MA39200A1 - Procédé de fabrication d'une solution injectable stable de noradrénaline à faible concentration - Google Patents
Procédé de fabrication d'une solution injectable stable de noradrénaline à faible concentrationInfo
- Publication number
- MA39200A1 MA39200A1 MA39200A MA39200A MA39200A1 MA 39200 A1 MA39200 A1 MA 39200A1 MA 39200 A MA39200 A MA 39200A MA 39200 A MA39200 A MA 39200A MA 39200 A1 MA39200 A1 MA 39200A1
- Authority
- MA
- Morocco
- Prior art keywords
- noradrenaline
- producing
- solution
- injectable solution
- stable low
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0023—Heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Dans un premier aspect, la présente invention concerne un procédé de production d'une solution injectable, stable à faible teneur en noradrénaline, qui comprend la dissolution de la noradrénaline et facultativement d'un excipient dans de l'eau désoxygénée ou dégazée, la filtration de la solution résultante de noradrénaline dans un courant d'azote, la répartition de la solution dans un courant d'azote, et la stérilisation, de préférence à chaud. L'invention concerne en outre une solution injectable, stable à faible teneur en noradrénaline, sensiblement exempte d'anti-oxydant et d'agents de conservation, ainsi que ses utilisations dans les domaines médical et pharmaceutique.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI20140306 | 2014-02-27 | ||
PCT/EP2015/054021 WO2015128418A1 (fr) | 2014-02-27 | 2015-02-26 | Procédé de fabrication d'une solution injectable stable de noradrénaline à faible concentration |
Publications (1)
Publication Number | Publication Date |
---|---|
MA39200A1 true MA39200A1 (fr) | 2017-06-30 |
Family
ID=50693780
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA39200A MA39200A1 (fr) | 2014-02-27 | 2015-02-26 | Procédé de fabrication d'une solution injectable stable de noradrénaline à faible concentration |
Country Status (41)
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UY35988A (es) | 2014-02-27 | 2015-09-30 | Sint Sa | Proceso para la producción de una solución inyectable de noradrenalina de baja concentración |
EP2990031B1 (fr) | 2014-08-28 | 2019-11-13 | Sun Pharmaceutical Industries Ltd | Forme de dosage parentéral de la norépinéphrine |
CA3051467C (fr) | 2017-01-30 | 2022-11-29 | Nevakar, Inc | Compositions de norepinephrine et procedes associes |
CN109394683A (zh) * | 2018-12-07 | 2019-03-01 | 远大医药(中国)有限公司 | 一种重酒石酸去甲肾上腺素注射液的制备方法 |
US10888534B2 (en) * | 2019-04-26 | 2021-01-12 | InfoRLife SA | Storage stable ready-to-use norepinephrine aqueous solutions in flexible plastic bags |
EP4114336A1 (fr) * | 2020-03-06 | 2023-01-11 | Baxter International Inc. | Système de récipient scellé conditionné de stockage stable de formulation pharmaceutique sensible à l'oxygène |
WO2022084775A1 (fr) * | 2020-10-21 | 2022-04-28 | Sintetica S.A. | Poches de perfusion prêtes à l'emploi, à faible nombre de particules subvisibles |
ES2959036T3 (es) | 2020-10-21 | 2024-02-19 | Sintetica S A | Soluciones inyectables estables de noradrenalina libres de antioxidantes |
US11331266B1 (en) * | 2020-10-29 | 2022-05-17 | Medefil, Inc. | Antioxidant free, norepinephrine bitartrate injection in amber glass vials |
US20220233473A1 (en) * | 2021-01-28 | 2022-07-28 | Cumberland Pharmaceuticals Inc. | Injectable solution of norepinephrine |
AR124867A1 (es) | 2021-02-15 | 2023-05-10 | Sintetica S A | Un medicamento en una bolsa de goteo intravenoso plegable lista para usar herméticamente sellada, método para hacer dicho medicamento y medicamento elaborado mediante dicho método |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2809619B1 (fr) * | 2000-06-06 | 2004-09-24 | Pharmatop | Nouvelles formulations aqueuses de principes actifs sensibles a l'oxydation et leur procede d'obtention |
FR2832063B1 (fr) * | 2001-11-15 | 2004-08-27 | Aguettant Lab | Procede de production de solutions stables de substances phenoliques et les solutions en resultant |
BRPI0311965B1 (pt) | 2002-06-20 | 2018-04-24 | Septodont Holding Sas | Formulação líquida estável e seu uso para aumentar fluxo sanguíneo em mamífero, método de preparação de forma de dosagem única de formulação líquida estável, bem como recipiente e kit |
US20040005401A1 (en) | 2002-07-05 | 2004-01-08 | Robert Becker | Method for applying a washcoat to suppport bodies |
US7078876B2 (en) | 2003-07-07 | 2006-07-18 | Pentadyne Power Corporation | Feedforward controller for synchronous reluctance machines |
FR2880807B1 (fr) * | 2005-01-19 | 2007-04-13 | Aguettant Sa Lab | Composition pharmaceutique injectable |
US7465489B2 (en) | 2005-11-15 | 2008-12-16 | Poly-Med, Inc. | Inorganic-organic melted-extruded hybrid filaments and medical applications thereof |
FR2894154B1 (fr) | 2005-12-06 | 2008-03-14 | Pharmatop Scr | Nouveau procede de stabilisation de substances minerales ou organiques sensibles a l'oxydation. |
EP2096433A1 (fr) | 2008-02-26 | 2009-09-02 | Siemens Aktiengesellschaft | Dispositif de contrôle non destructif de matériau d'un objet de test à l'aide d'ondes à ultrasons |
US8419689B2 (en) | 2008-09-30 | 2013-04-16 | Covidien Lp | Enclosing package for medical port and cover |
US8628805B2 (en) | 2009-06-04 | 2014-01-14 | Alk Ag | Stabilized composition comprising at least one adrenergic compound |
ES2432241T3 (es) * | 2009-06-04 | 2013-12-02 | Alk Ag | Composición estabilizada que comprende al menos un compuesto adrenérgico |
FR2963237B1 (fr) | 2010-07-28 | 2013-05-17 | Aguettant Lab | Nouvelle composition pharmaceutique utile pour prevenir ou traiter l'hypotension arterielle peroperatoire chez l'etre humain |
CN102525895B (zh) | 2012-01-04 | 2013-11-06 | 上海禾丰制药有限公司 | 重酒石酸去甲肾上腺素注射液及其制剂工艺 |
UY35988A (es) | 2014-02-27 | 2015-09-30 | Sint Sa | Proceso para la producción de una solución inyectable de noradrenalina de baja concentración |
US20160005871A1 (en) * | 2014-07-04 | 2016-01-07 | Semiconductor Energy Laboratory Co., Ltd. | Semiconductor device |
CA3051467C (fr) | 2017-01-30 | 2022-11-29 | Nevakar, Inc | Compositions de norepinephrine et procedes associes |
-
2015
- 2015-02-10 UY UY0001035988A patent/UY35988A/es unknown
- 2015-02-12 JO JOP/2015/0031A patent/JO3552B1/ar active
- 2015-02-13 AR ARP150100456A patent/AR101148A1/es not_active Application Discontinuation
- 2015-02-24 TW TW104105762A patent/TWI673065B/zh not_active IP Right Cessation
- 2015-02-26 CA CA2940347A patent/CA2940347C/fr active Active
- 2015-02-26 HU HUE15712064A patent/HUE038738T2/hu unknown
- 2015-02-26 WO PCT/EP2015/054021 patent/WO2015128418A1/fr active Application Filing
- 2015-02-26 ME MEP-2018-88A patent/ME03004B/fr unknown
- 2015-02-26 US US17/006,841 patent/USRE49555E1/en active Active
- 2015-02-26 KR KR1020167026245A patent/KR102306706B1/ko active IP Right Grant
- 2015-02-26 EA EA201691734A patent/EA031444B1/ru unknown
- 2015-02-26 PL PL15712064T patent/PL3110399T3/pl unknown
- 2015-02-26 PE PE2016001537A patent/PE20161375A1/es unknown
- 2015-02-26 EP EP15712064.3A patent/EP3110399B1/fr active Active
- 2015-02-26 MA MA39200A patent/MA39200A1/fr unknown
- 2015-02-26 MY MYPI2016703113A patent/MY179942A/en unknown
- 2015-02-26 CR CR20160420A patent/CR20160420A/es unknown
- 2015-02-26 ES ES15712064.3T patent/ES2663817T3/es active Active
- 2015-02-26 US US17/006,838 patent/USRE49443E1/en active Active
- 2015-02-26 MD MDA20160103A patent/MD4628C1/ro not_active IP Right Cessation
- 2015-02-26 UA UAA201609379A patent/UA118043C2/uk unknown
- 2015-02-26 PT PT157120643T patent/PT3110399T/pt unknown
- 2015-02-26 SG SG11201607094WA patent/SG11201607094WA/en unknown
- 2015-02-26 SI SI201530205T patent/SI3110399T1/en unknown
- 2015-02-26 LT LTEP15712064.3T patent/LT3110399T/lt unknown
- 2015-02-26 US US15/118,864 patent/US10251848B2/en not_active Ceased
- 2015-02-26 DK DK15712064.3T patent/DK3110399T3/en active
- 2015-02-26 AP AP2016009467A patent/AP2016009467A0/en unknown
- 2015-02-26 BR BR112016019804-2A patent/BR112016019804B1/pt active IP Right Grant
- 2015-02-26 AU AU2015222150A patent/AU2015222150B2/en active Active
- 2015-02-26 US US17/006,840 patent/USRE49422E1/en active Active
- 2015-02-26 MX MX2016011148A patent/MX367148B/es active IP Right Grant
- 2015-02-26 CN CN201580010039.4A patent/CN106061467B/zh active Active
- 2015-02-26 JP JP2016551222A patent/JP6635927B2/ja active Active
- 2015-02-26 RS RS20180352A patent/RS57044B1/sr unknown
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2016
- 2016-08-08 EC ECIEPI201665957A patent/ECSP16065957A/es unknown
- 2016-08-12 DO DO2016000210A patent/DOP2016000210A/es unknown
- 2016-08-17 CL CL2016002073A patent/CL2016002073A1/es unknown
- 2016-08-18 NI NI201600118A patent/NI201600118A/es unknown
- 2016-08-25 IL IL247501A patent/IL247501B/en active IP Right Grant
- 2016-08-26 PH PH12016501703A patent/PH12016501703B1/en unknown
- 2016-08-26 SV SV2016005265A patent/SV2016005265A/es unknown
-
2018
- 2018-04-04 HR HRP20180541TT patent/HRP20180541T1/hr unknown
- 2018-04-05 CY CY20181100385T patent/CY1120125T1/el unknown
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