JO3552B1 - عملية لإنتاج محلول نورادرينالين ذو تركيز منخفض مستقر قابل للحقن - Google Patents

عملية لإنتاج محلول نورادرينالين ذو تركيز منخفض مستقر قابل للحقن

Info

Publication number
JO3552B1
JO3552B1 JOP/2015/0031A JOP20150031A JO3552B1 JO 3552 B1 JO3552 B1 JO 3552B1 JO P20150031 A JOP20150031 A JO P20150031A JO 3552 B1 JO3552 B1 JO 3552B1
Authority
JO
Jordan
Prior art keywords
noradrenaline
solution
production
stable low
stable
Prior art date
Application number
JOP/2015/0031A
Other languages
English (en)
Inventor
Caronzolo Nicola
Donati Elisabetta
Mitidieri Augusto
Original Assignee
Sintetica S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50693780&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3552(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sintetica S A filed Critical Sintetica S A
Application granted granted Critical
Publication of JO3552B1 publication Critical patent/JO3552B1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

في أحد الجوانب، يتعلق الاختراع الحالي إلى عملية لإنتاج محلول قابل للحقن ثابت مع محتوى منخفض من النورادرينالين، الذي يشتمل على تذويب النورادرينالين ويفضل أي مسوغ في مياه غير مؤكسدة أو مفرغ الغاز، وترشيح محلول النورادرينالين الناتج في محتوى غاز النيتروجين، وتوزيع المحلول في محتوى غاز النيتروجين والتعقيم ويفضل التسخين. كما يقدم الاختراع محلول قابل للحقن ثابت بمحتوى منخفض من النُورْأَدْرِنالين، حر بشكل كبير من العوامل مضاد الأكسدة والمواد الحافظة وكذلك استخدامها في المجالات الطبية والصيدلانية.
JOP/2015/0031A 2014-02-27 2015-02-12 عملية لإنتاج محلول نورادرينالين ذو تركيز منخفض مستقر قابل للحقن JO3552B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI20140306 2014-02-27

Publications (1)

Publication Number Publication Date
JO3552B1 true JO3552B1 (ar) 2020-07-05

Family

ID=50693780

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2015/0031A JO3552B1 (ar) 2014-02-27 2015-02-12 عملية لإنتاج محلول نورادرينالين ذو تركيز منخفض مستقر قابل للحقن

Country Status (43)

Country Link
US (4) USRE49422E1 (ar)
EP (1) EP3110399B1 (ar)
JP (1) JP6635927B2 (ar)
KR (1) KR102306706B1 (ar)
CN (1) CN106061467B (ar)
AP (1) AP2016009467A0 (ar)
AR (1) AR101148A1 (ar)
AU (1) AU2015222150B2 (ar)
BR (1) BR112016019804B1 (ar)
CA (1) CA2940347C (ar)
CL (1) CL2016002073A1 (ar)
CR (1) CR20160420A (ar)
CY (1) CY1120125T1 (ar)
DK (1) DK3110399T3 (ar)
DO (1) DOP2016000210A (ar)
EA (1) EA031444B1 (ar)
EC (1) ECSP16065957A (ar)
ES (1) ES2663817T3 (ar)
GE (1) GEP20186829B (ar)
HR (1) HRP20180541T1 (ar)
HU (1) HUE038738T2 (ar)
IL (1) IL247501B (ar)
JO (1) JO3552B1 (ar)
LT (1) LT3110399T (ar)
MA (1) MA39200A1 (ar)
MD (1) MD4628C1 (ar)
ME (1) ME03004B (ar)
MX (1) MX367148B (ar)
MY (1) MY179942A (ar)
NI (1) NI201600118A (ar)
PE (1) PE20161375A1 (ar)
PH (1) PH12016501703B1 (ar)
PL (1) PL3110399T3 (ar)
PT (1) PT3110399T (ar)
RS (1) RS57044B1 (ar)
SG (1) SG11201607094WA (ar)
SI (1) SI3110399T1 (ar)
SM (1) SMT201800239T1 (ar)
SV (1) SV2016005265A (ar)
TW (1) TWI673065B (ar)
UA (1) UA118043C2 (ar)
UY (1) UY35988A (ar)
WO (1) WO2015128418A1 (ar)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY35988A (es) 2014-02-27 2015-09-30 Sint Sa Proceso para la producción de una solución inyectable de noradrenalina de baja concentración
PL2990031T3 (pl) 2014-08-28 2020-05-18 Sun Pharmaceutical Industries Ltd Pozajelitowa postać norepinefryny
CA3051467C (en) 2017-01-30 2022-11-29 Nevakar, Inc Norepinephrine compositions and methods therefor
US20250177328A1 (en) 2017-01-30 2025-06-05 Nevakar Injectables Inc. Norepinephrine compositions and methods therefor
CN109394683A (zh) * 2018-12-07 2019-03-01 远大医药（中国）有限公司 一种重酒石酸去甲肾上腺素注射液的制备方法
US10888534B2 (en) * 2019-04-26 2021-01-12 InfoRLife SA Storage stable ready-to-use norepinephrine aqueous solutions in flexible plastic bags
CA3174640A1 (en) * 2020-03-06 2021-09-10 Baxter International Inc. Packaged, sealed container system for stable storage of an oxygen sensitive pharmaceutical formulation
PL4051251T3 (pl) * 2020-10-21 2024-04-08 Sintetica S.A. Stabilne, wolne od antyoksydantów roztwory noradrenaliny do wstrzykiwania
US20220117843A1 (en) * 2020-10-21 2022-04-21 Sintetica S.A. Ready to use, noradrenaline drip bags, having low subvisible particle counts
US11331266B1 (en) * 2020-10-29 2022-05-17 Medefil, Inc. Antioxidant free, norepinephrine bitartrate injection in amber glass vials
US20220233473A1 (en) * 2021-01-28 2022-07-28 Cumberland Pharmaceuticals Inc. Injectable solution of norepinephrine
AR124867A1 (es) 2021-02-15 2023-05-10 Sintetica S A Un medicamento en una bolsa de goteo intravenoso plegable lista para usar herméticamente sellada, método para hacer dicho medicamento y medicamento elaborado mediante dicho método
CN116327697A (zh) * 2023-04-17 2023-06-27 福安药业集团庆余堂制药有限公司 一种重酒石酸去甲肾上腺素注射液及其制剂工艺

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BR0311965A (pt) 2002-06-20 2005-03-29 Novalar Pharmaceutical Inc Formulações estabilizadas de antagonistas de receptores alfa adrenérgicos e os seus usos
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FR2963237B1 (fr) 2010-07-28 2013-05-17 Aguettant Lab Nouvelle composition pharmaceutique utile pour prevenir ou traiter l'hypotension arterielle peroperatoire chez l'etre humain
CN102525895B (zh) 2012-01-04 2013-11-06 上海禾丰制药有限公司 重酒石酸去甲肾上腺素注射液及其制剂工艺
UY35988A (es) 2014-02-27 2015-09-30 Sint Sa Proceso para la producción de una solución inyectable de noradrenalina de baja concentración
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CA3051467C (en) 2017-01-30 2022-11-29 Nevakar, Inc Norepinephrine compositions and methods therefor

Also Published As

Publication number Publication date
US20170049720A1 (en) 2017-02-23
PL3110399T3 (pl) 2018-07-31
KR102306706B1 (ko) 2021-09-30
DOP2016000210A (es) 2016-11-30
AR101148A1 (es) 2016-11-30
USRE49443E1 (en) 2023-03-07
TWI673065B (zh) 2019-10-01
ECSP16065957A (es) 2017-01-31
MD4628B1 (ro) 2019-05-31
EP3110399A1 (en) 2017-01-04
MA39200A1 (fr) 2017-06-30
HUE038738T2 (hu) 2018-11-28
CL2016002073A1 (es) 2017-02-10
EA201691734A1 (ru) 2016-12-30
EA031444B1 (ru) 2019-01-31
USRE49555E1 (en) 2023-06-20
LT3110399T (lt) 2018-04-25
GEP20186829B (en) 2018-02-26
SMT201800239T1 (it) 2018-07-17
MY179942A (en) 2020-11-19
PH12016501703B1 (en) 2019-08-23
CN106061467B (zh) 2021-02-05
BR112016019804A2 (ar) 2017-08-15
AU2015222150A1 (en) 2016-10-13
CA2940347C (en) 2021-04-27
ME03004B (me) 2018-10-20
MD4628C1 (ro) 2019-12-31
JP2017506632A (ja) 2017-03-09
AP2016009467A0 (en) 2016-09-30
CN106061467A (zh) 2016-10-26
CA2940347A1 (en) 2015-09-03
WO2015128418A1 (en) 2015-09-03
SV2016005265A (es) 2017-01-18
US10251848B2 (en) 2019-04-09
MX2016011148A (es) 2016-12-09
PH12016501703A1 (en) 2016-12-19
MX367148B (es) 2019-08-07
KR20160122264A (ko) 2016-10-21
BR112016019804B1 (pt) 2022-03-03
EP3110399B1 (en) 2018-01-10
ES2663817T3 (es) 2018-04-17
SG11201607094WA (en) 2016-09-29
JP6635927B2 (ja) 2020-01-29
SI3110399T1 (en) 2018-05-31
AU2015222150B2 (en) 2019-12-05
HRP20180541T1 (hr) 2018-05-04
CR20160420A (es) 2016-12-14
RS57044B1 (sr) 2018-05-31
DK3110399T3 (en) 2018-04-09
MD20160103A2 (ro) 2017-01-31
UY35988A (es) 2015-09-30
TW201620499A (zh) 2016-06-16
UA118043C2 (uk) 2018-11-12
CY1120125T1 (el) 2018-12-12
PE20161375A1 (es) 2017-01-05
IL247501A0 (en) 2016-11-30
IL247501B (en) 2020-05-31
NI201600118A (es) 2016-10-03
USRE49422E1 (en) 2023-02-21
PT3110399T (pt) 2018-04-19

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