JP2000503989A - ガン化学増感において化学療法剤とともに使用するための医薬の調製におけるテキサフィリンの使用 - Google Patents
ガン化学増感において化学療法剤とともに使用するための医薬の調製におけるテキサフィリンの使用Info
- Publication number
- JP2000503989A JP2000503989A JP9526941A JP52694197A JP2000503989A JP 2000503989 A JP2000503989 A JP 2000503989A JP 9526941 A JP9526941 A JP 9526941A JP 52694197 A JP52694197 A JP 52694197A JP 2000503989 A JP2000503989 A JP 2000503989A
- Authority
- JP
- Japan
- Prior art keywords
- texaphyrin
- iii
- use according
- chemotherapeutic agent
- metal cation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- A61K31/33—Heterocyclic compounds
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0076—PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Inorganic Chemistry (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US08/591,318 | 1996-01-25 | ||
| US08/591,318 US5776925A (en) | 1996-01-25 | 1996-01-25 | Methods for cancer chemosensitization |
| PCT/US1997/000907 WO1997026915A1 (en) | 1996-01-25 | 1997-01-23 | Use of a thexaphyrin in the preparation of a medicament for use with a chemotherapeutic agent in cancer chemosensitization |
Publications (2)
| Publication Number | Publication Date |
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| JP2000503989A true JP2000503989A (ja) | 2000-04-04 |
| JP2000503989A5 JP2000503989A5 (cg-RX-API-DMAC7.html) | 2004-11-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP9526941A Pending JP2000503989A (ja) | 1996-01-25 | 1997-01-23 | ガン化学増感において化学療法剤とともに使用するための医薬の調製におけるテキサフィリンの使用 |
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| US (1) | US5776925A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0912196B9 (cg-RX-API-DMAC7.html) |
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| WO (1) | WO1997026915A1 (cg-RX-API-DMAC7.html) |
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| US5457183A (en) * | 1989-03-06 | 1995-10-10 | Board Of Regents, The University Of Texas System | Hydroxylated texaphyrins |
| US6482436B1 (en) | 1993-01-29 | 2002-11-19 | Ferx Incorporated | Magnetically responsive composition |
| US6200547B1 (en) * | 1994-01-26 | 2001-03-13 | Ferx Incorporated | Magnetically responsive compositions for carrying biologically active substances and methods of production and use |
| US5969111A (en) * | 1994-04-14 | 1999-10-19 | Board Of Regents, The University Of Texas System | Texaphyrins substituted with imidazole are provided |
| RU2106146C1 (ru) | 1995-07-17 | 1998-03-10 | Институт элементоорганических соединений РАН | Средство для подавления опухолевого роста |
| US6441025B2 (en) * | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
| JPH10279502A (ja) * | 1997-03-31 | 1998-10-20 | Katsuro Tachibana | 光感受性物質の励起方法 |
| US6022526A (en) * | 1997-07-30 | 2000-02-08 | Pharmacyclics, Inc. | Use of texaphyrins in detection of melanin and melanin metabolites diagnostic of melanotic melanoma |
| ATE376824T1 (de) | 1999-01-13 | 2007-11-15 | Alchemia Oncology Pty Ltd | Verwendung von hyaluronan zur herstellung eines medikaments zur erhöhung der wirksamkeit von zytotoxischen arzneimitteln |
| HK1049787B (en) | 1999-10-01 | 2014-07-25 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| US20030054977A1 (en) * | 1999-10-12 | 2003-03-20 | Cell Therapeutics, Inc. | Manufacture of polyglutamate-therapeutic agent conjugates |
| WO2001032210A2 (en) * | 1999-10-29 | 2001-05-10 | Pharmacyclics, Inc. | Compositions for treating atheroma and neoplastic tissue |
| US20030031676A1 (en) * | 1999-10-29 | 2003-02-13 | Pharmacyclics, Inc. | Conjugate compounds for treating atheroma and other diseases |
| US7579338B2 (en) * | 1999-10-29 | 2009-08-25 | Pharmacyclics, Inc. | Methods and compositions for treating atheroma, tumors and other neoplastic tissues |
| US20020077290A1 (en) * | 2000-03-17 | 2002-06-20 | Rama Bhatt | Polyglutamic acid-camptothecin conjugates and methods of preparation |
| US9066919B2 (en) * | 2000-07-14 | 2015-06-30 | Alchemia Oncology Pty Limited | Hyaluronan as a chemo-sensitizer in the treatment of cancer |
| AUPQ879500A0 (en) * | 2000-07-14 | 2000-08-10 | Meditech Research Limited | Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease |
| US6638924B2 (en) | 2000-08-30 | 2003-10-28 | Pharmacyclics, Inc. | Metallotexaphyrin derivatives |
| US7449454B2 (en) * | 2000-08-30 | 2008-11-11 | Pharmacyclics, Inc. | Metallotexaphyrin derivatives |
| AU2001290580A1 (en) * | 2000-08-30 | 2002-03-13 | Pharmacyclics, Inc. | Non-symmetric tripyrrannes in the synthesis of novel macrocycles |
| US20030188326A1 (en) | 2000-11-03 | 2003-10-02 | Dana Farber Cancer Institute | Methods and compositions for the diagnosis of cancer susceptibilities and defective DNA repair mechanisms and treatment thereof |
| AU2002236458A1 (en) * | 2000-11-17 | 2002-05-27 | Pharmacyclics, Inc. | Texaphyrin coordination compounds and uses thereof |
| US20050013853A1 (en) * | 2000-11-29 | 2005-01-20 | Irit Gil-Ad | Anti-proliferative drugs |
| IL139975A0 (en) * | 2000-11-29 | 2002-02-10 | Univ Ramot | Anti proliferative drugs |
| US6630454B2 (en) | 2001-09-10 | 2003-10-07 | Ramot At Tel-Aviv University Ltd. | Method and pharmaceutical composition for the treatment of cancer |
| WO2003039327A2 (en) | 2001-11-02 | 2003-05-15 | Dana-Farber Cancer Institute | Methods and compositions for the diagnosis of cancer susceptibilities and defective dna repair mechanisms and treatment thereof |
| EP1463511A4 (en) * | 2001-12-13 | 2005-09-28 | Pharmacyclics Inc | COMBINATORY ANTICANCER THERAPY |
| CN1615129A (zh) * | 2001-12-13 | 2005-05-11 | 环状药物公司 | 影响神经病学进展的方法 |
| US6984734B2 (en) | 2002-02-26 | 2006-01-10 | Board Of Regents, The University Of Texas System | Cyclo[n]pyrroles and methods thereto |
| US6723750B2 (en) | 2002-03-15 | 2004-04-20 | Allergan, Inc. | Photodynamic therapy for pre-melanomas |
| US20030224422A1 (en) * | 2002-04-08 | 2003-12-04 | St. Jude Children's Research Hospital, Inc. | Pre-and post therapy gene expression profiling to identify drug targets |
| US20040010218A1 (en) * | 2002-07-11 | 2004-01-15 | Henderson Barbara W. | Photodynamic therapy for the enhancement of vascular permeability to aid in drug delivery to diseased tissues |
| JP2004077714A (ja) * | 2002-08-15 | 2004-03-11 | Fuji Xerox Co Ltd | 光走査装置 |
| US7981928B2 (en) * | 2002-09-05 | 2011-07-19 | Nanodynamics, Inc. | Chemotherapy method using x-rays |
| US20080063605A1 (en) * | 2004-05-20 | 2008-03-13 | Wai-Fung Cheong | Method of Enhancing Visualization of Atherosclerotic Plaque |
| JP2006224318A (ja) * | 2005-02-15 | 2006-08-31 | Brother Ind Ltd | インクジェット記録装置 |
| JP4972929B2 (ja) * | 2005-03-25 | 2012-07-11 | ニプロ株式会社 | 放射線増感剤 |
| EP1704870A1 (en) | 2005-03-25 | 2006-09-27 | Nipro Corporation | Use of iron compounds as radiosensitizers |
| WO2007012133A1 (en) * | 2005-07-27 | 2007-02-01 | Alchemia Oncology Pty Limited | Therapeutic protocols using hyaluronan |
| US8319625B2 (en) * | 2005-09-01 | 2012-11-27 | Simplexgrinnell Lp | Fire alarm textual notification related application |
| EA013877B1 (ru) * | 2005-09-07 | 2010-08-30 | Алкемиа Онколоджи Пти Лимитед | Терапевтические композиции, содержащие гиалуроновую кислоту и терапевтические антитела, а также способы лечения |
| US20070072838A1 (en) | 2005-09-26 | 2007-03-29 | Pharmacyclics, Inc. | High-purity texaphyrin metal complexes |
| US20070078119A1 (en) * | 2005-09-30 | 2007-04-05 | Pharmacyclics, Inc. | Storage system for texaphyrin pharmaceutical formulations |
| JP5590882B2 (ja) * | 2006-06-26 | 2014-09-17 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | 化学療法増感剤としてのシステインに富む酸性分泌タンパク質（ｓｐａｒｃ） |
| US8287839B2 (en) * | 2006-12-04 | 2012-10-16 | Brookhaven Science Associates, Llc | Carboranylporphyrins and uses thereof |
| US8444953B2 (en) * | 2007-03-22 | 2013-05-21 | Brookhaven Science Associates, Llc | Symmetric and asymmetric halogen-containing metallocarboranylporphyrins and uses thereof |
| US20080279781A1 (en) * | 2007-05-10 | 2008-11-13 | Brookhaven Science Associates, Llc | Glycosylated Carboranylporphyrins and Uses Thereof |
| RU2438718C1 (ru) * | 2010-06-18 | 2012-01-10 | Федеральное государственное учреждение "Ростовский научно-исследовательский онкологический институт Федерального агентства по высокотехнологичной медицинской помощи" | Способ лечения сарком мягких тканей |
| US9662328B2 (en) | 2010-11-29 | 2017-05-30 | National Yang-Ming University | Targeting human thymidylate kinase induces DNA repair toxicity in malignant tumor cells |
| TWI445696B (zh) | 2010-11-29 | 2014-07-21 | Univ Nat Yang Ming | 標靶人類胸線核苷酸激酶誘導惡性腫瘤中的ｄｎａ修復毒性 |
| EP3154541A4 (en) | 2014-06-11 | 2017-12-20 | Board of Regents, The University of Texas System | Texaphyrin-pt(iv) conjugates and compositions for use in overcoming platinum resistance |
| EP3554475A4 (en) * | 2016-12-13 | 2020-08-19 | Health Research, Inc. | PHOTODYNAMIC THERAPY (PDT) IN THE NEAR INFRARED (NIR) IN COMBINATION WITH CHEMOTHERAPY |
| CN116264824A (zh) | 2020-08-14 | 2023-06-16 | 德克萨斯大学系统董事会 | 用于锰化学疗法、光声成像和光热疗法的德克萨卟啉衍生物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5457183A (en) * | 1989-03-06 | 1995-10-10 | Board Of Regents, The University Of Texas System | Hydroxylated texaphyrins |
| US5252720A (en) * | 1989-03-06 | 1993-10-12 | Board Of Regents, The University Of Texas System | Metal complexes of water soluble texaphyrins |
| US4935498A (en) * | 1989-03-06 | 1990-06-19 | Board Of Regents, The University Of Texas System | Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles |
| US5599923A (en) * | 1989-03-06 | 1997-02-04 | Board Of Regents, University Of Tx | Texaphyrin metal complexes having improved functionalization |
| US5559207A (en) * | 1989-03-06 | 1996-09-24 | Board Of Regents, University Of Texas | Texaphyrin metal complex mediated ester hydrolysis |
| US5607924A (en) * | 1992-01-21 | 1997-03-04 | Pharmacyclics, Inc. | DNA photocleavage using texaphyrins |
| US5258453A (en) * | 1992-01-21 | 1993-11-02 | University Of Utah | Drug delivery system for the simultaneous delivery of drugs activatable by enzymes and light |
| US5714328A (en) * | 1995-06-07 | 1998-02-03 | Board Of Regents, The University Of Texas System | RNA photocleavage using texaphyrins |
-
1996
- 1996-01-25 US US08/591,318 patent/US5776925A/en not_active Expired - Lifetime
-
1997
- 1997-01-23 AU AU18333/97A patent/AU715025B2/en not_active Ceased
- 1997-01-23 NZ NZ331513A patent/NZ331513A/en unknown
- 1997-01-23 CN CN97192481A patent/CN1093766C/zh not_active Expired - Fee Related
- 1997-01-23 DE DE69730961T patent/DE69730961T2/de not_active Expired - Fee Related
- 1997-01-23 AT AT97903873T patent/ATE277637T1/de not_active IP Right Cessation
- 1997-01-23 EP EP97903873A patent/EP0912196B9/en not_active Expired - Lifetime
- 1997-01-23 WO PCT/US1997/000907 patent/WO1997026915A1/en not_active Ceased
- 1997-01-23 ES ES97903873T patent/ES2227671T3/es not_active Expired - Lifetime
- 1997-01-23 JP JP9526941A patent/JP2000503989A/ja active Pending
- 1997-01-23 KR KR1019980705744A patent/KR19990082024A/ko not_active Ceased
-
1998
- 1998-07-22 IL IL12545998A patent/IL125459A0/xx unknown
- 1998-07-24 NO NO983429A patent/NO983429L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1093766C (zh) | 2002-11-06 |
| EP0912196B1 (en) | 2004-09-29 |
| DE69730961T2 (de) | 2005-11-24 |
| EP0912196B9 (en) | 2005-01-05 |
| CN1213313A (zh) | 1999-04-07 |
| AU1833397A (en) | 1997-08-20 |
| EP0912196A1 (en) | 1999-05-06 |
| DE69730961D1 (de) | 2004-11-04 |
| KR19990082024A (ko) | 1999-11-15 |
| IL125459A0 (en) | 1999-03-12 |
| US5776925A (en) | 1998-07-07 |
| ATE277637T1 (de) | 2004-10-15 |
| NZ331513A (en) | 2001-10-26 |
| AU715025B2 (en) | 2000-01-13 |
| ES2227671T3 (es) | 2005-04-01 |
| NO983429L (no) | 1998-09-24 |
| WO1997026915A1 (en) | 1997-07-31 |
| NO983429D0 (no) | 1998-07-24 |
| HK1018588A1 (en) | 1999-12-30 |
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