JP2000501063A - ファルネシル−タンパク質トランスフェラーゼ阻害剤の組み合わせ - Google Patents

ファルネシル−タンパク質トランスフェラーゼ阻害剤の組み合わせ

Info

Publication number
JP2000501063A
JP2000501063A JP9504573A JP50457397A JP2000501063A JP 2000501063 A JP2000501063 A JP 2000501063A JP 9504573 A JP9504573 A JP 9504573A JP 50457397 A JP50457397 A JP 50457397A JP 2000501063 A JP2000501063 A JP 2000501063A
Authority
JP
Japan
Prior art keywords
substituted
methyl
amino
unsubstituted
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9504573A
Other languages
English (en)
Japanese (ja)
Inventor
カスキー，チヤールズ・テイー
暹 西村
麻里 米本
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603091.1A external-priority patent/GB9603091D0/en
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Publication of JP2000501063A publication Critical patent/JP2000501063A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP9504573A 1995-06-29 1996-06-26 ファルネシル−タンパク質トランスフェラーゼ阻害剤の組み合わせ Pending JP2000501063A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US225195P 1995-06-29 1995-06-29
GBGB9603091.1A GB9603091D0 (en) 1996-02-14 1996-02-14 Combinations of inhibitors of farnesyl-protein transferase
GB60/002,251 1996-02-14
GB9603091.1 1996-02-14
PCT/US1996/011022 WO1997001275A1 (fr) 1995-06-29 1996-06-26 Combinaisons d'inhibiteurs de farnesyl-proteine transferase

Publications (1)

Publication Number Publication Date
JP2000501063A true JP2000501063A (ja) 2000-02-02

Family

ID=26308700

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9504573A Pending JP2000501063A (ja) 1995-06-29 1996-06-26 ファルネシル−タンパク質トランスフェラーゼ阻害剤の組み合わせ

Country Status (5)

Country Link
EP (1) EP0836383A1 (fr)
JP (1) JP2000501063A (fr)
AU (1) AU714072B2 (fr)
CA (1) CA2225255A1 (fr)
WO (1) WO1997001275A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0805154A1 (fr) * 1994-08-12 1997-11-05 Banyu Pharmaceutical Co., Ltd. Derive d'acide amique n,n-bisubstitue
DE69635114T2 (de) * 1995-08-09 2006-03-02 Banyu Pharmaceutical Co., Ltd. Proteinfarnesyltransferase-inhibitoren in kombination mit hmgcoa-reduktase-inhibitoren zur behandlung von aids
AU1619497A (en) * 1996-02-07 1997-08-28 Banyu Pharmaceutical Co., Ltd. Substituted amide derivatives
DE69714303T2 (de) * 1996-02-07 2003-01-23 Banyu Pharma Co Ltd N,n-disubstituierte carbonsaureamid-derivate
CA2244695C (fr) * 1996-02-07 2006-01-03 Banyu Pharmaceutical Co., Ltd. Derives d'acides d'amides cycliques
ATE221045T1 (de) * 1996-02-07 2002-08-15 Banyu Pharma Co Ltd Substituierte amid-derivate
GB9801231D0 (en) 1997-06-05 1998-03-18 Merck & Co Inc A method of treating cancer
EP1002793B1 (fr) 1997-06-09 2003-09-24 Takara Bio Inc. Substances physiologiquement actives tkr2449, leur procede de preparation et micro-organisme
JP2002538151A (ja) 1999-03-02 2002-11-12 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド カテプシンの可逆的インヒビターとして有用な化合物
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
US20030125326A1 (en) * 2000-02-29 2003-07-03 Rybak Mary Ellen Margaret Farnesyl protein transferase inhibitor combinations
ES2576643T3 (es) 2007-03-09 2016-07-08 Second Genome, Inc. Compuestos de bicicloheteroarilo como moduladores de P2X7 y usos de los mismos
WO2008143947A1 (fr) * 2007-05-14 2008-11-27 University Of South Florida Dérivés de farnésylamine et procédés d'utilisation
JP6463366B2 (ja) 2013-10-10 2019-01-30 イースタン バージニア メディカル スクール １２−リポキシゲナーゼ阻害物質としての４−（（２−ヒドロキシ−３−メトキシベンジル）アミノ）ベンゼンスルホンアミド誘導体
JO3637B1 (ar) 2015-04-28 2020-08-27 Janssen Sciences Ireland Uc مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv
TW201932470A (zh) 2017-11-29 2019-08-16 愛爾蘭商健生科學愛爾蘭無限公司 具有抗ｒｓｖ活性之吡唑并嘧啶
JP7305658B2 (ja) 2018-01-31 2023-07-10 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー 抗ｒｓｖ活性を有するシクロアルキル置換ピラゾロピリミジン
WO2019206828A1 (fr) 2018-04-23 2019-10-31 Janssen Sciences Ireland Unlimited Company Composés hétéroaromatiques ayant une activité contre vrs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5298655A (en) * 1991-09-27 1994-03-29 Merck & Co., Inc. Farnesyl pyrophosphate analogs
US5340828A (en) * 1991-09-30 1994-08-23 Merck & Co., Inc. Inhibitors of farnesyl protein transferase
US5245061A (en) * 1991-12-16 1993-09-14 Merck & Co., Inc. Inhibitors of farnesyl protein transferase
US5352705A (en) * 1992-06-26 1994-10-04 Merck & Co., Inc. Inhibitors of farnesyl protein transferase
EP0703905A1 (fr) * 1993-06-18 1996-04-03 Merck & Co. Inc. Inhibiteurs de farnesyle-proteine transferase
AU3192395A (en) * 1994-08-11 1996-03-07 Banyu Pharmaceutical Co., Ltd. Substituted amide derivative

Also Published As

Publication number Publication date
AU714072B2 (en) 1999-12-16
EP0836383A1 (fr) 1998-04-22
AU6399696A (en) 1997-01-30
WO1997001275A1 (fr) 1997-01-16
CA2225255A1 (fr) 1997-01-16

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