JP2000502061A5 - - Google Patents
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- Publication number
- JP2000502061A5 JP2000502061A5 JP1997520757A JP52075797A JP2000502061A5 JP 2000502061 A5 JP2000502061 A5 JP 2000502061A5 JP 1997520757 A JP1997520757 A JP 1997520757A JP 52075797 A JP52075797 A JP 52075797A JP 2000502061 A5 JP2000502061 A5 JP 2000502061A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56575695A | 1995-11-30 | 1995-11-30 | |
| US08/565,756 | 1995-11-30 | ||
| PCT/US1996/019721 WO1997019675A2 (en) | 1995-11-30 | 1996-11-27 | Complex cationic lipids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008078918A Division JP4965489B2 (ja) | 1995-11-30 | 2008-03-25 | カチオン脂質複合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2000502061A JP2000502061A (ja) | 2000-02-22 |
| JP2000502061A5 true JP2000502061A5 (enExample) | 2004-10-28 |
| JP4430135B2 JP4430135B2 (ja) | 2010-03-10 |
Family
ID=24259963
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP52075797A Expired - Fee Related JP4430135B2 (ja) | 1995-11-30 | 1996-11-27 | カチオン脂質複合体 |
| JP2008078918A Expired - Fee Related JP4965489B2 (ja) | 1995-11-30 | 2008-03-25 | カチオン脂質複合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008078918A Expired - Fee Related JP4965489B2 (ja) | 1995-11-30 | 2008-03-25 | カチオン脂質複合体 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US6670332B1 (enExample) |
| EP (1) | EP0863749A2 (enExample) |
| JP (2) | JP4430135B2 (enExample) |
| CA (1) | CA2237316C (enExample) |
| WO (1) | WO1997019675A2 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US6673776B1 (en) | 1989-03-21 | 2004-01-06 | Vical Incorporated | Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human |
| US6214804B1 (en) | 1989-03-21 | 2001-04-10 | Vical Incorporated | Induction of a protective immune response in a mammal by injecting a DNA sequence |
| US6867195B1 (en) | 1989-03-21 | 2005-03-15 | Vical Incorporated | Lipid-mediated polynucleotide administration to reduce likelihood of subject's becoming infected |
| EP0500799B1 (en) | 1989-11-16 | 1998-01-14 | Duke University | Particle mediated transformation of animal skin tissue cells |
| US6228844B1 (en) | 1991-11-12 | 2001-05-08 | Vical Incorporated | Stimulating vascular growth by administration of DNA sequences encoding VEGF |
| US6706694B1 (en) | 1990-03-21 | 2004-03-16 | Vical Incorporated | Expression of exogenous polynucleotide sequences in a vertebrate |
| US7105574B1 (en) | 1999-03-26 | 2006-09-12 | Vical Incorporated | Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines |
| US5641665A (en) * | 1994-11-28 | 1997-06-24 | Vical Incorporated | Plasmids suitable for IL-2 expression |
| EP0863749A2 (en) * | 1995-11-30 | 1998-09-16 | Vical Incorporated | Complex cationic lipids |
| JP2001523480A (ja) * | 1997-11-20 | 2001-11-27 | バイカル インコーポレイテッド | サイトカイン発現ポリヌクレオチドおよびそれらの組成物を用いた癌の処置 |
| US6043390A (en) | 1998-04-03 | 2000-03-28 | The Regents Of The University Of California | Pentaerythritol lipid derivatives and nucleic-acid complexes |
| US6583301B1 (en) * | 1998-04-08 | 2003-06-24 | Celltech R & D Limited | Lipids |
| US7078224B1 (en) * | 1999-05-14 | 2006-07-18 | Promega Corporation | Cell concentration and lysate clearance using paramagnetic particles |
| EP1459766B1 (en) * | 1999-03-26 | 2008-06-11 | Vical Incorporated | Adjuvant compositions for enhancing immune responses to polynucleotide-based vaccines |
| DE60012711T2 (de) | 1999-03-26 | 2005-08-18 | Vical, Inc., San Diego | Adjuvanszusammensetzungen zur erhöhung der immunantwort auf polynukleotid-basierende impfstoffe |
| US6696424B1 (en) | 1999-05-28 | 2004-02-24 | Vical Incorporated | Cytofectin dimers and methods of use thereof |
| DE60016205T2 (de) * | 1999-05-28 | 2005-12-01 | Vical, Inc., San Diego | Cytofectin-dimere und verfahren zu ihrer anwendung |
| EP1278551A2 (en) * | 2000-04-21 | 2003-01-29 | Vical Incorporated | Compositions and methods for (in vivo) delivery of polynucleotide-based therapeutics |
| US7935812B2 (en) * | 2002-02-20 | 2011-05-03 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of hepatitis C virus (HCV) expression using short interfering nucleic acid (siNA) |
| EP1575505A4 (en) * | 2002-09-10 | 2007-01-24 | Vical Inc | CODON OPTIMIZATION-BASED POLYNUCLEOTIDE VACCINES AGAINST BACILLUS ANTHRACIS INFECTION |
| CA2508279A1 (en) * | 2002-12-23 | 2004-07-22 | Vical Incorporated | Method for freeze-drying nucleic acid/block copolymer/cationic surfactant complexes |
| US7381422B2 (en) * | 2002-12-23 | 2008-06-03 | Vical Incorporated | Method for producing sterile polynucleotide based medicaments |
| US8080642B2 (en) * | 2003-05-16 | 2011-12-20 | Vical Incorporated | Severe acute respiratory syndrome DNA compositions and methods of use |
| JP5331340B2 (ja) * | 2004-05-18 | 2013-10-30 | バイカル インコーポレイテッド | インフルエンザウィルスワクチン組成物、及びその使用方法 |
| CA2569664C (en) * | 2004-06-07 | 2013-07-16 | Protiva Biotherapeutics, Inc. | Lipid encapsulated interfering rna |
| US20060134221A1 (en) * | 2004-12-03 | 2006-06-22 | Vical Incorporated | Methods for producing block copolymer/amphiphilic particles |
| CA2597724A1 (en) * | 2005-02-14 | 2007-08-02 | Sirna Therapeutics, Inc. | Cationic lipids and formulated molecular compositions containing them |
| US7404969B2 (en) * | 2005-02-14 | 2008-07-29 | Sirna Therapeutics, Inc. | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules |
| WO2007070381A2 (en) | 2005-12-09 | 2007-06-21 | Promega Corporation | Nucleic acid purification with a binding matrix |
| EP1996730A4 (en) * | 2006-03-08 | 2010-03-03 | Promega Corp | CLEANING OF SMALL RNA |
| JP2010513354A (ja) * | 2006-12-19 | 2010-04-30 | ノヴォソム アクチェンゲゼルシャフト | トランスフェクションエンハンサー要素を含む脂質および脂質集合体 |
| WO2008103276A2 (en) * | 2007-02-16 | 2008-08-28 | Merck & Co., Inc. | Compositions and methods for potentiated activity of biologicaly active molecules |
| WO2008148057A2 (en) | 2007-05-23 | 2008-12-04 | Vical Incorporated | Cationic lipids compositions and methods for enhancing immune responses to vaccines |
| WO2009129395A1 (en) * | 2008-04-16 | 2009-10-22 | Abbott Laboratories | Cationic lipids and uses thereof |
| US8569256B2 (en) | 2009-07-01 | 2013-10-29 | Protiva Biotherapeutics, Inc. | Cationic lipids and methods for the delivery of therapeutic agents |
| US9018187B2 (en) | 2009-07-01 | 2015-04-28 | Protiva Biotherapeutics, Inc. | Cationic lipids and methods for the delivery of therapeutic agents |
| US8039613B2 (en) | 2009-08-28 | 2011-10-18 | Promega Corporation | Methods of purifying a nucleic acid and formulation and kit for use in performing such methods |
| US8222397B2 (en) | 2009-08-28 | 2012-07-17 | Promega Corporation | Methods of optimal purification of nucleic acids and kit for use in performing such methods |
| US20130129811A1 (en) | 2010-04-28 | 2013-05-23 | Takeshi Kuboyama | Cationic lipid |
| KR101773643B1 (ko) | 2010-04-28 | 2017-08-31 | 교와 핫꼬 기린 가부시키가이샤 | 양이온성 지질 |
| US8956646B2 (en) | 2010-08-14 | 2015-02-17 | The Regents Of The University Of California | Zwitterionic lipids |
| JP2013095755A (ja) | 2011-11-02 | 2013-05-20 | Kyowa Hakko Kirin Co Ltd | カチオン性脂質 |
| JP6182457B2 (ja) | 2011-12-12 | 2017-08-16 | 協和発酵キリン株式会社 | カチオン性脂質を含有するドラックデリバリーシステムのための脂質ナノ粒子 |
| CN104159615B (zh) | 2011-12-12 | 2017-08-18 | 协和发酵麒麟株式会社 | 含有阳离子性脂质的组合的脂质纳米粒子 |
| TW201726599A (zh) | 2012-07-06 | 2017-08-01 | 協和醱酵麒麟有限公司 | 陽離子性脂質 |
| AU2013291125A1 (en) | 2012-07-16 | 2015-01-22 | Dicerna Pharmaceuticals, Inc. | RNAi pharmaceutical composition capable of suppressing expression of KRAS gene |
| US10525138B2 (en) | 2015-12-25 | 2020-01-07 | Kyowa Hakko Kirin Co., Ltd. | Compound as cationic lipid |
| IL276322B2 (en) * | 2018-02-01 | 2024-12-01 | Tufts College | Lipid-like nanocomplexes and uses thereof |
| AU2022281746B2 (en) | 2021-05-24 | 2025-01-16 | Suzhou Abogen Biosciences Co., Ltd. | Lipid compounds and lipid nanoparticle compositions |
| WO2025031498A1 (zh) | 2023-08-10 | 2025-02-13 | 浙江海昶生物医药技术有限公司 | Toll样受体激动剂及其应用 |
| WO2025036297A1 (zh) | 2023-08-11 | 2025-02-20 | 浙江海昶生物医药技术有限公司 | 一种具有靶向性的脂质组合物及其制备方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2368208A (en) | 1940-12-16 | 1945-01-30 | Emulsol Corp | Chemical compounds and method of preparing same |
| US3265719A (en) | 1959-12-28 | 1966-08-09 | American Cyanamid Co | Betaines |
| JPH0662517B2 (ja) * | 1985-01-07 | 1994-08-17 | シンテツクス(ユー・エス・エイ)インコーポレイテツド | 置換アルキルートリ置換アンモニウム界面活性剤 |
| US5049386A (en) | 1985-01-07 | 1991-09-17 | Syntex (U.S.A.) Inc. | N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| DE3618517A1 (de) | 1985-06-04 | 1986-12-04 | Lion Corp., Tokio/Tokyo | Emulgiermittel zur emulsionspolymerisation |
| US5068431A (en) | 1987-08-31 | 1991-11-26 | Witco Corporation | Methods of making new surface active compounds |
| US4864060A (en) | 1987-08-31 | 1989-09-05 | Witco Corporation | Surface active compounds, methods for making same and uses thereof |
| JP2801727B2 (ja) * | 1990-03-06 | 1998-09-21 | 花王株式会社 | 低刺激性界面活性剤 |
| US5279833A (en) | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| DE4013632A1 (de) | 1990-04-27 | 1991-10-31 | Max Planck Gesellschaft | Liposomen mit positiver ueberschussladung |
| AU7979491A (en) * | 1990-05-03 | 1991-11-27 | Vical, Inc. | Intracellular delivery of biologically active substances by means of self-assembling lipid complexes |
| JPH0525106A (ja) | 1991-07-22 | 1993-02-02 | Kao Corp | カルボキシベタイン誘導体及びこれを含有する化粧料 |
| US6001644A (en) | 1991-12-17 | 1999-12-14 | The Regents Of The University Of California | Mammalian transformation complex comprising a lipid carrier and DNA encoding CFTR |
| US5334761A (en) | 1992-08-28 | 1994-08-02 | Life Technologies, Inc. | Cationic lipids |
| WO1995002698A1 (en) * | 1993-07-12 | 1995-01-26 | Life Technologies, Inc. | Composition and methods for transfecting eukaryotic cells |
| KR960705798A (ko) | 1993-11-24 | 1996-11-08 | 벤자민 에프 맥그로우 | 피페라진의 양쪽친화성 유도체(amphiphilic derivatives of piperazine) |
| KR960705771A (ko) | 1993-11-24 | 1996-11-08 | 벤자민 에프 맥그로우 | 구아니딘의 양쪽친화성 유도체(amphiphilic derivatives of guanidine) |
| US5928944A (en) | 1994-02-04 | 1999-07-27 | The United States Of America As Represented By The Department Of Health And Human Services | Method of adenoviral-medicated cell transfection |
| US6075012A (en) * | 1994-02-11 | 2000-06-13 | Life Technologies, Inc. | Reagents for intracellular delivery of macromolecules |
| US5908635A (en) * | 1994-08-05 | 1999-06-01 | The United States Of America As Represented By The Department Of Health And Human Services | Method for the liposomal delivery of nucleic acids |
| US5780009A (en) | 1995-01-20 | 1998-07-14 | Nexia Biotechnologies, Inc. | Direct gene transfer into the ruminant mammary gland |
| US5739271A (en) | 1995-06-07 | 1998-04-14 | Gen-Probe Incorporated | Thiocationic lipids |
| US5711964A (en) * | 1995-06-07 | 1998-01-27 | United States Of America | Method for the intracellular delivery of biomolecules using liposomes containing cationic lipids and vitamin D |
| WO1996040961A1 (en) | 1995-06-07 | 1996-12-19 | Life Technologies, Inc. | Peptide-enhanced cationic lipid transfections |
| KR19990022597A (ko) * | 1995-06-07 | 1999-03-25 | 다니엘 엘. 캐시앙, 헨리 엘. 노르호프 | 티오양이온성 지질, 제약조성물 및 그 사용 방법 |
| AU7078396A (en) | 1995-09-27 | 1997-04-30 | Regents Of The University Of California, The | Polyfunctional cationic cytofectins, formulations and methods for generating active cytofectin:polynucleotide transfection complexes |
| US5869715A (en) * | 1995-09-27 | 1999-02-09 | The Reagents Of The University Of California | Polyfunctional cationic cytofectins |
| EP0863749A2 (en) | 1995-11-30 | 1998-09-16 | Vical Incorporated | Complex cationic lipids |
| US6077834A (en) * | 1996-02-09 | 2000-06-20 | Cheng; Pi-Wan | Receptor ligand-facilitated delivery of biologically active molecules |
| JP3258900B2 (ja) | 1996-03-22 | 2002-02-18 | 三洋電機株式会社 | 電気炊飯器 |
| US5962429A (en) * | 1996-11-22 | 1999-10-05 | University Of Iowa | Complexes of adenovirus with cationic molecules |
-
1996
- 1996-11-27 EP EP96943691A patent/EP0863749A2/en not_active Ceased
- 1996-11-27 WO PCT/US1996/019721 patent/WO1997019675A2/en not_active Ceased
- 1996-11-27 JP JP52075797A patent/JP4430135B2/ja not_active Expired - Fee Related
- 1996-11-27 CA CA2237316A patent/CA2237316C/en not_active Expired - Fee Related
-
1998
- 1998-06-05 US US09/092,486 patent/US6670332B1/en not_active Expired - Fee Related
-
2003
- 2003-12-30 US US10/748,853 patent/US8541628B2/en not_active Expired - Fee Related
-
2008
- 2008-03-25 JP JP2008078918A patent/JP4965489B2/ja not_active Expired - Fee Related