MX2019001459A - Sintesis de (s)-2-amino-4-metil-1-((r)-2-metiloxirano-2-il)-pentan -1-ona y sales farmacuticamente aceptables de la misma. - Google Patents
Sintesis de (s)-2-amino-4-metil-1-((r)-2-metiloxirano-2-il)-pentan -1-ona y sales farmacuticamente aceptables de la misma.Info
- Publication number
- MX2019001459A MX2019001459A MX2019001459A MX2019001459A MX2019001459A MX 2019001459 A MX2019001459 A MX 2019001459A MX 2019001459 A MX2019001459 A MX 2019001459A MX 2019001459 A MX2019001459 A MX 2019001459A MX 2019001459 A MX2019001459 A MX 2019001459A
- Authority
- MX
- Mexico
- Prior art keywords
- pharmaceutically acceptable
- synthesis
- acceptable salts
- ntan
- methyloxirane
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/1616—Coordination complexes, e.g. organometallic complexes, immobilised on an inorganic support, e.g. ship-in-a-bottle type catalysts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
- C07D301/02—Synthesis of the oxirane ring
- C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
- C07D301/12—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with hydrogen peroxide or inorganic peroxides or peracids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/70—Complexes comprising metals of Group VII (VIIB) as the central metal
- B01J2531/72—Manganese
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
La presente invención proporciona nuevos métodos para preparar el compuesto 5, y sales farmacéuticamente aceptables del mismo, de estructura (ver Fórmula). El compuesto 5, o una sal farmacéuticamente aceptable del mismo, es un intermedio importante en la síntesis de carfilzomib. La invención también proporciona métodos para preparar un catalizador de manganeso útil que puede usarse en la etapa de epoxidación de la presente invención.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662371686P | 2016-08-05 | 2016-08-05 | |
US201762536862P | 2017-07-25 | 2017-07-25 | |
PCT/US2017/045274 WO2018027021A1 (en) | 2016-08-05 | 2017-08-03 | Synthesis of (s)-2-amino-4-methyl-1-((r)-2-methyloxirane-2-yl)-pentan-1-one and pharmaceutically acceptable salts thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019001459A true MX2019001459A (es) | 2019-06-20 |
Family
ID=59593230
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019001459A MX2019001459A (es) | 2016-08-05 | 2017-08-03 | Sintesis de (s)-2-amino-4-metil-1-((r)-2-metiloxirano-2-il)-pentan -1-ona y sales farmacuticamente aceptables de la misma. |
Country Status (29)
Country | Link |
---|---|
US (1) | US11708341B2 (es) |
EP (1) | EP3494108B1 (es) |
JP (1) | JP7229912B2 (es) |
KR (1) | KR102482663B1 (es) |
CN (1) | CN109641863B (es) |
AU (1) | AU2017306546B2 (es) |
BR (1) | BR112019002191A2 (es) |
CA (1) | CA3032963A1 (es) |
CL (1) | CL2019000294A1 (es) |
CO (1) | CO2019001139A2 (es) |
CR (1) | CR20190113A (es) |
CY (1) | CY1124363T1 (es) |
DK (1) | DK3494108T3 (es) |
ES (1) | ES2842575T3 (es) |
HU (1) | HUE051980T2 (es) |
IL (1) | IL264549B (es) |
JO (1) | JOP20190016B1 (es) |
LT (1) | LT3494108T (es) |
MX (1) | MX2019001459A (es) |
PE (1) | PE20190404A1 (es) |
PH (1) | PH12019500232A1 (es) |
PL (1) | PL3494108T3 (es) |
PT (1) | PT3494108T (es) |
SG (2) | SG10201912268UA (es) |
SI (1) | SI3494108T1 (es) |
TN (1) | TN2019000028A1 (es) |
UA (1) | UA125648C2 (es) |
WO (1) | WO2018027021A1 (es) |
ZA (1) | ZA201900717B (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114195741A (zh) * | 2021-12-28 | 2022-03-18 | 南京格亚医药科技有限公司 | 一种卡非佐米关键中间体异构体的制备方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7232818B2 (en) | 2004-04-15 | 2007-06-19 | Proteolix, Inc. | Compounds for enzyme inhibition |
AU2005243140A1 (en) | 2004-05-10 | 2005-11-24 | Proteolix, Inc. | Synthesis of amino acid keto-epoxides |
JP2006028154A (ja) | 2004-06-14 | 2006-02-02 | Sumitomo Chemical Co Ltd | 光学活性化合物の製造方法 |
PL2261236T3 (pl) | 2004-12-07 | 2015-12-31 | Onyx Therapeutics Inc | Kompozycja do hamowania proteasomu |
TWI501773B (zh) | 2007-10-04 | 2015-10-01 | Onyx Therapeutics Inc | 結晶肽環氧酮蛋白酶抑制劑以及胺基酸酮環氧化物之合成 |
BRPI0919668A2 (pt) | 2008-10-21 | 2018-05-29 | Onyx Therapeutics, Inc. | terapia de combinação com epóxi-cetonas de peptídeo |
SG194417A1 (en) | 2012-05-08 | 2013-12-30 | Onyx Therapeutics Inc | Cylodextrin complexation methods for formulating peptide proteasome inhibitors |
WO2014011695A2 (en) | 2012-07-09 | 2014-01-16 | Onyx Therapeutics, Inc. | Prodrugs of peptide epoxy ketone protease inhibitors |
AU2013292647B2 (en) | 2012-07-18 | 2018-03-15 | Onyx Therapeutics, Inc. | Liposomal compositions of epoxyketone-based proteasome inhibitors |
DE102013104003B3 (de) | 2013-04-19 | 2014-03-13 | Glatt Systemtechnik Gmbh | Vorrichtung zum Einbringen einer definierten Menge eines zweiten Pulvers in einen Prozessbehälter |
CN104230857A (zh) * | 2014-08-19 | 2014-12-24 | 上海皓元生物医药科技有限公司 | 卡非佐米(Carfilzomib)的中间体化合物的制备方法及其中间体化合物 |
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2017
- 2017-08-03 ES ES17751954T patent/ES2842575T3/es active Active
- 2017-08-03 LT LTEP17751954.3T patent/LT3494108T/lt unknown
- 2017-08-03 PE PE2019000337A patent/PE20190404A1/es unknown
- 2017-08-03 DK DK17751954.3T patent/DK3494108T3/da active
- 2017-08-03 SI SI201730575T patent/SI3494108T1/sl unknown
- 2017-08-03 US US16/327,079 patent/US11708341B2/en active Active
- 2017-08-03 TN TNP/2019/000028A patent/TN2019000028A1/en unknown
- 2017-08-03 SG SG10201912268UA patent/SG10201912268UA/en unknown
- 2017-08-03 JP JP2019506144A patent/JP7229912B2/ja active Active
- 2017-08-03 EP EP17751954.3A patent/EP3494108B1/en active Active
- 2017-08-03 CN CN201780048527.3A patent/CN109641863B/zh active Active
- 2017-08-03 PL PL17751954T patent/PL3494108T3/pl unknown
- 2017-08-03 CR CR20190113A patent/CR20190113A/es unknown
- 2017-08-03 HU HUE17751954A patent/HUE051980T2/hu unknown
- 2017-08-03 JO JOP/2019/0016A patent/JOP20190016B1/ar active
- 2017-08-03 MX MX2019001459A patent/MX2019001459A/es unknown
- 2017-08-03 AU AU2017306546A patent/AU2017306546B2/en active Active
- 2017-08-03 KR KR1020197006357A patent/KR102482663B1/ko active IP Right Grant
- 2017-08-03 UA UAA201902137A patent/UA125648C2/uk unknown
- 2017-08-03 WO PCT/US2017/045274 patent/WO2018027021A1/en unknown
- 2017-08-03 PT PT177519543T patent/PT3494108T/pt unknown
- 2017-08-03 CA CA3032963A patent/CA3032963A1/en active Pending
- 2017-08-03 SG SG11201900991UA patent/SG11201900991UA/en unknown
- 2017-08-03 BR BR112019002191-4A patent/BR112019002191A2/pt active Search and Examination
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2019
- 2019-01-30 IL IL264549A patent/IL264549B/en unknown
- 2019-01-31 PH PH12019500232A patent/PH12019500232A1/en unknown
- 2019-02-04 ZA ZA2019/00717A patent/ZA201900717B/en unknown
- 2019-02-04 CL CL2019000294A patent/CL2019000294A1/es unknown
- 2019-02-07 CO CONC2019/0001139A patent/CO2019001139A2/es unknown
-
2021
- 2021-01-27 CY CY20211100067T patent/CY1124363T1/el unknown
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