JOP20210032A1 - طريقة لتحضير 2-[(3r)-3-مثيل مورفولين-4-يل]-4-(1-مثيل-1h-بيرازول-5-يل)-8-(1h-بيرازول-5-يل)-1، 7-نفثيريدين - Google Patents

طريقة لتحضير 2-[(3r)-3-مثيل مورفولين-4-يل]-4-(1-مثيل-1h-بيرازول-5-يل)-8-(1h-بيرازول-5-يل)-1، 7-نفثيريدين

Info

Publication number
JOP20210032A1
JOP20210032A1 JOP/2021/0032A JOP20210032A JOP20210032A1 JO P20210032 A1 JOP20210032 A1 JO P20210032A1 JO P20210032 A JOP20210032 A JO P20210032A JO P20210032 A1 JOP20210032 A1 JO P20210032A1
Authority
JO
Jordan
Prior art keywords
pyrazol
methylmorpholin
naphthyridine
methyl
preparing
Prior art date
Application number
JOP/2021/0032A
Other languages
English (en)
Inventor
Gerardus Gieling Reinerus
Elisabeth Hoogeveen Sonja
Cornelis Maria VAN OERS Matthijs
Nicolaas Sebastiaan Van Der Haas Hendricus
Platzek Johannes
Rubenbauer Philipp
Alexander DEKKER Jeroen
Original Assignee
Bayer Ag
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Bayer Pharma AG filed Critical Bayer Ag
Publication of JOP20210032A1 publication Critical patent/JOP20210032A1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

يشمل الاختراع الحالي طريقة لتحضير 2-[(3R)-3-مثيل مورفولين-4-يل]-4-(1-مثيل-1H-بيرازول-5-يل)-8-(1H-بيرازول-5-يل)-1، 7-نفثيريدين (يشار له فيما بعد "بمركب الصيغة (I)") بالإضافة إلى مركبات وسيطة مفيدة في تحضير مركب الصيغة (I). ويشمل الاختراع الحالي أيضاً الصورة متعددة الأشكال B لمركب الصيغة (I) بنقاء عال
JOP/2021/0032A 2018-08-24 2019-08-22 طريقة لتحضير 2-[(3r)-3-مثيل مورفولين-4-يل]-4-(1-مثيل-1h-بيرازول-5-يل)-8-(1h-بيرازول-5-يل)-1، 7-نفثيريدين JOP20210032A1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18190731 2018-08-24
PCT/EP2019/072467 WO2020039025A1 (en) 2018-08-24 2019-08-22 Method for preparing 2-[(3r)-3-methylmorpholin-4-yl]-4-[1-methyl-1h-pyrazol-5-yl)-8-(1h-pyrazol-5-yl)-1,7-naphthyridine

Publications (1)

Publication Number Publication Date
JOP20210032A1 true JOP20210032A1 (ar) 2021-02-23

Family

ID=63405064

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2021/0032A JOP20210032A1 (ar) 2018-08-24 2019-08-22 طريقة لتحضير 2-[(3r)-3-مثيل مورفولين-4-يل]-4-(1-مثيل-1h-بيرازول-5-يل)-8-(1h-بيرازول-5-يل)-1، 7-نفثيريدين

Country Status (26)

Country Link
US (1) US20210253573A1 (ar)
EP (1) EP3841101B1 (ar)
JP (1) JP7422741B2 (ar)
KR (1) KR20210049845A (ar)
CN (1) CN112823158B (ar)
AU (1) AU2019324521A1 (ar)
BR (1) BR112021001309A2 (ar)
CA (1) CA3110394A1 (ar)
CL (1) CL2021000454A1 (ar)
CO (1) CO2021001892A2 (ar)
DK (1) DK3841101T3 (ar)
ES (1) ES2950825T3 (ar)
FI (1) FI3841101T3 (ar)
HR (1) HRP20230611T1 (ar)
HU (1) HUE062332T2 (ar)
IL (1) IL280878A (ar)
JO (1) JOP20210032A1 (ar)
LT (1) LT3841101T (ar)
MX (1) MX2021002132A (ar)
PE (1) PE20210862A1 (ar)
PL (1) PL3841101T3 (ar)
PT (1) PT3841101T (ar)
RS (1) RS64362B1 (ar)
SG (1) SG11202101011RA (ar)
SI (1) SI3841101T1 (ar)
WO (1) WO2020039025A1 (ar)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI700283B (zh) 2014-08-04 2020-08-01 德商拜耳製藥公司 ２-(嗎啉-４-基)-１,７-萘啶
EP3661560A1 (en) 2017-08-04 2020-06-10 Bayer Pharma Aktiengesellschaft Combination of atr kinase inhibitors and pd-1/pd-l1 inhibitors
US11236070B2 (en) 2019-05-16 2022-02-01 Novartis Ag Chemical process

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2645583A1 (en) * 2006-03-20 2007-09-27 F. Hoffman-La Roche Ag Methods of inhibiting btk and syk protein kinases
WO2008150827A1 (en) 2007-05-29 2008-12-11 Smithkline Beecham Corporation Naphthyridine, derivatives as p13 kinase inhibitors
MX2011002367A (es) 2008-09-02 2011-04-04 Novartis Ag Inhibidores de cinasa biciclicos.
AU2012257513B2 (en) 2011-05-19 2017-05-11 Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO) Macrocyclic compounds as protein kinase inhibitors
TWI700283B (zh) 2014-08-04 2020-08-01 德商拜耳製藥公司 ２-(嗎啉-４-基)-１,７-萘啶
WO2018153970A1 (en) * 2017-02-24 2018-08-30 Bayer Pharma Aktiengesellschaft Solid forms of 2-[(3r)-3-methylmorpholin-4-yl]-4-(1-methyl-1h-pyrazol-5-yl)-8-(1h-pyrazol-5-yl)-1,7-naphthyridine

Also Published As

Publication number Publication date
AU2019324521A1 (en) 2021-03-11
US20210253573A1 (en) 2021-08-19
SI3841101T1 (sl) 2023-07-31
EP3841101A1 (en) 2021-06-30
SG11202101011RA (en) 2021-02-25
DK3841101T3 (da) 2023-07-31
CO2021001892A2 (es) 2021-03-08
HUE062332T2 (hu) 2023-10-28
PE20210862A1 (es) 2021-05-18
CA3110394A1 (en) 2020-02-27
KR20210049845A (ko) 2021-05-06
JP7422741B2 (ja) 2024-01-26
HRP20230611T1 (hr) 2023-09-15
WO2020039025A1 (en) 2020-02-27
JP2021535122A (ja) 2021-12-16
IL280878A (en) 2021-04-29
ES2950825T3 (es) 2023-10-13
RS64362B1 (sr) 2023-08-31
CN112823158A (zh) 2021-05-18
BR112021001309A2 (pt) 2021-04-27
MX2021002132A (es) 2021-04-28
PT3841101T (pt) 2023-07-25
EP3841101B1 (en) 2023-05-03
CN112823158B (zh) 2023-08-15
CL2021000454A1 (es) 2021-07-09
LT3841101T (lt) 2023-06-26
FI3841101T3 (fi) 2023-07-28
PL3841101T3 (pl) 2023-08-21

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