JP2000510232A - センサ及びこのセンサ用の改質した膜 - Google Patents
センサ及びこのセンサ用の改質した膜Info
- Publication number
- JP2000510232A JP2000510232A JP09534838A JP53483897A JP2000510232A JP 2000510232 A JP2000510232 A JP 2000510232A JP 09534838 A JP09534838 A JP 09534838A JP 53483897 A JP53483897 A JP 53483897A JP 2000510232 A JP2000510232 A JP 2000510232A
- Authority
- JP
- Japan
- Prior art keywords
- membrane
- sensor
- layer
- film
- hydrophilic component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
- B01D67/0081—After-treatment of organic or inorganic membranes
- B01D67/0093—Chemical modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/002—Electrode membranes
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Inorganic Chemistry (AREA)
- Manufacturing & Machinery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Steroid Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 生物学的試料中の検体を計測するためのセンサであって、膜(21)によ って覆われた又はこの膜を含む計測面を有し、計測されるべき検体は前記計測 面に向かって前記膜を透過し、この膜(21)は、前記試料に面する表面(2 6)上に遊離基(28、29)を備えている、前記センサにおいて、 親水性成分の鎖(30)が前記表面(26)上の前記遊離基(28)に化学 的に結合されるように前記親水性成分を前記表面(26)上に固定することに よって前記表面(26)を改質し、かくして前記表面(26)の親水性をその 未改質状態に対して高めた、ことを特徴とするセンサ。 2. 前記膜(21)は、一方の表面(26)から他方の表面まで延在する小孔 (25)を有する、ことを特徴とする請求項1に記載のセンサ(1)。 3. 前記膜(21)は二層又は多層の膜であり、前記試料に面した膜層(24 )は、層の一方の表面(26)から層の反対側の表面(27)まで延在する小 孔(25)を有する、ことを特徴とする請求項2に記載のセンサ(1)。 4. 前記親水性成分の鎖は、前記膜(24)の前記小孔(25)に入り込んで おり、前記小孔(25)の表面上の前記遊離基(28)に結合されている、こ とを特徴とする請求項2又は3に記載のセンサ(1)。 5. 前記試料に面した前記膜層(24)は、ポリエチレンテレフタレートを含 む、ことを特徴とする請求項1乃至4のうちのいずれか一項に記載のセンサ( 1)。 6. 前記親水性成分は、ポリエチレングリコールである、ことを特徴とする請 求項1乃至5のうちのいずれか一項に記載のセンサ(1)。 7. ポリエチレングリコールからなる鎖(30)は、前記膜層(24)の−C OOH遊離基(28)に結合されている、ことを特徴とする請求項6に記載の センサ(1)。 8. センサ(1)で使用するための、遊離基(28、29)を備えた表面(2 6)を持つ膜(21)において、 親水性成分の鎖(30)が前記表面(26)上の前記遊離基(28)に化学 的に結合されるように前記親水性成分を前記表面(26)上に固定することに よって前記表面(26)を改質し、かくして前記表面(26)の親水性をその 未改質状態に対して高めた、ことを特徴とするセンサ。 9. 前記膜(21)は、一方の表面(26)から他方の表面まで延在する小孔 (25)を有する、ことを特徴とする請求項8に記載の膜(21)。 10.前記膜(21)は二層又は多層の膜であり、前記試料に面した膜層(24) は、層の一方の表面(26)から層の反対側の表面(27)まで延在する小孔 (25)を有する、ことを特徴とする請求項9に記載の膜(21)。 11.前記親水性成分の鎖は、前記膜(24)の前記小孔(25)に入り込んでお り、前記小孔(25)の表面上の前記遊離基(28)に結合されている、こと を特徴とする請求項9又は10に記載の膜(21)。 12.前記試料に面した前記膜層(24)は、ポリエチレンテレフタレートを含む 、ことを特徴とする請求項8乃至11のうちのいずれか一項に記載の膜(21 )。 13.前記親水性成分は、ポリエチレングリコールである、ことを特徴とする請求 項8乃至12のうちのいずれか一項に記載の膜(21)。 14.ポリエチレングリコールからなる鎖(30)は、前記膜層(24)の−CO OH遊離基(28)に結合されている、ことを特徴とする請求項13に記載の 膜(21)。 15.前記膜は、主に円形の膜リング(3)によって延伸状態に保持される、こと を特徴とする請求項8乃至14のうちのいずれか一項に記載の膜(21)。 16.前記膜リング(3)は、電極(2)に取り付けられるようになった手段 (15)に連結されている、ことを特徴とする請求項15に記載の膜(21) 。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK36096 | 1996-03-29 | ||
DK0360/96 | 1996-03-29 | ||
PCT/DK1997/000111 WO1997036994A1 (en) | 1996-03-29 | 1997-03-14 | Sensor and modified membrane for the sensor |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2000510232A true JP2000510232A (ja) | 2000-08-08 |
JP3285879B2 JP3285879B2 (ja) | 2002-05-27 |
Family
ID=8092643
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53483897A Expired - Fee Related JP3285879B2 (ja) | 1996-03-29 | 1997-03-14 | センサ及びこのセンサ用の改質した膜 |
Country Status (7)
Country | Link |
---|---|
US (1) | US6099804A (ja) |
EP (1) | EP0889951B1 (ja) |
JP (1) | JP3285879B2 (ja) |
AT (1) | ATE267242T1 (ja) |
DE (1) | DE69729185T2 (ja) |
DK (1) | DK0889951T3 (ja) |
WO (1) | WO1997036994A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009156836A (ja) * | 2007-12-28 | 2009-07-16 | Horiba Ltd | 比較電極 |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1291762C (zh) | 1998-11-20 | 2006-12-27 | 科洛普拉斯特公司 | 对具有亲水涂层的医疗器械进行消毒的方法 |
US6582583B1 (en) * | 1998-11-30 | 2003-06-24 | The United States Of America As Represented By The Department Of Health And Human Services | Amperometric biomimetic enzyme sensors based on modified cyclodextrin as electrocatalysts |
GB9920170D0 (en) * | 1999-08-25 | 1999-10-27 | Univ Portsmouth | A passive sampling device |
WO2001090733A1 (en) * | 2000-05-23 | 2001-11-29 | Radiometer Medical A/S | A sensor membrane, a method for the preparation thereof, a sensor and a layered membrane structure for such sensor |
FR2820057A1 (fr) * | 2001-01-30 | 2002-08-02 | Ct De Transfert De Technologie | Membrane pour chambre d'encapsulation de cellules produisant au moins une substance biologiquement active et organe bio-artificiel comprenant une telle membrane |
WO2005041893A2 (en) * | 2003-10-31 | 2005-05-12 | Queststar Medical, Inc. | Detection of acute myocardial infarction biomarkers |
US20060275859A1 (en) * | 2005-05-17 | 2006-12-07 | Kjaer Thomas | Enzyme sensor including a water-containing spacer layer |
DK1885871T3 (da) * | 2005-05-17 | 2012-07-02 | Radiometer Medical Aps | Enzymsensor med et dækmembranlag af et porøst polymermaterial dækket af en hydrofil polymer |
WO2008011876A2 (de) | 2006-07-24 | 2008-01-31 | Biocer Entwicklungs Gmbh | Anordnung für online-messungen an zellen |
DE102007049013A1 (de) * | 2007-10-11 | 2009-04-16 | Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG | Sensor mit Langzeitstabilität für Bio-Prozesse |
CN102326072B (zh) * | 2008-12-22 | 2014-09-10 | 雷迪奥米特医学公司 | 平板传感器 |
US20110108758A1 (en) * | 2009-01-20 | 2011-05-12 | Driscoll Joseph A | Method for Making Phase Change Aggregates From a Microencapsulated Phase Change Material Liquid Emulsion |
DE102015015588B4 (de) * | 2015-12-04 | 2019-08-29 | Dräger Safety AG & Co. KGaA | Vorrichtung zur nicht-invasiven Erfassung von gasförmigen Stoffwechselprodukten auf der Haut und Verfahren zu deren kontinuierlicher Analyse |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3337763A1 (de) * | 1983-10-18 | 1985-05-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 8000 München | Verfahren und vorrichtung zur oberflaechenmodifizierung der poreninnenwaende von membranen |
DK169616B1 (da) * | 1986-08-27 | 1994-12-27 | Dow Danmark | Permeabel, porøs, polymerbehandlet plastmembran med hydrofil karakter, fremgangsmåder til fremstilling heraf samt anvendelse heraf |
US4885077A (en) * | 1988-11-17 | 1989-12-05 | Becton, Dickinson And Company | Composite membrane, method for its preparation and electrolyte sensor including same |
DE4002513C1 (en) * | 1990-01-29 | 1991-02-07 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung Ev, 8000 Muenchen, De | Modifying surface of membrane for e.g. dialysis - by coating with mono:functional polymer contg. at least one hydrophilic chain |
DK170103B1 (da) * | 1990-08-31 | 1995-05-22 | Radiometer Medical As | Elektrokemisk biosensor samt biosensormembran |
JP2957021B2 (ja) * | 1991-01-25 | 1999-10-04 | テルモ株式会社 | 医療用材料および医療用器具ならびに医療用材料の製造方法 |
US5543465A (en) * | 1993-03-19 | 1996-08-06 | Gambro Dialysatoren Gmbh & Co. | Process for the production of hydrophilic membranes |
US5670097A (en) * | 1994-12-08 | 1997-09-23 | Minnesota Mining And Manufacturing Company | Method of making blood gas sensors overcoats using permeable polymeric compositions |
US5700559A (en) * | 1994-12-16 | 1997-12-23 | Advanced Surface Technology | Durable hydrophilic surface coatings |
-
1997
- 1997-03-14 DK DK97917270T patent/DK0889951T3/da active
- 1997-03-14 AT AT97917270T patent/ATE267242T1/de not_active IP Right Cessation
- 1997-03-14 WO PCT/DK1997/000111 patent/WO1997036994A1/en active IP Right Grant
- 1997-03-14 DE DE69729185T patent/DE69729185T2/de not_active Expired - Lifetime
- 1997-03-14 EP EP97917270A patent/EP0889951B1/en not_active Expired - Lifetime
- 1997-03-14 JP JP53483897A patent/JP3285879B2/ja not_active Expired - Fee Related
- 1997-10-06 US US08/950,362 patent/US6099804A/en not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009156836A (ja) * | 2007-12-28 | 2009-07-16 | Horiba Ltd | 比較電極 |
Also Published As
Publication number | Publication date |
---|---|
EP0889951A1 (en) | 1999-01-13 |
DE69729185D1 (de) | 2004-06-24 |
EP0889951B1 (en) | 2004-05-19 |
ATE267242T1 (de) | 2004-06-15 |
JP3285879B2 (ja) | 2002-05-27 |
WO1997036994A1 (en) | 1997-10-09 |
DE69729185T2 (de) | 2004-11-25 |
US6099804A (en) | 2000-08-08 |
DK0889951T3 (da) | 2004-07-26 |
WO1997036994A8 (en) | 1999-08-19 |
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