JOP20190016B1 - تخليق (اس)-2- أمينو -4- ميثيل -1-((ار)-2- ميثيل أوكسيران -2- يل)- بنتان -1- أون وأملاح مقبولة صيدلانياً منه - Google Patents

تخليق (اس)-2- أمينو -4- ميثيل -1-((ار)-2- ميثيل أوكسيران -2- يل)- بنتان -1- أون وأملاح مقبولة صيدلانياً منه

Info

Publication number
JOP20190016B1
JOP20190016B1 JOP/2019/0016A JOP20190016A JOP20190016B1 JO P20190016 B1 JOP20190016 B1 JO P20190016B1 JO P20190016 A JOP20190016 A JO P20190016A JO P20190016 B1 JOP20190016 B1 JO P20190016B1
Authority
JO
Jordan
Prior art keywords
pharmaceutically acceptable
synthesis
acceptable salts
methyloxirane
pentan
Prior art date
Application number
JOP/2019/0016A
Other languages
English (en)
Inventor
Xianqing Shi
Sheng Cui
Matthew Beaver
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of JOP20190016A1 publication Critical patent/JOP20190016A1/ar
Application granted granted Critical
Publication of JOP20190016B1 publication Critical patent/JOP20190016B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
    • C07D301/12—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with hydrogen peroxide or inorganic peroxides or peracids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/1616—Coordination complexes, e.g. organometallic complexes, immobilised on an inorganic support, e.g. ship-in-a-bottle type catalysts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/70—Complexes comprising metals of Group VII (VIIB) as the central metal
    • B01J2531/72—Manganese

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epoxy Compounds (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

يتعلق الاختراع الحالي بتقديم طرق جديدة لتحضير المركب 5، وأملاح مقبولة صيدلانياً منه، بالبنية. صورة المركب 5 يكون المركب 5، أو ملح مقبول صيدلانياً منه، عبارة عن مركب وسيط مهم في تخليق الكارفيلزوميب. يقدم الاختراع أيضاً طرق لتحضير محفز منجنيز مفيد يمكن استخدامه في خطوة إدخال الإيبوكسيد وفقاً للاختراع الحالي.
JOP/2019/0016A 2016-08-05 2017-08-03 تخليق (اس)-2- أمينو -4- ميثيل -1-((ار)-2- ميثيل أوكسيران -2- يل)- بنتان -1- أون وأملاح مقبولة صيدلانياً منه JOP20190016B1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662371686P 2016-08-05 2016-08-05
US201762536862P 2017-07-25 2017-07-25
PCT/US2017/045274 WO2018027021A1 (en) 2016-08-05 2017-08-03 Synthesis of (s)-2-amino-4-methyl-1-((r)-2-methyloxirane-2-yl)-pentan-1-one and pharmaceutically acceptable salts thereof

Publications (2)

Publication Number Publication Date
JOP20190016A1 JOP20190016A1 (ar) 2019-02-04
JOP20190016B1 true JOP20190016B1 (ar) 2023-03-28

Family

ID=59593230

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2019/0016A JOP20190016B1 (ar) 2016-08-05 2017-08-03 تخليق (اس)-2- أمينو -4- ميثيل -1-((ار)-2- ميثيل أوكسيران -2- يل)- بنتان -1- أون وأملاح مقبولة صيدلانياً منه

Country Status (29)

Country Link
US (1) US11708341B2 (ar)
EP (1) EP3494108B1 (ar)
JP (1) JP7229912B2 (ar)
KR (1) KR102482663B1 (ar)
CN (1) CN109641863B (ar)
AU (1) AU2017306546B2 (ar)
BR (1) BR112019002191A2 (ar)
CA (1) CA3032963A1 (ar)
CL (1) CL2019000294A1 (ar)
CO (1) CO2019001139A2 (ar)
CR (1) CR20190113A (ar)
CY (1) CY1124363T1 (ar)
DK (1) DK3494108T3 (ar)
ES (1) ES2842575T3 (ar)
HU (1) HUE051980T2 (ar)
IL (1) IL264549B (ar)
JO (1) JOP20190016B1 (ar)
LT (1) LT3494108T (ar)
MX (1) MX2019001459A (ar)
PE (1) PE20190404A1 (ar)
PH (1) PH12019500232A1 (ar)
PL (1) PL3494108T3 (ar)
PT (1) PT3494108T (ar)
SG (2) SG10201912268UA (ar)
SI (1) SI3494108T1 (ar)
TN (1) TN2019000028A1 (ar)
UA (1) UA125648C2 (ar)
WO (1) WO2018027021A1 (ar)
ZA (1) ZA201900717B (ar)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114195741A (zh) * 2021-12-28 2022-03-18 南京格亚医药科技有限公司 一种卡非佐米关键中间体异构体的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7232818B2 (en) 2004-04-15 2007-06-19 Proteolix, Inc. Compounds for enzyme inhibition
WO2005111009A2 (en) 2004-05-10 2005-11-24 Proteolix, Inc. Synthesis of amino acid keto-epoxides
JP2006028154A (ja) 2004-06-14 2006-02-02 Sumitomo Chemical Co Ltd 光学活性化合物の製造方法
ATE499109T1 (de) 2004-12-07 2011-03-15 Proteolix Inc Zusammensetzung zur proteasomhemmung
US8367617B2 (en) * 2007-10-04 2013-02-05 Onyx Therapeutics, Inc. Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides
EP3090737A1 (en) 2008-10-21 2016-11-09 Onyx Therapeutics, Inc. Combination therapy with peptide epoxyketones
AU2012238318B2 (en) 2012-05-08 2014-02-13 Onyx Therapeutics, Inc. Cyclodextrin complexation methods for formulating peptide proteasome inhibitors
TW201414751A (zh) 2012-07-09 2014-04-16 歐尼克斯治療公司 肽環氧酮蛋白酶抑制劑之前驅藥物
JP2015524411A (ja) 2012-07-18 2015-08-24 オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． エポキシケトン系プロテアソーム阻害剤のリポソーム組成物
DE102013104003B3 (de) 2013-04-19 2014-03-13 Glatt Systemtechnik Gmbh Vorrichtung zum Einbringen einer definierten Menge eines zweiten Pulvers in einen Prozessbehälter
CN104230857A (zh) 2014-08-19 2014-12-24 上海皓元生物医药科技有限公司 卡非佐米(Carfilzomib)的中间体化合物的制备方法及其中间体化合物

Also Published As

Publication number Publication date
WO2018027021A1 (en) 2018-02-08
EP3494108B1 (en) 2020-10-28
JP2019525945A (ja) 2019-09-12
UA125648C2 (uk) 2022-05-11
PE20190404A1 (es) 2019-03-13
CA3032963A1 (en) 2018-02-08
SG11201900991UA (en) 2019-03-28
AU2017306546A1 (en) 2019-02-21
PT3494108T (pt) 2021-01-05
KR102482663B1 (ko) 2022-12-29
PL3494108T3 (pl) 2021-04-19
JP7229912B2 (ja) 2023-02-28
KR20190039184A (ko) 2019-04-10
CY1124363T1 (el) 2022-07-22
ES2842575T3 (es) 2021-07-14
CL2019000294A1 (es) 2019-05-03
DK3494108T3 (da) 2021-01-11
CO2019001139A2 (es) 2019-02-19
US20210284617A1 (en) 2021-09-16
BR112019002191A2 (pt) 2019-05-21
CN109641863A (zh) 2019-04-16
IL264549B (en) 2022-02-01
SI3494108T1 (sl) 2021-02-26
LT3494108T (lt) 2021-01-25
MX2019001459A (es) 2019-06-20
ZA201900717B (en) 2023-06-28
PH12019500232A1 (en) 2019-10-21
US11708341B2 (en) 2023-07-25
JOP20190016A1 (ar) 2019-02-04
AU2017306546B2 (en) 2021-10-21
CR20190113A (es) 2019-04-25
CN109641863B (zh) 2023-10-20
SG10201912268UA (en) 2020-02-27
HUE051980T2 (hu) 2021-04-28
TN2019000028A1 (en) 2020-07-15
EP3494108A1 (en) 2019-06-12

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