WO2016159576A3 - 1,2 나프토퀴논 유도체 및 이의 제조방법 - Google Patents

1,2 나프토퀴논 유도체 및 이의 제조방법 Download PDF

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Publication number
WO2016159576A3
WO2016159576A3 PCT/KR2016/003030 KR2016003030W WO2016159576A3 WO 2016159576 A3 WO2016159576 A3 WO 2016159576A3 KR 2016003030 W KR2016003030 W KR 2016003030W WO 2016159576 A3 WO2016159576 A3 WO 2016159576A3
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WO
WIPO (PCT)
Prior art keywords
preparing same
naphthoquinone derivative
pharmaceutically acceptable
naphthoquinone
derivative
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PCT/KR2016/003030
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English (en)
French (fr)
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WO2016159576A2 (ko
Inventor
이휘성
이미정
김보정
이강우
노태철
서강식
김진환
민기남
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주식회사 케이티앤지생명과학
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Publication of WO2016159576A2 publication Critical patent/WO2016159576A2/ko
Publication of WO2016159576A3 publication Critical patent/WO2016159576A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

본 발명은 화학식 (1)로 표시되는 화합물, 그것의 약제학적으로 허용되는 염, 수화물, 용매화물, 프로드럭, 토토머(tautomer), 거울상 이성질체 또는 약학적으로 허용 가능한 부분입체 이성질체를 제공한다.
PCT/KR2016/003030 2015-03-27 2016-03-25 1,2 나프토퀴논 유도체 및 이의 제조방법 WO2016159576A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20150043068 2015-03-27
KR10-2015-0043068 2015-03-27

Publications (2)

Publication Number Publication Date
WO2016159576A2 WO2016159576A2 (ko) 2016-10-06
WO2016159576A3 true WO2016159576A3 (ko) 2017-03-23

Family

ID=57007013

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2016/003030 WO2016159576A2 (ko) 2015-03-27 2016-03-25 1,2 나프토퀴논 유도체 및 이의 제조방법

Country Status (2)

Country Link
KR (2) KR102005068B1 (ko)
WO (1) WO2016159576A2 (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11684610B2 (en) 2018-04-09 2023-06-27 Yungjin Pharm. Co., Ltd. Pharmaceutical composition including 1,2-naphthoquinone derivative compound for prevention or treatment of solid cancers or blood cancers
EP3782620B1 (en) * 2018-04-09 2023-12-20 Huen Co., Ltd. Pharmaceutical composition comprising 1,2-naphthoquinone derivative for use in preventing or treating acute myeloid or lymphoblastic leukemia
KR102201768B1 (ko) * 2019-02-28 2021-01-12 주식회사 엘마이토테라퓨틱스 벤조인다졸론 화합물 및 그 용도
KR102247694B1 (ko) * 2019-05-31 2021-05-03 주식회사 엘마이토테라퓨틱스 나프토퀴논 또는 벤조인다졸 화합물을 유효성분으로 포함하는 염증성 질환 치료용 약학적 조성물
JP2023007515A (ja) * 2019-12-10 2023-01-19 国立大学法人京都大学 発光材料、有機発光素子および化合物
KR102512398B1 (ko) * 2020-08-17 2023-03-22 주식회사 엘마이토테라퓨틱스 이미다조퀴놀린 또는 벤조인다졸론 화합물, 및 그 제조 중간체

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04330010A (ja) * 1991-02-21 1992-11-18 Sumitomo Pharmaceut Co Ltd 神経成長因子の産生または分泌促進剤
US5502214A (en) * 1993-07-19 1996-03-26 Dana Farber Cancer Institute 1,2-benzoquinones and methods for making and using same
KR20080099174A (ko) * 2007-05-07 2008-11-12 주식회사 머젠스 비만, 당뇨, 대사성 질환, 퇴행성 질환 및 미토콘드리아이상 질환의 치료 또는 예방을 위한 나프토퀴논계 약제조성물
WO2012006104A2 (en) * 2010-06-28 2012-01-12 Academia Sinica, Taiwan Compounds and methods for treating tuberculosis infection
CN103022496A (zh) * 2012-12-28 2013-04-03 南开大学 一类锂二次电池用芳香稠环醌类化合物正极材料
EP2767532A1 (en) * 2012-12-21 2014-08-20 National Institute of Radiological Sciences Novel compound for imaging tau protein accumulated in the brain
KR20150080423A (ko) * 2013-12-30 2015-07-09 주식회사 케이티앤지생명과학 1,2 나프토퀴논 유도체 및 이의 제조방법

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* Cited by examiner, † Cited by third party
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JP4330010B2 (ja) * 2005-01-28 2009-09-09 パピエ・シー有限会社 鑑賞魚用水槽の冷却装置
KR20080047956A (ko) * 2006-11-27 2008-05-30 주식회사 엠디바이오알파 발기부전의 치료 및 예방을 위한 약제 조성물
US20100209513A1 (en) * 2007-10-11 2010-08-19 In Geun Jo Pharmaceutical composition containing micronized particles of naphthoquinone-based compound

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04330010A (ja) * 1991-02-21 1992-11-18 Sumitomo Pharmaceut Co Ltd 神経成長因子の産生または分泌促進剤
US5502214A (en) * 1993-07-19 1996-03-26 Dana Farber Cancer Institute 1,2-benzoquinones and methods for making and using same
KR20080099174A (ko) * 2007-05-07 2008-11-12 주식회사 머젠스 비만, 당뇨, 대사성 질환, 퇴행성 질환 및 미토콘드리아이상 질환의 치료 또는 예방을 위한 나프토퀴논계 약제조성물
WO2012006104A2 (en) * 2010-06-28 2012-01-12 Academia Sinica, Taiwan Compounds and methods for treating tuberculosis infection
EP2767532A1 (en) * 2012-12-21 2014-08-20 National Institute of Radiological Sciences Novel compound for imaging tau protein accumulated in the brain
CN103022496A (zh) * 2012-12-28 2013-04-03 南开大学 一类锂二次电池用芳香稠环醌类化合物正极材料
KR20150080423A (ko) * 2013-12-30 2015-07-09 주식회사 케이티앤지생명과학 1,2 나프토퀴논 유도체 및 이의 제조방법

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CHEN, J. ET AL.: "Design, Synthesis, and Characterization of New Embelin Derivatives as Potent Inhibitors of X-linked Inhibitor of Apoptosis Protein", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, no. 22, 2006, pages 5805 - 5808, XP027966089 *
DATABASE STN [O] 16 November 1984 (1984-11-16), retrieved from STN Database accession no. 16290-01-0 *
DATABASE STN [O] 16 November 1984 (1984-11-16), retrieved from STN Database accession no. 38982-08-0 *
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DATABASE STN [O] 16 November 1984 (1984-11-16), retrieved from STN Database accession no. 52112-43-3 *
KUBO, A. ET AL.: "Synthesis of Renierone, 7-methoxy-1,6-dimethyl-5,8-dihydroisoquinoline -5,8-dione and N-formyl-1,2-dydrorenierone, Antimicrobial Metabolites from a Marine Sponge, Reniera sp.", CHEM. PHARM. BULL., vol. 34, no. 10, 1986, pages 4056 - 4058 , 4061-4062, XP055373681 *
LUMIBAO, C. Y. ET AL.: "Electrochemical and Electrocatalytic Properties of Imidazole Analogues of the Redox Cofactor Pyrroloquinoline Quinone", ELECTROANALYSIS, vol. 20, no. 20, 2008, pages 2177 - 2184, XP055373686 *

Also Published As

Publication number Publication date
WO2016159576A2 (ko) 2016-10-06
KR102005068B1 (ko) 2019-07-30
KR102342250B1 (ko) 2021-12-23
KR20160116296A (ko) 2016-10-07
KR20180088627A (ko) 2018-08-06

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