JOP20200149B1 - مركبات ترايزولو بنزازيبين كعوامل مضادة لمستقبل ?اسوبريسين v1a - Google Patents
مركبات ترايزولو بنزازيبين كعوامل مضادة لمستقبل ?اسوبريسين v1aInfo
- Publication number
- JOP20200149B1 JOP20200149B1 JOP/2020/0149A JOP20200149A JOP20200149B1 JO P20200149 B1 JOP20200149 B1 JO P20200149B1 JO P20200149 A JOP20200149 A JO P20200149A JO P20200149 B1 JOP20200149 B1 JO P20200149B1
- Authority
- JO
- Jordan
- Prior art keywords
- receptor antagonists
- compounds
- well
- triazolobenzazepines
- vasopressin
- Prior art date
Links
- 239000002464 receptor antagonist Substances 0.000 title abstract 2
- 229940044551 receptor antagonist Drugs 0.000 title abstract 2
- 102000004136 Vasopressin Receptors Human genes 0.000 title 1
- 108090000643 Vasopressin Receptors Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- WAYZQLIRXHPOCN-UHFFFAOYSA-N 5,6-dihydro-4h-[1,2,4]triazolo[4,3-a][1]benzazepine Chemical class C1CCC2=NN=CN2C2=CC=CC=C21 WAYZQLIRXHPOCN-UHFFFAOYSA-N 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C07D223/10—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
غير متوفر
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU1700521A HU231206B1 (hu) | 2017-12-15 | 2017-12-15 | Triazolobenzazepinek |
PCT/IB2018/060077 WO2019116324A1 (en) | 2017-12-15 | 2018-12-14 | Triazolobenzazepines as vasopressin v1a receptor antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
JOP20200149A1 JOP20200149A1 (ar) | 2020-06-10 |
JOP20200149B1 true JOP20200149B1 (ar) | 2022-10-30 |
Family
ID=89992589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2020/0149A JOP20200149B1 (ar) | 2017-12-15 | 2018-12-14 | مركبات ترايزولو بنزازيبين كعوامل مضادة لمستقبل ?اسوبريسين v1a |
Country Status (22)
Country | Link |
---|---|
US (1) | US11298363B2 (ar) |
EP (1) | EP3724192B1 (ar) |
JP (1) | JP7428647B2 (ar) |
KR (1) | KR20200100111A (ar) |
CN (1) | CN111479813B (ar) |
AR (1) | AR113933A1 (ar) |
AU (1) | AU2018385724B2 (ar) |
BR (1) | BR112020011880A2 (ar) |
CA (1) | CA3085562A1 (ar) |
CL (1) | CL2020001564A1 (ar) |
CU (1) | CU24630B1 (ar) |
EA (1) | EA202091344A1 (ar) |
HU (1) | HU231206B1 (ar) |
IL (1) | IL275084B2 (ar) |
JO (1) | JOP20200149B1 (ar) |
MX (1) | MX2020006204A (ar) |
PE (1) | PE20210671A1 (ar) |
PH (1) | PH12020500548A1 (ar) |
SG (1) | SG11202005299VA (ar) |
TN (1) | TN2020000083A1 (ar) |
TW (1) | TWI826406B (ar) |
WO (1) | WO2019116324A1 (ar) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
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TW202202495A (zh) | 2020-03-26 | 2022-01-16 | 匈牙利商羅特格登公司 | 作為gamma-胺基丁酸A受體次單元alpha 5受體調節劑之㖠啶及吡啶并〔3,4-c〕嗒𠯤衍生物 |
TWI804119B (zh) * | 2020-12-21 | 2023-06-01 | 大陸商上海濟煜醫藥科技有限公司 | 三氮唑類三并環衍生物及其製備方法和應用 |
HUP2100338A1 (hu) | 2021-09-29 | 2023-04-28 | Richter Gedeon Nyrt | GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok |
WO2023164710A1 (en) * | 2022-02-28 | 2023-08-31 | The Trustees Of Columbia University In The City Of New York | Avpr1a blockade to reduce social isolation-induced anxiety in females |
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EP0382185B1 (en) | 1989-02-10 | 1994-06-15 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
FR2679903B1 (fr) | 1991-08-02 | 1993-12-03 | Elf Sanofi | Derives de la n-sulfonyl indoline portant une fonction amidique, leur preparation, les compositions pharmaceutiques en contenant. |
US5723606A (en) | 1993-07-21 | 1998-03-03 | Yamanouchi Pharmaceutical Co., Ltd. | Condensed benzazepine derivative and pharmaceutical composition thereof |
MX9606510A (es) | 1994-06-15 | 1997-03-29 | Otsuka Pharma Co Ltd | Derivados benzoheterociclicos. |
FR2740136B1 (fr) | 1995-10-24 | 1998-01-09 | Sanofi Sa | Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant |
AU2001256769A1 (en) | 2000-05-19 | 2001-11-26 | Merck Patent Gmbh | Triazole derivatives |
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CA2425892A1 (en) | 2000-11-28 | 2003-04-11 | Hiroyuki Koshio | 1,4,5,6-tetrahydroimidazo[4,5-d]diazepine derivative or salt thereof |
WO2003031407A2 (en) | 2001-10-12 | 2003-04-17 | Serenix Pharmaceuticals, Llc | β-LACTAMYL VASOPRESSIN VlaANTAGONISTS |
JP2005104838A (ja) | 2003-01-09 | 2005-04-21 | Tanabe Seiyaku Co Ltd | 縮合フラン化合物 |
GB0303852D0 (en) * | 2003-02-19 | 2003-03-26 | Pfizer Ltd | Triazole compounds useful in therapy |
KR100750028B1 (ko) * | 2003-02-19 | 2007-08-16 | 화이자 인코포레이티드 | 치료에 유용한 트리아졸 화합물 |
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JP2008510789A (ja) | 2004-08-25 | 2008-04-10 | ファイザー・インク | トリアゾロベンゾジアゼピン及びバゾプレシンアンタゴニストとしてのそれらの使用 |
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BRPI0612988A2 (pt) | 2005-07-14 | 2010-12-14 | Hoffmann La Roche | derivados de indol-3-il-carbonil-espiro-piperidina como antagonistas de receptor v1a |
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BRPI0614692A2 (pt) | 2005-07-29 | 2009-05-19 | Hoffmann La Roche | derivados de indol-3-il-carbonil-piperidina e piperazina |
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CA2901577A1 (en) | 2013-02-18 | 2014-08-21 | The Scripps Research Institute | Modulators of vasopressin receptors with therapeutic potential |
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CN106349241B (zh) * | 2015-07-15 | 2020-04-21 | 上海翰森生物医药科技有限公司 | 具有hsp90抑制活性的三唑衍生物及其制备方法和应用 |
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WO2017191107A1 (en) | 2016-05-03 | 2017-11-09 | Bayer Pharma Aktiengesellschaft | Amide-substituted phenyltriazole derivatives and uses thereof |
-
2017
- 2017-12-15 HU HU1700521A patent/HU231206B1/hu unknown
-
2018
- 2018-12-12 TW TW107144774A patent/TWI826406B/zh active
- 2018-12-13 AR ARP180103643A patent/AR113933A1/es unknown
- 2018-12-14 PE PE2020000640A patent/PE20210671A1/es unknown
- 2018-12-14 KR KR1020207020172A patent/KR20200100111A/ko not_active Application Discontinuation
- 2018-12-14 CU CU2020000048A patent/CU24630B1/es unknown
- 2018-12-14 TN TNP/2020/000083A patent/TN2020000083A1/en unknown
- 2018-12-14 SG SG11202005299VA patent/SG11202005299VA/en unknown
- 2018-12-14 AU AU2018385724A patent/AU2018385724B2/en active Active
- 2018-12-14 EP EP18836400.4A patent/EP3724192B1/en active Active
- 2018-12-14 JP JP2020532928A patent/JP7428647B2/ja active Active
- 2018-12-14 WO PCT/IB2018/060077 patent/WO2019116324A1/en active Application Filing
- 2018-12-14 EA EA202091344A patent/EA202091344A1/ru unknown
- 2018-12-14 JO JOP/2020/0149A patent/JOP20200149B1/ar active
- 2018-12-14 MX MX2020006204A patent/MX2020006204A/es unknown
- 2018-12-14 US US16/954,085 patent/US11298363B2/en active Active
- 2018-12-14 CA CA3085562A patent/CA3085562A1/en active Pending
- 2018-12-14 CN CN201880080932.8A patent/CN111479813B/zh active Active
- 2018-12-14 BR BR112020011880-0A patent/BR112020011880A2/pt unknown
-
2020
- 2020-06-03 IL IL275084A patent/IL275084B2/en unknown
- 2020-06-09 PH PH12020500548A patent/PH12020500548A1/en unknown
- 2020-06-11 CL CL2020001564A patent/CL2020001564A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
TWI826406B (zh) | 2023-12-21 |
BR112020011880A2 (pt) | 2020-11-24 |
KR20200100111A (ko) | 2020-08-25 |
JP7428647B2 (ja) | 2024-02-06 |
CN111479813A (zh) | 2020-07-31 |
AR113933A1 (es) | 2020-07-01 |
EA202091344A1 (ru) | 2020-09-09 |
PH12020500548A1 (en) | 2021-01-25 |
HU231206B1 (hu) | 2021-10-28 |
CU20200048A7 (es) | 2021-03-11 |
TN2020000083A1 (en) | 2022-01-06 |
JOP20200149A1 (ar) | 2020-06-10 |
SG11202005299VA (en) | 2020-07-29 |
AU2018385724B2 (en) | 2023-05-25 |
TW201938170A (zh) | 2019-10-01 |
PE20210671A1 (es) | 2021-04-05 |
US11298363B2 (en) | 2022-04-12 |
US20210260072A1 (en) | 2021-08-26 |
EP3724192B1 (en) | 2022-08-03 |
AU2018385724A1 (en) | 2020-07-09 |
HUP1700521A2 (en) | 2019-06-28 |
CA3085562A1 (en) | 2019-06-20 |
CN111479813B (zh) | 2023-03-21 |
EP3724192A1 (en) | 2020-10-21 |
JP2021506821A (ja) | 2021-02-22 |
CU24630B1 (es) | 2022-12-12 |
CL2020001564A1 (es) | 2020-11-06 |
IL275084A (en) | 2020-07-30 |
IL275084B2 (en) | 2023-06-01 |
MX2020006204A (es) | 2020-08-27 |
WO2019116324A1 (en) | 2019-06-20 |
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