JP2000502088A5 - - Google Patents

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Publication number
JP2000502088A5
JP2000502088A5 JP1997522457A JP52245797A JP2000502088A5 JP 2000502088 A5 JP2000502088 A5 JP 2000502088A5 JP 1997522457 A JP1997522457 A JP 1997522457A JP 52245797 A JP52245797 A JP 52245797A JP 2000502088 A5 JP2000502088 A5 JP 2000502088A5
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JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP1997522457A
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English (en)
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JP2000502088A (ja
JP4112004B2 (ja
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Priority claimed from PCT/EP1996/005362 external-priority patent/WO1997022587A1/en
Publication of JP2000502088A publication Critical patent/JP2000502088A/ja
Publication of JP2000502088A5 publication Critical patent/JP2000502088A5/ja
Application granted granted Critical
Publication of JP4112004B2 publication Critical patent/JP4112004B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Figure 2000502088
Figure 2000502088
Figure 2000502088
Figure 2000502088
Figure 2000502088
Figure 2000502088
Figure 2000502088
JP52245797A 1995-12-15 1996-12-03 ＴＮＦ―αおよびマトリックスメタロプロテイナーゼ阻害剤としての、α―置換アリールスルホンアミドヒドロキサム酸 Expired - Fee Related JP4112004B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US866195P 1995-12-15 1995-12-15
US60/008,661 1995-12-15
PCT/EP1996/005362 WO1997022587A1 (en) 1995-12-15 1996-12-03 Alpha-substituted arylsulphonamido hydroxamic acids as tnf-alpha and matrix metalloproteinase inhibitors

Publications (3)

Publication Number Publication Date
JP2000502088A JP2000502088A (ja) 2000-02-22
JP2000502088A5 true JP2000502088A5 (ja) 2004-11-04
JP4112004B2 JP4112004B2 (ja) 2008-07-02

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP52245797A Expired - Fee Related JP4112004B2 (ja) 1995-12-15 1996-12-03 ＴＮＦ―αおよびマトリックスメタロプロテイナーゼ阻害剤としての、α―置換アリールスルホンアミドヒドロキサム酸

Country Status (27)

Country Link
US (1) US5770624A (ja)
EP (1) EP0873312B1 (ja)
JP (1) JP4112004B2 (ja)
KR (1) KR100452941B1 (ja)
CN (1) CN1173948C (ja)
AR (1) AR005068A1 (ja)
AT (1) ATE219058T1 (ja)
AU (1) AU709489B2 (ja)
BR (1) BR9612136B1 (ja)
CZ (1) CZ292431B6 (ja)
DE (1) DE69621830T2 (ja)
DK (1) DK0873312T3 (ja)
EA (1) EA002019B1 (ja)
ES (1) ES2178724T3 (ja)
HK (1) HK1011536A1 (ja)
HU (1) HU226123B1 (ja)
IL (1) IL124524A (ja)
MX (1) MX9804793A (ja)
NO (1) NO311643B1 (ja)
NZ (1) NZ324287A (ja)
PL (1) PL187136B1 (ja)
PT (1) PT873312E (ja)
SK (1) SK78998A3 (ja)
TR (1) TR199801105T2 (ja)
TW (1) TW453995B (ja)
WO (1) WO1997022587A1 (ja)
ZA (1) ZA9610532B (ja)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0874830T3 (da) * 1995-12-08 2003-04-22 Agouron Pharma Metalloproteinaseinhibitor, farmaceutisk præparat indeholdende denne og den farmaceutiske anvendelse samt en fremgangsmåde til fremstilling deraf
US6500948B1 (en) 1995-12-08 2002-12-31 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
US5929097A (en) * 1996-10-16 1999-07-27 American Cyanamid Company Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
US5962481A (en) * 1996-10-16 1999-10-05 American Cyanamid Company Preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
US6548524B2 (en) 1996-10-16 2003-04-15 American Cyanamid Company Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors
US5977408A (en) * 1996-10-16 1999-11-02 American Cyanamid Company Preparation and use of β-sulfonamido hydroxamic acids as matrix metalloproteinase and TACE inhibitors
US6228869B1 (en) 1996-10-16 2001-05-08 American Cyanamid Company Ortho-sulfonamido bicyclic hydroxamic acids as matrix metalloproteinase and TACE inhibitors
US6008243A (en) * 1996-10-24 1999-12-28 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
US6174915B1 (en) 1997-03-25 2001-01-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US5985900A (en) * 1997-04-01 1999-11-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
IL127496A0 (en) * 1997-12-19 1999-10-28 Pfizer Prod Inc The use of MMP inhibitors for the treatment of ocular angiogenesis
US6492394B1 (en) * 1998-12-22 2002-12-10 Syntex (U.S.A.) Llc Sulfonamide hydroxamates
US20040122011A1 (en) * 1998-12-23 2004-06-24 Pharmacia Corporation Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy
US6277885B1 (en) 1999-01-27 2001-08-21 American Cyanamid Company Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors
CN1178915C (zh) 1999-01-27 2004-12-08 惠氏控股有限公司 含有炔基的异羟肟酸衍生物、其制备及其作为基质金属蛋白酶抑制剂/TNF-α转变酶抑制剂的用途
US6762178B2 (en) 1999-01-27 2004-07-13 Wyeth Holdings Corporation Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors
US6225311B1 (en) 1999-01-27 2001-05-01 American Cyanamid Company Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors
US6313123B1 (en) 1999-01-27 2001-11-06 American Cyanamid Company Acetylenic sulfonamide thiol tace inhibitors
US6326516B1 (en) 1999-01-27 2001-12-04 American Cyanamid Company Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors
US6200996B1 (en) 1999-01-27 2001-03-13 American Cyanamid Company Heteroaryl acetylenic sulfonamide and phosphinic acid amide hydroxamic acid tace inhibitors
US6340691B1 (en) 1999-01-27 2002-01-22 American Cyanamid Company Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors
US6946473B2 (en) 1999-01-27 2005-09-20 Wyeth Holdings Corporation Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors
US6753337B2 (en) 1999-01-27 2004-06-22 Wyeth Holdings Corporation Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors
GB9918684D0 (en) * 1999-08-09 1999-10-13 Novartis Ag Organic compounds
GB9922825D0 (en) * 1999-09-25 1999-11-24 Smithkline Beecham Biolog Medical use
US6531128B1 (en) * 2000-02-08 2003-03-11 Pharmacia Corporation Methods for treating glaucoma
EP1267903A4 (en) * 2000-02-08 2003-08-06 Pharmacia Corp METHODS OF TREATING GLAUCOMA
US6465508B1 (en) 2000-02-25 2002-10-15 Wyeth Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase inhibitors
NZ520657A (en) 2000-03-21 2004-11-26 Procter & Gamble Heterocyclic side chain containing, N-substituted metalloprotease inhibitors
JP2003528082A (ja) 2000-03-21 2003-09-24 ザ プロクター アンド ギャンブル カンパニー ニフッ化酪酸メタロプロテアーゼ阻害物質
EP1265887A2 (en) * 2000-03-21 2002-12-18 The Procter & Gamble Company Carbocyclic side chain containing metalloprotease inhibitors
EP1265886A2 (en) * 2000-03-21 2002-12-18 The Procter & Gamble Company Carbocyclic side chain containing, n-substituted metalloprotease inhibitors
BR0213736A (pt) 2001-11-01 2004-10-19 Wyeth Corp ácidos hidroxâmicos de sulfonamida de arila alênica como metaloproteinase matriz e inibidores de tace
PE20030701A1 (es) 2001-12-20 2003-08-21 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
GB0208176D0 (en) * 2002-04-09 2002-05-22 Novartis Ag Organic compounds
AU2003253346A1 (en) * 2002-07-29 2004-02-23 Novartis Ag Use or arylsulfonamido-substituted hydroxamid acid matrix metalloproteinase inhibitors for the treatment or prevention of toxemia
WO2004056353A2 (en) * 2002-12-20 2004-07-08 Novartis Ag Device and method for delivering mmp inhibitors
AU2003304456A1 (en) 2002-12-23 2005-03-16 Wyeth Holdings Corporation Acetylenic aryl sulfonate hydroxamic acid tace and matrix metalloproteinase inhibitors
US8231858B2 (en) 2003-02-10 2012-07-31 Ge Healthcare Limited Diagnostic imaging agents with MMP inhibitory activity
JP2006517216A (ja) * 2003-02-11 2006-07-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗コリン作用剤とｔａｃｅ阻害剤に基づく新規な医薬組成物
WO2007141029A1 (en) * 2006-06-08 2007-12-13 Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) Specific protease inhibitors and their use in cancer therapy
FR2947270B1 (fr) 2009-06-30 2011-08-26 Galderma Res & Dev Nouveaux composes benzene-sulfonamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique
FR2947268B1 (fr) 2009-06-30 2011-08-26 Galderma Res & Dev Nouveaux composes benzene-sulfonamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique
US20140275108A1 (en) 2013-03-15 2014-09-18 Galderma Research & Development Novel benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics
GB201510758D0 (en) 2015-06-18 2015-08-05 Ucb Biopharma Sprl Novel TNFa structure for use in therapy
ES2695533T3 (es) 2016-02-01 2019-01-08 Galderma Res & Dev Compuestos de bencenosulfonamida, método para su síntesis y uso de los mismos en medicina y cosméticos
GB201621907D0 (en) 2016-12-21 2017-02-01 Ucb Biopharma Sprl And Sanofi Antibody epitope

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5646167A (en) * 1993-01-06 1997-07-08 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamix acids
US5455258A (en) * 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
US5552419A (en) * 1993-01-06 1996-09-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
US5506242A (en) * 1993-01-06 1996-04-09 Ciba-Geigy Corporation Arylsufonamido-substituted hydroxamic acids
DK0766665T3 (da) * 1994-06-22 1999-12-06 British Biotech Pharm Metalloproteinaseinhibitorer
US5863949A (en) * 1995-03-08 1999-01-26 Pfizer Inc Arylsulfonylamino hydroxamic acid derivatives

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