JP2000356594A - ダイナミック・レンジの広い光検出システム - Google Patents
ダイナミック・レンジの広い光検出システムInfo
- Publication number
- JP2000356594A JP2000356594A JP2000136666A JP2000136666A JP2000356594A JP 2000356594 A JP2000356594 A JP 2000356594A JP 2000136666 A JP2000136666 A JP 2000136666A JP 2000136666 A JP2000136666 A JP 2000136666A JP 2000356594 A JP2000356594 A JP 2000356594A
- Authority
- JP
- Japan
- Prior art keywords
- detection system
- light detection
- output
- photomultiplier tube
- output signal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J1/00—Photometry, e.g. photographic exposure meter
- G01J1/42—Photometry, e.g. photographic exposure meter using electric radiation detectors
- G01J1/44—Electric circuits
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J43/00—Secondary-emission tubes; Electron-multiplier tubes
- H01J43/04—Electron multipliers
- H01J43/30—Circuit arrangements not adapted to a particular application of the tube and not otherwise provided for
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Photometry And Measurement Of Optical Pulse Characteristics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Spectrometry And Color Measurement (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US313102 | 1999-05-17 | ||
| US09/313,102 US6355921B1 (en) | 1999-05-17 | 1999-05-17 | Large dynamic range light detection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000356594A true JP2000356594A (ja) | 2000-12-26 |
| JP2000356594A5 JP2000356594A5 (enExample) | 2007-06-21 |
Family
ID=23214395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000136666A Pending JP2000356594A (ja) | 1999-05-17 | 2000-05-10 | ダイナミック・レンジの広い光検出システム |
Country Status (3)
| Country | Link |
|---|---|
| US (2) | US6355921B1 (enExample) |
| JP (1) | JP2000356594A (enExample) |
| GB (1) | GB2350187B (enExample) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007518991A (ja) * | 2004-01-14 | 2007-07-12 | ルミネックス・コーポレーション | ダイナミックレンジを拡大する方法及びシステム |
| JP2009244010A (ja) * | 2008-03-31 | 2009-10-22 | Mitsui Eng & Shipbuild Co Ltd | 蛍光検出装置 |
| JP2012253024A (ja) * | 2011-06-06 | 2012-12-20 | Toshiba Corp | 光センサ、ガンマ線検出器、及び陽電子放出コンピュータ断層撮影装置 |
| JP2013072727A (ja) * | 2011-09-27 | 2013-04-22 | Shimadzu Corp | 分光蛍光光度計 |
| JP2016017766A (ja) * | 2014-07-04 | 2016-02-01 | 株式会社島津製作所 | 光検出回路及び光量測定装置 |
| US9877689B2 (en) | 2015-09-30 | 2018-01-30 | Kabushiki Kaisha Toshiba | Detection device and data processing method |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5631734A (en) * | 1994-02-10 | 1997-05-20 | Affymetrix, Inc. | Method and apparatus for detection of fluorescently labeled materials |
| DE10110925A1 (de) * | 2001-03-07 | 2002-09-12 | Zeiss Carl Jena Gmbh | Verfahren zur Photonenzählung in Laser-Scanning-Systemen |
| US7309568B2 (en) | 2001-09-26 | 2007-12-18 | Hitachi, Ltd. | Method in inspecting DNA and apparatus therefor |
| ATE467115T1 (de) | 2002-03-15 | 2010-05-15 | Affymetrix Inc | System und verfahren zur abtastung von biologischen materialien |
| US20060149503A1 (en) * | 2004-12-30 | 2006-07-06 | Minor James M | Methods and systems for fast least squares optimization for analysis of variance with covariants |
| US7248973B2 (en) * | 2002-04-23 | 2007-07-24 | Agilent Technologies, Inc. | Metrics for characterizing chemical arrays based on analysis of variance (ANOVA) factors |
| RU2250441C2 (ru) * | 2002-06-19 | 2005-04-20 | Жувикин Георгий Викторович | Система регистрации светового излучения в большом динамическом диапазоне |
| US20050112689A1 (en) * | 2003-04-04 | 2005-05-26 | Robert Kincaid | Systems and methods for statistically analyzing apparent CGH data anomalies and plotting same |
| US20050216459A1 (en) * | 2002-08-08 | 2005-09-29 | Aditya Vailaya | Methods and systems, for ontological integration of disparate biological data |
| US6825929B2 (en) * | 2002-09-30 | 2004-11-30 | Agilent Technologies, Inc. | Simultaneously reading different regions of a chemical array |
| US7825929B2 (en) * | 2003-04-04 | 2010-11-02 | Agilent Technologies, Inc. | Systems, tools and methods for focus and context viewing of large collections of graphs |
| US7750908B2 (en) * | 2003-04-04 | 2010-07-06 | Agilent Technologies, Inc. | Focus plus context viewing and manipulation of large collections of graphs |
| US7317415B2 (en) | 2003-08-08 | 2008-01-08 | Affymetrix, Inc. | System, method, and product for scanning of biological materials employing dual analog integrators |
| US7348144B2 (en) | 2003-08-13 | 2008-03-25 | Agilent Technologies, Inc. | Methods and system for multi-drug treatment discovery |
| US7324677B2 (en) | 2003-10-14 | 2008-01-29 | Agilent Technologies, Inc. | Feature quantitation methods and system |
| US6972639B2 (en) * | 2003-12-08 | 2005-12-06 | Werlatone, Inc. | Bi-level coupler |
| US7157681B1 (en) * | 2003-12-16 | 2007-01-02 | Wolfgang Tetzlaff | Photomultiplier tube gain stabilization for radiation dosimetry system |
| US6985834B2 (en) * | 2003-12-16 | 2006-01-10 | Agilent Technologies, Inc. | Methods and system for comparing data values across multiple platforms |
| US20050170378A1 (en) * | 2004-02-03 | 2005-08-04 | Yakhini Zohar H. | Methods and systems for joint analysis of array CGH data and gene expression data |
| DE102004009104A1 (de) * | 2004-02-25 | 2005-09-22 | Berthold Technologies Gmbh & Co. Kg | Verfahren und Vorrichtung zum Nachweis ionisierender Strahlung |
| US8321138B2 (en) * | 2005-07-29 | 2012-11-27 | Agilent Technologies, Inc. | Method of characterizing quality of hybridized CGH arrays |
| US20070031883A1 (en) * | 2004-03-04 | 2007-02-08 | Kincaid Robert H | Analyzing CGH data to identify aberrations |
| US20050227221A1 (en) * | 2004-04-09 | 2005-10-13 | Minor James M | Methods and systems for evaluating and for comparing methods of testing tissue samples |
| US7332700B2 (en) * | 2004-04-26 | 2008-02-19 | Bruce Masato Ishimoto | Photomultiplier tube with dynode modulation for photon-counting |
| US7159959B2 (en) * | 2004-05-05 | 2007-01-09 | Agilent Technologies, Inc. | Methods and systems for detecting errors in printhead pattern data and for preventing erroneous printing |
| US20050282174A1 (en) * | 2004-06-19 | 2005-12-22 | Webb Peter G | Methods and systems for selecting nucleic acid probes for microarrays |
| US20060004527A1 (en) * | 2004-07-01 | 2006-01-05 | Sampas Nicholas M | Methods, systems and computer readable media for identifying dye-normalization probes |
| US20060056671A1 (en) * | 2004-09-15 | 2006-03-16 | Jayati Ghosh | Automated feature extraction processes and systems |
| US20060064246A1 (en) * | 2004-09-20 | 2006-03-23 | Medberry Scott L | Automated Processing of chemical arrays and systems therefore |
| US7877213B2 (en) | 2004-09-23 | 2011-01-25 | Agilent Technologies, Inc. | System and methods for automated processing of multiple chemical arrays |
| US20070099227A1 (en) * | 2004-10-12 | 2007-05-03 | Curry Bo U | Significance analysis using data smoothing with shaped response functions |
| US20060247867A1 (en) * | 2005-04-29 | 2006-11-02 | Delenstarr Glenda C | Customized and dynamic association of probe type with feature extraction algorithms |
| US7304288B2 (en) * | 2005-07-06 | 2007-12-04 | The United States Of America As Represented By The Secretary Of The Navy | Laser pulse counter |
| US7333907B2 (en) * | 2005-07-29 | 2008-02-19 | Agilent Technologies, Inc. | System and methods for characterization of chemical arrays for quality control |
| DE102005047271A1 (de) * | 2005-08-15 | 2007-02-22 | Berthold Detection Systems Gmbh | Verfahren zum Messen der Lichtintensität einer Lichtquelle in der Bioanalytik |
| US7463357B2 (en) * | 2005-11-29 | 2008-12-09 | Agilent Technologies, Inc. | Wide dynamic range chemical array reader |
| US20070178480A1 (en) * | 2006-01-31 | 2007-08-02 | Corson John F | Extended dynamic range reading of chemical arrays |
| US20070255512A1 (en) * | 2006-04-28 | 2007-11-01 | Delenstarr Glenda C | Methods and systems for facilitating analysis of feature extraction outputs |
| US20070275389A1 (en) * | 2006-05-24 | 2007-11-29 | Anniek De Witte | Array design facilitated by consideration of hybridization kinetics |
| US20080171665A1 (en) * | 2006-05-24 | 2008-07-17 | Minor James M | Programmed changes in hybridization conditions to improve probe signal quality |
| US7437249B2 (en) | 2006-06-30 | 2008-10-14 | Agilent Technologies, Inc. | Methods and systems for detrending signal intensity data from chemical arrays |
| US8077951B2 (en) | 2006-10-12 | 2011-12-13 | Agilent Technologies, Inc. | Method and system for dynamic, automated detection of outlying feature and feature background regions during processing of data scanned from a chemical array |
| US7881876B2 (en) * | 2006-10-12 | 2011-02-01 | Agilent Technologies, Inc. | Methods and systems for removing offset bias in chemical array data |
| US20080153094A1 (en) * | 2006-10-13 | 2008-06-26 | Minor James M | Reduction of nonspecific binding in nucleic acid assays and nucleic acid synthesis reactions |
| US20090149342A1 (en) * | 2006-10-13 | 2009-06-11 | Welldoc Communications | Method for reduction of nonspecific binding in nucleic acid assays, nucleic acid synthesis and multiplex amplification reactions |
| US20080090236A1 (en) * | 2006-10-13 | 2008-04-17 | Yakhini Zohar H | Methods and systems for identifying tumor progression in comparative genomic hybridization data |
| US20080102453A1 (en) * | 2006-10-31 | 2008-05-01 | Jayati Ghosh | Methods and systems and analysis of CGH data |
| FR2909444B1 (fr) | 2006-12-04 | 2009-02-13 | Biospace Lab | Procede et installation d'imagerie |
| US7683299B2 (en) * | 2007-07-09 | 2010-03-23 | Bio-Rad Laboratories, Inc. | Extended dynamic range system design using a photomultiplier tube and solid state detector |
| US7956332B2 (en) * | 2008-10-29 | 2011-06-07 | General Electric Company | Multi-layer radiation detector assembly |
| DE102009015586A1 (de) | 2009-03-30 | 2010-10-14 | Perkinelmer Optoelectronics Gmbh & Co.Kg | Sensorausleseschaltung, Sensor und Verfahren zum Auslesen eines Sensorelements |
| US9767342B2 (en) | 2009-05-22 | 2017-09-19 | Affymetrix, Inc. | Methods and devices for reading microarrays |
| GB0918629D0 (en) * | 2009-10-23 | 2009-12-09 | Thermo Fisher Scient Bremen | Detection apparatus for detecting charged particles, methods for detecting charged particles and mass spectometer |
| GB0918630D0 (en) * | 2009-10-23 | 2009-12-09 | Thermo Fisher Scient Bremen | Detection apparatus for detecting charged particles, methods for detecting charged particles and mass spectrometer |
| US8188420B2 (en) | 2009-11-14 | 2012-05-29 | Avago Technologies Ecbu Ip (Singapore) Pte. Ltd. | High resolution optical encoder systems having a set of light detecting elements each comprising a pair of complementary detectors (as amended) |
| KR20140128962A (ko) | 2011-12-22 | 2014-11-06 | 라디센스 다이어그나스틱스 리미티드 | 미세유체 시스템에서 생체 샘플에 대해 고해상도로 즉석에서 넓은 동적 범위에 걸쳐 다중 컬러로 발광 검출을 하기 위한 시스템 및 방법 |
| WO2014078774A2 (en) * | 2012-11-19 | 2014-05-22 | Perkinelmer Health Sciences, Inc. | Optical detectors and methods of using them |
| AU2013344493B2 (en) | 2012-11-19 | 2017-09-14 | Perkinelmer U.S. Llc | Ion detectors and methods of using them |
| US9847214B2 (en) * | 2013-11-26 | 2017-12-19 | Perkinelmer Health Sciences, Inc. | Detectors and methods of using them |
| US20180275058A1 (en) * | 2015-09-02 | 2018-09-27 | SeLux Diagnostics, Inc. | Systems and methods for multiplexed detection of biomarkers |
| US10416199B2 (en) * | 2017-01-17 | 2019-09-17 | International Business Machines Corporation | Measuring flux, current, or integrated charge of low energy particles |
| CN108318132B (zh) * | 2018-04-03 | 2024-02-20 | 福建海创光电技术股份有限公司 | 一种扩大apd线性探测范围的装置 |
| US11959847B2 (en) | 2019-09-12 | 2024-04-16 | Cytonome/St, Llc | Systems and methods for extended dynamic range detection of light |
| CN115185219B (zh) * | 2022-07-26 | 2025-03-04 | 赋同量子科技(浙江)有限公司 | 一种snspd宽动态响应范围的调控电路 |
| CN116067934B (zh) * | 2023-03-28 | 2023-07-18 | 赛默飞世尔(上海)仪器有限公司 | 用于信号采集的方法和设备 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3571493A (en) * | 1967-10-20 | 1971-03-16 | Texas Instruments Inc | Intensity modulated laser imagery display |
| US3843257A (en) * | 1971-11-30 | 1974-10-22 | Monsanto Res Corp | Microwave-excited emission detector |
| US3941478A (en) * | 1975-03-24 | 1976-03-02 | North American Philips Corporation | Second harmonic analyzer |
| US4590368A (en) | 1983-02-22 | 1986-05-20 | Baird Corporation | Digital gain adjuster circuit for photomultiplier tubes |
| CA1233271A (en) | 1984-06-26 | 1988-02-23 | David S. Mothersole | Cache disable for a data processor |
| SU1350508A1 (ru) | 1986-01-07 | 1987-11-07 | Институт Оптики Атмосферы Со Ан Ссср | Счетчик фотонов |
| EP0280731B1 (en) | 1986-08-28 | 1992-07-22 | Shimadzu Corporation | Amplification degree stabilizer for photomultiplier tubes |
| WO1990009637A1 (en) | 1989-02-13 | 1990-08-23 | Research Corporation Technologies, Inc. | Method and means for parallel frequency acquisition in frequency domain fluorometry |
| DE3915692A1 (de) | 1989-05-13 | 1990-11-22 | Strahlen Umweltforsch Gmbh | Verfahren und anordnung zur bestimmung schnell veraenderlicher fluoreszenzvorgaenge |
| EP0552241B1 (en) | 1990-10-10 | 2000-06-28 | The University Of Maryland | Method and apparatus for performing phase fluorescence lifetime measurements in flow cytometry |
| JPH0526810A (ja) | 1991-07-23 | 1993-02-02 | Hamamatsu Photonics Kk | 微粒子の螢光検出装置 |
| US5264693A (en) | 1992-07-01 | 1993-11-23 | The United States Of America As Represented By The Secretary Of The Navy | Microelectronic photomultiplier device with integrated circuitry |
| JP2575270B2 (ja) | 1992-11-10 | 1997-01-22 | 浜松ホトニクス株式会社 | 核酸の塩基配列決定方法、単一分子検出方法、その装置及び試料の作成方法 |
| US5475227A (en) | 1992-12-17 | 1995-12-12 | Intevac, Inc. | Hybrid photomultiplier tube with ion deflector |
| US5493111A (en) | 1993-07-30 | 1996-02-20 | Litton Systems, Inc. | Photomultiplier having cascaded microchannel plates, and method for fabrication |
| US5631734A (en) | 1994-02-10 | 1997-05-20 | Affymetrix, Inc. | Method and apparatus for detection of fluorescently labeled materials |
| US5582705A (en) | 1995-05-19 | 1996-12-10 | Iowa State University Research Foundation, Inc. | Multiplexed capillary electrophoresis system |
| DE19618601C2 (de) | 1996-05-09 | 2000-04-13 | Stratec Elektronik Gmbh | Verfahren und Anordnung zur Lichtdetektion |
-
1999
- 1999-05-17 US US09/313,102 patent/US6355921B1/en not_active Expired - Fee Related
-
2000
- 2000-05-08 GB GB0011109A patent/GB2350187B/en not_active Expired - Fee Related
- 2000-05-10 JP JP2000136666A patent/JP2000356594A/ja active Pending
-
2002
- 2002-02-04 US US10/068,419 patent/US6518556B2/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007518991A (ja) * | 2004-01-14 | 2007-07-12 | ルミネックス・コーポレーション | ダイナミックレンジを拡大する方法及びシステム |
| JP2009244010A (ja) * | 2008-03-31 | 2009-10-22 | Mitsui Eng & Shipbuild Co Ltd | 蛍光検出装置 |
| JP2012253024A (ja) * | 2011-06-06 | 2012-12-20 | Toshiba Corp | 光センサ、ガンマ線検出器、及び陽電子放出コンピュータ断層撮影装置 |
| JP2013072727A (ja) * | 2011-09-27 | 2013-04-22 | Shimadzu Corp | 分光蛍光光度計 |
| JP2016017766A (ja) * | 2014-07-04 | 2016-02-01 | 株式会社島津製作所 | 光検出回路及び光量測定装置 |
| US9877689B2 (en) | 2015-09-30 | 2018-01-30 | Kabushiki Kaisha Toshiba | Detection device and data processing method |
Also Published As
| Publication number | Publication date |
|---|---|
| GB0011109D0 (en) | 2000-06-28 |
| US6518556B2 (en) | 2003-02-11 |
| US6355921B1 (en) | 2002-03-12 |
| US20020070330A1 (en) | 2002-06-13 |
| GB2350187A (en) | 2000-11-22 |
| GB2350187B (en) | 2004-02-25 |
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