリール
ククラ，マイケル・ジヨセフ
ゲイセン，ヨハン・ヨゼフ・グスタブ・ヘンドリク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of JP2000511549A publication Critical patent/JP2000511549A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP10500202A 1996-05-31 1997-05-26 細胞移動阻害剤としての１―（１ｈ―ピロール―２―イルメチル）―２―ピペリドン Pending JP2000511549A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP96201501 1996-05-31
EP96201501.2 1996-05-31
PCT/EP1997/002775 WO1997046552A1 (en) 1996-05-31 1997-05-26 1-(1h-pyrrol-2-ylmethyl)-2-piperidone as cell migration inhibitor

Publications (1)

Publication Number Publication Date
JP2000511549A true JP2000511549A (ja) 2000-09-05

Family

ID=8224030

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10500202A Pending JP2000511549A (ja) 1996-05-31 1997-05-26 細胞移動阻害剤としての１―（１ｈ―ピロール―２―イルメチル）―２―ピペリドン

Country Status (8)

Country Link
US (1) US6054468A (enExample)
EP (1) EP0906305A1 (enExample)
JP (1) JP2000511549A (enExample)
KR (1) KR20000010698A (enExample)
AU (1) AU725585B2 (enExample)
CA (1) CA2254757A1 (enExample)
NZ (1) NZ332545A (enExample)
WO (1) WO1997046552A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000076511A1 (en) 1999-06-11 2000-12-21 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
US6358979B1 (en) 1999-06-11 2002-03-19 Merck & Co., Inc. N-cyclopentyl modulators of chemokine receptor activity
US6500844B1 (en) 1999-06-11 2002-12-31 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
US6472410B1 (en) 1999-06-11 2002-10-29 Merck & Co., Inc. N-cyclopentyl modulators of chemokine receptor activity
AU5600100A (en) 1999-06-11 2001-01-02 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
WO2000076513A1 (en) 1999-06-11 2000-12-21 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
US7012100B1 (en) * 2002-06-04 2006-03-14 Avolix Pharmaceuticals, Inc. Cell migration inhibiting compositions and methods and compositions for treating cancer
US20030236290A1 (en) * 2002-06-12 2003-12-25 Gabriel Fenteany Inhibitors of animal cell motility and growth
US20050095648A1 (en) * 2003-10-30 2005-05-05 Mario Geysen Method for designing linear epitopes and algorithm therefor and polypeptide epitopes
WO2005067980A2 (en) * 2004-01-12 2005-07-28 Pointilliste, Inc. Design of therapeutics and therapeutics

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9510944D0 (en) * 1995-05-31 1995-07-26 Bogaert Thierry Assays and processes for the identification of compounds which control cell behaviour,the compounds identified and their use in the control of cell behaviour

Also Published As

Publication number Publication date
NZ332545A (enExample) 2000-01-28
AU3168997A (en) 1998-01-05
EP0906305A1 (en) 1999-04-07
CA2254757A1 (en) 1997-12-11
KR20000010698A (ko) 2000-02-25
WO1997046552A1 (en) 1997-12-11
AU725585B2 (en) 2000-10-12
US6054468A (en) 2000-04-25

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