JOP20190016A1 - تخليق (اس)-2- أمينو -4- ميثيل -1-((ار)-2- ميثيل أوكسيران -2- يل)- بنتان -1- أون وأملاح مقبولة صيدلانياً منه - Google Patents
تخليق (اس)-2- أمينو -4- ميثيل -1-((ار)-2- ميثيل أوكسيران -2- يل)- بنتان -1- أون وأملاح مقبولة صيدلانياً منهInfo
- Publication number
- JOP20190016A1 JOP20190016A1 JOP/2019/0016A JOP20190016A JOP20190016A1 JO P20190016 A1 JOP20190016 A1 JO P20190016A1 JO P20190016 A JOP20190016 A JO P20190016A JO P20190016 A1 JOP20190016 A1 JO P20190016A1
- Authority
- JO
- Jordan
- Prior art keywords
- pharmaceutically acceptable
- synthesis
- acceptable salts
- methyloxirane
- pentan
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/1616—Coordination complexes, e.g. organometallic complexes, immobilised on an inorganic support, e.g. ship-in-a-bottle type catalysts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
- C07D301/02—Synthesis of the oxirane ring
- C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
- C07D301/12—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with hydrogen peroxide or inorganic peroxides or peracids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/70—Complexes comprising metals of Group VII (VIIB) as the central metal
- B01J2531/72—Manganese
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epoxy Compounds (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
يتعلق الاختراع الحالي بتقديم طرق جديدة لتحضير المركب 5، وأملاح مقبولة صيدلانياً منه، بالبنية. صورة المركب 5 يكون المركب 5، أو ملح مقبول صيدلانياً منه، عبارة عن مركب وسيط مهم في تخليق الكارفيلزوميب. يقدم الاختراع أيضاً طرق لتحضير محفز منجنيز مفيد يمكن استخدامه في خطوة إدخال الإيبوكسيد وفقاً للاختراع الحالي.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662371686P | 2016-08-05 | 2016-08-05 | |
US201762536862P | 2017-07-25 | 2017-07-25 | |
PCT/US2017/045274 WO2018027021A1 (en) | 2016-08-05 | 2017-08-03 | Synthesis of (s)-2-amino-4-methyl-1-((r)-2-methyloxirane-2-yl)-pentan-1-one and pharmaceutically acceptable salts thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
JOP20190016A1 true JOP20190016A1 (ar) | 2019-02-04 |
JOP20190016B1 JOP20190016B1 (ar) | 2023-03-28 |
Family
ID=59593230
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2019/0016A JOP20190016B1 (ar) | 2016-08-05 | 2017-08-03 | تخليق (اس)-2- أمينو -4- ميثيل -1-((ار)-2- ميثيل أوكسيران -2- يل)- بنتان -1- أون وأملاح مقبولة صيدلانياً منه |
Country Status (29)
Country | Link |
---|---|
US (1) | US11708341B2 (ar) |
EP (1) | EP3494108B1 (ar) |
JP (1) | JP7229912B2 (ar) |
KR (1) | KR102482663B1 (ar) |
CN (1) | CN109641863B (ar) |
AU (1) | AU2017306546B2 (ar) |
BR (1) | BR112019002191A2 (ar) |
CA (1) | CA3032963A1 (ar) |
CL (1) | CL2019000294A1 (ar) |
CO (1) | CO2019001139A2 (ar) |
CR (1) | CR20190113A (ar) |
CY (1) | CY1124363T1 (ar) |
DK (1) | DK3494108T3 (ar) |
ES (1) | ES2842575T3 (ar) |
HU (1) | HUE051980T2 (ar) |
IL (1) | IL264549B (ar) |
JO (1) | JOP20190016B1 (ar) |
LT (1) | LT3494108T (ar) |
MX (1) | MX2019001459A (ar) |
PE (1) | PE20190404A1 (ar) |
PH (1) | PH12019500232A1 (ar) |
PL (1) | PL3494108T3 (ar) |
PT (1) | PT3494108T (ar) |
SG (2) | SG11201900991UA (ar) |
SI (1) | SI3494108T1 (ar) |
TN (1) | TN2019000028A1 (ar) |
UA (1) | UA125648C2 (ar) |
WO (1) | WO2018027021A1 (ar) |
ZA (1) | ZA201900717B (ar) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114195741A (zh) * | 2021-12-28 | 2022-03-18 | 南京格亚医药科技有限公司 | 一种卡非佐米关键中间体异构体的制备方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7232818B2 (en) | 2004-04-15 | 2007-06-19 | Proteolix, Inc. | Compounds for enzyme inhibition |
US20050256324A1 (en) * | 2004-05-10 | 2005-11-17 | Proteolix, Inc. | Synthesis of amino acid keto-epoxides |
JP2006028154A (ja) | 2004-06-14 | 2006-02-02 | Sumitomo Chemical Co Ltd | 光学活性化合物の製造方法 |
HUE027850T2 (en) | 2004-12-07 | 2016-11-28 | Onyx Therapeutics Inc | Preparation for proteasome inhibition |
DK2207791T4 (da) | 2007-10-04 | 2019-10-07 | Onyx Therapeutics Inc | Krystallinske peptidepoxyketon-proteasehæmmere og syntese af aminosyreketoepoxider |
ES2617560T3 (es) | 2008-10-21 | 2017-06-19 | Onyx Therapeutics, Inc. | Combinación del inhibidor del proteasoma de epoxicetona peptídica carfilzomib con melfalán para su uso en el tratamiento del mieloma múltiple |
US20130303482A1 (en) | 2012-05-08 | 2013-11-14 | Onyx Therapeutics, Inc. | Cylodextrin Complexation Methods for Formulating Peptide Proteasome Inhibitors |
EP2869820A4 (en) | 2012-07-09 | 2016-02-17 | Onyx Therapeutics Inc | PRODRUGS OF PEPTIDEPOXIDE KETONE PROTEASE INHIBITORS |
US10022326B2 (en) | 2012-07-18 | 2018-07-17 | Onyx Therapeutics, Inc. | Liposomal compositions of epoxyketone-based proteasome inhibitors |
DE102013104003B3 (de) | 2013-04-19 | 2014-03-13 | Glatt Systemtechnik Gmbh | Vorrichtung zum Einbringen einer definierten Menge eines zweiten Pulvers in einen Prozessbehälter |
CN104230857A (zh) * | 2014-08-19 | 2014-12-24 | 上海皓元生物医药科技有限公司 | 卡非佐米(Carfilzomib)的中间体化合物的制备方法及其中间体化合物 |
-
2017
- 2017-08-03 EP EP17751954.3A patent/EP3494108B1/en active Active
- 2017-08-03 UA UAA201902137A patent/UA125648C2/uk unknown
- 2017-08-03 CN CN201780048527.3A patent/CN109641863B/zh active Active
- 2017-08-03 PT PT177519543T patent/PT3494108T/pt unknown
- 2017-08-03 CA CA3032963A patent/CA3032963A1/en active Pending
- 2017-08-03 MX MX2019001459A patent/MX2019001459A/es unknown
- 2017-08-03 CR CR20190113A patent/CR20190113A/es unknown
- 2017-08-03 SI SI201730575T patent/SI3494108T1/sl unknown
- 2017-08-03 KR KR1020197006357A patent/KR102482663B1/ko active IP Right Grant
- 2017-08-03 ES ES17751954T patent/ES2842575T3/es active Active
- 2017-08-03 WO PCT/US2017/045274 patent/WO2018027021A1/en unknown
- 2017-08-03 SG SG11201900991UA patent/SG11201900991UA/en unknown
- 2017-08-03 PE PE2019000337A patent/PE20190404A1/es unknown
- 2017-08-03 DK DK17751954.3T patent/DK3494108T3/da active
- 2017-08-03 TN TNP/2019/000028A patent/TN2019000028A1/en unknown
- 2017-08-03 AU AU2017306546A patent/AU2017306546B2/en active Active
- 2017-08-03 BR BR112019002191-4A patent/BR112019002191A2/pt active Search and Examination
- 2017-08-03 JO JOP/2019/0016A patent/JOP20190016B1/ar active
- 2017-08-03 SG SG10201912268UA patent/SG10201912268UA/en unknown
- 2017-08-03 JP JP2019506144A patent/JP7229912B2/ja active Active
- 2017-08-03 LT LTEP17751954.3T patent/LT3494108T/lt unknown
- 2017-08-03 US US16/327,079 patent/US11708341B2/en active Active
- 2017-08-03 HU HUE17751954A patent/HUE051980T2/hu unknown
- 2017-08-03 PL PL17751954T patent/PL3494108T3/pl unknown
-
2019
- 2019-01-30 IL IL264549A patent/IL264549B/en unknown
- 2019-01-31 PH PH12019500232A patent/PH12019500232A1/en unknown
- 2019-02-04 CL CL2019000294A patent/CL2019000294A1/es unknown
- 2019-02-04 ZA ZA2019/00717A patent/ZA201900717B/en unknown
- 2019-02-07 CO CONC2019/0001139A patent/CO2019001139A2/es unknown
-
2021
- 2021-01-27 CY CY20211100067T patent/CY1124363T1/el unknown
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