CA2254757A1 - 1-(1h-pyrrol-2-ylmethyl)-2-piperidone as cell migration inhibitor - Google Patents
1-(1h-pyrrol-2-ylmethyl)-2-piperidone as cell migration inhibitor Download PDFInfo
- Publication number
- CA2254757A1 CA2254757A1 CA002254757A CA2254757A CA2254757A1 CA 2254757 A1 CA2254757 A1 CA 2254757A1 CA 002254757 A CA002254757 A CA 002254757A CA 2254757 A CA2254757 A CA 2254757A CA 2254757 A1 CA2254757 A1 CA 2254757A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- pyrrol
- piperidone
- ylmethyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000012292 cell migration Effects 0.000 title claims abstract description 13
- BYNFRFJRDIGXOL-UHFFFAOYSA-N 1-(1h-pyrrol-2-ylmethyl)piperidin-2-one Chemical compound O=C1CCCCN1CC1=CC=CN1 BYNFRFJRDIGXOL-UHFFFAOYSA-N 0.000 title claims description 4
- 239000003112 inhibitor Substances 0.000 title description 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 49
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 14
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- 206010027476 Metastases Diseases 0.000 claims abstract description 8
- 230000009401 metastasis Effects 0.000 claims abstract description 8
- 239000003937 drug carrier Substances 0.000 claims abstract description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 20
- 201000010099 disease Diseases 0.000 claims description 10
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- ULBCJDXDVAJYNI-UHFFFAOYSA-N methyl 5-aminopentanoate Chemical compound COC(=O)CCCCN ULBCJDXDVAJYNI-UHFFFAOYSA-N 0.000 claims description 2
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 claims description 2
- ZSKGQVFRTSEPJT-UHFFFAOYSA-N pyrrole-2-carboxaldehyde Chemical compound O=CC1=CC=CN1 ZSKGQVFRTSEPJT-UHFFFAOYSA-N 0.000 claims 1
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- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96201501 | 1996-05-31 | ||
| EP96201501.2 | 1996-05-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2254757A1 true CA2254757A1 (en) | 1997-12-11 |
Family
ID=8224030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002254757A Abandoned CA2254757A1 (en) | 1996-05-31 | 1997-05-26 | 1-(1h-pyrrol-2-ylmethyl)-2-piperidone as cell migration inhibitor |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6054468A (enExample) |
| EP (1) | EP0906305A1 (enExample) |
| JP (1) | JP2000511549A (enExample) |
| KR (1) | KR20000010698A (enExample) |
| AU (1) | AU725585B2 (enExample) |
| CA (1) | CA2254757A1 (enExample) |
| NZ (1) | NZ332545A (enExample) |
| WO (1) | WO1997046552A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000076511A1 (en) | 1999-06-11 | 2000-12-21 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| US6358979B1 (en) | 1999-06-11 | 2002-03-19 | Merck & Co., Inc. | N-cyclopentyl modulators of chemokine receptor activity |
| US6500844B1 (en) | 1999-06-11 | 2002-12-31 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| US6472410B1 (en) | 1999-06-11 | 2002-10-29 | Merck & Co., Inc. | N-cyclopentyl modulators of chemokine receptor activity |
| AU5600100A (en) | 1999-06-11 | 2001-01-02 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| WO2000076513A1 (en) | 1999-06-11 | 2000-12-21 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| US7012100B1 (en) * | 2002-06-04 | 2006-03-14 | Avolix Pharmaceuticals, Inc. | Cell migration inhibiting compositions and methods and compositions for treating cancer |
| US20030236290A1 (en) * | 2002-06-12 | 2003-12-25 | Gabriel Fenteany | Inhibitors of animal cell motility and growth |
| US20050095648A1 (en) * | 2003-10-30 | 2005-05-05 | Mario Geysen | Method for designing linear epitopes and algorithm therefor and polypeptide epitopes |
| WO2005067980A2 (en) * | 2004-01-12 | 2005-07-28 | Pointilliste, Inc. | Design of therapeutics and therapeutics |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9510944D0 (en) * | 1995-05-31 | 1995-07-26 | Bogaert Thierry | Assays and processes for the identification of compounds which control cell behaviour,the compounds identified and their use in the control of cell behaviour |
-
1997
- 1997-05-26 CA CA002254757A patent/CA2254757A1/en not_active Abandoned
- 1997-05-26 JP JP10500202A patent/JP2000511549A/ja active Pending
- 1997-05-26 KR KR1019980708778A patent/KR20000010698A/ko not_active Ceased
- 1997-05-26 US US09/194,315 patent/US6054468A/en not_active Expired - Fee Related
- 1997-05-26 NZ NZ332545A patent/NZ332545A/xx unknown
- 1997-05-26 EP EP97927065A patent/EP0906305A1/en not_active Withdrawn
- 1997-05-26 AU AU31689/97A patent/AU725585B2/en not_active Ceased
- 1997-05-26 WO PCT/EP1997/002775 patent/WO1997046552A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| NZ332545A (enExample) | 2000-01-28 |
| AU3168997A (en) | 1998-01-05 |
| EP0906305A1 (en) | 1999-04-07 |
| JP2000511549A (ja) | 2000-09-05 |
| KR20000010698A (ko) | 2000-02-25 |
| WO1997046552A1 (en) | 1997-12-11 |
| AU725585B2 (en) | 2000-10-12 |
| US6054468A (en) | 2000-04-25 |
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| Date | Code | Title | Description |
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| FZDE | Discontinued |