EA201992832A1 - Подкожное введение adamts13 - Google Patents

Подкожное введение adamts13

Info

Publication number
EA201992832A1
EA201992832A1 EA201992832A EA201992832A EA201992832A1 EA 201992832 A1 EA201992832 A1 EA 201992832A1 EA 201992832 A EA201992832 A EA 201992832A EA 201992832 A EA201992832 A EA 201992832A EA 201992832 A1 EA201992832 A1 EA 201992832A1
Authority
EA
Eurasian Patent Office
Prior art keywords
adamts13
scream
introduction
formulations
introduction adamts13
Prior art date
Application number
EA201992832A
Other languages
English (en)
Inventor
Александра Натали Копик
Вернер Хелльригль
Барбара Плаймауэр
Ханспетер Роттенштайнер
Ева-Мария Мухич
Original Assignee
Баксалта Инкорпорейтед
Баксалта Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Баксалта Инкорпорейтед, Баксалта Гмбх filed Critical Баксалта Инкорпорейтед
Publication of EA201992832A1 publication Critical patent/EA201992832A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24087—ADAMTS13 endopeptidase (3.4.24.87)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Настоящее изобретение относится к способам подкожного введения составов ADAMTS13 для лечения заболевания или состояния, ассоциированного с дисфункцией ADAMTS13 и ФВ. Кроме того, в настоящем документе представлены доказательства неожиданно высокой биодоступности составов ADAMTS13 для подкожного введения.
EA201992832A 2013-03-15 2014-03-13 Подкожное введение adamts13 EA201992832A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361794659P 2013-03-15 2013-03-15

Publications (1)

Publication Number Publication Date
EA201992832A1 true EA201992832A1 (ru) 2020-05-31

Family

ID=50549463

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201591758A EA034546B1 (ru) 2013-03-15 2014-03-13 Способ лечения заболевания, связанного с расстройством системы свертывания крови и способ лечения эпизода кровотечения у млекопитающего
EA201992832A EA201992832A1 (ru) 2013-03-15 2014-03-13 Подкожное введение adamts13

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201591758A EA034546B1 (ru) 2013-03-15 2014-03-13 Способ лечения заболевания, связанного с расстройством системы свертывания крови и способ лечения эпизода кровотечения у млекопитающего

Country Status (19)

Country Link
US (4) US9611467B2 (ru)
EP (2) EP2968483B1 (ru)
JP (4) JP6484216B2 (ru)
KR (5) KR102102087B1 (ru)
CN (2) CN114259558A (ru)
AU (5) AU2013203062C1 (ru)
BR (1) BR112015023542A8 (ru)
CA (1) CA2905058A1 (ru)
DK (1) DK2968483T3 (ru)
EA (2) EA034546B1 (ru)
ES (1) ES2906550T3 (ru)
HK (1) HK1220131A1 (ru)
IL (3) IL241305B (ru)
MX (2) MX2015012783A (ru)
PL (1) PL2968483T3 (ru)
PT (1) PT2968483T (ru)
SG (3) SG10202001227QA (ru)
TW (4) TWI786563B (ru)
WO (1) WO2014151968A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013203062C1 (en) 2013-03-15 2018-06-28 Takeda Pharmaceutical Company Limited Subcutaneous administration of adamts13
GB201510870D0 (en) * 2015-05-26 2015-08-05 Baxalta Inc And Katholieke Universiteit Leuven And Baxalta Gmbh Treatment of infarction
CN116159130A (zh) 2016-08-04 2023-05-26 武田药品工业株式会社 使用adamts13治疗、改善和/或预防镰状细胞病、急性肺损伤和/或急性呼吸窘迫综合征中的血管阻塞危象
WO2020214033A1 (en) * 2019-04-17 2020-10-22 Erasmus University Medical Center Rotterdam Papain-like cysteine peptidase medicaments and uses thereof
WO2021198781A2 (en) 2020-04-02 2021-10-07 Takeda Pharmaceutical Company Limited Adamts13 variant, compositions, and uses thereof
CN115835904A (zh) 2020-05-22 2023-03-21 武田药品工业有限公司 用于治疗和诊断冠状病毒疾病并发症的adamts13组合物和方法
MX2023005661A (es) * 2020-11-18 2023-05-26 Green Cross Corp Variante de adamts13 que tiene actividad o velocidad de escape incrementada contra un autoanticuerpo.
GB202102208D0 (en) * 2021-02-17 2021-03-31 Univ Manchester Adamts13 variant

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL113010A0 (en) 1994-03-31 1995-10-31 Pharmacia Ab Pharmaceutical formulation comprising factor VIII or factor ix with an activity of at least 200 IU/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration
US6926894B2 (en) 2000-11-22 2005-08-09 Baxter Aktiengesellschaft Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV
US7037658B2 (en) * 2001-08-16 2006-05-02 Regents Of University Of Michigan Methods and compositions for detecting variant ADAMTS13 genes
US7763430B2 (en) 2003-04-22 2010-07-27 Baxter International Inc. Diagnostic assay for anti-von Willebrand Factor cleaving protease (ADAMTS13) antibodies
ES2382104T3 (es) * 2005-06-17 2012-06-05 Baxter International Inc. Composiciones con actividad trombolítica que comprenden ADAMTS13
JP2009539757A (ja) * 2006-06-16 2009-11-19 バクスター・インターナショナル・インコーポレイテッド 血栓溶解活性を有するａｄａｍｔｓ１３含有組成物
WO2009140140A1 (en) * 2008-05-12 2009-11-19 Immune Disease Institute Von willebrand factor (vwf) inhibitors for treatment or prevention of infarction
US20120148557A1 (en) * 2009-08-20 2012-06-14 Ulrich Kronthaler Albumin fused coagulation factors for non-intravenous administration in the therapy and prophylactic treatment of bleeding disorders
DK3167897T3 (da) * 2009-09-21 2021-04-19 Baxalta GmbH Stabiliserede væskeformige og lyofiliserede adamts13-formuleringer
ES2761692T5 (es) * 2010-07-08 2023-07-05 Takeda Pharmaceuticals Co Método de producción de vWF recombinante de alto peso molecular en cultivo celular
AU2013203062C1 (en) 2013-03-15 2018-06-28 Takeda Pharmaceutical Company Limited Subcutaneous administration of adamts13

Also Published As

Publication number Publication date
CA2905058A1 (en) 2014-09-25
EA034546B1 (ru) 2020-02-19
KR20210021107A (ko) 2021-02-24
KR102365936B1 (ko) 2022-02-23
KR20190022926A (ko) 2019-03-06
AU2016231547B2 (en) 2018-03-15
AU2018203665A1 (en) 2018-06-14
TW202017591A (zh) 2020-05-16
BR112015023542A8 (pt) 2019-12-03
JP7238088B2 (ja) 2023-03-13
US20170224785A1 (en) 2017-08-10
IL290486B1 (en) 2023-04-01
PL2968483T3 (pl) 2022-04-04
EP2968483A1 (en) 2016-01-20
KR20160016756A (ko) 2016-02-15
US11779635B2 (en) 2023-10-10
KR102218489B1 (ko) 2021-02-22
KR102102087B1 (ko) 2020-04-20
TWI690326B (zh) 2020-04-11
IL273365A (en) 2020-05-31
AU2020202738B2 (en) 2022-06-09
IL241305A0 (en) 2015-11-30
ES2906550T3 (es) 2022-04-19
EA201591758A8 (ru) 2017-03-31
NZ751610A (en) 2020-11-27
BR112015023542A2 (pt) 2017-07-18
AU2022211908B2 (en) 2023-11-30
CN105407912A (zh) 2016-03-16
IL241305B (en) 2020-04-30
JP2023071821A (ja) 2023-05-23
TW202138003A (zh) 2021-10-16
AU2013203062C1 (en) 2018-06-28
EA201591758A1 (ru) 2016-03-31
AU2018203665B2 (en) 2020-01-30
US10413600B2 (en) 2019-09-17
JP6484216B2 (ja) 2019-03-13
DK2968483T3 (da) 2022-02-14
SG10202001227QA (en) 2020-03-30
MX2021002513A (es) 2021-04-28
SG11201507271QA (en) 2015-10-29
WO2014151968A1 (en) 2014-09-25
TWI740207B (zh) 2021-09-21
EP2968483B1 (en) 2021-12-01
US11185575B2 (en) 2021-11-30
KR102513872B1 (ko) 2023-03-27
AU2022211908A1 (en) 2022-09-01
EP3960196A1 (en) 2022-03-02
NZ712440A (en) 2020-11-27
TW202313664A (zh) 2023-04-01
JP6998333B2 (ja) 2022-02-10
AU2013203062A1 (en) 2014-10-02
MX2015012783A (es) 2016-04-28
JP2019142850A (ja) 2019-08-29
AU2013203062B2 (en) 2016-06-23
IL290486A (en) 2022-04-01
US20200101144A1 (en) 2020-04-02
IL273365B (en) 2022-05-01
TW201513881A (zh) 2015-04-16
US9611467B2 (en) 2017-04-04
NZ749570A (en) 2020-11-27
JP2022027991A (ja) 2022-02-14
KR20220027266A (ko) 2022-03-07
HK1220131A1 (zh) 2017-04-28
IL290486B2 (en) 2023-08-01
AU2016231547A1 (en) 2016-10-06
US20220080032A1 (en) 2022-03-17
US20140271611A1 (en) 2014-09-18
PT2968483T (pt) 2022-02-23
CN114259558A (zh) 2022-04-01
SG10201707074TA (en) 2017-10-30
KR20200041394A (ko) 2020-04-21
TWI786563B (zh) 2022-12-11
AU2020202738A1 (en) 2020-05-14
JP2016517421A (ja) 2016-06-16
WO2014151968A8 (en) 2015-10-15

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